LOCUS       NM_012025               3032 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus Rac GTPase-activating protein 1 (Racgap1), transcript
            variant 1, mRNA.
ACCESSION   NM_012025
VERSION     NM_012025.8
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3032)
  AUTHORS   Xie,X., Sun,L., Duan,Y., Lv,Z., Yao,X., Wang,C., Chen,X., Tian,S.,
            Yan,L., Shao,Y., Luo,H. and Liu,J.
  TITLE     SRSF2 in Sertoli cells is essential for testicular development and
            spermatogenesis in mice
  JOURNAL   FASEB J 37 (5), e22918 (2023)
   PUBMED   37039821
REFERENCE   2  (bases 1 to 3032)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3032)
  AUTHORS   Zhou,W., Zhao,S., Xu,S., Sun,Z., Liang,Y. and Ding,X.
  TITLE     RacGAP1 ameliorates acute kidney injury by promoting proliferation
            and suppressing apoptosis of renal tubular cells
  JOURNAL   Biochem Biophys Res Commun 527 (3), 624-630 (2020)
   PUBMED   32423815
  REMARK    GeneRIF: RacGAP1 ameliorates acute kidney injury by promoting
            proliferation and suppressing apoptosis of renal tubular cells.
REFERENCE   4  (bases 1 to 3032)
  AUTHORS   Naiman,N., Fujioka,K., Fujino,M., Valerius,M.T., Potter,S.S.,
            McMahon,A.P. and Kobayashi,A.
  TITLE     Repression of Interstitial Identity in Nephron Progenitor Cells by
            Pax2 Establishes the Nephron-Interstitium Boundary during Kidney
            Development
  JOURNAL   Dev Cell 41 (4), 349-365 (2017)
   PUBMED   28535371
REFERENCE   5  (bases 1 to 3032)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   6  (bases 1 to 3032)
  AUTHORS   Thut,C.J., Rountree,R.B., Hwa,M. and Kingsley,D.M.
  TITLE     A large-scale in situ screen provides molecular evidence for the
            induction of eye anterior segment structures by the developing lens
  JOURNAL   Dev Biol 231 (1), 63-76 (2001)
   PUBMED   11180952
REFERENCE   7  (bases 1 to 3032)
  AUTHORS   Kawashima,T., Hirose,K., Satoh,T., Kaneko,A., Ikeda,Y., Kaziro,Y.,
            Nosaka,T. and Kitamura,T.
  TITLE     MgcRacGAP is involved in the control of growth and differentiation
            of hematopoietic cells
  JOURNAL   Blood 96 (6), 2116-2124 (2000)
   PUBMED   10979956
REFERENCE   8  (bases 1 to 3032)
  AUTHORS   Arar,C., Ott,M.O., Toure,A. and Gacon,G.
  TITLE     Structure and expression of murine mgcRacGAP: its developmental
            regulation suggests a role for the Rac/MgcRacGAP signalling pathway
            in neurogenesis
  JOURNAL   Biochem J 343 Pt 1 (Pt 1), 225-230 (1999)
   PUBMED   10493933
REFERENCE   9  (bases 1 to 3032)
  AUTHORS   Wooltorton,E.J., Haliotis,T. and Mueller,C.R.
  TITLE     Identification and characterization of a transcript for a novel Rac
            GTPase-activating protein in terminally differentiating 3T3-L1
            adipocytes
  JOURNAL   DNA Cell Biol 18 (4), 265-273 (1999)
   PUBMED   10235109
REFERENCE   10 (bases 1 to 3032)
  AUTHORS   Toure,A., Dorseuil,O., Morin,L., Timmons,P., Jegou,B., Reibel,L.
            and Gacon,G.
  TITLE     MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42
            similar to Drosophila rotundRacGAP gene product, is expressed in
            male germ cells
  JOURNAL   J Biol Chem 273 (11), 6019-6023 (1998)
   PUBMED   9497316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139317.4.
            
            On Sep 8, 2022 this sequence version replaced NM_012025.7.
            
            Transcript Variant: This variant (1) is the longest transcript.
