LOCUS       NM_001276400            1659 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus RAD21-like (S. pombe) (Rad21l), mRNA.
ACCESSION   NM_001276400
VERSION     NM_001276400.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1659)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1659)
  AUTHORS   Oura,S., Hino,T., Satoh,T., Noda,T., Koyano,T., Isotani,A.,
            Matsuyama,M., Akira,S., Ishiguro,K.I. and Ikawa,M.
  TITLE     Trim41 is required to regulate chromosome axis protein dynamics and
            meiosis in male mice
  JOURNAL   PLoS Genet 18 (6), e1010241 (2022)
   PUBMED   35648791
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1659)
  AUTHORS   Bhattacharyya,T., Walker,M., Powers,N.R., Brunton,C., Fine,A.D.,
            Petkov,P.M. and Handel,M.A.
  TITLE     Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA
            Double-Strand Break Formation in Mammalian Spermatocytes
  JOURNAL   Curr Biol 29 (6), 1002-1018 (2019)
   PUBMED   30853435
  REMARK    Erratum:[Curr Biol. 2021 Mar 22;31(6):1351. doi:
            10.1016/j.cub.2021.03.002.. PMID: 33756132]
REFERENCE   4  (bases 1 to 1659)
  AUTHORS   Rong,M., Miyauchi,S. and Lee,J.
  TITLE     Ectopic expression of meiotic cohesin RAD21L promotes adjacency of
            homologous chromosomes in somatic cells
  JOURNAL   J Reprod Dev 63 (3), 227-234 (2017)
   PUBMED   28239026
  REMARK    GeneRIF: when ectopically expressed in somatic cells, can promote
            homologous chromosome adjacency, which resembles the homolog
            pairing normally seen during meiosis
REFERENCE   5  (bases 1 to 1659)
  AUTHORS   Jordan,P.W., Eyster,C., Chen,J., Pezza,R.J. and Rankin,S.
  TITLE     Sororin is enriched at the central region of synapsed meiotic
            chromosomes
  JOURNAL   Chromosome Res 25 (2), 115-128 (2017)
   PUBMED   28050734
REFERENCE   6  (bases 1 to 1659)
  AUTHORS   Herran,Y., Gutierrez-Caballero,C., Sanchez-Martin,M., Hernandez,T.,
            Viera,A., Barbero,J.L., de Alava,E., de Rooij,D.G., Suja,J.A.,
            Llano,E. and Pendas,A.M.
  TITLE     The cohesin subunit RAD21L functions in meiotic synapsis and
            exhibits sexual dimorphism in fertility
  JOURNAL   EMBO J 30 (15), 3091-3105 (2011)
   PUBMED   21743440
  REMARK    GeneRIF: These results provide in vivo evidence that RAD21L is
            essential for male fertility and in females for the maintenance of
            fertility during natural aging.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1659)
  AUTHORS   Gutierrez-Caballero,C., Herran,Y., Sanchez-Martin,M., Suja,J.A.,
            Barbero,J.L., Llano,E. and Pendas,A.M.
  TITLE     Identification and molecular characterization of the mammalian
            alpha-kleisin RAD21L
  JOURNAL   Cell Cycle 10 (9), 1477-1487 (2011)
   PUBMED   21527826
  REMARK    GeneRIF: RAD21L is identified as a novel subunit of the cohesin
            complex with homology to the RAD21/REC8/alpha-kleisin subfamily
            expressed in mouse testis.
REFERENCE   8  (bases 1 to 1659)
  AUTHORS   Ishiguro,K., Kim,J., Fujiyama-Nakamura,S., Kato,S. and Watanabe,Y.
  TITLE     A new meiosis-specific cohesin complex implicated in the cohesin
            code for homologous pairing
  JOURNAL   EMBO Rep 12 (3), 267-275 (2011)
   PUBMED   21274006
  REMARK    GeneRIF: study identifes a new mammalian cohesin subunit, RAD21L,
            with sequence similarity to RAD21 and REC8; RAD21L localizes along
            axial elements in early meiotic prophase, in a manner that is
            spatiotemporally different to either REC8 or RAD21
REFERENCE   9  (bases 1 to 1659)
  AUTHORS   Lee,J. and Hirano,T.
