LOCUS       NM_011237               2046 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus RAD9 checkpoint clamp component A (Rad9a), mRNA.
ACCESSION   NM_011237
VERSION     NM_011237.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2046)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2046)
  AUTHORS   Akagawa,R., Nabeshima,Y.I. and Kawauchi,T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2046)
  AUTHORS   Jiang,D., Burger,C.A., Casasent,A.K., Albrecht,N.E., Li,F. and
            Samuel,M.A.
  TITLE     Spatiotemporal gene expression patterns reveal molecular
            relatedness between retinal laminae
  JOURNAL   J Comp Neurol 528 (5), 729-755 (2020)
   PUBMED   31609468
REFERENCE   4  (bases 1 to 2046)
  AUTHORS   Huang,L., Meng,T.G., Ma,X.S., Wang,Z.B., Qi,S.T., Chen,Q.,
            Zhang,Q.H., Liang,Q.X., Wang,Z.W., Hu,M.W., Guo,L., Ouyang,Y.C.,
            Hou,Y., Zhao,Y. and Sun,Q.Y.
  TITLE     Rad9a is involved in chromatin decondensation and post-zygotic
            embryo development in mice
  JOURNAL   Cell Death Differ 26 (5), 969-980 (2019)
   PUBMED   30154445
  REMARK    GeneRIF: RAD9A may also play an important role in maternal
            chromatin reprogramming. In summary, our data reveal an important
            role of RAD9A in zygotic chromatin reprogramming and female
            fertility.
REFERENCE   5  (bases 1 to 2046)
  AUTHORS   Albrecht,N.E., Alevy,J., Jiang,D., Burger,C.A., Liu,B.I., Li,F.,
            Wang,J., Kim,S.Y., Hsu,C.W., Kalaga,S., Udensi,U., Asomugha,C.,
            Bohat,R., Gaspero,A., Justice,M.J., Westenskow,P.D., Yamamoto,S.,
            Seavitt,J.R., Beaudet,A.L., Dickinson,M.E. and Samuel,M.A.
  TITLE     Rapid and Integrative Discovery of Retina Regulatory Molecules
  JOURNAL   Cell Rep 24 (9), 2506-2519 (2018)
   PUBMED   30157441
REFERENCE   6  (bases 1 to 2046)
  AUTHORS   Hopkins,K.M., Wang,X., Berlin,A., Hang,H., Thaker,H.M. and
            Lieberman,H.B.
  TITLE     Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint
            control genes in normal and cancerous testicular tissue
  JOURNAL   Cancer Res 63 (17), 5291-5298 (2003)
   PUBMED   14500360
  REMARK    GeneRIF: HRAD9 and Mrad9 are part of a gene family and reveal a new
            genetic element encoding a product that interacts with multiple,
            known cell cycle checkpoint control proteins.
REFERENCE   7  (bases 1 to 2046)
  AUTHORS   Hang,H., Rauth,S.J., Hopkins,K.M. and Lieberman,H.B.
  TITLE     Mutant alleles of Schizosaccharomyces pombe rad9(+) alter
            hydroxyurea resistance, radioresistance and checkpoint control
  JOURNAL   Nucleic Acids Res 28 (21), 4340-4349 (2000)
   PUBMED   11058134
REFERENCE   8  (bases 1 to 2046)
  AUTHORS   Venclovas,C. and Thelen,M.P.
  TITLE     Structure-based predictions of Rad1, Rad9, Hus1 and Rad17
            participation in sliding clamp and clamp-loading complexes
  JOURNAL   Nucleic Acids Res 28 (13), 2481-2493 (2000)
   PUBMED   10871397
REFERENCE   9  (bases 1 to 2046)
  AUTHORS   Hang,H., Rauth,S.J., Hopkins,K.M., Davey,S.K. and Lieberman,H.B.
  TITLE     Molecular cloning and tissue-specific expression of Mrad9, a murine
            orthologue of the Schizosaccharomyces pombe rad9+ checkpoint
            control gene
  JOURNAL   J Cell Physiol 177 (2), 241-247 (1998)
   PUBMED   9766521
REFERENCE   10 (bases 1 to 2046)
  AUTHORS   Richter,M.F., Dumenil,G., Uze,G., Fellous,M. and Pellegrini,S.
