LOCUS       NM_001039556            2913 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus RAD54 homolog B (S. cerevisiae) (Rad54b), transcript
            variant 1, mRNA.
ACCESSION   NM_001039556 XM_485355 XM_907416
VERSION     NM_001039556.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2913)
  AUTHORS   Mai,Y., Lin,T., Zhang,L., Yang,W., Liu,S., Wang,M., Liu,P., Li,Z.
            and Luo,W.
  TITLE     RAD54B inhibits vascular endothelial senescence via suppression of
            CHK1/p53/p21 pathway
  JOURNAL   Can J Physiol Pharmacol 102 (2), 137-149 (2024)
   PUBMED   37748205
  REMARK    GeneRIF: RAD54B inhibits vascular endothelial senescence via
            suppression of CHK1/p53/p21 pathway.
REFERENCE   2  (bases 1 to 2913)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2913)
  AUTHORS   Qiao,W., Huang,P., Wang,X. and Meng,L.
  TITLE     Susceptibility to DNA damage caused by abrogation of Rad54 homolog
            B: A putative mechanism for chemically induced cleft palate
  JOURNAL   Toxicology 456, 152772 (2021)
   PUBMED   33823233
  REMARK    GeneRIF: Susceptibility to DNA damage caused by abrogation of Rad54
            homolog B: A putative mechanism for chemically induced cleft
            palate.
REFERENCE   4  (bases 1 to 2913)
  AUTHORS   Russo,A., Cordelli,E., Salvitti,T., Palumbo,E. and Pacchierotti,F.
  TITLE     Rad54/Rad54B deficiency is associated to increased chromosome
            breakage in mouse spermatocytes
  JOURNAL   Mutagenesis 33 (4), 323-332 (2018)
   PUBMED   30204892
  REMARK    GeneRIF: Rad54/Rad54B deficiency may impact on the DNA integrity of
            developing mouse gametes.
REFERENCE   5  (bases 1 to 2913)
  AUTHORS   Yu,Y., Zuo,X., He,M., Gao,J., Fu,Y., Qin,C., Meng,L., Wang,W.,
            Song,Y., Cheng,Y., Zhou,F., Chen,G., Zheng,X., Wang,X., Liang,B.,
            Zhu,Z., Fu,X., Sheng,Y., Hao,J., Liu,Z., Yan,H., Mangold,E.,
            Ruczinski,I., Liu,J., Marazita,M.L., Ludwig,K.U., Beaty,T.H.,
            Zhang,X., Sun,L. and Bian,Z.
  TITLE     Genome-wide analyses of non-syndromic cleft lip with palate
            identify 14 novel loci and genetic heterogeneity
  JOURNAL   Nat Commun 8, 14364 (2017)
   PUBMED   28232668
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2913)
  AUTHORS   Kirshner,M., Rathavs,M., Nizan,A., Essers,J., Kanaar,R., Shiloh,Y.
            and Barzilai,A.
  TITLE     Analysis of the relationships between ATM and the Rad54 paralogs
            involved in homologous recombination repair
  JOURNAL   DNA Repair (Amst) 8 (2), 253-261 (2009)
   PUBMED   19061978
REFERENCE   7  (bases 1 to 2913)
  AUTHORS   Derijck,A., van der Heijden,G., Giele,M., Philippens,M. and de
            Boer,P.
  TITLE     DNA double-strand break repair in parental chromatin of mouse
            zygotes, the first cell cycle as an origin of de novo mutation
  JOURNAL   Hum Mol Genet 17 (13), 1922-1937 (2008)
   PUBMED   18353795
REFERENCE   8  (bases 1 to 2913)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   9  (bases 1 to 2913)
  AUTHORS   Wesoly,J., Agarwal,S., Sigurdsson,S., Bussen,W., Van Komen,S.,
            Qin,J., van Steeg,H., van Benthem,J., Wassenaar,E., Baarends,W.M.,
            Ghazvini,M., Tafel,A.A., Heath,H., Galjart,N., Essers,J.,
            Grootegoed,J.A., Arnheim,N., Bezzubova,O., Buerstedde,J.M., Sung,P.
            and Kanaar,R.
  TITLE     Differential contributions of mammalian Rad54 paralogs to
            recombination, DNA damage repair, and meiosis
  JOURNAL   Mol Cell Biol 26 (3), 976-989 (2006)
   PUBMED   16428451
REFERENCE   10 (bases 1 to 2913)
  AUTHORS   Bross,L., Wesoly,J., Buerstedde,J.M., Kanaar,R. and Jacobs,H.
  TITLE     Somatic hypermutation does not require Rad54 and Rad54B-mediated
            homologous recombination
  JOURNAL   Eur J Immunol 33 (2), 352-357 (2003)
   PUBMED   12548566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732538.6.
