LOCUS       NM_009012               5153 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RAD50 double strand break repair protein (Rad50),
            mRNA.
ACCESSION   NM_009012
VERSION     NM_009012.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5153)
  AUTHORS   Liu,Y., Lin,Z., Yan,J., Zhang,X. and Tong,M.H.
  TITLE     A Rad50-null mutation in mouse germ cells causes reduced DSB
            formation, abnormal DSB end resection and complete loss of germ
            cells
  JOURNAL   Development 151 (8) (2024)
   PUBMED   38512324
  REMARK    GeneRIF: A Rad50-null mutation in mouse germ cells causes reduced
            DSB formation, abnormal DSB end resection and complete loss of germ
            cells.
REFERENCE   2  (bases 1 to 5153)
  AUTHORS   Zhang,H., Jiang,J.C., Wu,Y.W., Yu,Y.S., Wang,H.N., Ding,N.Z. and
            Fan,H.Y.
  TITLE     The RNA ligase RNA terminal phosphate cyclase B regulates mRNA
            alternative splicing and is required for mouse oocyte development
            and maintenance
  JOURNAL   Development 149 (19) (2022)
   PUBMED   36178098
REFERENCE   3  (bases 1 to 5153)
  AUTHORS   Kazi,S., Castaneda,J.M., Savolainen,A., Xu,Y., Liu,N., Qiao,H.,
            Ramirez-Solis,R., Nozawa,K., Yu,Z., Matzuk,M.M. and
            Prunskaite-Hyyrylainen,R.
  TITLE     MRNIP interacts with sex body chromatin to support meiotic
            progression, spermatogenesis, and male fertility in mice
  JOURNAL   FASEB J 36 (9), e22479 (2022)
   PUBMED   35920200
REFERENCE   4  (bases 1 to 5153)
  AUTHORS   Zhan,X., Cui,R., Geng,X., Li,J., Zhou,Y., He,L., Cao,C., Zhang,C.,
            Chen,Z. and Ying,S.
  TITLE     LPS-induced mitochondrial DNA synthesis and release facilitate
            RAD50-dependent acute lung injury
  JOURNAL   Signal Transduct Target Ther 6 (1), 103 (2021)
   PUBMED   33654053
  REMARK    GeneRIF: LPS-induced mitochondrial DNA synthesis and release
            facilitate RAD50-dependent acute lung injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5153)
  AUTHORS   Dar,A.A., Sawada,K., Dybas,J.M., Moser,E.K., Lewis,E.L., Park,E.,
            Fazelinia,H., Spruce,L.A., Ding,H., Seeholzer,S.H. and Oliver,P.M.
  TITLE     The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by
            aiding the repair of damaged DNA
  JOURNAL   PLoS Biol 19 (2), e3001041 (2021)
   PUBMED   33524014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5153)
  AUTHORS   Zhu,Y., Jong,M.C., Frazer,K.A., Gong,E., Krauss,R.M., Cheng,J.F.,
            Boffelli,D. and Rubin,E.M.
  TITLE     Genomic interval engineering of mice identifies a novel modulator
            of triglyceride production
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1137-1142 (2000)
   PUBMED   10655497
REFERENCE   7  (bases 1 to 5153)
  AUTHORS   Lee,C.K., Klopp,R.G., Weindruch,R. and Prolla,T.A.
  TITLE     Gene expression profile of aging and its retardation by caloric
            restriction
  JOURNAL   Science 285 (5432), 1390-1393 (1999)
   PUBMED   10464095
REFERENCE   8  (bases 1 to 5153)
  AUTHORS   Luo,G., Yao,M.S., Bender,C.F., Mills,M., Bladl,A.R., Bradley,A. and
            Petrini,J.H.
