LOCUS       NM_001297606            1813 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus RAD23 homolog A, nucleotide excision repair protein
            (Rad23a), transcript variant 1, mRNA.
ACCESSION   NM_001297606 XM_006530774
VERSION     NM_001297606.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1813)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1813)
  AUTHORS   Xing,L., Simon,J.M., Ptacek,T.S., Yi,J.J., Loo,L., Mao,H.,
            Wolter,J.M., McCoy,E.S., Paranjape,S.R., Taylor-Blake,B. and
            Zylka,M.J.
  TITLE     Autism-linked UBE3A gain-of-function mutation causes interneuron
            and behavioral phenotypes when inherited maternally or paternally
            in mice
  JOURNAL   Cell Rep 42 (7), 112706 (2023)
   PUBMED   37389991
REFERENCE   3  (bases 1 to 1813)
  AUTHORS   Zhang,Y.J., Gendron,T.F., Grima,J.C., Sasaguri,H., Jansen-West,K.,
            Xu,Y.F., Katzman,R.B., Gass,J., Murray,M.E., Shinohara,M.,
            Lin,W.L., Garrett,A., Stankowski,J.N., Daughrity,L., Tong,J.,
            Perkerson,E.A., Yue,M., Chew,J., Castanedes-Casey,M., Kurti,A.,
            Wang,Z.S., Liesinger,A.M., Baker,J.D., Jiang,J.,
            Lagier-Tourenne,C., Edbauer,D., Cleveland,D.W., Rademakers,R.,
            Boylan,K.B., Bu,G., Link,C.D., Dickey,C.A., Rothstein,J.D.,
            Dickson,D.W., Fryer,J.D. and Petrucelli,L.
  TITLE     C9ORF72 poly(GA) aggregates sequester and impair HR23 and
            nucleocytoplasmic transport proteins
  JOURNAL   Nat Neurosci 19 (5), 668-677 (2016)
   PUBMED   26998601
  REMARK    GeneRIF: data demonstrate that sequestration and impairment of
            nuclear HR23 and nucleocytoplasmic transport proteins is an outcome
            of, and a contributor to, poly(GA) pathology.
REFERENCE   4  (bases 1 to 1813)
  AUTHORS   Lodder,E.M., Scicluna,B.P., Beekman,L., Arends,D., Moerland,P.D.,
            Tanck,M.W., Adriaens,M.E. and Bezzina,C.R.
  TITLE     Integrative genomic approach identifies multiple genes involved in
            cardiac collagen deposition
  JOURNAL   Circ Cardiovasc Genet 7 (6), 790-798 (2014)
   PUBMED   25217174
REFERENCE   5  (bases 1 to 1813)
  AUTHORS   Bergink,S., Toussaint,W., Luijsterburg,M.S., Dinant,C.,
            Alekseev,S., Hoeijmakers,J.H., Dantuma,N.P., Houtsmuller,A.B. and
            Vermeulen,W.
  TITLE     Recognition of DNA damage by XPC coincides with disruption of the
            XPC-RAD23 complex
  JOURNAL   J Cell Biol 196 (6), 681-688 (2012)
   PUBMED   22431748
  REMARK    GeneRIF: the mammalian RAD23 proteins play a direct role in damage
            recognition by enhancing the binding of XPC to DNA damage in living
            cells in addition to stabilizing XPC. RAD23 proteins rapidly
            dissociated from XPC upon binding to damaged DNA.
REFERENCE   6  (bases 1 to 1813)
  AUTHORS   Boutet,S.C., Disatnik,M.H., Chan,L.S., Iori,K. and Rando,T.A.
  TITLE     Regulation of Pax3 by proteasomal degradation of monoubiquitinated
            protein in skeletal muscle progenitors
  JOURNAL   Cell 130 (2), 349-362 (2007)
   PUBMED   17662948
  REMARK    Erratum:[Cell. 2023 Apr 27;186(9):2035. doi:
            10.1016/j.cell.2023.03.018.. PMID: 37116471]
REFERENCE   7  (bases 1 to 1813)
  AUTHORS   Okuda,Y., Nishi,R., Ng,J.M., Vermeulen,W., van der Horst,G.T.,
            Mori,T., Hoeijmakers,J.H., Hanaoka,F. and Sugasawa,K.
  TITLE     Relative levels of the two mammalian Rad23 homologs determine
            composition and stability of the xeroderma pigmentosum group C
            protein complex
  JOURNAL   DNA Repair (Amst) 3 (10), 1285-1295 (2004)
   PUBMED   15336624
REFERENCE   8  (bases 1 to 1813)
  AUTHORS   Ng,J.M., Vermeulen,W., van der Horst,G.T., Bergink,S., Sugasawa,K.,
            Vrieling,H. and Hoeijmakers,J.H.
