LOCUS       NM_001411716            3882 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus RAD21 cohesin complex component (Rad21), transcript
            variant 2, mRNA.
ACCESSION   NM_001411716 XM_006520645
VERSION     NM_001411716.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3882)
  AUTHORS   Zhu,C., Xu,J., Lin,J., Liu,J. and Yu,E.
  TITLE     Double-strand-break repair protein rad21 homolog/Synaptotagmin-7
            alleviates Alzheimer's disease in mice by promoting M2 polarization
            of microglia
  JOURNAL   Brain Res Bull 214, 110994 (2024)
   PUBMED   38830486
  REMARK    GeneRIF: Double-strand-break repair protein rad21
            homolog/Synaptotagmin-7 alleviates Alzheimer's disease in mice by
            promoting M2 polarization of microglia.
REFERENCE   2  (bases 1 to 3882)
  AUTHORS   Kumar,P., Zhang,N., Lee,J., Cheng,H., Kurtz,K., Conneely,S.E.,
            Sasidharan,R., Rau,R.E. and Pati,D.
  TITLE     Cohesin Subunit RAD21 Regulates the Differentiation and
            Self-Renewal of Hematopoietic Stem and Progenitor Cells
  JOURNAL   Stem Cells 41 (10), 971-985 (2023)
   PUBMED   37534584
  REMARK    GeneRIF: Cohesin Subunit RAD21 Regulates the Differentiation and
            Self-Renewal of Hematopoietic Stem and Progenitor Cells.
REFERENCE   3  (bases 1 to 3882)
  AUTHORS   Kiefer,L., Chiosso,A., Langen,J., Buckley,A., Gaudin,S.,
            Rajkumar,S.M., Servito,G.I.F., Cha,E.S., Vijay,A., Yeung,A.,
            Horta,A., Mui,M.H. and Canzio,D.
  TITLE     WAPL functions as a rheostat of Protocadherin isoform diversity
            that controls neural wiring
  JOURNAL   Science 380 (6651), eadf8440 (2023)
   PUBMED   37347873
REFERENCE   4  (bases 1 to 3882)
  AUTHORS   Yoon,S., Choi,E.H., Park,S.J. and Kim,K.P.
  TITLE     alpha-Kleisin subunit of cohesin preserves the genome integrity of
            embryonic stem cells
  JOURNAL   BMB Rep 56 (2), 108-113 (2023)
   PUBMED   36571142
  REMARK    GeneRIF: alpha-Kleisin subunit of cohesin preserves the genome
            integrity of embryonic stem cells.
REFERENCE   5  (bases 1 to 3882)
  AUTHORS   Deng,P., Wang,Z., Chen,J., Liu,S., Yao,X., Liu,S., Liu,L., Yu,Z.,
            Huang,Y., Xiong,Z., Xiao,R., Gao,J., Liang,W., Chen,J., Liu,H.,
            Hong,J.H., Chan,J.Y., Guan,P., Chen,J., Wang,Y., Yin,J., Li,J.,
            Zheng,M., Zhang,C., Zhou,P., Kang,T., Teh,B.T., Yu,Q., Zuo,Z.,
            Jiang,Q., Liu,J., Xiong,Y., Xia,X. and Tan,J.
  TITLE     RAD21 amplification epigenetically suppresses interferon signaling
            to promote immune evasion in ovarian cancer
  JOURNAL   J Clin Invest 132 (22), e159628 (2022)
   PUBMED   36201246
  REMARK    GeneRIF: RAD21 amplification epigenetically suppresses interferon
            signaling to promote immune evasion in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3882)
  AUTHORS   Uehara,K. and Muramatsu,T.
  TITLE     Molecular cloning and characterization of
            beta-1,4-galactosyltransferase expressed in mouse testis
  JOURNAL   Eur J Biochem 244 (3), 706-712 (1997)
   PUBMED   9108238
REFERENCE   7  (bases 1 to 3882)
  AUTHORS   McKay,M.J., Troelstra,C., van der Spek,P., Kanaar,R., Smit,B.,
            Hagemeijer,A., Bootsma,D. and Hoeijmakers,J.H.