  TITLE     Disruption of mRad50 causes embryonic stem cell lethality, abnormal
            embryonic development, and sensitivity to ionizing radiation
  JOURNAL   Proc Natl Acad Sci U S A 96 (13), 7376-7381 (1999)
   PUBMED   10377422
REFERENCE   9  (bases 1 to 5153)
  AUTHORS   Frazer,K.A., Ueda,Y., Zhu,Y., Gifford,V.R., Garofalo,M.R.,
            Mohandas,N., Martin,C.H., Palazzolo,M.J., Cheng,J.F. and Rubin,E.M.
  TITLE     Computational and biological analysis of 680 kb of DNA sequence
            from the human 5q31 cytokine gene cluster region
  JOURNAL   Genome Res 7 (5), 495-512 (1997)
   PUBMED   9149945
REFERENCE   10 (bases 1 to 5153)
  AUTHORS   Kim,K.K., Daud,A.I., Wong,S.C., Pajak,L., Tsai,S.C., Wang,H.,
            Henzel,W.J. and Field,L.J.
  TITLE     Mouse RAD50 has limited epitopic homology to p53 and is expressed
            in the adult myocardium
  JOURNAL   J Biol Chem 271 (46), 29255-29264 (1996)
   PUBMED   8910585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645741.15.
            
            On Jul 26, 2007 this sequence version replaced NM_009012.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U66887.1, SRR1660813.176853.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-393               AL645741.15        93976-94368         c
            394-477             AL645741.15        93034-93117         c
            478-629             AL645741.15        89006-89157         c
            630-815             AL645741.15        85871-86056         c
            816-1020            AL645741.15        85163-85367         c
            1021-1149           AL645741.15        82332-82460         c
            1150-1315           AL645741.15        81950-82115         c
            1316-1509           AL645741.15        79757-79950         c
            1510-1716           AL645741.15        79162-79368         c
            1717-1899           AL645741.15        75144-75326         c
            1900-2057           AL645741.15        73199-73356         c
            2058-2233           AL645741.15        71175-71350         c
            2234-2471           AL645741.15        70251-70488         c
            2472-2661           AL645741.15        67082-67271         c
            2662-2788           AL645741.15        66439-66565         c
            2789-2982           AL645741.15        65914-66107         c
            2983-3093           AL645741.15        62951-63061         c
            3094-3186           AL645741.15        61952-62044         c
            3187-3300           AL645741.15        61747-61860         c
            3301-3428           AL645741.15        56679-56806         c
            3429-3653           AL645741.15        55071-55295         c
            3654-3739           AL645741.15        42582-42667         c
            3740-3882           AL645741.15        41926-42068         c
            3883-4016           AL645741.15        39283-39416         c
            4017-5153           AL645741.15        36568-37704         c
FEATURES             Location/Qualifiers
     source          1..5153
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.98 cM"
     gene            1..5153
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /note="RAD50 double strand break repair protein"
                     /db_xref="GeneID:19360"
                     /db_xref="MGI:MGI:109292"
     exon            1..393
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..4203