  TITLE     A novel regulation mechanism of DNA repair by damage-induced and
            RAD23-dependent stabilization of xeroderma pigmentosum group C
            protein
  JOURNAL   Genes Dev 17 (13), 1630-1645 (2003)
   PUBMED   12815074
  REMARK    GeneRIF: analysis of mHR23A/B double-mutant cells showed that HR23
            proteins function in nucleotide excision repair by governing
            xeroderma pigmentosum group C protein stability via partial
            protection against proteasomal degradation
REFERENCE   9  (bases 1 to 1813)
  AUTHORS   Chambers,D.M. and Abbott,C.M.
  TITLE     Isolation and mapping of novel mouse brain cDNA clones containing
            trinucleotide repeats, and demonstration of novel alleles in
            recombinant inbred strains
  JOURNAL   Genome Res 6 (8), 715-723 (1996)
   PUBMED   8858346
REFERENCE   10 (bases 1 to 1813)
  AUTHORS   van der Spek,P.J., Visser,C.E., Hanaoka,F., Smit,B., Hagemeijer,A.,
            Bootsma,D. and Hoeijmakers,J.H.
  TITLE     Cloning, comparative mapping, and RNA expression of the mouse
            homologues of the Saccharomyces cerevisiae nucleotide excision
            repair gene RAD23
  JOURNAL   Genomics 31 (1), 20-27 (1996)
   PUBMED   8808275
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155163.4.
            
            On Mar 13, 2020 this sequence version replaced NM_001297606.1.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.472562.1, BC145372.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AC155163.4         185154-185312       c
            160-321             AC155163.4         183454-183615       c
            322-503             AC155163.4         183129-183310       c
            504-559             AC155163.4         182933-182988       c
            560-687             AC155163.4         182667-182794       c
            688-766             AC155163.4         182349-182427       c
            767-900             AC155163.4         182120-182253       c
            901-1065            AC155163.4         180415-180579       c
            1066-1813           AC155163.4         179587-180334       c
FEATURES             Location/Qualifiers
     source          1..1813
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.2 cM"
     gene            1..1813
                     /gene="Rad23a"
                     /gene_synonym="2310040P19Rik; HR23A; mHR23A"
                     /note="RAD23 homolog A, nucleotide excision repair
                     protein"
                     /db_xref="GeneID:19358"
                     /db_xref="MGI:MGI:105126"
     exon            1..159
                     /gene="Rad23a"
                     /gene_synonym="2310040P19Rik; HR23A; mHR23A"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1179
                     /gene="Rad23a"
                     /gene_synonym="2310040P19Rik; HR23A; mHR23A"
                     /note="isoform 1 is encoded by transcript variant 1; UV
                     excision repair protein RAD23 homolog A; RAD23a homolog"
                     /codon_start=1
                     /product="UV excision repair protein RAD23 homolog A
                     isoform 1"
                     /protein_id="NP_001284535.1"
                     /db_xref="CCDS:CCDS80908.1"
                     /db_xref="GeneID:19358"
                     /db_xref="MGI:MGI:105126"
                     /translation="MAVTITLKTLQQQTFKIRMEPDETVKVLKEKIEAEKGRDAFPVA
                     GQKLIYAGKILSDDVPIKEYHIDEKNFVVVMVTKAKAGQGIPAPPEASPTAVPEPSTP
                     FPPVLASGMSHPPPTSREDKSPSEESTTTTSPESISGSVPSSGSSGREEDAASTLVTG
                     SEYETMLTEIMSMGYERERVVAALRASYNNPHRAVEYLLTGIPGSPEPEHGSVQESQA
                     PEQPATEAAGENPLEFLRDQPQFQNMRQVIQQNPALLPALLQQLGQENPQLLQQISRH
                     QEQFIQMLNEPPGELADISDVEGEVGAIGEEAPQMNYIQVTPQEKEAIERLKALGFPE
                     SLVIQAYFACEKNENLAANFLLSQNFDDE"
     exon            160..321
                     /gene="Rad23a"
                     /gene_synonym="2310040P19Rik; HR23A; mHR23A"
