LOCUS       NM_001166381            1680 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus RAD52 homolog, DNA repair protein (Rad52), transcript
            variant 1, mRNA.
ACCESSION   NM_001166381
VERSION     NM_001166381.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1680)
  AUTHORS   Xu,Y., Zhou,H., Post,G., Zan,H. and Casali,P.
  TITLE     Rad52 mediates class-switch DNA recombination to IgD
  JOURNAL   Nat Commun 13 (1), 980 (2022)
   PUBMED   35190531
  REMARK    GeneRIF: Rad52 mediates class-switch DNA recombination to IgD.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1680)
  AUTHORS   Wang,J., Oh,Y.T., Li,Z., Dou,J., Tang,S., Wang,X., Wang,H.,
            Takeda,S. and Wang,Y.
  TITLE     RAD52 Adjusts Repair of Single-Strand Breaks via Reducing
            DNA-Damage-Promoted XRCC1/LIG3alpha Co-localization
  JOURNAL   Cell Rep 34 (2), 108625 (2021)
   PUBMED   33440161
  REMARK    GeneRIF: RAD52 Adjusts Repair of Single-Strand Breaks via Reducing
            DNA-Damage-Promoted XRCC1/LIG3alpha Co-localization.
REFERENCE   3  (bases 1 to 1680)
  AUTHORS   Wang,H., Li,S., Oaks,J., Ren,J., Li,L. and Wu,X.
  TITLE     The concerted roles of FANCM and Rad52 in the protection of common
            fragile sites
  JOURNAL   Nat Commun 9 (1), 2791 (2018)
   PUBMED   30022024
  REMARK    GeneRIF: Suppression of Rad52 expression in combination with FANCM
            knockout drastically reduces cell and tumor growth, suggesting a
            synthetic lethality interaction between these two genes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1680)
  AUTHORS   Sullivan-Reed,K., Bolton-Gillespie,E., Dasgupta,Y., Langer,S.,
            Siciliano,M., Nieborowska-Skorska,M., Hanamshet,K., Belyaeva,E.A.,
            Bernhardy,A.J., Lee,J., Moore,M., Zhao,H., Valent,P.,
            Matlawska-Wasowska,K., Muschen,M., Bhatia,S., Bhatia,R.,
            Johnson,N., Wasik,M.A., Mazin,A.V. and Skorski,T.
  TITLE     Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic
            Lethality in BRCA-Deficient Tumor Cells
  JOURNAL   Cell Rep 23 (11), 3127-3136 (2018)
   PUBMED   29898385
REFERENCE   5  (bases 1 to 1680)
  AUTHORS   Lieberman,R., Pan,J., Zhang,Q. and You,M.
  TITLE     Rad52 deficiency decreases development of lung squamous cell
            carcinomas by enhancing immuno-surveillance
  JOURNAL   Oncotarget 8 (21), 34032-34044 (2017)
   PUBMED   28415565
  REMARK    GeneRIF: Results demonstrate that Rad52 depletion increased cell
            death, decreased myeloid cell frequency, and augmented the activity
            of CD8+ T cells and NK effectors that ultimately led to reduced
            tumor growth. These data provide support for the notion of RAD52 as
            a potential oncogene, implicating a major role for the combined
            processes of recombinational repair and host immunity in
            determining risk for Squamous Cell.
REFERENCE   6  (bases 1 to 1680)
  AUTHORS   Klein,H.L.
  TITLE     Genetic control of intrachromosomal recombination
  JOURNAL   Bioessays 17 (2), 147-159 (1995)
   PUBMED   7748165
  REMARK    Review article
REFERENCE   7  (bases 1 to 1680)
  AUTHORS   Shen,Z., Denison,K., Lobb,R., Gatewood,J.M. and Chen,D.J.
  TITLE     The human and mouse homologs of the yeast RAD52 gene: cDNA cloning,
            sequence analysis, assignment to human chromosome 12p12.2-p13, and
            mRNA expression in mouse tissues
  JOURNAL   Genomics 25 (1), 199-206 (1995)
   PUBMED   7774919
REFERENCE   8  (bases 1 to 1680)
  AUTHORS   Li,X., Rosahl,T.W., Sudhof,T.C. and Francke,U.
