LOCUS       NM_009013               1884 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RAD51 associated protein 1 (Rad51ap1), transcript
            variant 1, mRNA.
ACCESSION   NM_009013
VERSION     NM_009013.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1884)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1884)
  AUTHORS   Wang,Y., Li,Y., Ran,C., Le,W., Dong,J., Wang,X., Chen,B. and
            Jiang,X.
  TITLE     The gene RAD51AP1 promotes the progression of pancreatic cancer via
            the PI3K/Akt/NF-kappaB signaling pathway
  JOURNAL   Neoplasma 70 (6), 722-732 (2023)
   PUBMED   37962862
  REMARK    GeneRIF: The gene RAD51AP1 promotes the progression of pancreatic
            cancer via the PI3K/Akt/NF-kappaB signaling pathway.
REFERENCE   3  (bases 1 to 1884)
  AUTHORS   Bridges,A.E., Ramachandran,S., Tamizhmani,K., Parwal,U., Lester,A.,
            Rajpurohit,P., Morera,D.S., Hasanali,S.L., Arjunan,P., Jedeja,R.N.,
            Patel,N., Martin,P.M., Korkaya,H., Singh,N., Manicassamy,S.,
            Prasad,P.D., Lokeshwar,V.B., Lokeshwar,B.L., Ganapathy,V. and
            Thangaraju,M.
  TITLE     RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and
            Sensitizes to Chemotherapy
  JOURNAL   Mol Cancer Res 19 (9), 1486-1497 (2021)
   PUBMED   34099522
  REMARK    GeneRIF: RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell
            Renewal and Sensitizes to Chemotherapy.
REFERENCE   4  (bases 1 to 1884)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1884)
  AUTHORS   Bridges,A.E., Ramachandran,S., Pathania,R., Parwal,U., Lester,A.,
            Rajpurohit,P., Morera,D.S., Patel,N., Singh,N., Korkaya,H.,
            Manicassamy,S., Prasad,P.D., Lokeshwar,V.B., Lokeshwar,B.L.,
            Ganapathy,V. and Thangaraju,M.
  TITLE     RAD51AP1 Deficiency Reduces Tumor Growth by Targeting Stem Cell
            Self-Renewal
  JOURNAL   Cancer Res 80 (18), 3855-3866 (2020)
   PUBMED   32665355
  REMARK    GeneRIF: RAD51AP1 Deficiency Reduces Tumor Growth by Targeting Stem
            Cell Self-Renewal.
REFERENCE   6  (bases 1 to 1884)
  AUTHORS   Zeng,F., Baldwin,D.A. and Schultz,R.M.
  TITLE     Transcript profiling during preimplantation mouse development
  JOURNAL   Dev Biol 272 (2), 483-496 (2004)
   PUBMED   15282163
REFERENCE   7  (bases 1 to 1884)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   8  (bases 1 to 1884)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   9  (bases 1 to 1884)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   10 (bases 1 to 1884)
  AUTHORS   Mizuta,R., LaSalle,J.M., Cheng,H.L., Shinohara,A., Ogawa,H.,
            Copeland,N., Jenkins,N.A., Lalande,M. and Alt,F.W.
  TITLE     RAB22 and RAB163/mouse BRCA2: proteins that specifically interact
            with the RAD51 protein
  JOURNAL   Proc Natl Acad Sci U S A 94 (13), 6927-6932 (1997)
   PUBMED   9192668
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB620338.1, AK079525.1, AK077829.1 and AW457762.1.
            
            On Nov 29, 2016 this sequence version replaced NM_009013.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079525.1, AK011379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BB620338.1         2-12
            12-1082             AK079525.1         2-1072
            1083-1605           AK077829.1         1081-1603
            1606-1884           AW457762.1         1-279               c
FEATURES             Location/Qualifiers
     source          1..1884
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 61.92 cM"
     gene            1..1884
                     /gene="Rad51ap1"
                     /gene_synonym="2510006L10Rik; RAB22"
                     /note="RAD51 associated protein 1"
                     /db_xref="GeneID:19362"
                     /db_xref="MGI:MGI:1098224"
     exon            1..94
                     /gene="Rad51ap1"
                     /gene_synonym="2510006L10Rik; RAB22"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1091
                     /gene="Rad51ap1"
                     /gene_synonym="2510006L10Rik; RAB22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RAD51-interacting protein"
                     /codon_start=1
                     /product="RAD51-associated protein 1 isoform 1"
                     /protein_id="NP_033039.2"
                     /db_xref="CCDS:CCDS39644.1"
                     /db_xref="GeneID:19362"
                     /db_xref="MGI:MGI:1098224"
                     /translation="MVRPIRNRKPINYSQFEDSGNDSDDDFISSSTPVNKSKTVPKVL
