LOCUS       NM_008143               1254 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus receptor for activated C kinase 1 (Rack1), mRNA.
ACCESSION   NM_008143
VERSION     NM_008143.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1254)
  AUTHORS   Lyu,C., Vaddi,P.K., Elshafae,S., Pradeep,A., Ma,D. and Chen,S.
  TITLE     Unveiling RACK1: a key regulator of the PI3K/AKT pathway in
            prostate cancer development
  JOURNAL   Oncogene 44 (5), 322-335 (2025)
   PUBMED   39537875
REFERENCE   2  (bases 1 to 1254)
  AUTHORS   Cheng,Q., Yang,X., Zou,T., Sun,L., Zhang,X., Deng,L., Wu,M.,
            Gai,W., Jiang,H., Guo,T., Lu,Y., Dong,J., Niu,C., Pan,W. and
            Zhang,J.
  TITLE     RACK1 enhances STAT3 stability and promotes T follicular helper
            cell development and function during blood-stage Plasmodium
            infection in mice
  JOURNAL   PLoS Pathog 20 (7), e1012352 (2024)
   PUBMED   39024388
  REMARK    GeneRIF: RACK1 enhances STAT3 stability and promotes T follicular
            helper cell development and function during blood-stage Plasmodium
            infection in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1254)
  AUTHORS   Chen,M., Wang,G., Xu,Z., Sun,J., Liu,B., Chang,L., Gu,J., Ruan,Y.,
            Gao,X. and Song,S.
  TITLE     Loss of RACK1 promotes glutamine addiction via activating
            AKT/mTOR/ASCT2 axis to facilitate tumor growth in gastric cancer
  JOURNAL   Cell Oncol (Dordr) 47 (1), 113-128 (2024)
   PUBMED   37578594
  REMARK    GeneRIF: Loss of RACK1 promotes glutamine addiction via activating
            AKT/mTOR/ASCT2 axis to facilitate tumor growth in gastric cancer.
REFERENCE   4  (bases 1 to 1254)
  AUTHORS   Yang,W., Zhuang,Y., Wu,H., Su,S., Li,Y., Wang,C., Tian,Z., Peng,L.,
            Zhang,X., Liu,J., Pei,X., Yuan,W., Hu,X., Meng,B., Li,D., Zhang,Y.,
            Shan,H., Pan,Z. and Lu,Y.
  TITLE     Substrate-dependent interaction of SPOP and RACK1 aggravates
            cardiac fibrosis following myocardial infarction
  JOURNAL   Cell Chem Biol 30 (10), 1248-1260 (2023)
   PUBMED   37442135
  REMARK    GeneRIF: Substrate-dependent interaction of SPOP and RACK1
            aggravates cardiac fibrosis following myocardial infarction.
REFERENCE   5  (bases 1 to 1254)
  AUTHORS   Ran,J., Yin,H., Xu,Y., Wang,Y., Li,G., Wu,X., Peng,L., Peng,Y. and
            Fang,R.
  TITLE     RACK1 mediates NLRP3 inflammasome activation during Pasteurella
            multocida infection
  JOURNAL   Vet Res 54 (1), 73 (2023)
   PUBMED   37684678
  REMARK    GeneRIF: RACK1 mediates NLRP3 inflammasome activation during
            Pasteurella multocida infection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1254)
  AUTHORS   Takenaka,M., Imai,E., Kaneko,T., Ito,T., Moriyama,T., Yamauchi,A.,
            Hori,M., Kawamoto,S. and Okubo,K.
  TITLE     Isolation of genes identified in mouse renal proximal tubule by
            comparing different gene expression profiles
  JOURNAL   Kidney Int 53 (3), 562-572 (1998)
   PUBMED   9507200
REFERENCE   7  (bases 1 to 1254)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   8  (bases 1 to 1254)
  AUTHORS   Palis,J. and Kingsley,P.D.
  TITLE     Differential gene expression during early murine yolk sac
            development
  JOURNAL   Mol Reprod Dev 42 (1), 19-27 (1995)
   PUBMED   8562047
REFERENCE   9  (bases 1 to 1254)
  AUTHORS   Imai,Y., Suzuki,Y., Tohyama,M., Wanaka,A. and Takagi,T.
  TITLE     Cloning and expression of a neural differentiation-associated gene,
            p205, in the embryonal carcinoma cell line P19 and in the
            developing mouse
  JOURNAL   Brain Res Mol Brain Res 24 (1-4), 313-319 (1994)
   PUBMED   7968370
  REMARK    Erratum:[Brain Res Mol Brain Res 1994 Sep;25(3-4):369-70]
REFERENCE   10 (bases 1 to 1254)
  AUTHORS   Guillemot,F., Billault,A. and Auffray,C.
