LOCUS       NM_009015               3093 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus RAD54 like (S. cerevisiae) (Rad54l), transcript
            variant 1, mRNA.
ACCESSION   NM_009015
VERSION     NM_009015.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3093)
  AUTHORS   Tanori M, Pannicelli A, Pasquali E, Casciati A, Antonelli F,
            Giardullo P, Leonardi S, Tanno B, De Stefano I, Saran A, Mancuso M
            and Pazzaglia S.
  TITLE     Cancer risk from low dose radiation in Ptch1+/- mice with inactive
            DNA repair systems: Therapeutic implications for medulloblastoma
  JOURNAL   DNA Repair (Amst) 74, 70-79 (2019)
   PUBMED   30606609
REFERENCE   2  (bases 1 to 3093)
  AUTHORS   Russo A, Cordelli E, Salvitti T, Palumbo E and Pacchierotti F.
  TITLE     Rad54/Rad54B deficiency is associated to increased chromosome
            breakage in mouse spermatocytes
  JOURNAL   Mutagenesis 33 (4), 323-332 (2018)
   PUBMED   30204892
REFERENCE   3  (bases 1 to 3093)
  AUTHORS   Zhou L, Dai H, Wu J, Zhou M, Yuan H, Du J, Yang L, Wu X, Xu H, Hua
            Y, Xu J, Zheng L and Shen B.
  TITLE     Role of FEN1 S187 phosphorylation in counteracting oxygen-induced
            stress and regulating postnatal heart development
  JOURNAL   FASEB J 31 (1), 132-147 (2017)
   PUBMED   27694478
REFERENCE   4  (bases 1 to 3093)
  AUTHORS   Ghamrasni SE, Cardoso R, Li L, Guturi KK, Bjerregaard VA, Liu Y,
            Venkatesan S, Hande MP, Henderson JT, Sanchez O, Hickson ID, Hakem
            A and Hakem R.
  TITLE     Rad54 and Mus81 cooperation promotes DNA damage repair and
            restrains chromosome missegregation
  JOURNAL   Oncogene 35 (37), 4836-4845 (2016)
   PUBMED   26876210
  REMARK    GeneRIF: Our study highlights the importance of the cooperation
            between Rad54 and Mus81 for mediating DNA DSB repair and
            restraining chromosome missegregation.
REFERENCE   5  (bases 1 to 3093)
  AUTHORS   Tanori M, Casciati A, Berardinelli F, Leonardi S, Pasquali E,
            Antonelli F, Tanno B, Giardullo P, Pannicelli A, Babini G, De
            Stefano I, Sgura A, Mancuso M, Saran A and Pazzaglia S.
  TITLE     Synthetic lethal genetic interactions between Rad54 and PARP-1 in
            mouse development and oncogenesis
  JOURNAL   Oncotarget 8 (60), 100958-100974 (2016)
   PUBMED   29254138
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3093)
  AUTHORS   Essers J, van Steeg H, de Wit J, Swagemakers SM, Vermeij M,
            Hoeijmakers JH and Kanaar R.
  TITLE     Homologous and non-homologous recombination differentially affect
            DNA damage repair in mice
  JOURNAL   EMBO J 19 (7), 1703-1710 (2000)
   PUBMED   10747037
REFERENCE   7  (bases 1 to 3093)
  AUTHORS   Tan TL, Essers J, Citterio E, Swagemakers SM, de Wit J, Benson FE,
            Hoeijmakers JH and Kanaar R.
  TITLE     Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51
            foci formation
  JOURNAL   Curr Biol 9 (6), 325-328 (1999)
   PUBMED   10209103
REFERENCE   8  (bases 1 to 3093)
  AUTHORS   Jacobs H, Fukita Y, van der Horst GT, de Boer J, Weeda G, Essers J,
            de Wind N, Engelward BP, Samson L, Verbeek S, de Murcia JM, de
            Murcia G, te Riele H and Rajewsky K.
  TITLE     Hypermutation of immunoglobulin genes in memory B cells of DNA
            repair-deficient mice
  JOURNAL   J Exp Med 187 (11), 1735-1743 (1998)
   PUBMED   9607915
REFERENCE   9  (bases 1 to 3093)
  AUTHORS   Essers J, Hendriks RW, Swagemakers SM, Troelstra C, de Wit J,
            Bootsma D, Hoeijmakers JH and Kanaar R.
  TITLE     Disruption of mouse RAD54 reduces ionizing radiation resistance and
            homologous recombination
  JOURNAL   Cell 89 (2), 195-204 (1997)
   PUBMED   9108475
REFERENCE   10 (bases 1 to 3093)
  AUTHORS   Kanaar R, Troelstra C, Swagemakers SM, Essers J, Smit B, Franssen
            JH, Pastink A, Bezzubova OY, Buerstedde JM, Clever B, Heyer WD and
            Hoeijmakers JH.
