LOCUS       NM_053269               3927 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus RAD51 paralog C (Rad51c), transcript variant 2, mRNA.
ACCESSION   NM_053269
VERSION     NM_053269.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3927)
  AUTHORS   Tomaszowski,K.H., Roy,S., Guerrero,C., Shukla,P., Keshvani,C.,
            Chen,Y., Ott,M., Wu,X., Zhang,J., DiNardo,C.D., Schindler,D. and
            Schlacher,K.
  TITLE     Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi
            anemia, cancer and polygenic replication stress
  JOURNAL   Nat Commun 14 (1), 1333 (2023)
   PUBMED   36906610
  REMARK    GeneRIF: Hypomorphic Brca2 and Rad51c double mutant mice display
            Fanconi anemia, cancer and polygenic replication stress.
            Erratum:[Nat Commun. 2024 Mar 12;15(1):2214. doi:
            10.1038/s41467-024-46561-9.. PMID: 38472265]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3927)
  AUTHORS   Rojas,E., Martinez-Pacheco,M., Rodriguez-Sastre,M.A.,
            Ramos-Espinosa,P. and Valverde,M.
  TITLE     Post-transcriptional regulation of Rad51c by miR-222 contributes
            cellular transformation
  JOURNAL   PLoS One 15 (1), e0221681 (2020)
   PUBMED   31923208
  REMARK    GeneRIF: we demonstrate that miR-222 up-regulation, directly
            regulates Rad51c expression negatively, and impairs homologous
            recombination of double-strand break DNA repair during the
            initiation stage of cell transformation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3927)
  AUTHORS   Tumiati,M., Munne,P.M., Edgren,H., Eldfors,S., Hemmes,A. and
            Kuznetsov,S.G.
  TITLE     Rad51c- and Trp53-double-mutant mouse model reveals common features
            of homologous recombination-deficient breast cancers
  JOURNAL   Oncogene 35 (35), 4601-4610 (2016)
   PUBMED   26820992
  REMARK    GeneRIF: Similar to other BC models, Rad51c/p53 double-mutant mouse
            mammary tumors also reveal a propensity for genomic instability,
            but lack the focal amplification of the Met locus or distinct
            mutational signatures reported for other HR genes
REFERENCE   4  (bases 1 to 3927)
  AUTHORS   Tumiati,M., Hemmes,A., Uusivirta,S., Koopal,S., Kankainen,M.,
            Lehtonen,E. and Kuznetsov,S.G.
  TITLE     Loss of Rad51c accelerates tumourigenesis in sebaceous glands of
            Trp53-mutant mice
  JOURNAL   J Pathol 235 (1), 136-146 (2015)
   PUBMED   25270124
  REMARK    GeneRIF: a critical synergy between Rad51c and Trp53 in tumour
            progression and provide a predictable in vivo model system for
            studying mechanisms of Rad51c-mediated carcinogenesis
REFERENCE   5  (bases 1 to 3927)
  AUTHORS   Badie,S., Escandell,J.M., Bouwman,P., Carlos,A.R., Thanasoula,M.,
            Gallardo,M.M., Suram,A., Jaco,I., Benitez,J., Herbig,U.,
            Blasco,M.A., Jonkers,J. and Tarsounas,M.
  TITLE     BRCA2 acts as a RAD51 loader to facilitate telomere replication and
            capping
  JOURNAL   Nat Struct Mol Biol 17 (12), 1461-1469 (2010)
   PUBMED   21076401
REFERENCE   6  (bases 1 to 3927)
  AUTHORS   Kuznetsov,S.G., Haines,D.C., Martin,B.K. and Sharan,S.K.
  TITLE     Loss of Rad51c leads to embryonic lethality and modulation of
            Trp53-dependent tumorigenesis in mice
  JOURNAL   Cancer Res 69 (3), 863-872 (2009)
   PUBMED   19155299
  REMARK    GeneRIF: Rad51c mutation in DH-cis mice promoted the development of
            tumors of specialized sebaceous glands and suppressed tumors
            characteristic of Trp53 mutation. In addition, DH-cis females
            developed tumors significantly earlier than any other group.
REFERENCE   7  (bases 1 to 3927)
  AUTHORS   Kuznetsov,S., Pellegrini,M., Shuda,K., Fernandez-Capetillo,O.,
            Liu,Y., Martin,B.K., Burkett,S., Southon,E., Pati,D.,
            Tessarollo,L., West,S.C., Donovan,P.J., Nussenzweig,A. and
            Sharan,S.K.
