LOCUS       NM_001044371            2735 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus RAD17 checkpoint clamp loader component (Rad17),
            transcript variant 2, mRNA.
ACCESSION   NM_001044371
VERSION     NM_001044371.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2735)
  AUTHORS   Akagawa,R., Nabeshima,Y.I. and Kawauchi,T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2735)
  AUTHORS   Koss,M., Bolze,A., Brendolan,A., Saggese,M., Capellini,T.D.,
            Bojilova,E., Boisson,B., Prall,O.W., Elliott,D.A., Solloway,M.,
            Lenti,E., Hidaka,C., Chang,C.P., Mahlaoui,N., Harvey,R.P.,
            Casanova,J.L. and Selleri,L.
  TITLE     Congenital asplenia in mice and humans with mutations in a
            Pbx/Nkx2-5/p15 module
  JOURNAL   Dev Cell 22 (5), 913-926 (2012)
   PUBMED   22560297
REFERENCE   3  (bases 1 to 2735)
  AUTHORS   Kumar,A., Fernandez-Capetillo,O. and Carrera,A.C.
  TITLE     Nuclear phosphoinositide 3-kinase beta controls double-strand break
            DNA repair
  JOURNAL   Proc Natl Acad Sci U S A 107 (16), 7491-7496 (2010)
   PUBMED   20368419
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11145.
            Fernadez-Capetillo, Oscar [corrected to Fernandez-Capetillo,
            Oscar]]
REFERENCE   4  (bases 1 to 2735)
  AUTHORS   Chesnokova,V., Wong,C., Zonis,S., Gruszka,A., Wawrowsky,K.,
            Ren,S.G., Benshlomo,A. and Yu,R.
  TITLE     Diminished pancreatic beta-cell mass in securin-null mice is caused
            by beta-cell apoptosis and senescence
  JOURNAL   Endocrinology 150 (6), 2603-2610 (2009)
   PUBMED   19213844
REFERENCE   5  (bases 1 to 2735)
  AUTHORS   Derradji,H., Bekaert,S., De Meyer,T., Jacquet,P., Abou-El-Ardat,K.,
            Ghardi,M., Arlette,M. and Baatout,S.
  TITLE     Ionizing radiation-induced gene modulations, cytokine content
            changes and telomere shortening in mouse fetuses exhibiting
            forelimb defects
  JOURNAL   Dev Biol 322 (2), 302-313 (2008)
   PUBMED   18722365
REFERENCE   6  (bases 1 to 2735)
  AUTHORS   von Deimling,F., Scharf,J.M., Liehr,T., Rothe,M., Kelter,A.R.,
            Albers,P., Dietrich,W.F., Kunkel,L.M., Wernert,N. and Wirth,B.
  TITLE     Human and mouse RAD17 genes: identification, localization, genomic
            structure and histological expression pattern in normal testis and
            seminoma
  JOURNAL   Hum Genet 105 (1-2), 17-27 (1999)
   PUBMED   10480350
REFERENCE   7  (bases 1 to 2735)
  AUTHORS   Bao,S., Chang,M.S., Auclair,D., Sun,Y., Wang,Y., Wong,W.K.,
            Zhang,J., Liu,Y., Qian,X., Sutherland,R., Magi-Galluzi,C.,
            Weisberg,E., Cheng,E.Y., Hao,L., Sasaki,H., Campbell,M.S.,
            Kraeft,S.K., Loda,M., Lo,K.M. and Chen,L.B.
  TITLE     HRad17, a human homologue of the Schizosaccharomyces pombe
            checkpoint gene rad17, is overexpressed in colon carcinoma
  JOURNAL   Cancer Res 59 (9), 2023-2028 (1999)
   PUBMED   10232579
REFERENCE   8  (bases 1 to 2735)
  AUTHORS   Bluyssen,H.A., Naus,N.C., van Os,R.I., Jaspers,I., Hoeijmakers,J.H.
            and de Klein,A.
  TITLE     Human and mouse homologs of the Schizosaccharomyces pombe rad17+
            cell cycle checkpoint control gene
  JOURNAL   Genomics 55 (2), 219-228 (1999)
   PUBMED   9933569
REFERENCE   9  (bases 1 to 2735)
  AUTHORS   Bao,S., Shen,X., Shen,K., Liu,Y. and Wang,X.F.
