LOCUS       NM_011234               2144 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus RAD51 recombinase (Rad51), transcript variant 1, mRNA.
ACCESSION   NM_011234
VERSION     NM_011234.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2144)
  AUTHORS   Ito,M., Yun,Y., Kulkarni,D.S., Lee,S., Sandhu,S., Nunez,B., Hu,L.,
            Lee,K., Lim,N., Hirota,R.M., Prendergast,R., Huang,C., Huang,I. and
            Hunter,N.
  TITLE     Distinct and interdependent functions of three RING proteins
            regulate recombination during mammalian meiosis
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2412961121 (2025)
   PUBMED   39761402
REFERENCE   2  (bases 1 to 2144)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2144)
  AUTHORS   Ye,Z., Xu,S., Shi,Y., Cheng,X., Zhang,Y., Roy,S., Namjoshi,S.,
            Longo,M.A., Link,T.M., Schlacher,K., Peng,G., Yu,D., Wang,B.,
            Tainer,J.A. and Ahmed,Z.
  TITLE     GRB2 stabilizes RAD51 at reversed replication forks suppressing
            genomic instability and innate immunity against cancer
  JOURNAL   Nat Commun 15 (1), 2132 (2024)
   PUBMED   38459011
  REMARK    GeneRIF: GRB2 stabilizes RAD51 at reversed replication forks
            suppressing genomic instability and innate immunity against cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2144)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2144)
  AUTHORS   Ito,M., Furukohri,A., Matsuzaki,K., Fujita,Y., Toyoda,A. and
            Shinohara,A.
  TITLE     FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic
            DNA replication and meiotic recombination
  JOURNAL   Nat Commun 14 (1), 6857 (2023)
   PUBMED   37891173
  REMARK    GeneRIF: FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in
            pre-meiotic DNA replication and meiotic recombination.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2144)
  AUTHORS   Chiannilkulchai,N., Pasturaud,P., Richard,I., Auffray,C. and
            Beckmann,J.S.
  TITLE     A primary expression map of the chromosome 15q15 region containing
            the recessive form of limb-girdle muscular dystrophy (LGMD2A) gene
  JOURNAL   Hum Mol Genet 4 (4), 717-725 (1995)
   PUBMED   7633422
REFERENCE   7  (bases 1 to 2144)
  AUTHORS   Matsuda,Y. and Chapman,V.M.
  TITLE     Application of fluorescence in situ hybridization in genome
            analysis of the mouse
  JOURNAL   Electrophoresis 16 (2), 261-272 (1995)
   PUBMED   7774567
  REMARK    Review article
REFERENCE   8  (bases 1 to 2144)
  AUTHORS   Takahashi,E., Matsuda,Y., Hori,T., Yasuda,N., Tsuji,S., Mori,M.,
            Yoshimura,Y., Yamamoto,A., Morita,T. and Matsushiro,A.
  TITLE     Chromosome mapping of the human (RECA) and mouse (Reca) homologs of
            the yeast RAD51 and Escherichia coli recA genes to human (15q15.1)
            and mouse (2F1) chromosomes by direct R-banding fluorescence in
            situ hybridization
  JOURNAL   Genomics 19 (2), 376-378 (1994)
   PUBMED   8188269
REFERENCE   9  (bases 1 to 2144)
  AUTHORS   Morita,T., Yoshimura,Y., Yamamoto,A., Murata,K., Mori,M.,
            Yamamoto,H. and Matsushiro,A.
  TITLE     A mouse homolog of the Escherichia coli recA and Saccharomyces
            cerevisiae RAD51 genes
  JOURNAL   Proc Natl Acad Sci U S A 90 (14), 6577-6580 (1993)
   PUBMED   8341671
REFERENCE   10 (bases 1 to 2144)
  AUTHORS   Shinohara,A., Ogawa,H., Matsuda,Y., Ushio,N., Ikeo,K. and Ogawa,T.
  TITLE     Cloning of human, mouse and fission yeast recombination genes
            homologous to RAD51 and recA
  JOURNAL   Nat Genet 4 (3), 239-243 (1993)
   PUBMED   8358431
  REMARK    Erratum:[Nat Genet 1993 Nov;5(3):312]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772264.8.