  TITLE     Specific contribution of Tyk2 JH regions to the binding and the
            expression of the interferon alpha/beta receptor component IFNAR1
  JOURNAL   J Biol Chem 273 (38), 24723-24729 (1998)
   PUBMED   9733772
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC140073.4.
            
            On Mar 21, 2007 this sequence version replaced NM_011237.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF045663.1, AK165833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC140073.4         221836-221956
            122-192             AC140073.4         222040-222110
            193-321             AC140073.4         222382-222510
            322-436             AC140073.4         222860-222974
            437-536             AC140073.4         223068-223167
            537-646             AC140073.4         225659-225768
            647-756             AC140073.4         225853-225962
            757-821             AC140073.4         226036-226100
            822-959             AC140073.4         226189-226326
            960-1161            AC140073.4         227057-227258
            1162-2046           AC140073.4         227357-228241
FEATURES             Location/Qualifiers
     source          1..2046
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.89 cM"
     gene            1..2046
                     /gene="Rad9a"
                     /gene_synonym="Rad9"
                     /note="RAD9 checkpoint clamp component A"
                     /db_xref="GeneID:19367"
                     /db_xref="MGI:MGI:1328356"
     exon            1..121
                     /gene="Rad9a"
                     /gene_synonym="Rad9"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1257
                     /gene="Rad9a"
                     /gene_synonym="Rad9"
                     /EC_number="3.1.11.2"
                     /note="Rad9-like protein; mRAD9; DNA repair exonuclease
                     rad9 homolog A; RAD9 homolog A"
                     /codon_start=1
                     /product="cell cycle checkpoint control protein RAD9A"
                     /protein_id="NP_035367.1"
                     /db_xref="CCDS:CCDS29422.1"
                     /db_xref="GeneID:19367"
                     /db_xref="MGI:MGI:1328356"
                     /translation="MKCLITGGNVKVLGKAVHSLSRIGDELYLEPLKDGLSLRTVNSS
                     RSAYACFLFAPLFFQQYQAASPGQDLLRCKILMKAFLSVFRSLAIVEKSVEKCCISLS
                     GSHSHLVVQLHCKYGVKKTHNLSFQDCESLQAVFDPASCPHLLRTPARVLAEAVLSFP
                     LALTEVTLGIGRGRRVILRSYQEEEADSTSKAMVTETSIGDEDFQQLHAPEGIAVTFC
                     LKEFRGLLSFAESANLPLTIHFDVPGRPVIFTIEDSLLDAHFVLATLLEQDSCSQGPC
                     SPKPHQPVPQKQAHSTPHLDDFTSDDIDCYMIAMETTGGNEGSGAQPSTSLPPVSLAS
                     HDLAPTSEEEAEPSTVPGTPPPKKFRSLFFGSILAPVHSPQGPNPVLAEDSDGEG"
     exon            122..192
                     /gene="Rad9a"
                     /gene_synonym="Rad9"
                     /inference="alignment:Splign:2.1.0"
     exon            193..321
                     /gene="Rad9a"
                     /gene_synonym="Rad9"
                     /inference="alignment:Splign:2.1.0"
     exon            322..436
                     /gene="Rad9a"
                     /gene_synonym="Rad9"
                     /inference="alignment:Splign:2.1.0"
     exon            437..536
                     /gene="Rad9a"
                     /gene_synonym="Rad9"
                     /inference="alignment:Splign:2.1.0"
     exon            537..646
                     /gene="Rad9a"
                     /gene_synonym="Rad9"
                     /inference="alignment:Splign:2.1.0"