  TITLE     The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae
            Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage
            checkpoint
  JOURNAL   Cell Growth Differ 9 (12), 961-967 (1998)
   PUBMED   9869296
REFERENCE   10 (bases 1 to 2735)
  AUTHORS   Udell,C.M., Lee,S.K. and Davey,S.
  TITLE     HRAD1 and MRAD1 encode mammalian homologues of the fission yeast
            rad1(+) cell cycle checkpoint control gene
  JOURNAL   Nucleic Acids Res 26 (17), 3971-3976 (1998)
   PUBMED   9705507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165159.2, BY129390.1, AK134277.1 and BC066855.1.
            
            On Sep 25, 2013 this sequence version replaced NM_001044371.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134277.1, AK162016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC165159.2         108154-108155       c
            3-46                BY129390.1         3-46
            47-2718             AK134277.1         2-2673
            2719-2735           BC066855.1         2837-2853
FEATURES             Location/Qualifiers
     source          1..2735
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 53.23 cM"
     gene            1..2735
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /note="RAD17 checkpoint clamp loader component"
                     /db_xref="GeneID:19356"
                     /db_xref="MGI:MGI:1333807"
     exon            1..112
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     exon            113..216
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..2241
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /note="isoform 1 is encoded by transcript variant 2; cell
                     cycle checkpoint protein RAD17; RAD17 homolog"
                     /codon_start=1
                     /product="cell cycle checkpoint protein RAD17 isoform 1"
                     /protein_id="NP_001037836.1"
                     /db_xref="CCDS:CCDS26733.1"
                     /db_xref="GeneID:19356"
                     /db_xref="MGI:MGI:1333807"
                     /translation="MSETFLRPKVSSTKVTDWVAPAFDDFEANTAITTITASSLTFSN
                     SSHRRKYLPSTLESNRLSARKRGRLSLEQTHGLETSRERLSDNEPWVDKYKPETQHEL
                     AVHKKKIEEVETWLKAQVLEVKPKQGGSVLLITGPPGCGKTTTIKILSKELGIQVQEW
                     VNPILPDFQKDDYKELLSLESNFSVVPYQSQIAVFNDFLLRATKYSKLQMLGDDLTTD
                     KKIILVEELPNQFYRDPNALHEILRKHVQIGRCPLVFIVSDSVSGDNNQRLLFPRNIQ
                     EECSVSNISFNPVAPTIMMKFLNRIVTIEASKNGEKIIVPNKTSLELLCQGCSGDIRS
                     AINSLQFSSSKGENSSWSKKKRMSLKSDAAISKSKQKKKHNSTLENQEIQAIGGKDVS
                     LFLFRALGKILYCKRAPLTELDSPRLPAHLSEHDRDTLLVQPEEIVEMSHMPGDFFNL
                     YLHQNYIDFFAEVDDLVPASEFLSFADILGGDWNTRSLLREYSTSVATRGVMHSNKAR
                     GFAHCQGGSSFRPLHKPQWFLIQKKYRENCLAAKALFVDFCLPALCLQTQLLPYLALL
                     TIPMRNKAQISFIQDVGRLPLKRSFGRLKMEALTDRELGLIDPDSGDESPHSGGQPAQ
                     EAPGEPAQAAQNADPETWSLPLSQNSGSDLPASQPQPFSSKVDMEEEEEEEEDIIIED
                     YDSEET"
     exon            217..471
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     exon            472..555
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     exon            556..712
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     exon            713..849
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     exon            850..902
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1028
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1098
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1210
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1393
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1479
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1626
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1773
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1894