  TITLE     RAD51C deficiency in mice results in early prophase I arrest in
            males and sister chromatid separation at metaphase II in females
  JOURNAL   J Cell Biol 176 (5), 581-592 (2007)
   PUBMED   17312021
  REMARK    GeneRIF: RAD51C has a late role in meiotic recombination.
REFERENCE   8  (bases 1 to 3927)
  AUTHORS   Liu,Y., Tarsounas,M., O'regan,P. and West,S.C.
  TITLE     Role of RAD51C and XRCC3 in genetic recombination and DNA repair
  JOURNAL   J Biol Chem 282 (3), 1973-1979 (2007)
   PUBMED   17114795
  REMARK    GeneRIF: the RAD51C-XRCC3-associated Holliday junction resolvase
            complex associates with crossovers and may play an essential role
            in the resolution of recombination intermediates prior to
            chromosome segregation
REFERENCE   9  (bases 1 to 3927)
  AUTHORS   Godthelp,B.C., Wiegant,W.W., van Duijn-Goedhart,A., Scharer,O.D.,
            van Buul,P.P., Kanaar,R. and Zdzienicka,M.Z.
  TITLE     Mammalian Rad51C contributes to DNA cross-link resistance, sister
            chromatid cohesion and genomic stability
  JOURNAL   Nucleic Acids Res 30 (10), 2172-2182 (2002)
   PUBMED   12000837
REFERENCE   10 (bases 1 to 3927)
  AUTHORS   Leasure,C.S., Chandler,J., Gilbert,D.J., Householder,D.B.,
            Stephens,R., Copeland,N.G., Jenkins,N.A. and Sharan,S.K.
  TITLE     Sequence, chromosomal location and expression analysis of the
            murine homologue of human RAD51L2/RAD51C
  JOURNAL   Gene 271 (1), 59-67 (2001)
   PUBMED   11410366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669902.8, BY720217.1, BC090648.1 and AL596130.13.
            
            On May 18, 2018 this sequence version replaced NM_053269.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090648.1, SRR1660819.148112.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL669902.8         18070-18080         c
            12-67               BY720217.1         12-67
            68-2965             BC090648.1         1-2898
            2966-3927           AL596130.13        191219-192180       c
FEATURES             Location/Qualifiers
     source          1..3927
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 52.08 cM"
     gene            1..3927
                     /gene="Rad51c"
                     /gene_synonym="R51H3; Rad51l2"
                     /note="RAD51 paralog C"
                     /db_xref="GeneID:114714"
                     /db_xref="MGI:MGI:2150020"
     exon            1..203
                     /gene="Rad51c"
                     /gene_synonym="R51H3; Rad51l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1186
                     /gene="Rad51c"
                     /gene_synonym="R51H3; Rad51l2"
                     /note="isoform 2 is encoded by transcript variant 2; DNA
                     repair protein RAD51 homolog 3; RAD51-like protein 2;
                     RAD51 homolog C"
                     /codon_start=1
                     /product="DNA repair protein RAD51 homolog 3 isoform 2"
                     /protein_id="NP_444499.1"
                     /db_xref="CCDS:CCDS25212.1"
                     /db_xref="GeneID:114714"
                     /db_xref="MGI:MGI:2150020"
                     /translation="MQRELVGYPLSPAVRGKLVAAGFQTAEDVLEVKPSELSKEVGIS
                     KEEALETLQILRRECLTNKPRCAGTSVANEKCTALELLEQEHTQGFIITFCSALDNIL
                     GGGIPLMKTTEVCGVPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRV
                     VSLATACIQHLHLIAGTHTEEEHQKALKDFTLENILSHIYYFRCHDYTELLAQVYLLP