  TITLE     Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA
            repair gene: evidence for functional conservation
  JOURNAL   Curr Biol 6 (7), 828-838 (1996)
   PUBMED   8805304
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY716729.1, CN669448.1, AK161644.1 and X97796.1.
            
            [WARNING] On Oct 13, 2023 this sequence was replaced by
            NM_009015.4.
            
            On Apr 2, 2008 this sequence version replaced NM_009015.2.
            
            Transcript Variant: This variant (1) and variants 2 and 3 encode
            the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X97796.1, BC021643.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               BY716729.1         1-211
            212-659             CN669448.1         170-617
            660-3032            AK161644.1         283-2655
            3033-3093           X97796.1           2492-2552
FEATURES             Location/Qualifiers
     source          1..3093
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.1 cM"
     gene            1..3093
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /note="RAD54 like (S. cerevisiae)"
                     /db_xref="GeneID:19366"
                     /db_xref="MGI:MGI:894697"
     exon            1..628
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     CDS             626..2869
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /EC_number="3.6.4.12"
                     /note="mHR54; mRAD54; RAD54 homolog"
                     /codon_start=1
                     /product="DNA repair and recombination protein RAD54-like"
                     /protein_id="NP_033041.3"
                     /db_xref="CCDS:CCDS18504.1"
                     /db_xref="GeneID:19366"
                     /db_xref="MGI:MGI:894697"
                     /translation="MRRSLAPSQLARRKPEDRSSDDEDWQPGTVTPKKRKSSSETQVQ
                     ECFLSPFRKPLTQLLNRPPCLDSSQHEAFIRSILSKPFKVPIPNYQGPLGSRALGLKR
                     AGVRRALHDPLEEGALVLYEPPPLSAHDQLKLDKEKLPVHVVVDPILSKVLRPHQREG
                     VKFLWECVTSRRIPGSHGCIMADEMGLGKTLQCITLMWTLLRQSPECKPEIEKAVVVS
                     PSSLVKNWYNEVEKWLGGRIQPLAIDGGSKDEIDRKLEGFMNQRGARVPSPILIISYE
                     TFRLHVGVLKKGNVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLE
                     YFSLVHFVNSGILGTAHEFKKHFELPILKSRDAAASEADRQRGEERLRELIGIVNRCL
                     IRRTSDILSKYLPVKIEQVVCCRLTPLQTELYKRFLRQAKPEEELREGKMSVSSLSSI
                     TSLKKLCNHPALIYDKCVAEEDGFEGTLGIFPPGYNSKAVEPQLSGKMLVLDYILAVT
                     RSRSSDKVVLVSNYTQTLDLFEKLCRVRRYLYVRLDGTMSIKKRAKVVERFNSPSSPD
                     FVFMLSSKAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKICYIYRLLSA
                     GTIEEKIFQRQSHKKALSSCVVDEEQDVERHFSLGELKELFTLDEASLSDTHDRLHCR
                     RCVNNRQVWPPPDGSDCTSDLAQWNHSTDKRGLQDEVLQAAWDASSTAITFVFHQRSH
                     EEQRGLH"
     exon            629..715
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     exon            716..835
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     exon            836..896
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1032
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1102
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1391
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1516
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1667
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1794
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1869
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2000
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2111
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2235
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2314
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2494
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2658
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..3075
                     /gene="Rad54l"