            Variants 1-5 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144608.1, AF212321.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AC139317.4         49943-50059
            118-248             AC139317.4         58043-58173
            249-337             AC139317.4         58595-58683
            338-543             AC139317.4         61747-61952
            544-680             AC139317.4         63792-63928
            681-750             AC139317.4         65365-65434
            751-804             AC139317.4         67271-67324
            805-885             AC139317.4         68771-68851
            886-1003            AC139317.4         69369-69486
            1004-1134           AC139317.4         70327-70457
            1135-1299           AC139317.4         72768-72932
            1300-1395           AC139317.4         75009-75104
            1396-1594           AC139317.4         75185-75383
            1595-1700           AC139317.4         77223-77328
            1701-1833           AC139317.4         77507-77639
            1834-1957           AC139317.4         77874-77997
            1958-2063           AC139317.4         79242-79347
            2064-3032           AC139317.4         80102-81070
FEATURES             Location/Qualifiers
     source          1..3032
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.13 cM"
     gene            1..3032
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /note="Rac GTPase-activating protein 1"
                     /db_xref="GeneID:26934"
                     /db_xref="MGI:MGI:1349423"
     exon            1..117
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     exon            118..248
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     exon            249..337
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..2139
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /note="male germ cell RacGap"
                     /codon_start=1
                     /product="rac GTPase-activating protein 1"
                     /protein_id="NP_036155.1"
                     /db_xref="CCDS:CCDS27825.1"
                     /db_xref="GeneID:26934"
                     /db_xref="MGI:MGI:1349423"
                     /translation="MDTTMVNLWTLFEQLVRRMEIINEGNESIEFIQVVKDFEDFRKK
                     YQRTNQELEKFKDLLLKAETGRSALDVKLKHARNQVDVEIKRRQRAEAECAKLEQQIQ
                     LIRDILMCDTSGSIQLSEEQKSALAFLNRGQASSGHAGNNRLSTIDESGSILSDISFD
                     KTDESLDWDSSLVKNFKMKKREKRRSNSRQFIDGPPGPVKKTCSIGSTVDQANESIVA
                     KTTVTVPSDGGPIEAVSTIETLPSWTRSRGKSGPLQPVNSDSALNSRPLEPRTDTDNL
                     GTPQNTGGMRLHDFVSKTVIKPESCVPCGKRIKFGKLSLKCRDCRLVSHPECRDRCPL
                     PCIPPLVGTPVKIGEGMLADFVSQASPMIPAIVVSCVNEIEQRGLTEAGLYRISGCDR
                     TVKELKEKFLKVKTVPLLSKVDDIHVICSLLKDFLRNLKEPLLTFWLSKAFMEAAEIT
                     DEDNSTAAMYQAVSELPQANRDTLAFLMIHLQRVSQSPDTKMDIANLAKVFGPTIVAH
                     TVPNPDPVTMFQDIKRQLKVVERLLSLPLEYWNQFMMVDQENIDSQRGNGNSTPRTPD
                     VKVSLLGPVTTPEFQLVKTPLSSSLSQRLYNLSKSTPRFGNKSKSATNLGQQGKFFPA
                     PYLK"
     exon            338..543
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     exon            544..680
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     exon            681..750
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     exon            751..804
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     exon            805..885
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1003
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1134
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1299
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1395
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1594
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1700
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1833
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1957
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2063
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..3032