                     DFLSDHPKVQLVIIDGIAFPFRHDLEDLSLRTRLLNGLAQQMISLANNHRLAVILTNQ
                     MTTKIDKNQALLVPALGESWGHAATIRLIFHWEQKQRFATLYKSPSQKESTIPFQITP
                     QGFRDAVVTAASSQTESSLNFRKRSREPEEEC"
     exon            204..462
                     /gene="Rad51c"
                     /gene_synonym="R51H3; Rad51l2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..629
                     /gene="Rad51c"
                     /gene_synonym="R51H3; Rad51l2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..763
                     /gene="Rad51c"
                     /gene_synonym="R51H3; Rad51l2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..895
                     /gene="Rad51c"
                     /gene_synonym="R51H3; Rad51l2"
                     /inference="alignment:Splign:2.1.0"
     exon            896..962
                     /gene="Rad51c"
                     /gene_synonym="R51H3; Rad51l2"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1023
                     /gene="Rad51c"
                     /gene_synonym="R51H3; Rad51l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1084
                     /gene="Rad51c"
                     /gene_synonym="R51H3; Rad51l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..3927
                     /gene="Rad51c"
                     /gene_synonym="R51H3; Rad51l2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1995..2000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rad51c"
                     /gene_synonym="R51H3; Rad51l2"
                     /note="hexamer: AATAAA"
     polyA_site      2019
                     /gene="Rad51c"
                     /gene_synonym="R51H3; Rad51l2"
                     /note="major polyA site"
     regulatory      3388..3393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rad51c"
                     /gene_synonym="R51H3; Rad51l2"
                     /note="hexamer: AATAAA"
     polyA_site      3409
                     /gene="Rad51c"
                     /gene_synonym="R51H3; Rad51l2"
ORIGIN      
        1 gtttccagcg ctttcgcgcc tcttgctcta cgtcactgcg tgcgtagccg ccgagctctc
       61 aaaaaaaaaa aaaaaaaaaa aaaaaatgca gcgggagttg gtgggttatc cgctgtctcc
      121 agcggtgcgc gggaagctgg tggctgcggg gtttcagacg gcggaggacg tcctagaggt
      181 gaagccctcc gagctcagca aagaagttgg gatatctaaa gaggaagcct tggaaactct
      241 acaaattcta agaagagaat gtctcacaaa taaaccaaga tgtgccggta catctgtggc
      301 aaacgagaag tgcacagcac tggaacttct cgagcaagag catacccagg gcttcataat
      361 caccttctgt tcagcactcg ataacattct tgggggtgga atacccctaa tgaagacgac
      421 agaagtttgt ggtgtaccag gtgttggaaa aacacagtta tgtatgcaat tggcagtaga
      481 tgtgcagatt ccagaatgtt ttgggggcgt ggccggtgaa gcagtattta ttgatacaga
      541 gggaagtttt atggttgata gagtggtcag ccttgcaact gcctgcattc agcaccttca
      601 tctcatagca ggaacacaca cggaagaaga acatcagaaa gccttgaagg attttactct
      661 tgaaaatatt ctttcccata tttattattt tcgttgtcat gattatactg agctgctggc
      721 acaagtctat ctccttccag atttcctttc agatcatcca aaggtgcagc tagtgataat
      781 agacggaatt gcttttccct ttcgtcatga ccttgaagat ctatcccttc gtactcgatt
      841 actaaatggc ctcgcccaac aaatgatcag ccttgcaaat aatcacagat tagctgttat
      901 tttaactaat cagatgacaa caaagattga taaaaatcaa gctttgcttg ttcctgcatt
      961 aggggaaagc tgggggcatg ctgctacaat aaggctcatt tttcactggg aacaaaagca
     1021 aagatttgca acattgtaca agtcaccaag ccagaaggag tctacgatac catttcagat
     1081 cacacctcag ggatttagag acgctgttgt cactgctgcc tcatcacaga cagagagttc