  TITLE     Physical linkage of a guanine nucleotide-binding protein-related
            gene to the chicken major histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 86 (12), 4594-4598 (1989)
   PUBMED   2499885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK017772.1.
            
            On Apr 6, 2007 this sequence version replaced NM_008143.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017772.1, AK159797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1254              AK017772.1         2-1255
FEATURES             Location/Qualifiers
     source          1..1254
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 28.77 cM"
     gene            1..1254
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
                     /note="receptor for activated C kinase 1"
                     /db_xref="GeneID:14694"
                     /db_xref="MGI:MGI:101849"
     exon            1..213
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1058
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
                     /note="guanine nucleotide binding protein, beta 2, related
                     sequence 1; guanine nucleotide-binding protein subunit
                     beta-2-like 1; activated protein kinase C receptor;
                     guanine nucleotide binding protein (G protein), beta
                     polypeptide 2 like 1 sequence 1; 12-3; receptor of
                     activated protein kinase C 1; guanine nucleotide binding
                     protein related; guanine nucleotide binding protein (G
                     protein), beta polypeptide 2-like 1; receptor of activated
                     protein C kinase 1"
                     /codon_start=1
                     /product="small ribosomal subunit protein RACK1"
                     /protein_id="NP_032169.1"
                     /db_xref="CCDS:CCDS24585.1"
                     /db_xref="GeneID:14694"
                     /db_xref="MGI:MGI:101849"
                     /translation="MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWK
                     LTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV
                     GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNS
                     SNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML
                     WDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVIS
                     TSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR"
     exon            214..385
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
                     /inference="alignment:Splign:2.1.0"
     exon            386..533
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
                     /inference="alignment:Splign:2.1.0"
     exon            534..629
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
                     /inference="alignment:Splign:2.1.0"
     exon            630..740
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
                     /inference="alignment:Splign:2.1.0"
     exon            741..881
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
                     /inference="alignment:Splign:2.1.0"
     exon            882..992
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1254
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1082..1087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
                     /note="hexamer: AATAAA"
     polyA_site      1097
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
     polyA_site      1101
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
                     /note="major polyA site"
     polyA_site      1151
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
     regulatory      1201..1206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
                     /note="hexamer: AGTAAA"
     polyA_site      1243
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
     polyA_site      1251
                     /gene="Rack1"
                     /gene_synonym="GB-like; Gnb2-rs1; Gnb2l1; p205"
ORIGIN      
        1 ctttttctcc acagggtcgt ggtggcagcc gctgtggtgc ttggctctct gagctatccg
       61 gtgccatcct tgtcgctgcg gcgaccctcg catcaactgc agccatgacc gagcagatga
      121 cccttcgcgg gacccttaag ggccacaatg gatgggtaac acagatcgcc accacaccgc
      181 agttcccgga catgatcctg tctgcgtctc gagacaagac catcatcatg tggaagctga
      241 ccagagatga gaccaactat ggcataccac agcgtgctct gagaggtcac tcccacttcg
      301 ttagtgatgt tgttatctcc tctgatggtc agtttgccct ctcgggctcc tgggacggaa
      361 cgctgcgcct ctgggatctc acaacgggca ccaccacaag gcgatttgtc ggccacacca
      421 aggatgtgtt gagcgtggcc ttctcctctg acaaccggca gattgtctct gggtcccgag
      481 acaagaccat aaagttatgg aatactctgg gtgtctgcaa gtacacggtc caggatgaga
      541 gtcattcaga atgggtgtct tgtgtccgct tctccccgaa cagcagcaac cctatcatcg
      601 tctcctgcgg atgggacaag ctggtcaagg tgtggaatct ggctaactgc aagctaaaga
      661 ccaaccacat tggccacact ggctacctga acacagtgac tgtctctcca gatggatccc
      721 tctgtgcttc tggaggcaag gatggccagg ctatgctgtg ggatctcaat gaaggcaagc
      781 acctctacac tttagatggt ggggacatca tcaatgcctt gtgcttcagc cccaaccgct
      841 actggctctg cgctgccact ggccccagca tcaagatctg ggacttggag ggcaagatca
      901 ttgtagatga attgaagcaa gaagttatca gcaccagcag caaggcagag ccaccccagt
      961 gtacctcttt ggcatggtct gctgatggcc agactctgtt tgctggctat acagacaact
     1021 tggtgcgagt atggcaggta actattggta cccgctaaaa gttttatgac aaagtcttag
     1081 aaataaactg gctttctgaa actggcttct atatgtgagt cctggaagct gagtccctgg
     1141 ttctactgca agagcagacc actggtgttt actatcctgg catgtaagca gtaacagcta
     1201 agtaaacaca tcagatgtca tttcatcacc aattagacaa aaatccatca actt
//