                     KQDKPKPNLKNLQKEEVLPTEPPKKRVALDDKVFQRGLEVALALSVKELPTLTNQVKK
                     SKEKSTDKQGKEKTENTGKPPHVSNCSVASDDVEDLDKITEEGDASSVEGERKSPSQA
                     KAPRRRAPSEGSDGSSANDTESESATGEGSESDPDFDESKESDEDFGVRRSKESKKKT
                     VQKKPAGEKKERKSKPKCEASVTSVDPAPAAIKSGSPSLPQAVGLPSEATRKPAIMCS
                     PSAESKRPKWVPPAASGSRNSSSNALAGTPAKSPSQSLRLGLSRLAPVKRLHPSATSS
                     QVR"
     exon            95..150
                     /gene="Rad51ap1"
                     /gene_synonym="2510006L10Rik; RAB22"
                     /inference="alignment:Splign:2.1.0"
     exon            151..286
                     /gene="Rad51ap1"
                     /gene_synonym="2510006L10Rik; RAB22"
                     /inference="alignment:Splign:2.1.0"
     exon            287..396
                     /gene="Rad51ap1"
                     /gene_synonym="2510006L10Rik; RAB22"
                     /inference="alignment:Splign:2.1.0"
     exon            397..483
                     /gene="Rad51ap1"
                     /gene_synonym="2510006L10Rik; RAB22"
                     /inference="alignment:Splign:2.1.0"
     exon            484..636
                     /gene="Rad51ap1"
                     /gene_synonym="2510006L10Rik; RAB22"
                     /inference="alignment:Splign:2.1.0"
     exon            637..795
                     /gene="Rad51ap1"
                     /gene_synonym="2510006L10Rik; RAB22"
                     /inference="alignment:Splign:2.1.0"
     exon            796..945
                     /gene="Rad51ap1"
                     /gene_synonym="2510006L10Rik; RAB22"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1871
                     /gene="Rad51ap1"
                     /gene_synonym="2510006L10Rik; RAB22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1846..1851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rad51ap1"
                     /gene_synonym="2510006L10Rik; RAB22"
                     /note="hexamer: AATAAA"
     polyA_site      1871
                     /gene="Rad51ap1"
                     /gene_synonym="2510006L10Rik; RAB22"
                     /note="major polyA site"
ORIGIN      
        1 gtctggtttt cggcgggaat tgaaaccgcc acagctgctc cccagctcca gagcactgct
       61 gctctaggca gggcaccatg gtgcgtccta tcagaaatag aaaaccaata aattattcac
      121 agtttgaaga ttctggcaat gactctgatg atgattttat ttcttcatcc acacctgtaa
      181 acaagtcaaa aactgtgcca aaggtattaa agcaagacaa accaaaacct aacttgaaga
      241 atctccaaaa agaagaggtc ttaccaacag aaccccctaa aaaaagggtg gctttagatg
      301 acaaggtctt ccaaagaggt ctagaagttg ccctggcttt atctgtgaag gaacttccaa
      361 cactcaccaa ccaagtaaag aagtccaaag agaaaagcac tgacaaacaa ggcaaagaga
      421 aaacagaaaa tacgggtaaa cctcctcatg tctctaactg cagtgtagcc agtgatgatg
      481 tagaagattt ggacaagatc acagaggagg gggacgcctc gagtgttgaa ggggagagga
      541 agtcaccatc tcaagccaag gctccgcgga ggagagcacc ttctgaaggc agcgatggca
      601 gcagtgctaa cgacacggag tcggagagcg ccactggtga aggttcagaa agtgatcctg
      661 attttgatga gagtaaagaa agtgatgaag actttggtgt gagaagaagt aaagaatcaa
      721 agaagaaaac agtgcagaag aaacctgcag gggaaaagaa ggaaaggaaa tcaaaaccca
      781 aatgtgaggc atcagtgact tcagtagacc cagctccagc tgccatcaag tcaggatctc
      841 catctttacc ccaggcagtt ggtcttcctt ctgaggccac taggaaacca gcaataatgt
      901 gcagcccttc agctgaaagc aagaggccca agtgggtccc cccagctgcc tctgggagca
      961 ggaactctag cagcaatgca ttggcaggaa cacctgccaa gtccccgagt cagagcctgc
     1021 gtctgggcct ctcccgatta gcgccagtta agcgcttgca tccaagtgcc acaagcagcc
     1081 aagtgcggta gcaggaaagg actgctggga cccttgggac tgcaagcagg gttgtcatat
     1141 tcagcttcca cataagagaa cctttaatgg gtcacatgaa ggaccatgtc tgtgtgtgat
     1201 tctggtctca tcaaagcctt tctgtccttc agcaaagggt tctgggacct ctccttgtgg
     1261 cactcctgaa gagtgtgttg tgttttcttg tgtttataag ccactgtcac tcgggctctg
     1321 cggcacgtct gtaatcacat gtctcccagc tctggcatgg gagcatcctg ggtccttcag
     1381 gaggcattgc tgaaatcttt cccatactac atttcttcag gtttattcca agcttactct
     1441 ctttgtctag gtctttttag taagaattct gcttttgtac atattaacat gttgactcta
     1501 ctgcagcatg tgttcctaca tgggacaggt ggttagtgta cagcagatag aatctcatga
     1561 cgctgtatga acttttcaaa acctttaata aacatgaaaa gatgtaagct atgctcattg
     1621 ataccatgta tgtacctgca tgtgtacgtg ttgctaaaat gagtcttctg tggtcaaaat
     1681 aagcaggggg aggagtgtct tcatcattga gatgaagccc aaggttgaaa gctgtcacct
     1741 ccacgcccct gtcacagctg atgcatcgtc tcaggaagct ctggtttact gtcagtaaaa
     1801 gcaattattt ttatagtaag aaatcaactt gtttctgatt actttaataa agtctaatgt
     1861 ttactgtaaa aaaaaaaaaa aaaa
//
