LOCUS       NM_009014               1858 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus RAD51 paralog B (Rad51b), transcript variant 1, mRNA.
ACCESSION   NM_009014
VERSION     NM_009014.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1858)
  AUTHORS   Dickinson,K., Hammond,L., Akpa,M., Chu,L.L., Lalonde,C.T.,
            Goumba,A. and Goodyer,P.
  TITLE     WT1 regulates expression of DNA repair gene Neil3 during
            nephrogenesis
  JOURNAL   Am J Physiol Renal Physiol 324 (3), F245-F255 (2023)
   PUBMED   36546838
REFERENCE   2  (bases 1 to 1858)
  AUTHORS   Franca,M.M., Condezo,Y.B., Elzaiat,M., Felipe-Medina,N.,
            Sanchez-Saez,F., Munoz,S., Sainz-Urruela,R., Martin-Hervas,M.R.,
            Garcia-Valiente,R., Sanchez-Martin,M.A., Astudillo,A., Mendez,J.,
            Llano,E., Veitia,R.A., Mendonca,B.B. and Pendas,A.M.
  TITLE     A truncating variant of RAD51B associated with primary ovarian
            insufficiency provides insights into its meiotic and somatic
            functions
  JOURNAL   Cell Death Differ 29 (12), 2347-2361 (2022)
   PUBMED   35624308
  REMARK    GeneRIF: A truncating variant of RAD51B associated with primary
            ovarian insufficiency provides insights into its meiotic and
            somatic functions.
REFERENCE   3  (bases 1 to 1858)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1858)
  AUTHORS   Liu,Q., Wang,G., Chen,Y., Li,G., Yang,D. and Kang,J.
  TITLE     A miR-590/Acvr2a/Rad51b axis regulates DNA damage repair during
            mESC proliferation
  JOURNAL   Stem Cell Reports 3 (6), 1103-1117 (2014)
   PUBMED   25458897
  REMARK    GeneRIF: Our study shows that a miR-590/Acvr2a/Rad51b signaling
            axis ensures the stabilization of mESCs by balancing DNA damage
            repair and rapid proliferation during self-renewal.
REFERENCE   5  (bases 1 to 1858)
  AUTHORS   Zhao,Y., Ransom,J.F., Li,A., Vedantham,V., von Drehle,M.,
            Muth,A.N., Tsuchihashi,T., McManus,M.T., Schwartz,R.J. and
            Srivastava,D.
  TITLE     Dysregulation of cardiogenesis, cardiac conduction, and cell cycle
            in mice lacking miRNA-1-2
  JOURNAL   Cell 129 (2), 303-317 (2007)
   PUBMED   17397913
REFERENCE   6  (bases 1 to 1858)
  AUTHORS   Shu,Z., Smith,S., Wang,L., Rice,M.C. and Kmiec,E.B.
  TITLE     Disruption of muREC2/RAD51L1 in mice results in early embryonic
            lethality which can Be partially rescued in a p53(-/-) background
  JOURNAL   Mol Cell Biol 19 (12), 8686-8693 (1999)
   PUBMED   10567591
REFERENCE   7  (bases 1 to 1858)
  AUTHORS   Cartwright,R., Dunn,A.M., Simpson,P.J., Tambini,C.E. and Thacker,J.
  TITLE     Isolation of novel human and mouse genes of the recA/RAD51
            recombination-repair gene family
  JOURNAL   Nucleic Acids Res 26 (7), 1653-1659 (1998)
   PUBMED   9512535
REFERENCE   8  (bases 1 to 1858)
  AUTHORS   Rice,M.C., Smith,S.T., Bullrich,F., Havre,P. and Kmiec,E.B.
  TITLE     Isolation of human and mouse genes based on homology to REC2, a
            recombinational repair gene from the fungus Ustilago maydis
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7417-7422 (1997)
   PUBMED   9207106
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK032913.1.