  TITLE     RAD21L, a novel cohesin subunit implicated in linking homologous
            chromosomes in mammalian meiosis
  JOURNAL   J Cell Biol 192 (2), 263-276 (2011)
   PUBMED   21242291
  REMARK    GeneRIF: The results suggest that cohesin complexes containing
            RAD21L may be involved in synapsis initiation and crossover
            recombination between homologous chromosomes.
REFERENCE   10 (bases 1 to 1659)
  AUTHORS   Kouznetsova,A., Benavente,R., Pastink,A. and Hoog,C.
  TITLE     Meiosis in mice without a synaptonemal complex
  JOURNAL   PLoS One 6 (12), e28255 (2011)
   PUBMED   22164254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB602048.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB574185.1, AB602048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1659              AB602048.1         1-1659
FEATURES             Location/Qualifiers
     source          1..1659
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.83 cM"
     gene            1..1659
                     /gene="Rad21l"
                     /gene_synonym="Gm14160; MeiRAD21L; Rad21l1"
                     /note="RAD21-like (S. pombe)"
                     /db_xref="GeneID:668929"
                     /db_xref="MGI:MGI:3652039"
     CDS             1..1659
                     /gene="Rad21l"
                     /gene_synonym="Gm14160; MeiRAD21L; Rad21l1"
                     /codon_start=1
                     /product="double-strand-break repair protein rad21-like
                     protein 1"
                     /protein_id="NP_001263329.1"
                     /db_xref="CCDS:CCDS50747.2"
                     /db_xref="GeneID:668929"
                     /db_xref="MGI:MGI:3652039"
                     /translation="MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIQKI
                     ISPKVKIALRTSGHLLLGVVRIYNRKAKYLLADCSEAFLKMKMTFRPGLVDLPKENFE
                     AAYNTITLPEEFHDFEIYNINEIDISEPLAQNQSRPEEITLREEYSNDLLFQAGSFGD
                     EPEILRRHSFFDDNILMNSSGLVVEHSSGSFAEEKSLFFDNGDGFGDEGAAGEMIDNL
                     LQDESTFLEEAYLNKEVSLPPELPSSIMVEPGNSDDQCIPEDEEINEITLLSNEDEGF
                     TLDPIDDLDIADRRRRKKRRLLVDPVKEISSKAMHRQLASFMDTLMVLDLAPPTQRLM
                     MWKKRGGVDMLLSTATQDLINDELKMLFTKCFLSSDYKLAKLTLKESVRKEVGNQQIA
                     EPSVMGEPNSHSELDQPQDWKDVTDESVGSFQENVNMNVNSEQDILGMISPAVEGLSS
                     MNGSLAQENCPAELESSGSKQNTEAEKWNQRLFQTLNVLREFNKMGMQSFSLKKLCRN
                     SDRKQAAAKFYTLLILKKHRAIELSQSVPYADIIATVGPMFYKM"
     exon            1..144
                     /gene="Rad21l"
                     /gene_synonym="Gm14160; MeiRAD21L; Rad21l1"
                     /inference="alignment:Splign:2.1.0"
     exon            145..274
                     /gene="Rad21l"
                     /gene_synonym="Gm14160; MeiRAD21L; Rad21l1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..368
                     /gene="Rad21l"
                     /gene_synonym="Gm14160; MeiRAD21L; Rad21l1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..475
                     /gene="Rad21l"
                     /gene_synonym="Gm14160; MeiRAD21L; Rad21l1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..646
                     /gene="Rad21l"
                     /gene_synonym="Gm14160; MeiRAD21L; Rad21l1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..739