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3008..3013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /note="hexamer: AATAAA"
     polyA_site      3032
                     /gene="Racgap1"
                     /gene_synonym="Band25; gtl11; GTPase; MgcRacGAP;
                     mKIAA1478"
                     /note="major polyA site"
ORIGIN      
        1 acactgccgt tagtgaggcg cgtcgctggt agacagcagc cctcctgggg cgcggcggcc
       61 ggagagtgag cgccgcgggc cggacggggt tgcgtgtgcg cggggccggg agcctcgggt
      121 ttctctgtgt agccctggct gtcctggaac tcactctgta gaccaggacc caaacccaag
      181 agatctgctt gcttttgcac ctcaagacta aatctaaagg tgtgcaccgc tacagcctgg
      241 ctttataaaa agatggatac tacaatggtg aatttgtgga ctctgtttga gcagcttgtg
      301 cgccggatgg agattatcaa tgaaggaaat gaaagcattg aattcatcca ggttgtgaag
      361 gacttcgagg acttccgaaa gaagtatcaa agaaccaacc aggagctgga gaaattcaaa
      421 gacctattgt tgaaagcaga gactgggcgg agcgccctgg acgtgaagct gaagcatgcc
      481 cgtaatcaag tggacgtgga gatcaagcgg aggcagcgcg ctgaggcaga gtgtgcaaag
      541 ctggaacaac agattcagct gattcgagac atactcatgt gtgacacatc tggcagtatt
      601 cagctgagcg aggaacaaaa atcagctctc gctttcctca accgaggcca agcatccagt
      661 ggccacgccg gcaacaatag actgtcaacg attgatgaat ctggttccat tttatcagat
      721 atcagctttg acaagactga tgaatcactg gactgggatt cttctttggt gaagaatttc
      781 aaaatgaaga aacgagagaa gaggcgctcc aacagtagac agttcatcga cggccctcct
      841 gggcctgtga agaaaacttg ttccattggc tctacagtag accaggcaaa tgaatcaata
      901 gttgcaaaaa ctacagtgac tgttcccagt gatgggggac ccattgaagc tgtgtctact
      961 attgagacat tgccgtcctg gaccaggagt cgcgggaagt caggaccttt acaacctgtg
     1021 aacagtgact ccgctctgaa cagcaggcca ctggagccaa gaactgacac agacaatttg
     1081 ggcacacctc agaatactgg aggcatgcgc ttgcacgact tcgtctcaaa gacggttatt
     1141 aagcctgaat cttgtgttcc gtgtggaaag cggatcaagt ttggcaagct gtctctgaag
     1201 tgtcgagact gtcgtttggt ctcccatcca gaatgtcggg accgatgtcc ccttccctgc
     1261 atcccccccc tggtggggac accggttaag attggagagg gcatgctggc cgacttcgtg
     1321 tcgcaggctt ctcccatgat ccctgccatt gtcgtcagct gtgtcaatga gatcgagcag
     1381 cgaggcctga ctgaggcagg cttgtacagg atctcaggct gtgaccgcac agtgaaagaa
     1441 ctgaaagaaa aattccttaa ggtgaaaact gtgcccctcc tcagcaaagt ggacgatatc
     1501 cacgtcatct gcagcctcct gaaggacttc ctgcgcaacc tcaaagagcc cctcctgacc
     1561 ttctggctga gcaaagcctt catggaggca gcagagataa cagatgaaga caacagcaca
     1621 gccgccatgt accaggctgt cagtgagctg ccccaggcca acagggacac gctagccttc
     1681 cttatgatcc acctacagag agtgtctcag agtccagaca ctaagatgga tattgccaat
     1741 ctagctaaag tctttggccc tacaatagtt gcccatactg tgcccaatcc agatccagtg
     1801 acaatgttcc aggacatcaa acgtcagctc aaggtggtgg agcgcctact ctctctcccc
     1861 ttggagtact ggaatcagtt catgatggtg gaccaagaga acatagacag ccagcgaggc
     1921 aatggaaact caacaccacg cacaccagac gttaaagtga gcttactggg gcctgtgacc
     1981 actcctgaat tccagcttgt caagactcct ttatcaagtt ccctgtcaca gaggttgtac
     2041 aacctctcca agagcacacc cagatttggg aacaagagca agtctgccac caacttaggt
     2101 caacagggca aatttttccc tgctccgtac ctcaagtaaa gctgtgtctg cctgtgttta
     2161 ctgcacgaga cacccctgtc tgctcttcag cctcctgtgt aatgactact tttagcattt
     2221 tccagacttt aaataaagtt gaacgcgtat gagagtttga gtgttgcata gctccctccc
     2281 acctggacac ttagcacctt tactagttgt cgggagcttt aaaataggag atctttacca
     2341 gggccgaagg ggaaatgggt ataagttggg gctcttaggg ggaggggaga ggagatccct
     2401 ttggcttaaa gccaaatact gctcatgaaa tgactttgct gtggtgtcac ttagacaatg
     2461 acagaaactg tacctcttag gtaacgtctt agttatctca ggacaggata aagagctgcg
     2521 cagcggcccc ttctcagaac acaggcctct tcctccttcg gggactgaca agaagcttgg
     2581 agccctcagc gggatgggcc gggccactga tctgaggatg cttcacttct gtctgggtta
     2641 agctgagaaa gtgccacagg ctctgatctc acacagcgtg ctgtttctag ccagcctctg
     2701 cctggatttt gcagtcaaag tcaggttgat ctgaagccga attcgttctg atgcctgacc
     2761 cccttgtttg tccagtggag cccatttaaa aagtcagcta gcagttcaga agacaatttt
     2821 catatagcaa gaaagttagc tgcttctgtc tttggtgaag tttttctgtg aaacagatct
     2881 atatatgtga acattggctt ttttggttag cattttccag tgttcaaaat ggcttccttc
     2941 cctgggatgt tttctgaccc atactaaccc ttacctgtaa catgtatctg gaatattatg
     3001 tggaaaaaat aaatagcttt ttcaaagtga aa
//