            
            On Apr 6, 2007 this sequence version replaced NM_009014.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1858              AK032913.1         2-1859
FEATURES             Location/Qualifiers
     source          1..1858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 35.51 cM"
     gene            1..1858
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /note="RAD51 paralog B"
                     /db_xref="GeneID:19363"
                     /db_xref="MGI:MGI:1099436"
     exon            1..51
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /inference="alignment:Splign:2.1.0"
     exon            52..157
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1126
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     repair protein RAD51 homolog 2; RAD51-like protein 1;
                     RAD51 homolog B"
                     /codon_start=1
                     /product="DNA repair protein RAD51 homolog 2 isoform 1"
                     /protein_id="NP_033040.2"
                     /db_xref="CCDS:CCDS88360.1"
                     /db_xref="GeneID:19363"
                     /db_xref="MGI:MGI:1099436"
                     /translation="MSSKKLRRVGLSPELCDRLSRYQIVNCQHFLSLSPLELMKVTGL
                     SYRGVHELLHTVSKACAPQMQTAYELKTRRSAHLSPAFLSTTLCALDEALHGGVPCGS
                     LTEITGPPGCGKTQFCIMMSVLATLPTSLGGLEGAVVYIDTESAFTAERLVEIAESRF
                     PQYFNTEEKLLLTSSRVHLCRELTCEGLLQRLESLEEEIISKGVKLVIVDSIASVVRK
                     EFDPKLQGNIKERNKFLGKGASLLKYLAGEFSIPVILTNQITTHLSGALPSQADLVSP
                     ADDLSLSEGTSGSSCLVAALGNTWGHCVNTRLILQYLDSERRQILIAKSPLAAFTSFV
                     YTIKGEGLVLQGHERP"
     exon            158..271
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..388
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..525
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..645
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..829
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..926
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1030
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1109
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1858
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1172..1177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /note="hexamer: AATGAA"
     polyA_site      1201
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /note="major polyA site"
     regulatory      1521..1526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /note="hexamer: AATAAA"
     polyA_site      1546
                     /gene="Rad51b"
                     /gene_synonym="mREC2; R51H2; Rad51l1"
                     /note="major polyA site"
ORIGIN      
        1 agagtaccaa ccaaccagag ccccagatgt tgctgctcgc acttttcgcg gattctttgg
       61 gagccctgga aacatgagca gcaagaaact aagacgagtg ggtttatctc cagagctgtg
      121 tgaccgttta agcagatacc agattgttaa ctgtcagcac tttttaagtc tctccccact
      181 agaacttatg aaagtgactg gcctgagtta cagaggtgtc cacgagcttc ttcatacagt
      241 aagcaaggcc tgtgccccgc agatgcaaac ggcttatgag ttaaagacac gaaggtctgc
      301 acatctctca ccggcattcc tgtctactac cctgtgcgcc ttggatgaag cattgcacgg
      361 tggtgtgcct tgtggatctc tcacagagat tacaggtcca ccaggttgcg gaaaaactca
      421 gttttgcata atgatgagtg tcttagctac attacctacc agcctgggag gattagaagg
      481 ggctgtggtc tacatcgaca cagagtctgc atttactgct gagagactgg ttgagattgc
      541 ggaatctcgt tttccacaat attttaacac tgaggaaaaa ttgcttctga ccagcagtag
      601 agttcatctt tgccgagagc tcacctgtga ggggcttcta caaaggcttg agtctttgga
      661 ggaagagatc atttcgaaag gagttaagct tgtgattgtt gactccattg cttctgtggt
      721 cagaaaggag tttgacccga agcttcaagg caacatcaaa gaaaggaaca agttcttggg
      781 caaaggagcg tccttactga agtacctggc aggggagttt tcaatcccag ttatcttgac
      841 gaatcaaatt acgacccatc tgagtggagc cctcccttct caagcagacc tggtgtctcc
      901 agctgatgat ttgtccctgt ctgaaggcac ttctggatcc agctgtttgg tagctgcact
      961 aggaaacaca tggggtcact gtgtgaacac ccggctgatt ctccagtacc ttgattcaga
     1021 gagaaggcag attctcattg ccaagtctcc tctggctgcc ttcacctcct ttgtctacac
     1081 catcaagggg gaaggcctgg ttcttcaagg ccacgaaaga ccatagggat actgtgacct
     1141 ttgtctagtg ctgattgcat gtgactcatg aaatgaaaca ggactgcgct gcttggaaaa
     1201 aggaaacgga agccaacata atgaggatta attggttggt tgctgttgag gtggtaacag
     1261 tgatttcaga cccggaaggt gaagatgaag aagcctttat ccagtctctg gatgcagagg
     1321 ctaggggctc caccaccgtg ggatgtcagc ggccatcgta ataatttgca cttacacagc
     1381 acctttcagc catgcccctc aaagtggttc agccacatta attaattaaa gcccacaatc
     1441 cccctaggga gagcaggagg gggactaaca agatttgtaa ttacagaagg gaacatttcc
     1501 gaataaagta ttgttccgca aataaaaaga ataggtgtac aaagaaccgg ggtctccaaa
     1561 gagtaactga ttcacaaatg aaatatcgaa accgtggggg aaactgaagg cggccatggg
     1621 cgtgggggtc tgctctagtg tcagagggag gtcgatggcc tcagaactcg ctgacaggct
     1681 cagacctcac ttcggagcag agcgtgcatg gtattagtgt tgtttggaag gtcattagtg
     1741 ctgtgactat tgtaagtata aattcacgtt ccactggtat attgtgcata gcctcgcaga
     1801 acaaagagtg aaattcttgc agtatttaat aaaggatgaa gtggtttctt tagagttg
//