                     /gene="Rad21l"
                     /gene_synonym="Gm14160; MeiRAD21L; Rad21l1"
                     /inference="alignment:Splign:2.1.0"
     exon            740..853
                     /gene="Rad21l"
                     /gene_synonym="Gm14160; MeiRAD21L; Rad21l1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1080
                     /gene="Rad21l"
                     /gene_synonym="Gm14160; MeiRAD21L; Rad21l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1177
                     /gene="Rad21l"
                     /gene_synonym="Gm14160; MeiRAD21L; Rad21l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1302
                     /gene="Rad21l"
                     /gene_synonym="Gm14160; MeiRAD21L; Rad21l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1392
                     /gene="Rad21l"
                     /gene_synonym="Gm14160; MeiRAD21L; Rad21l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1470
                     /gene="Rad21l"
                     /gene_synonym="Gm14160; MeiRAD21L; Rad21l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1659
                     /gene="Rad21l"
                     /gene_synonym="Gm14160; MeiRAD21L; Rad21l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttctaca ctcatgtgct tatgagtaaa cgggggccat tggccaagat atggcttgca
       61 gctcactggg agaagaaact tacaaaggcc catgtgttcg agtgtaatct agaaataacc
      121 attcaaaaaa ttatttcacc taaggtgaaa attgcactcc gaacttcagg acaccttctt
      181 ttgggggttg ttcgaatcta caacaggaag gcaaaatacc ttctggcaga ctgcagtgaa
      241 gcattcctta agatgaagat gacatttcgc ccaggactgg ttgacctccc caaagagaat
      301 tttgaagcag cttacaacac tatcacatta ccagaagaat ttcatgattt tgaaatctac
      361 aatataaatg agattgatat ttcggagccc cttgctcaga accaaagtag accagaggaa
      421 atcacactta gagaagaata tagcaatgat ctacttttcc aagctgggag ctttggggat
      481 gaacctgaaa tcctcagaag acatagcttc tttgatgaca acatattaat gaactccagt
      541 ggtcttgtag tcgaacatag ttctggaagc ttcgctgagg aaaaatcttt gttctttgac
      601 aatggagatg gatttggaga tgaaggagct gcaggagaaa tgattgacaa tctattgcaa
      661 gatgagagta cctttttaga agaagcatat ttgaacaaag aagtgtctct gcctcctgag
      721 cttcccagta gtataatggt agaaccaggt aattcagatg accaatgtat acctgaagat
      781 gaagaaataa atgaaataac attattatca aatgaagatg aaggatttac tctggaccca
      841 attgatgatt tagatattgc tgacaggagg agaaggaaaa agaggagatt gctggtagat
      901 ccagtcaagg agataagcag caaggctatg cataggcagc ttgcttcctt tatggacact
      961 ctcatggttc tggaccttgc accccccaca caaagattga tgatgtggaa gaagcgggga
     1021 ggagtggata tgcttctgtc aactgctacc caggatttga ttaatgacga attgaaaatg
     1081 ttgtttacaa aatgcttcct gtcctctgac tataaacttg caaaattgac actgaaggag
     1141 tcagtaagga aagaagtggg aaaccagcag attgcagaac cctcagtgat gggagagcca
     1201 aattcccaca gtgagttaga tcaaccccaa gattggaagg atgtgactga tgaatctgtg
     1261 ggtagctttc aggagaacgt caacatgaat gttaactctg agcaggatat tcttggaatg
     1321 atttctccag ctgttgaggg attgtcttca atgaatgggt ccttggccca agaaaattgt
     1381 ccagctgaat tggagtcatc aggcagcaaa caaaatactg aggcagaaaa atggaatcaa
     1441 agattatttc aaacattaaa tgtgttacgg gaattcaaca aaatgggaat gcagtccttt
     1501 agtctgaaaa agctatgcag aaatagtgac cgaaaacagg cagctgccaa attttatact
     1561 cttctcatcc tgaaaaaaca tcgtgctatt gagctgagcc agagtgttcc ctatgcagat
     1621 attatagcta cagtgggacc aatgttctat aagatgtga
//