     1141 tttgaatttc cggaaacggt cacgagaacc agaggaagaa tgctgaccaa atgctgatgc
     1201 cagtgtatcc agttaactga tgatgtgcta gtcagagtgt agtgtgtgtg tgtgtgtgtg
     1261 tgcactgtgt gtgtgtgtgc actgtgtgtg tgtgtgtgca ctgtgtgtgt gcgggtgcct
     1321 acaaaagcaa gcggagggtg gtggatctcg tggaactgga gttagaagta actgaaccac
     1381 catgaaggtg ctgagaacca gaacctagtc ctgcaagaac caaaaatgtt cccaactgct
     1441 gagccatcca tctctccagc tcctccaccc tgtctctgag gcagggtctt ctgttttgtc
     1501 tcttcattct ccaggtctgc acactttaac tacttctgtt ttggcctcct gtctcactag
     1561 gaaccctggg atgcaggtgt gtagcacact gtgggctctg agaattgaac tcaggtcgtc
     1621 aggcttgcag agcaagggct tttacccact gaacatcttt ctaggccctc cttaaatttt
     1681 aagaaaaaaa tctctccctg aacgtggagc tcactgcttc agggccacct atctacccca
     1741 gcagcaccaa gatgcacaca tgtgctgcac tgcaccagct tttattatat gccgtcctca
     1801 tgcctgcatg tcaggcactt tacccatgga gctgtttccc tagctcctga aaagattttc
     1861 tgaagcactg ttctataatt atattttaat gtgtttttat tttgagtaat gtggaaagct
     1921 gaccttatgt tacctatctg gatttaccac ccagagtgga aaatttcttt gtcaattgcc
     1981 taaaaaataa tagaaataaa acactataat atgtttgaag tgtgtgtata tgtatctgtg
     2041 tgtttgccaa ctgtgtggag gccttcaaag catggaagag ggcatcatgt cccctagaac
     2101 tggagttata tgtggttggc tgccagatat gggatcttaa gtaatttctg agtcatgtct
     2161 ctgtccctcc atattcttaa atgtagcttt gggggcctag agagaggacg caggagttaa
     2221 gagcacttgt tgctctttta gaagacctgg atcagttatc agcaccaagt aactccagtt
     2281 ccaggggatc tgaccccccc cctcctcagc cctccacgga cactaagcat gtatatagta
     2341 tacatacata cttgtaggca gaacactcaa acaaatacga aataaaatta aaaataaaca
     2401 aatgtagctt tgaaagcaat taacatatca ctgtttagtt agttgagttg gtttggtttg
     2461 ctgactcctg gtctgtgtgt cctccttgct gctgggttgc ccagagcacc tcctgcaagc
     2521 cattgttgga ggcagcacac agtctgtaat aggggttgaa ggtctgtgcc tcccctccaa
     2581 gtctttgtgc ctggggacag ctaagcccta gagagaggca gagccaggtt tggctccaag
     2641 tcagggccaa gagtatgtat gggagaggct ggaagagaag gccttctctg agagatttag
     2701 gtctgaagcc cctccccacc ctggaatcct tgatgaagaa atagatggtc ctttctttga
     2761 tggtggatgt gaatgcatac accttactca aggtgaacca gggattaaat accttttgca
     2821 ggaagaaatg cccaggaagg ggaagctcat tggctgaaca ctcagggcct gtgtagctac
     2881 ttcattagca tggagaactc caggttctta tgctgtgtga ctgatgggtg ttatgattac
     2941 gtgttccaga acagattccc tggggtttga acgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3001 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtggtggtgg tggtgttttg aatagatttg
     3061 gcctacacag actcatatat ttgaatgctt ggcctttggg gagtggcact attaggtgta
     3121 acgttggaat agtgtggcct ttgtaggagg taatgtgtca ctgtgggggc agatttttag
     3181 gtctccaatg ctcaagtcat gcccagtgtg acatacaatc tcctgctgtc tgtggatcaa
     3241 actatagaac tctcagctcc tctagtacca tgtctgtctg catgccgcca tgctttccac
     3301 catgatgata atggaccttt ggcagcccca aattaatttt ttttttcctt taaaaaagtt
     3361 gctatggtca tgttgtctct ttatagcaat aaaacccaaa ctaagactct gtgtgtgtat
     3421 acatctttct atttagccct ggctggcctg gaattcacta tgtagatctc ttgtcaaaca
     3481 aaagagatct acctgtctgc ctctaggctt aaaggagtac agtccattcc tatagttaat
     3541 tttgtggatg gtttacaaat ttgagctgat gaaattagtt ttagtgacct cagtctattt
     3601 gtttaatttt tgttatttgt cattttaaag ggaaaatttc aaagctatgt gtagccattg
     3661 aaatatgtcc tctagaatag ttagattatg gtaaactttg tttgttttgg ggtttttttt
     3721 gtttttgttt ttgtttttga gacagggttt ctctgtatag ccctggctgt cctggaactc
     3781 actttgtaga ccaggctggc ctcgaactca gaaatccacc tgcctctgcc tcccgagtgc
     3841 tatggtaaac tttaaatgta gattattatt tatatctacg tttttgaagt gcagtgtgaa
     3901 taaataaaaa ttctggactt ttaaaaa
//