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1952
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2721
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2702..2707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /note="hexamer: ATTAAA"
     polyA_site      2721
                     /gene="Rad17"
                     /gene_synonym="MmRad24"
                     /note="major polyA site"
ORIGIN      
        1 ccaggaggcg ggccctccaa cagcctgcgg ctgagccggg agggctgggt ggcgaagtac
       61 agccccggtt ctccgctttt ttccgcccgc gaggggacgc agctcccgga aagtgaatta
      121 tacttcaaca tactctaaat tgtatgctac tgatgggaac tgttaaagtt tataatgtca
      181 gaaactttcc ttagaccaaa ggtgtcttcc acaaaggtga cagactgggt agctccagcc
      241 tttgatgact ttgaggccaa caccgccatc accaccatca ctgcgtcatc tttaactttc
      301 agtaactcca gtcacagaag aaaatatttg ccctccacat tagaaagtaa cagattgtcg
      361 gctagaaaaa gaggaaggct ctctttagaa cagactcatg gtctagaaac ttcaagagag
      421 cgtctgtccg acaatgagcc gtgggtggat aaatataaac cagaaactca gcatgaactt
      481 gctgttcata aaaagaaaat tgaagaggtc gaaacctggt taaaagctca agtcttagaa
      541 gtgaagccaa aacagggtgg gtctgtttta ttaataacag gtcctccagg atgtggaaag
      601 acaactacta taaaaatact gtcaaaggaa cttgggatcc aagtacaaga atgggttaat
      661 cctattttac cagacttcca aaaagatgat tacaaggagt tacttagttt agaatcaaac
      721 ttctctgtag ttccatacca atctcagata gcagtcttca atgactttct attaagagcc
      781 accaagtaca gcaaactgca gatgcttgga gacgatctga caactgataa gaagatcatt
      841 ctggtggaag agttacctaa ccagttttat cgagacccta acgctttaca tgagattcta
      901 agaaagcatg tgcagattgg ccggtgtcct cttgtattta tagtctctga cagtgtcagt
      961 ggagacaata atcagcggct actcttcccc agaaacattc aagaagagtg ttctgtttca
     1021 aacattagtt tcaaccctgt ggcaccaaca attatgatga aatttcttaa tcgaattgtg
     1081 actatagaag ctagtaagaa tggagaaaaa attattgttc ctaataaaac ttctctggag
     1141 ttgctctgtc aaggatgttc tggtgatatc agaagtgcaa taaacagcct gcagttctcg
     1201 tcttcaaaag gagagaacag ttcgtggtca aagaagaaaa gaatgtcatt gaaatcggat
     1261 gctgccatat caaaatcaaa acaaaaaaag aaacataata gtactttgga aaatcaagag
     1321 attcaagcta ttggtggaaa agatgtttct ctttttctct tcagagcttt ggggaagatt
     1381 ctgtactgta aaagagcgcc tttaacagag ttagactcac ctcgcctgcc tgctcacttg
     1441 tcagagcacg accgggacac tttacttgtt cagcctgagg aaatagtaga aatgtcacac
     1501 atgccaggag acttttttaa tttatacctt caccaaaact acatagattt cttcgctgaa
     1561 gtagatgatc ttgtgccagc cagtgagttt ctgagttttg cagatatcct cggtggtgat
     1621 tggaatacac gctcgttact cagggaatat agtacatccg tagctacaag aggtgtgatg
     1681 cattccaaca aagcccgggg gttcgctcac tgccaaggag gatcaagctt tcgaccctta
     1741 cataagcccc agtggtttct aatacagaaa aagtatcggg aaaattgcct ggcagcaaaa
     1801 gcactctttg ttgacttctg cctaccagct ttgtgtctcc agactcagct cttgccatat
     1861 cttgctcttc tgaccattcc aatgcgaaat aaagctcaga tttcttttat ccaagatgtt
     1921 ggaagacttc ctttgaagcg aagctttgga aggttgaaaa tggaagccct gactgaccga
     1981 gagctggggc tgatagaccc tgacagtggg gatgagtccc cgcacagcgg agggcagccg
     2041 gctcaggaag ctcccggtga acccgcgcag gctgctcaga atgccgaccc agagacctgg
     2101 tcccttccgc tgagtcagaa cagcgggagc gatctgcctg ccagccagcc tcagcccttt
     2161 tcctccaaag tggacatgga agaagaggag gaggaagagg aagacataat aatagaggac
     2221 tatgacagcg aggagacata gagaacagcc tgccaatcag gttgctcctt gagagataaa
     2281 ttttagtcta ttcagtggta cttgaacacg tctctgaagg acaagcaatt tgttaattgc
     2341 tcagttcctt atcgtattcg tcacagcaac tgacgactgt catcttgaag taaagcaggt
     2401 ctcaagtact cagtgcttag tatttattta gtcttgtgaa tggtttgagg agaagtcacg
     2461 gtgtgaagtg tatgaatgtt gtactaaata tcaaaatgtg aaggagtaat ccagaatata
     2521 cggactttat ggggtgttgg aaatttgatt tataaaacag tttaggatgc aattatgagt
     2581 ataaataaac cttgtgcctt acttacagtt tgcatctagc ttttcggata ccatttttgg
     2641 tatgttgtac agtggaatat tttagatact tctggaaagt atttacataa tttatatcaa
     2701 aattaaaaac gttggatttc aaaaaaaaaa aaaaa
//