                     /gene_synonym="RAD54"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggaggctct taacgcgcgc tttgggaaga ggaagaataa ggggaaagat accggagtcg
       61 ctctttgcct ctcttcagct tctaagattc tcctcctccc aacctggatt tttaactggt
      121 ccttcctggg ttcctgttta acttcccaca aggcgttcct aggtctctgc ttgccttcct
      181 cacactgagg tttgatgtcg gtccagctct ggtaaattct atccctctcc taagaattca
      241 ggcgtctcgc cttcgtactt aagactgtac tttttcgtag gtgttactct cagggaagca
      301 gcccagctag ggacgttatt ccaactccac tttgctcatc tgcaacttca atctgtcttc
      361 tttcccatcc tagatttaga cccagctccg cttggacttg gctttggata ttttgacctt
      421 gaggaacttg gggaccgaca ttcctggttt ggacccaagc ctcatcctct gattgcatcc
      481 cctcccctca taccgactct taagacaata ttttcaatga tatagcaact tccttttata
      541 gcatcccctg gtcctgcatt ctctgttgct gagtgctttt aacttcgctg atgggcactt
      601 gacatttgat gcttctgggg ccaggatgag gaggagctta gctcccagcc agttggctag
      661 gaggaaacca gaagacagat catcagatga tgaagactgg cagcctggga cagtaactcc
      721 taagaaacgc aagtccagca gtgagaccca ggtccaggag tgtttcctgt ctccttttcg
      781 gaagcccttg actcagctac tcaaccggcc accttgtctg gatagcagtc aacatgaagc
      841 atttattcga agtattttgt caaagccttt caaggtcccc atcccaaatt atcaaggtcc
      901 cctgggctct cgtgcattgg gcctgaaaag ggctggagtt cgtcgtgccc ttcatgaccc
      961 tctggaagaa ggtgccttgg ttctctatga gcctccccca ctcagcgccc atgaccaact
     1021 gaagcttgac aaggaaaaac tccctgttca cgtggttgtt gatcctattc tcagtaaggt
     1081 attgcggcct catcagagag agggagtgaa gttcctatgg gagtgtgtca ccagtcgtcg
     1141 aattcctgga agccatggct gcatcatggc tgatgagatg ggcctgggga agacactgca
     1201 gtgcatcaca ttgatgtgga cacttttacg ccagagccca gaatgcaagc cagaaatcga
     1261 gaaggcagtg gtggtgtcac cttctagcct ggtgaagaac tggtacaatg aggttgagaa
     1321 atggcttgga gggaggattc aacctctggc catcgatgga ggctcgaagg acgagataga
     1381 ccgaaaactg gaaggattca tgaaccagcg tggagctaga gtgccttccc ccatcctcat
     1441 catttcctat gagactttcc gcctgcatgt tggagttctt aaaaaaggaa atgttggact
     1501 ggtcatatgt gacgagggcc acaggctaaa gaactctgag aatcagactt accaggctct
     1561 ggacagcttg aataccagcc ggcgggtgct aatctccggg acccccatcc aaaatgattt
     1621 gctggagtat ttcagcttgg tgcactttgt aaattctggc attttgggaa ctgcccatga
     1681 attcaagaag cattttgagt tgccaatttt gaagagtcga gatgcagctg ccagtgaggc
     1741 agacaggcag cgtggggagg agcgtctgcg ggagctcatc ggtattgtga acaggtgcct
     1801 gatacggaga acatctgata tcctctctaa gtatctgccc gtgaagattg agcaggtggt
     1861 ttgttgtagg ctgacacccc ttcaaactga gctatacaag agatttctga gacaggctaa
     1921 gcctgaagaa gaattgcgtg agggcaagat gagtgtgtct tccctgtctt ctatcacctc
     1981 tctaaagaag ctgtgtaatc atccagctct aatctatgac aagtgtgtgg cagaggagga
     2041 tggctttgag ggcactttgg gtatcttccc acctggttat aactctaaag ctgtagagcc
     2101 acagttgtca ggtaagatgc tggtccttga ttacattctg gccgtgactc gaagccgtag
     2161 cagtgacaaa gtcgtgctgg tgtctaatta tactcagaca ttggatctct ttgaaaagct
     2221 gtgccgggtt cgaaggtact tgtatgttcg cctggatggc acgatgtcca ttaagaagcg
     2281 agccaaggtt gtggagcgct tcaatagccc atcgagccct gattttgttt tcatgctgag
     2341 cagcaaagcc gggggctgtg gtcttaacct cattggtgct aaccgactgg tcatgtttga
     2401 tcctgactgg aatccagcca atgatgaaca agctatggcc cgagtctggc gtgatggtca
     2461 aaagaagatc tgctatatct accgactgct atctgcagga acaattgagg agaagatctt
     2521 tcagcggcag agccacaaga aggctctgag cagctgtgtg gtggacgagg agcaggatgt
     2581 ggagcgccac ttttctcttg gtgagcttaa agagctgttt actctggatg aagcaagcct
     2641 cagtgacaca catgacagat tgcattgccg ccgttgtgta aacaaccgtc aggtctggcc
     2701 accccctgat ggttctgact gcacttcaga cctggctcag tggaaccaca gcacagataa
     2761 acgagggctc caggatgagg tactccaggc tgcctgggat gcttcatcta cagccatcac
     2821 cttcgtcttc caccagcgtt ctcatgagga gcagcgcggt cttcactgat aatcagctgg
     2881 tctggatgta gttgtttggg aaaggataca gggaaagggg gttctctgcc tcatgaggct
     2941 ctgctcagtt ttattctctg ggagaaaatc atcaagaagg gctgcatgat gtttgcccaa
     3001 aatttatttt ataagaaaaa cttttttggt ttaaaaaaaa aaaagaaaaa gaaaggaata
     3061 aaggcatgaa agggaaaaaa aaaaaaaaaa aaa
//