            
            On Jan 4, 2023 this sequence version replaced NM_001039556.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057604.1, SRR13422590.411257.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AL732538.6         72186-72269
            85-235              AL732538.6         76583-76733
            236-347             AL732538.6         83077-83188
            348-542             AL732538.6         106877-107071
            543-815             AL732538.6         108923-109195
            816-978             AL732538.6         111088-111250
            979-1204            AL732538.6         112932-113157
            1205-1412           AL732538.6         114807-115014
            1413-1552           AL732538.6         118122-118261
            1553-1843           AL732538.6         119302-119592
            1844-2019           AL732538.6         122550-122725
            2020-2281           AL732538.6         123560-123821
            2282-2348           AL732538.6         125628-125694
            2349-2549           AL732538.6         125874-126074
            2550-2913           AL732538.6         128699-129062
FEATURES             Location/Qualifiers
     source          1..2913
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 5.11 cM"
     gene            1..2913
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /note="RAD54 homolog B (S. cerevisiae)"
                     /db_xref="GeneID:623474"
                     /db_xref="MGI:MGI:3605986"
     exon            1..84
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            85..235
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2761
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     repair and recombination protein RAD54B"
                     /codon_start=1
                     /product="DNA repair and recombination protein RAD54B
                     isoform 1"
                     /protein_id="NP_001034645.1"
                     /db_xref="CCDS:CCDS17970.1"
                     /db_xref="GeneID:623474"
                     /db_xref="MGI:MGI:3605986"
                     /translation="MRRSAAPSQVQGKSFKKTRFIPPGRSNADVSKEITKMSPDPKLF
                     QGAEQSQNDPGVCSSNPCPSEGIPREVGDGTRVDPLPPVHSASKEITESKAQEEEASS
                     LLKYFSVVWCKASKKKHKKWEGDAILIVRGRSFTLKDLEGKDIGRGIGYKFKDLENVE
                     EGQTLIIGGKEIEILGTISSDDFNSGKCFQHGSGSPAVPSSQAARKCFSNPFKSVCQS
                     TQAQGKRWNDCRPRHNPCTPNALVMPRPDENHQRMFNRHCSPIVDVVIDPHLVHHLRP
                     HQKDGIIFLYECVMGMRAVGKCGAILADEMGLGKTLQCISLIWTLQCQGPYGGKPVIK
                     KTLIVTPGSLVNNWRKEFQKWLGSERIKIFTVDQDHKVEEFINSTFHSVLIISYEMLL
                     RSLDQIKTIPFGLLICDEGHRLKNSSIKTTTALSSLSCEKTVILTGTPVQNDLQEFFA
                     LVDFVNPGILGSLSSYRKIYEEPIIISREPSSSKEERELGERRATELTRLTGRFILRR
                     TQEVINKYLPPKIENVVFCRPGALQIELYRKLLRSQSVRFCLQGLLENSAHLICIGAL
                     KKLCNHPCLLFSSVKGKEFSSSCEENEERNLCQGLLSVFPAGYNPLQFSEEESGKLQV
                     LVKLLAVIHELRPTEKVILVSNYRQTLNVLEEVCKRHGYACARLDGQTPVSQRQHIVD
                     SFNSKYSTDFIFLLSSKAGGVGLNLIGGSHLILYDIDWNPATDIQAMSRVWRDGQKHP
                     VHIYRLLTTGTIEEKIYQRQISKQGLSGAVVDLTRSSEHIQFSVEELKNLFTLHESSH
                     CVTHDLLDCECTGEKGHTEDASEGPVASRQCQFGPQKSDALRPLSMSQLKQWKHFSGD
                     HLNLPDPFLERIRENVSFFFQNITNQAPAV"
     exon            236..347
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            348..542
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            543..815
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            816..978
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1204
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1412
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1552
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1843
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2019
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2281
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2348