  TITLE     Sequence conservation of the rad21 Schizosaccharomyces pombe DNA
            double-strand break repair gene in human and mouse
  JOURNAL   Genomics 36 (2), 305-315 (1996)
   PUBMED   8812457
REFERENCE   8  (bases 1 to 3882)
  AUTHORS   Yu,S., Ozawa,M., Naved,A.F., Miyauchi,T., Muramatsu,H. and
            Muramatsu,T.
  TITLE     cDNA cloning and sequence analysis of a novel calcium binding
            protein with oligoproline motif
  JOURNAL   Cell Struct Funct 20 (4), 263-268 (1995)
   PUBMED   8521526
REFERENCE   9  (bases 1 to 3882)
  AUTHORS   Haaf,T., Golub,E.I., Reddy,G., Radding,C.M. and Ward,D.C.
  TITLE     Nuclear foci of mammalian Rad51 recombination protein in somatic
            cells after DNA damage and its localization in synaptonemal
            complexes
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 2298-2302 (1995)
   PUBMED   7892263
REFERENCE   10 (bases 1 to 3882)
  AUTHORS   Sanger,F., Nicklen,S. and Coulson,A.R.
  TITLE     DNA sequencing with chain-terminating inhibitors
  JOURNAL   Proc Natl Acad Sci U S A 74 (12), 5463-5467 (1977)
   PUBMED   271968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160550.6.
            
            On Aug 31, 2022 this sequence version replaced XM_006520645.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.3518785.1,
                                           SRR17253013.2884529.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-491               AC160550.6         133963-134453       c
            492-666             AC160550.6         125257-125431       c
            667-796             AC160550.6         120773-120902       c
            797-896             AC160550.6         118827-118926       c
            897-1003            AC160550.6         116565-116671       c
            1004-1210           AC160550.6         115814-116020       c
            1211-1336           AC160550.6         114930-115055       c
            1337-1459           AC160550.6         114474-114596       c
            1460-1683           AC160550.6         112649-112872       c
            1684-1855           AC160550.6         111079-111250       c
            1856-2004           AC160550.6         110516-110664       c
            2005-2154           AC160550.6         109310-109459       c
            2155-2238           AC160550.6         107683-107766       c
            2239-3882           AC160550.6         105332-106975       c
FEATURES             Location/Qualifiers
     source          1..3882
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 19.54 cM"
     gene            1..3882
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /note="RAD21 cohesin complex component"
                     /db_xref="GeneID:19357"
                     /db_xref="MGI:MGI:108016"
     exon            1..491
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..666
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             523..2430
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /note="PW29; SCC1 homolog; pokeweed agglutinin-binding
                     protein 29; RAD21 homolog"
                     /codon_start=1
                     /product="double-strand-break repair protein rad21
                     homolog"
                     /protein_id="NP_001398645.1"
                     /db_xref="GeneID:19357"
                     /db_xref="MGI:MGI:108016"