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /note="mRad50; RAD50 homolog"
                     /codon_start=1
                     /product="DNA repair protein RAD50"
                     /protein_id="NP_033038.2"
                     /db_xref="CCDS:CCDS24684.1"
                     /db_xref="GeneID:19360"
                     /db_xref="MGI:MGI:109292"
                     /translation="MSRIEKMSILGVRSFGIEDKDKQIISFFSPLTILVGPNGAGKTT
                     IIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQIRLQFRDVNGEMVAVHRSMLC
                     SQKNKKTEFKTLEGVITRMKHGEKVSLSSKCAEIDREMISCLGVSKSVLNNVIFCHQE
                     DSNWPLSEGKALKQKFDEIFSATRYIKALDTLRQVRQTQGQKVKECQTELKYLKQNKE
                     KACEIRDQITSKEAQLASSQEIVRSYEDELEPLKNRLKEIEHNLSKIMKLDNEIKALE
                     SRKKQMEKDNSELEQKMEKVFQGTDEQLNDLYHNHQRTVREKERRLVDCQRELEKLNK
                     EARLLNQEKAELLVEQGRLQLQADRHQEHIRARDSLIQSLATHLELDGFERGPFSERQ
                     IKNFHELVKERQEREAKTASQLLSDLTDKEALKQRQLDELRDRKSGLGRTIELKTEIL
                     TKKQSELRHVRSELQQLEGSSDRILELDQELTKAERELSKAEKNSSIETLKAEVMSLQ
                     NEKADLDRSLRKLDQEMEQLNHHTTTRTQMEMLTKDKTDKDEQIRKIKSRHSDELTSL
                     LGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASAEQNKNHINNELKKKEEQLSS
                     YEDKLFDVCGSQDLESDLGRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCP
                     VCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKERRRDEMLGLVPVRQSII
                     DLKEKEIPELRNRLQSVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERF
                     QMELKDVERKIAQQAAKLQGVDLDRTVQQVNQEKQEKQHRLDTVTSKIELNRKLIQDQ
                     QEQIQHLKSKTNELKSEKLQIATNLQRRQQMEEQSVELSTEVQSLNREIKDAKEQISP
                     LETALEKLQQEKEELIHRKHTSNKMAQDKINDIKEKVKNIHGYMKDIENYIQDGKDDY
                     KKQKETELNGVAVQLNECEKHREKINKDMGTMRQDIDTQKIQERWLQDNLTLRKRRDE
                     LKEVEEERKQHLKEMGQMQVLQMKNEHQKLEENIDTIKRNHSLALGRQKGYEDEILHF
                     KKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKI
                     IRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAG
                     QKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSQQRNF
                     QLLVITHDEDFVELLGRSEYVEKFYRVKKNMDQCSEIVKCSISSLGSYVH"
     exon            394..477
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            478..629
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            630..815
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1020
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1149
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1315
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1509
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1716
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1899
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2057
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2233
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2471
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2661
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2788
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2982
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            2983..3093
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3186
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3300
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3428
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..3653
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            3654..3739