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2549
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2913
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2892..2897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2913
                     /gene="Rad54b"
                     /gene_synonym="E130016E03Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtaggaaggc gggaagctcg agctggtcgg cggcaggcgt tggtacctgc tgcggggcgc
       61 tcgcgatttc ggtcagcctg cggggttagt attgctgagg atgagaagat ctgcagcacc
      121 aagtcaggtg cagggaaagt cctttaaaaa aacaagattc atacctccag gaagaagtaa
      181 tgcagatgtg agtaaggaga tcacaaagat gagtccagat ccaaaactgt ttcagggtgc
      241 tgaacagtca caaaatgatc caggtgtatg cagttcaaat ccttgcccca gtgagggaat
      301 ccctagggaa gtgggtgatg ggactagagt agatccactt cctccagttc attcggcctc
      361 taaagaaatc acagagtcca aggcacaaga agaggaagct agcagcttgc ttaaatattt
      421 cagtgttgtt tggtgtaaag cttcaaagaa aaaacacaaa aagtgggaag gcgatgctat
      481 tcttattgta agaggaaggt ccttcacatt gaaagatttg gaaggaaaag atattggaag
      541 aggcattgga tacaaattca aggaccttga gaatgtagaa gagggccaaa cattgataat
      601 tggtgggaaa gaaatagaaa tcctggggac aatctcttct gatgacttca acagtggcaa
      661 gtgttttcag cacggaagtg gaagtcctgc tgtcccaagt tctcaggctg ccaggaaatg
      721 cttttctaac cctttcaaaa gtgtgtgtca gtcaacgcaa gcacagggaa aaagatggaa
      781 tgactgcaga ccgcgccata acccgtgcac accaaatgcc cttgttatgc cgcgcccaga
      841 cgagaatcac cagcggatgt ttaataggca ctgctctcct attgtggatg tcgtgataga
      901 ccctcacctt gtacaccacc tccgaccaca tcagaaagac ggaatcatct tcctctatga
      961 gtgtgtgatg ggaatgagag cagttggcaa atgtggcgct attcttgctg atgaaatggg
     1021 cttagggaaa acgttgcagt gtatctcgct catctggacc ctacagtgtc aggggcccta
     1081 tggcggcaag ccagtaataa agaagacact cattgttacc cctggaagcc tggtgaataa
     1141 ttggaggaaa gaatttcaaa aatggctggg aagtgaaagg atcaagatat tcaccgttga
     1201 tcaggaccat aaagtcgagg agtttatcaa ttctacattt cattcagttc ttatcatcag
     1261 ttatgaaatg ttacttcgtt ccctagatca aattaagact atcccatttg gccttctgat
     1321 ctgtgatgag ggacaccgtt tgaagaacag cagcatcaag acaacgacgg ccctttctag
     1381 cctctcctgt gagaagacag taattctcac tggtacccca gttcagaatg atttgcaaga
     1441 gttttttgca ttagttgatt ttgttaatcc aggaatatta gggtctctgt cgtcttacag
     1501 gaaaatatat gaagaaccca tcattatatc aagagagcct tcttcttcta aggaagagag
     1561 agagttaggg gagagaagag caactgagct cacgcgcctc actggacgtt ttatccttag
     1621 aagaactcag gaagtcatca ataaatatct cccgcctaag atagagaatg tagtcttttg
     1681 ccgaccagga gcattgcaga ttgaacttta ccgaaagctg ctgcgctctc agtctgtgag
     1741 gttctgtttg caaggactat tggaaaatag tgctcacctc atctgcatag gggccctaaa
     1801 gaagctgtgc aaccaccctt gcctcttgtt cagctctgtg aagggcaaag aatttagctc
     1861 aagttgtgag gaaaatgaag aaagaaatct atgccaaggc ttgctgtctg tgttccctgc
     1921 tggctacaac cctctgcagt tctctgagga agagtcagga aaactacagg tgttagtcaa
     1981 gctcctggca gtgatccatg aacttcgtcc cactgagaaa gtgattttgg tatccaacta
     2041 cagacaaacc ttgaatgttc tagaagaagt atgtaagcgt catggatatg cttgtgcaag
     2101 acttgatggc caaacaccag tctctcaaag gcagcacatt gttgatagtt tcaatagtaa
     2161 atactctact gattttattt ttttattaag ttcaaaagct ggtggtgtgg gacttaatct
     2221 cattggagga tctcacttaa ttctctatga tatcgattgg aacccagcta ctgatatcca
     2281 ggccatgtct agagtatgga gagatggtca gaagcatcct gtacatattt acagactcct
     2341 gactacaggt acaatagagg aaaagatcta tcaaaggcag atcagtaagc aaggcctttc
     2401 tggggcagtg gtagacctaa ccagatcatc tgaacatatc cagttttcag tggaagagct
     2461 taaaaacttg ttcacactac atgaaagttc acattgtgtc actcatgacc tgcttgactg
     2521 tgagtgcaca ggggaaaaag gtcacaccga ggatgcgtcc gaaggccccg tcgcctcccg
     2581 acagtgtcag ttcggccctc agaagtctga cgccttgaga cctctgtcca tgtcacagct
     2641 gaagcagtgg aaacattttt ctggagacca tttaaatctt ccagatccat ttctcgaaag
     2701 aatacgggaa aatgtgtcgt tctttttcca gaatataacc aaccaagctc ctgccgtcta
     2761 atgaaggact gcttcctaac atgcctttgc tccccttaaa aattaataca ggagttaaat
     2821 gtaattttga aaatgaacaa aattatttaa atggtagtga actttgtttc acaatatgct
     2881 tatttaaata cagtaaaagc tgagttgttt gct
//