  TITLE     Mapping of synapsin II (SYN2) genes to human chromosome 3p and
            mouse chromosome 6 band F
  JOURNAL   Cytogenet Cell Genet 71 (3), 301-305 (1995)
   PUBMED   7587399
REFERENCE   9  (bases 1 to 1680)
  AUTHORS   Muris,D.F., Bezzubova,O., Buerstedde,J.M., Vreeken,K.,
            Balajee,A.S., Osgood,C.J., Troelstra,C., Hoeijmakers,J.H.,
            Ostermann,K., Schmidt,H. et al.
  TITLE     Cloning of human and mouse genes homologous to RAD52, a yeast gene
            involved in DNA repair and recombination
  JOURNAL   Mutat Res 315 (3), 295-305 (1994)
   PUBMED   7526206
REFERENCE   10 (bases 1 to 1680)
  AUTHORS   Kramerov,D.A., Tillib,S.V., Ryskov,A.P. and Georgiev,G.P.
  TITLE     Nucleotide sequence of small polyadenylated B2 RNA
  JOURNAL   Nucleic Acids Res 13 (18), 6423-6437 (1985)
   PUBMED   2414725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117667.9.
            
            On Aug 3, 2022 this sequence version replaced NM_001166381.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z32767.1, SRR13422589.395310.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC117667.9         48165-48284         c
            121-214             AC117667.9         39859-39952         c
            215-316             AC117667.9         37897-37998         c
            317-410             AC117667.9         37008-37101         c
            411-478             AC117667.9         36763-36830         c
            479-597             AC117667.9         35648-35766         c
            598-673             AC117667.9         34958-35033         c
            674-873             AC117667.9         32214-32413         c
            874-1025            AC117667.9         31923-32074         c
            1026-1106           AC117667.9         30810-30890         c
            1107-1328           AC117667.9         29972-30193         c
            1329-1680           AC117667.9         28177-28528         c
FEATURES             Location/Qualifiers
     source          1..1680
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 56.86 cM"
     gene            1..1680
                     /gene="Rad52"
                     /gene_synonym="Rad52yh"
                     /note="RAD52 homolog, DNA repair protein"
                     /db_xref="GeneID:19365"
                     /db_xref="MGI:MGI:101949"
     exon            1..120
                     /gene="Rad52"
                     /gene_synonym="Rad52yh"
                     /inference="alignment:Splign:2.1.0"
     exon            121..214
                     /gene="Rad52"
                     /gene_synonym="Rad52yh"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1390
                     /gene="Rad52"
                     /gene_synonym="Rad52yh"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     repair protein RAD52 homolog"
                     /codon_start=1
                     /product="DNA repair protein RAD52 homolog isoform 1"
                     /protein_id="NP_001159853.1"
                     /db_xref="CCDS:CCDS51887.1"
                     /db_xref="GeneID:19365"
                     /db_xref="MGI:MGI:101949"
                     /translation="MAGPEEAVHRGCDNHPPFVGGKSVLLFGQSQYTADEYQAIQKAL
                     RQRLGPEYISSRMAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNG
                     KFYVGVCAFVKVQLKDGSYHEDVGYGVSEGLRSKALSLEKARKEAVTDGLKRALRSFG
                     NALGNCILDKDYLRSLNKLPRQLPLDVDLTKTKREDFEPSVEQARYNSCRQNEALGLP
                     KPQEVTSPCRSSPPHDSNIKLQGAKDISSSCSLAATLESDATHQRKLRKLRQKQLQQQ
                     FREQMETRRQSHAPAEEVAAKHAAVLPAPPKHSTPVTAASELLQEKVVFPDNLEENLE
                     MWDLTPDLEDIIKPLCRAEPAQTSATRTFNNQDSVPHIHCHQKPQEKPGPGHLQTCNT
                     NQHVLGSREDSEPHRKSQDLKKRKLDPS"
     exon            215..316
                     /gene="Rad52"
                     /gene_synonym="Rad52yh"