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3882
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..4016
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     exon            4017..5153
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5126..5131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /note="hexamer: ATTAAA"
     polyA_site      5143
                     /gene="Rad50"
                     /gene_synonym="Mrell; Rad50l"
                     /note="major polyA site"
ORIGIN      
        1 ccaggtcgtg cgaggcggga atgtgcgagc ttacggttgc tggctcgctt ggcttttctg
       61 ggctgtgcag accctaaccg gcccgcgccc tcccgggaaa ccgaagcccg cggggccgga
      121 agtgctctcg ccaccggagc tcctgctcgc agcgcgtgtt cggaactttt gggtcctctc
      181 gcggcgttcc ttcccggctt gcccagcttc cgccttgagg ttaaaactcg cccctggcac
      241 tgagtaaagg aacgtggtgc aaacatgtcc cggatcgaaa agatgagcat tctgggcgtg
      301 cgaagttttg ggatagagga taaagataag cagattatct ctttcttcag ccccctcaca
      361 attttggttg gacccaatgg ggcggggaag acgaccatca ttgaatgtct aaagtatatt
      421 tgtactggag atttccctcc tggaaccaaa ggaaatacat ttgttcatga tcccaaggtt
      481 gctcaagaaa cagacgtgcg ggcccagatt cgcctgcagt ttcgagatgt gaatggagag
      541 atggtagctg tgcacaggtc tatgctttgc agtcagaaaa ataaaaaaac agaatttaaa
      601 accttggaag gagtcattac tagaatgaag catggtgaaa aagtcagtct cagctccaaa
      661 tgtgcagaaa tcgacagaga aatgataagt tgtcttgggg tttccaagtc tgtgctaaac
      721 aatgttattt tctgtcacca agaagactcc aactggcctt taagtgaagg aaaggctttg
      781 aagcaaaaat ttgatgagat tttttcggca acaaggtaca ttaaagcctt agatacactt
      841 cgacaggtgc gtcagacaca gggtcagaaa gtaaaagagt gtcaaacgga attgaaatat
      901 ctgaagcaaa ataaggagaa agcgtgtgag atccgagatc agattacgag taaggaagcc
      961 cagttagcgt cttcgcagga aattgtcagg tcctacgagg atgagcttga gccattgaag
     1021 aatcgcctga aagagattga acacaacctg tctaaaataa tgaaacttga taatgaaatt
     1081 aaagccttgg agagccgaaa gaaacaaatg gagaaagata acagtgaatt agaacagaaa
     1141 atggaaaagg tttttcaagg gactgatgag cagctaaatg acttgtatca caatcaccag
     1201 agaacagtaa gggagaaaga aaggcgcctg gtagactgcc agcgagaact ggagaagctg
     1261 aataaagaag cacggctcct caaccaggaa aaagcagagc tgcttgtgga gcagggtcgt
     1321 ctacagctac aggcagatcg ccatcaagag cacatccgag ccagagactc attaattcag
     1381 tctttggcaa cacatcttga attggatggt tttgagcgtg gaccattcag tgaaagacag
     1441 attaaaaatt ttcatgaact tgtgaaagag agacaggaaa gagaagctaa aactgccagc
     1501 cagctcttga gcgacctgac agacaaagaa gctctgaagc agaggcagct tgatgagctg
     1561 agggacagga agagcggact ggggaggacg attgagctga agacagagat cctcacgaag
     1621 aagcagagcg agctgcggca cgtgaggagt gagctgcagc agctggaggg ctcctccgac
     1681 aggattctgg aactggacca ggagctcacg aaagctgaac gtgaattaag caaggccgag
     1741 aaaaatagca gcatagaaac cctaaaagca gaggtaatga gcctccaaaa tgagaaagct
     1801 gacctggaca ggagcttgcg aaagctggac caggagatgg agcagttaaa ccatcataca
     1861 acaacccgca cacagatgga gatgctcacc aaagacaaaa ctgacaaaga tgaacagatc
     1921 agaaaaataa agtctaggca cagtgatgaa ctaacttcac tgttggggta ctttcctaac
     1981 aaaaaacagc ttgaagactg gcttcattct aaatccaaag aaattaatca gaccagggac
     2041 agacttgcca aactgaacaa agagctagct tcagctgaac aaaataaaaa tcatataaat
     2101 aatgagctaa agaaaaagga agaacagttg tccagttatg aagataagct atttgatgtt
     2161 tgtggtagcc aagatttgga aagtgatttg ggcagactta aagaagaaat tgaaaagtcc
     2221 tcaaagcagc gagccatgct ggcaggagcc acagcagttt actcccagtt cattacgcag
     2281 ctgacagatg aaaaccagtc ctgctgccca gtctgtcaga gagtatttca gacagaggct
     2341 gagttacagg aagtcatcag cgacttgcag tccaagctga ggcttgctcc agataaactc