     exon            647..756
                     /gene="Rad9a"
                     /gene_synonym="Rad9"
                     /inference="alignment:Splign:2.1.0"
     exon            757..821
                     /gene="Rad9a"
                     /gene_synonym="Rad9"
                     /inference="alignment:Splign:2.1.0"
     exon            822..959
                     /gene="Rad9a"
                     /gene_synonym="Rad9"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1161
                     /gene="Rad9a"
                     /gene_synonym="Rad9"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..2046
                     /gene="Rad9a"
                     /gene_synonym="Rad9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1507..1512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rad9a"
                     /gene_synonym="Rad9"
                     /note="hexamer: AATACA"
     polyA_site      1537
                     /gene="Rad9a"
                     /gene_synonym="Rad9"
ORIGIN      
        1 agtcgtagta gctgctggga ctcattatat gtcctatccc gtcccggttc gtgtgcaaaa
       61 caagctcgat ttttgtgctt atgtactatg aagtgcctga tcaccggggg caacgtgaag
      121 gtgctgggca aggctgtcca ttcgctatcc cgaatcgggg acgagctcta tctggaaccc
      181 ttgaaggacg ggctctccct acggactgtg aactcgtccc gttctgccta tgcctgcttc
      241 ctttttgccc cactcttctt ccagcagtac caggcggctt cccctggtca ggacctgctg
      301 cgctgtaaga tcctgatgaa ggccttcctg tccgtcttcc gctctctggc aattgtggag
      361 aagtctgtgg agaagtgctg tatctccctc agtggcagcc acagccacct ggtggtccag
      421 ctccactgca agtatggggt caagaagaca cacaacctct ccttccagga ctgtgagtcc
      481 ctgcaggctg tcttcgaccc agcctcatgc cctcacttat tgcgcacccc agcacgggtt
      541 ctggcagagg ctgttctgtc ctttcccctt gcattgactg aggtgacact gggcattggc
      601 cgtggccggc gggtcatcct gcgcagctac caggaagagg aggcagacag caccagcaaa
      661 gccatggtga ctgagaccag cattggggat gaggacttcc agcagctgca tgccccagaa
      721 gggatagctg tcaccttctg cctcaaggaa tttcgggggc tcctgagctt tgcagagtca
      781 gcgaatttgc ctcttactat ccacttcgat gttccaggca ggccagtcat ctttactatt
      841 gaggattcct tgctggatgc ccactttgtc ttggccacac tcttagagca agactcatgt
      901 tcccagggcc cgtgttcccc aaaaccccac cagccagtgc ctcagaagca ggcacacagc
      961 acaccccact tagatgactt taccagtgat gacattgact gttacatgat tgccatggaa
     1021 accactggag gcaatgaggg ctccggggca cagccttcca catccctccc acctgtctcc
     1081 ctggcctccc atgaccttgc ccccacctca gaggaggaag ctgagcccag tacagtgcct
     1141 gggactcccc cacccaagaa gtttcgttca ctgttctttg gctccatcct ggcccctgta
     1201 cactccccgc agggtcccaa ccctgtgctg gctgaagaca gtgatggtga agggtgaatt
     1261 tgagaaatta aagtctgtgt tcaaaggctc acggaccaga agcaggcccg cccactgagt
     1321 tgggcgtcag tccttagaca tggacatgga aatggaaaaa ggcatacccc acttggctgt
     1381 ctgctgcaga gctgcctagg aaccatgttt ggtctgtgtt ctgtatttat tcagcctata
     1441 ccaatcatgt ctctggtgcc cacctgtcac ctgacagatc cctcatcctt tactttgagg
     1501 ctctagaata caaattctgg ccaaagccag aaacttagct tcctcagtct cctgcctcta
     1561 aaacaggaag atcagtattg aacaccctct gccaatcatg aactccccgc cagaccctcc
     1621 tgtgggccaa aggaactgtt tctctttcct aacacttggg ccttggccta gaatcctaat
     1681 agcctctgga cctgattgtg tgtcactggt gttgccctgg ctgggcccat gttcagccac
     1741 tcagtctgcc ctcccaggtg gctttgtacc aaagaactgc tggcccactg tctgggacgg
     1801 gacaagagag acagaggcta tggtgagaat ccagctttga cctttattca agagaccaga
     1861 tgggttgccc caggatctgg ctgccagcca tgcaaggctg gagacccaca atctggtctg
     1921 ccattgccct gagctgcagc cttggcccca ggattccact tgcagccacc acaggtgctg
     1981 gtgggaggga gccctgggag attagatgct gctattgatt ctttaaaaaa taaaggaaag
     2041 acactt
//