            
            On Apr 24, 2018 this sequence version replaced NM_011234.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027384.1, AK011242.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AL772264.8         99157-99377         c
            222-310             AL772264.8         95791-95879         c
            311-448             AL772264.8         93446-93583         c
            449-566             AL772264.8         90648-90765         c
            567-658             AL772264.8         88316-88407         c
            659-753             AL772264.8         85034-85128         c
            754-867             AL772264.8         80574-80687         c
            868-997             AL772264.8         77988-78117         c
            998-1119            AL772264.8         77683-77804         c
            1120-2144           AL772264.8         76118-77142         c
FEATURES             Location/Qualifiers
     source          1..2144
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.92 cM"
     gene            1..2144
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
                     /note="RAD51 recombinase"
                     /db_xref="GeneID:19361"
                     /db_xref="MGI:MGI:97890"
     exon            1..221
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
                     /inference="alignment:Splign:2.1.0"
     exon            222..310
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1243
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
                     /note="RAD51 homolog A"
                     /codon_start=1
                     /product="DNA repair protein RAD51 homolog 1"
                     /protein_id="NP_035364.1"
                     /db_xref="CCDS:CCDS16590.1"
                     /db_xref="GeneID:19361"
                     /db_xref="MGI:MGI:97890"
                     /translation="MAMQMQLEASADTSVEEESFGPQPISRLEQCGINANDVKKLEEA
                     GYHTVEAVAYAPKKELINIKGISEAKADKILTEAAKLVPMGFTTATEFHQRRSEIIQI
                     TTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYI
                     DTEGTFRPERLLAVAERYGLSGSDVLDNVAYARGFNTDHQTQLLYQASAMMVESRYAL
                     LIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGA
                     AMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGV
                     GDAKD"
     exon            311..448
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
                     /inference="alignment:Splign:2.1.0"
     exon            449..566
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
                     /inference="alignment:Splign:2.1.0"
     exon            567..658
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
                     /inference="alignment:Splign:2.1.0"
     exon            659..753
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
                     /inference="alignment:Splign:2.1.0"
     exon            754..867
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
                     /inference="alignment:Splign:2.1.0"
     exon            868..997
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1119
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..2144
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1777..1782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
                     /note="hexamer: AATAAA"
     polyA_site      1795
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
                     /note="major polyA site"
     regulatory      1968..1973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
                     /note="hexamer: AATAAG"
     polyA_site      1995
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
     polyA_site      2089
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
     regulatory      2123..2128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
                     /note="hexamer: ATTAAA"
     polyA_site      2144
                     /gene="Rad51"
                     /gene_synonym="Rad51a; Reca"
ORIGIN      
        1 tgaggatttg gcgggatttc cgaaagtcgc gcgccgtgcg cagatccgcg cctgggcaaa
       61 gccgaggcgc tcccacaggt gtggccagga agactgaaat ttttcgtaga aaacctgaca
      121 gaggagcaac gaagcgcgtt cgagccgggt gaagtggggg gagtgtggtg tgtgcagagc
      181 cggctgcccg gaggagcgag cggcccgtgg ccgcgggaca gtcatggcta tgcaaatgca
      241 gcttgaagca agtgcagata cttcagtgga agaagaaagt tttggtccac agcctatttc
      301 acggttagag cagtgtggca taaatgccaa tgatgtgaag aaattagaag aagccggtta
      361 ccatacagtg gaggctgttg cttatgcacc gaagaaggaa ctaataaata ttaagggaat
      421 tagtgaagcc aaagctgaca aaattctgac tgaggcagca aaattggttc caatgggttt
      481 caccacggca actgagtttc accagcgccg gtcagagatc atacagataa ctactggctc
      541 caaagagctg gacaagctgc ttcaaggtgg aattgagact ggatctatca cagagatgtt
      601 tggagaattc cgaactggga agacacagat ctgtcatacg ttggctgtta catgccagct
      661 ccccattgac cgtggtggag gtgaagggaa ggccatgtac attgacaccg agggcacctt
      721 taggccggag cggctgctag cagtagctga gagatacggt ctctctggca gcgatgtcct
      781 agataatgta gcatatgcgc gagggttcaa cacagaccac cagacccagc tcctttacca
      841 agcgtcagcc atgatggtag aatccaggta tgcactgctt attgtagaca gtgctactgc
      901 cctttacaga acagactact cagggcgggg agagctttca gccaggcaaa tgcatttggc
      961 cagatttctg aggatgctgc ttcgacttgc tgatgagttt ggtgtcgcag tggtaatcac
     1021 caaccaggta gtagcccaag tagatggagc agccatgttc gctgcagatc ccaaaaaacc
     1081 cattggaggg aacatcatcg ctcatgcgtc aaccaccagg ctgtacctga gaaaaggaag
     1141 aggggagacc agaatctgca aaatctatga ctctccctgt cttcctgaag ctgaagctat
     1201 gtttgccatt aatgcagatg gagtgggcga tgccaaagac tgactcctta ggctttcttt
     1261 cctgtgatgc tatacggctt ttctaaatgc tctacagcta atggagagga ctgtgtactg
     1321 ggcttcttca caggctcatg ttgtgactgc cccgcatggc ttccgggaaa acaactattg
     1381 tatcagctct ctggtagcag aaacacatct gatctgaaag gtttcctgta gagtctatta
     1441 ataactgatt tctttggtgt ttagaggaga agtatgaaat agcaggtgtg gggcagtctt
     1501 ttgtcttcag gagaagtaaa ctggaaagat ccgagtactc tcacttctca aggatggtaa
     1561 actaaatgcc tgaggatctg taagtgggaa tgggtggttt acacattctt ttctctgtaa
     1621 gacagatgca aacttagtta tatgcctgaa ctgtcacatc attttaaaat ttatttttga
     1681 ttaaggagtc ttacatgcag catgctagac tacgatccct gcatgcttgt tctctaaatt
     1741 actaagactt cacttaagga aatttgttct gctgctaata aagtagttgt gtgcagtgga
     1801 tgtgttattt gctggagata ttctagtgca aactgaatat tgcaaaacag ggtttctata
     1861 acagctttcg gtactgtgtt gttcgttatg gtcagctgca gttgtaaagt gtgaacctga
     1921 aagaaagccc agcattcagg ttactgcatt gtagcctttg gccgaagaat aagaacccca
     1981 ggctggttta ctgtatcttt cctgtggtct ttgtttttat tgtataagtt ttgtgttgca
     2041 gaggtctgac attactcaaa taactctaca tcaggagtat ttccaaaaac tatagtcttc
     2101 ttttgagtca ttgagtctca ttattaaaag aatttcaaaa caga
//