     2401 aagtcaacag aatcggaact gaagaaaaaa gagcggcgcc gtgatgaaat gcttgggctt
     2461 gtgcccgtga ggcaaagcat aattgatttg aaggaaaagg aaataccaga attaagaaac
     2521 cgactacaga gtgtcaatag agacatacag cgcctaaaga atgacataga agagcaggaa
     2581 acactcttgg gtacaataat gcctgaagaa gaaagtgcta aagtgtgcct gacagatgtt
     2641 acaatcatgg agaggttcca gatggagctg aaagatgttg aaaggaaaat tgcacagcag
     2701 gcagctaagc tgcagggagt agacttggac cggactgtcc agcaggttaa ccaggaaaag
     2761 caggaaaagc agcacaggct ggatacagtt accagtaaga ttgaattgaa ccgtaagctt
     2821 atacaggacc agcaggaaca aatccaacac ctgaaaagta aaacaaatga gctgaagtca
     2881 gagaagctgc agatagccac caatttgcaa cggcgccagc aaatggagga gcagagtgtg
     2941 gaattatcca ctgaagtcca gtctttaaac agagaaataa aggatgctaa agaacaaata
     3001 agccctttgg agacagcatt ggaaaagttg cagcaggaaa aagaagaatt aatccacaga
     3061 aaacatacaa gtaacaaaat ggctcaggat aaaattaatg atatcaaaga gaaagttaaa
     3121 aatattcatg gttacatgaa agacatagag aattatattc aagatggaaa agatgactac
     3181 aagaagcaaa aagaaactga acttaatgga gttgctgttc aactaaatga atgtgagaaa
     3241 cacagagaaa agataaataa agacatggga accatgaggc aagacatcga cacacagaag
     3301 atacaggaaa ggtggctaca ggataacctt acactaagaa aaaggagaga tgaactaaaa
     3361 gaagtggaag aagaacgaaa acaacacttg aaggagatgg gacaaatgca agttttacaa
     3421 atgaaaaatg agcatcagaa gttggaagag aacatagaca ctataaagag aaatcacagt
     3481 ttggcattgg ggcgtcagaa aggctatgaa gacgaaattc ttcactttaa aaaggagctc
     3541 cgagaacctc agttccggga tgccgaggaa aagtacagag aaatgatgat cgtcatgagg
     3601 accacagagc tggtgaacaa ggacctcgac atctactaca agactcttga ccaagcaatt
     3661 atgaaatttc acagtatgaa aatggaagaa atcaacaaaa ttattcgtga tctttggcgg
     3721 agtacctatc gtgggcaaga tattgaatac atagaaattc gatctgatgc tgatgaaaat
     3781 gtatcggctt ctgataaaag gcgaaattac aactaccgag tggtgatgct gaagggggac
     3841 acagccttgg acatgcgtgg acgatgcagt gctggacaga aggtgctagc gtctctcatc
     3901 atccgactgg ccctggcgga aaccttctgt ctgaactgtg gcatccttgc cttggatgag
     3961 ccgacaacaa atctcgaccg agaaaacatt gagtctcttg cacatgcttt ggttgagatc
     4021 ataaaaagtc gctcacagca gcgcaacttc caacttctgg taatcactca cgatgaagat
     4081 tttgtggagc tcttagggcg atctgagtat gtggagaaat tctacagggt gaagaagaac
     4141 atggaccagt gctcagagat tgtcaagtgc agcatcagct ccctgggttc ttatgttcac
     4201 taacttgtct tgggaaggat atggattgtg tgacgggaac catgtgtgtc aggtttgaga
     4261 gtccctaaga tcgggaggct gccttgagtg aagatgaaca cagttcccac aggcctagca
     4321 acctcccagc accactcagc ctttcatttc ctgccaactg aatgtcatcc agataaacag
     4381 tgctgacagg aggggtggac atttaaacac attactattt tctctgaagc ttgaaggtat
     4441 atttaatacg tagccctgct gtcacatgaa tccatgcaca cgacctgtct gagtctaggt
     4501 ctcccctgaa accacagtca ttgaacgggg ctggcagagt gacagaagcc atcggtgatc
     4561 atttagtgga atacgcagtt cgctccccat gcagccatac cagataggta ccctggctgg
     4621 ctgttagaga agagtttccc cagtcctgac ctcatctgcc catcatgcag aagcctggcg
     4681 ctctcctctg tgtctgtcat gtctatctat gtggcctggc cccagttact ctcaatagca
     4741 ggttctcctg tggctggaaa ggagactcac gcagctggag cctgctccac gcacagacct
     4801 gcaaaggcaa accacatttt cactccagag gctgagcctg gtgaagtcca gtacacatct
     4861 ccacggcatt gccagctgaa gcctcctgtg aagacaggac acatctaagt cacacgcttc
     4921 cagatgtcac taacagttct ctcactcagc tgggtggcct gttctgtgcc atctgcagat
     4981 ttgttgggtg tcacctctag aacaaaggtt ttttcttccc actgtcttcc ttcaggaata
     5041 taaaaccacg tcaatcaaat gcatactgag aatagatcat aagaaaaatt actttaaaat
     5101 aattctttgg tatacaatgt tatctattaa agacaaaagc aaatatttgt gta
//