                     /translation="MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESI
                     ISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENRE
                     AAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDF
                     GDFGMDDREIMREGSAFEDDDMLVSTSASNLLLEPEQSTSNLNEKMNHLEYEDQYKDD
                     NFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNGSLGGPD
                     SPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDS
                     KTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFFLPAQPLWNNRLLKLFTRC
                     LTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREEQQPQQQQPQPQRDVIDEPIIE
                     EPSRLQDSVMEASRTTIEESAMPPPPPQGVKRKAGQIDPEPSIPPQQVEQMEIPPVEL
                     PPEEPPNICQLIPELELLPEKEKEKEKEKEEEEEEEDEDASGGDQDQEERRWNKRTQQ
                     MLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDI
                     IATPGPRFHII"
     exon            667..796
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..896
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1003
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1210
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1336
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1459
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1683
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1855
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..2004
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2154
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2238
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..3882
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3858..3863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /note="hexamer: AATAAA"
     polyA_site      3882
                     /gene="Rad21"
                     /gene_synonym="mHR21; mKIAA0078; SCC1"
                     /note="major polyA site"
ORIGIN      
        1 gtaacggccg ccatcttgtt tgtttgagtg aatcggaaaa ggaggcggcg gccgtggcgg
       61 tggcgggagc agctccgagg ctacaccgca caagggctcc ccctctcccc gccccctccc
      121 ctgacccttc cccccctccc cgggccaccc acccctcccg gctccccgcc gagatccagg
      181 taagcgatcg ggccgacccc tcctcgggct ctggctccct ccccggtgct ctgccccgcc
      241 gggttgctcc cggggcgcgg gctccgcggc ccgcagttgc ggtgcgaggc ggccggcgtt
      301 gcggcccccg agtgctgcca gctcccgggc agcgcccggc gaccccgcgc tctccgggcc
      361 ccctacgtcc cggggccgcc ctcgcctggg ggggttcctc gctgccccgg ggccgtgcac
      421 cgcgcctgct gacttcctaa tggttccgcc gcagtccagg gcccacaaaa gcgaccctcg
      481 gccgcgcgga ggtttcttct tatttcatag caaataagaa aaatgttcta cgcacatttt
      541 gtcctcagta aacgagggcc tctggccaaa atctggctgg cggcccattg ggacaagaag
      601 ctaaccaaag cccatgtatt tgagtgcaac ttagagagca gtgtggagag catcatctca
      661 ccaaaggtga agatggcgct gcggacgtca ggacaccttc tcctgggagt agtccgcatc
      721 tatcacagga aagccaaata cctcctcgca gactgtaatg aagcatttat taaaataaag
      781 atggcgtttc ggccaggtgt tgtcgatcta cctgaggaaa atcgggaagc agcttataat
      841 gccattactt tacctgagga attccacgat tttgatcagc cactgccaga tttagatgat
      901 attgacgtcg cccagcagtt cagcctgaac caaagcagag tagaagagat aaccatgaga
      961 gaagaagtcg gaaacatcag tatcctacag gaaaatgact ttggtgactt cggaatggat
     1021 gaccgtgaaa taatgagaga aggcagtgct ttcgaggatg acgacatgtt agtgagcacc
     1081 agcgcttcca accttctcct cgagccagag cagagcacca gcaacctgaa tgaaaagatg
     1141 aatcacttag agtacgaaga ccagtacaaa gatgacaatt ttggagaagg aaatgatggc