                     /inference="alignment:Splign:2.1.0"
     exon            317..410
                     /gene="Rad52"
                     /gene_synonym="Rad52yh"
                     /inference="alignment:Splign:2.1.0"
     exon            411..478
                     /gene="Rad52"
                     /gene_synonym="Rad52yh"
                     /inference="alignment:Splign:2.1.0"
     exon            479..597
                     /gene="Rad52"
                     /gene_synonym="Rad52yh"
                     /inference="alignment:Splign:2.1.0"
     exon            598..673
                     /gene="Rad52"
                     /gene_synonym="Rad52yh"
                     /inference="alignment:Splign:2.1.0"
     exon            674..873
                     /gene="Rad52"
                     /gene_synonym="Rad52yh"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1025
                     /gene="Rad52"
                     /gene_synonym="Rad52yh"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1106
                     /gene="Rad52"
                     /gene_synonym="Rad52yh"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1328
                     /gene="Rad52"
                     /gene_synonym="Rad52yh"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1680
                     /gene="Rad52"
                     /gene_synonym="Rad52yh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1660..1665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rad52"
                     /gene_synonym="Rad52yh"
                     /note="hexamer: ATTAAA"
     polyA_site      1680
                     /gene="Rad52"
                     /gene_synonym="Rad52yh"
                     /note="major polyA site"
ORIGIN      
        1 ctgtttttct ttgggcgagg actctgagct tgcagagtct ccattccttc tgcgaggccc
       61 tctccggctt cccggcaggc acccggaccg agctcctgcg tgcaccgcgt tccgaagcgc
      121 ggtcaacatg gctgggcctg aagaagcagt ccacagaggg tgtgacaacc atcctccctt
      181 tgttggtggg aagtctgtgc tcctctttgg acagagccag tatacagcgg atgaatacca
      241 ggccatccag aaagctctga gacagagact gggtccagag tacattagca gccgcatggc
      301 tggaggaggt cagaaggtgt gttatattga aggtcatcgg gtaattaatc tggccaatga
      361 gatgtttggt tacaatggct gggcacactc catcacccag caaaatgtgg attttgttga
      421 cctcaacaat ggcaagttct acgtgggagt ctgtgcattt gtaaaggtgc agttaaagga
      481 tggttcctat catgaggacg tgggctatgg agttagtgag ggcctccgtt caaaggcctt
      541 gtcactggag aaggccagga aggaggctgt gactgatggg ctgaagcgag cactcaggag
      601 ttttgggaat gcacttggaa actgtattct ggacaaagac tatctgaggt cactaaataa
      661 gcttccacga cagctccctc ttgatgtgga tttaactaaa acaaagagag aagattttga
      721 accatctgta gaacaggcaa gatacaacag ctgccgacag aatgaagcat tgggactccc
      781 caaaccacag gaagtgactt ccccttgcag atcaagcccc ccacatgact cgaacattaa
      841 gcttcagggg gctaaggaca tcagcagctc ctgcagtctg gccgccacct tggagagtga
      901 cgccactcac cagaggaagc tccggaagct ccggcagaag cagctccagc agcagttccg
      961 ggaacagatg gagactcgcc ggcagagcca tgcacctgcc gaagaggtgg cagccaagca
     1021 tgcggcagta cttccagccc ctccaaaaca cagcacccct gtaactgcag cctcagaact
     1081 cctccaggag aaagtcgtct ttccagataa ccttgaagag aaccttgaaa tgtgggacct
     1141 tactccagac ttagaggaca tcattaagcc cttgtgtaga gcagaaccag cccaaacttc
     1201 tgccactcga accttcaaca accaggacag cgtcccacat atccattgcc atcagaaacc
     1261 acaagaaaag cctggacctg ggcacctgca gacctgcaac accaaccagc atgttctagg
     1321 tagcagagaa gactctgaac ctcataggaa gagccaggac ctgaagaaaa ggaaactaga
     1381 tccatcctga gactcaagat gtcactagac cgtcacaaaa ggactttgga aaactgcagt
     1441 ttggtcacaa aattgttcca ccttggctca tgctgaactc tttagaggac tatagaggaa
     1501 gctaactact taaaaaggtt gtcatacccc atgatgggaa ggaggccaac agataaactt
     1561 tgttcagtat tactcactcc taagctgatt ctaggacctt gcaggctgcc tttcatttaa
     1621 cgatgttgcc caccaagccc cagcatgact gttacctaca ttaaattatg tgtgacctca
//