                     /inference="alignment:Splign:2.1.0"
     exon            322..503
                     /gene="Rad23a"
                     /gene_synonym="2310040P19Rik; HR23A; mHR23A"
                     /inference="alignment:Splign:2.1.0"
     exon            504..559
                     /gene="Rad23a"
                     /gene_synonym="2310040P19Rik; HR23A; mHR23A"
                     /inference="alignment:Splign:2.1.0"
     exon            560..687
                     /gene="Rad23a"
                     /gene_synonym="2310040P19Rik; HR23A; mHR23A"
                     /inference="alignment:Splign:2.1.0"
     exon            688..766
                     /gene="Rad23a"
                     /gene_synonym="2310040P19Rik; HR23A; mHR23A"
                     /inference="alignment:Splign:2.1.0"
     exon            767..900
                     /gene="Rad23a"
                     /gene_synonym="2310040P19Rik; HR23A; mHR23A"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1065
                     /gene="Rad23a"
                     /gene_synonym="2310040P19Rik; HR23A; mHR23A"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1813
                     /gene="Rad23a"
                     /gene_synonym="2310040P19Rik; HR23A; mHR23A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1788..1793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rad23a"
                     /gene_synonym="2310040P19Rik; HR23A; mHR23A"
                     /note="hexamer: AATAAA"
     polyA_site      1813
                     /gene="Rad23a"
                     /gene_synonym="2310040P19Rik; HR23A; mHR23A"
                     /note="major polyA site"
ORIGIN      
        1 gcggcgcggc tgggcgctaa gatggcggcg gcgtgagttg catgtagtac gaggatcccg
       61 gggctgccgc attgctccgg ccccgccatg gccgtcacca tcacccttaa aacgttgcag
      121 cagcagacct tcaagatccg catggaacct gacgagacgg taaaggtgct gaaggagaag
      181 atagaagctg agaagggtag agatgctttc cccgtggctg gacagaaact catctatgct
      241 ggcaagatct tgagtgacga tgttcccatc aaggaatacc atatagatga gaagaacttt
      301 gtggttgtca tggtgaccaa ggccaaagct ggccagggta tcccggcacc cccagaggcc
      361 tcacccactg ctgtcccgga gccctccaca cctttccctc cagtcctggc atcaggcatg
      421 tctcatcccc cacctaccag cagagaggac aagagcccat cagaggagtc aaccaccaca
      481 acatctccag aatccatttc tggctctgtt ccctcttcag gtagcagcgg gcgagaggaa
      541 gacgcagctt ccacattagt gactggctct gaatatgaga cgatgctgac tgagatcatg
      601 tccatgggct acgagcggga gcgggttgtg gccgcattga gggccagcta caacaacccc
      661 caccgagctg tggagtactt gctcacggga attccaggaa gccctgagcc tgaacatggt
      721 tctgtccagg aaagccaggc gcctgagcag ccggccacag aagcagcagg ggagaacccc
      781 ctggagttcc tgcgggacca gcctcagttc cagaacatgc ggcaagtgat tcaacagaac
      841 ccagcgctcc tgcctgctct gctccagcag ctgggtcagg aaaaccctca gctcctgcag
      901 caaattagcc gtcaccagga gcagttcatc cagatgttga atgagcctcc cggggagctg
      961 gcggacatct ctgatgtaga gggggaggtt ggtgccatag gtgaggaggc cccacagatg
     1021 aactatatcc aggtgacacc gcaggagaag gaggctatag aaaggctgaa ggcactgggc
     1081 ttcccagaga gcctggtgat ccaggcctac ttcgcgtgtg aaaaaaatga gaatttggct
     1141 gccaacttcc tcctgagtca gaactttgat gatgagtgat tctgggaggc cagggcctcc
     1201 ccccttccct ccctccccac tccacagacg tttataagag aaagtatata tatatatata
     1261 taacatatat atattcatgt ttaagaggaa gaatatcaaa aaccattaaa aaaacaacaa
     1321 caaaaaaaaa cccagcccag cttcccaccc tcctgaagtg gcccccattc ccatatcagt
     1381 ccgagaagac ctgggccaga cagctgtccc cgtcctctta acagcccagc ctactcaaaa
     1441 gttgttggca agaccatgag gcgacagatg ggcccctctt ggcctctgtc ccagctccct
     1501 gcagccagat ggaggggcgc ctgcctgctt ccccatccct gaagcatccc caaggacaac
     1561 cctccttcct ccaccatgat gaggggaagc tggagcccta agctttgatc ctctattgga
     1621 gtggcccaga tctttccatc tggagtaagt ctatgttaga agccaaaggc cttctcccca
     1681 gtctggcctt ggcctccagc ctggaaaagg ggttatcatc agttctgaag gccaaggcca
     1741 ccccttcccc aggacagaac cacatctctg ataaaggttt tgacgtgaat aaagttttaa
     1801 aaatgagccc taa
//