     1201 ggtatattag atgacaaact tataagtaat aatgatggtg gcatctttga cgatccccct
     1261 gccttgtctg aggcaggggt catgttgcca gagcaacctg cacatgatga catggatgaa
     1321 gatgacaatg gctcactggg tgggccggat agtcccgact ctgtggatcc tgtcgaaccg
     1381 atgccaacta tgactgatca gacaactctc gtcccaaacg aggaagaagc ttttgcgttg
     1441 gagcccattg atataactgt caaagagaca aaagccaaga ggaagaggaa gctgattgtt
     1501 gacagtgtca aagaattgga tagtaagacc attagagccc agcttagcga ttattctgat
     1561 attgttacga ctctggacct ggctccgcca accaagaagc ttatgatgtg gaaagagaca
     1621 ggaggagtgg aaaagctctt ctttttacca gcacagcccc tgtggaataa ccggctactg
     1681 aagctcttca cacgctgcct taccccactt gtaccagaag accttaggaa gagaaggaaa
     1741 gggggagagg cagataatct ggatgagttc ctcaaagagt ttgagaatcc agaggttccc
     1801 agagaggagc agcagccaca gcagcagcag ccacagccgc agcgagatgt catcgatgag
     1861 cccattatag aagagccaag ccgcctccag gactcagtga tggaggccag cagaacaacc
     1921 atagaagaat cagccatgcc cccaccaccc cctcaaggag ttaagcggaa agccgggcaa
     1981 atagacccag agccttcgat acctcctcag caggtagagc aaatggaaat accaccagta
     2041 gaacttcccc cagaggagcc tccaaatatc tgtcagctga tcccggagtt agagctccta
     2101 ccggagaagg agaaggaaaa agagaaggag aaggaagagg aggaggagga ggaggatgaa
     2161 gatgcttcag ggggtgatca ggatcaagag gaaaggagat ggaacaaacg cactcagcag
     2221 atgcttcatg gtcttcagcg agctcttgct aaaactggag cagagtctat cagtttgctt
     2281 gagctgtgtc gaaacacaaa ccgaaagcag gcagcagcaa agttctacag ctttttggtt
     2341 cttaagaagc agcaagccat cgagctcaca caggaagagc cgtacagtga catcattgca
     2401 acccctggac cacggttcca tattatctga ggagctagat gtgttcgagc tagtgataac
     2461 tcactagtac atacaaattg cccccgtgtg cagggcacca aaacccttta agaaagtttt
     2521 tagatttctg tttgtacaaa aatctttgcc ttttctttct tctttttccc cccagtgttt
     2581 ctaattttgt caaccatatt tttaagggaa actgcttatt tgggttgggt ttgtattcct
     2641 ggagaaaaca gtagcccaag aacccagaag acttttaaca gttcagaaca gatgtgtgca
     2701 atattggtgc atgtaagaat atggagtaac agtcaaaagg caccattttt aatgttagtt
     2761 ttccattact atgttgaaag gaaaacctgc ctaggaaaat gcctgacact ttaagaactg
     2821 tggtttgagt cccttgacag gaagagaaaa atgtcttccc atcagtgaaa ccaacggtct
     2881 ggttaaccac tgtagtaggg atagtgtgtg aagcatcgtg cttgtcttct tgatcatgtt
     2941 taaagtaaat ccacactgag caagaatttg tgaggttgtg ctgactgatc ttcttcggct
     3001 attatgttct gaaatcattc cgtgagtctt aggacctctg atgctatgca ccgcagctca
     3061 gaacgatcag acgtctacag tggcgtgact cctcaggggc tgcagatcac tctcagaggt
     3121 gtttggatgt ttgcttgaat aatgagatca tggaagcaga cattcccctg cctgctgaag
     3181 ggcagaccaa tgagagacta ccccagattg acttccttta agcaaacagt gctgtaaaaa
     3241 ctaatggctt ctctgatatt tattataaat gttagtactc atctttttcc aaggctgcac
     3301 actcctgtat ttgcaactta tttttaataa ctttgcaact ataatcctgt atcagtttcc
     3361 tataatttaa gtggagaaaa acatcctaat aaaggcttta ttattaacag accagatagc
     3421 accagaaatt atgtgactat ataaatatca aaacatgttc actttgtagg acaaaattat
     3481 gttgaaaagt tctagcttaa gtgttggcac ttttatgggg gggaaatcag ttttaaaact
     3541 aagacttcca tgtataccca gtaatttaaa attatgtgaa atattttaaa tttgtgaact
     3601 cgtaattact actttaatga ttcagtttct cgagaatggt aattgtataa aattgctctt
     3661 gcagttttct tttcaatacg acgtgcctgt aaccatggat gtcccctttg taaaaagaca
     3721 ctgtagataa ttgaatgttt gattatagaa aggtcgttag tttcttgtta aacattttgt
     3781 tagtccagtt tttgtcgctt attgggttta atattgttct tgaaaatagt cgatgctatg
     3841 ttatgtataa cttttctaat aaaagttgtg tttcaagctg ta
//
