LOCUS       NM_133223               1078 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus Rac family small GTPase 3 (Rac3), mRNA.
ACCESSION   NM_133223
VERSION     NM_133223.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1078)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1078)
  AUTHORS   Nakamura,T., Sakaguchi,H., Mohri,H., Ninoyu,Y., Goto,A.,
            Yamaguchi,T., Hishikawa,Y., Matsuda,M., Saito,N. and Ueyama,T.
  TITLE     Dispensable role of Rac1 and Rac3 after cochlear hair cell
            specification
  JOURNAL   J Mol Med (Berl) 101 (7), 843-854 (2023)
   PUBMED   37204479
  REMARK    GeneRIF: Dispensable role of Rac1 and Rac3 after cochlear hair cell
            specification.
REFERENCE   3  (bases 1 to 1078)
  AUTHORS   Kounoupa,Z., Tivodar,S., Theodorakis,K., Kyriakis,D., Denaxa,M. and
            Karagogeos,D.
  TITLE     Rac1 and Rac3 GTPases and TPC2 are required for axonal outgrowth
            and migration of cortical interneurons
  JOURNAL   J Cell Sci 136 (6) (2023)
   PUBMED   36744839
  REMARK    GeneRIF: Rac1 and Rac3 GTPases and TPC2 are required for axonal
            outgrowth and migration of cortical interneurons.
REFERENCE   4  (bases 1 to 1078)
  AUTHORS   Chen,F., Gurler,S.B., Novo,D., Selli,C., Alferez,D.G., Eroglu,S.,
            Pavlou,K., Zhang,J., Sims,A.H., Humphreys,N.E., Adamson,A.,
            Campbell,A., Sansom,O.J., Tournier,C., Clarke,R.B., Brennan,K.,
            Streuli,C.H. and Ucar,A.
  TITLE     RAC1B function is essential for breast cancer stem cell maintenance
            and chemoresistance of breast tumor cells
  JOURNAL   Oncogene 42 (9), 679-692 (2023)
   PUBMED   36599922
  REMARK    GeneRIF: RAC1B function is essential for breast cancer stem cell
            maintenance and chemoresistance of breast tumor cells.
REFERENCE   5  (bases 1 to 1078)
  AUTHORS   Katayama,K.I., Zheng,Y. and Inoue,N.
  TITLE     Rac-deficient cerebellar granule neurons die before they migrate to
            the internal granule layer
  JOURNAL   Sci Rep 12 (1), 14848 (2022)
   PUBMED   36050459
  REMARK    GeneRIF: Rac-deficient cerebellar granule neurons die before they
            migrate to the internal granule layer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1078)
  AUTHORS   Ueyama,T., Eto,M., Kami,K., Tatsuno,T., Kobayashi,T., Shirai,Y.,
            Lennartz,M.R., Takeya,R., Sumimoto,H. and Saito,N.
  TITLE     Isoform-specific membrane targeting mechanism of Rac during Fc
            gamma R-mediated phagocytosis: positive charge-dependent and
            independent targeting mechanism of Rac to the phagosome
  JOURNAL   J Immunol 175 (4), 2381-2390 (2005)
   PUBMED   16081809
REFERENCE   7  (bases 1 to 1078)
  AUTHORS   Cho,Y.J., Zhang,B., Kaartinen,V., Haataja,L., de Curtis,I.,
            Groffen,J. and Heisterkamp,N.
  TITLE     Generation of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused
            lymphoblastic leukemia
  JOURNAL   Mol Cell Biol 25 (13), 5777-5785 (2005)
   PUBMED   15964830
  REMARK    GeneRIF: The role of Rac3 was studied in Bcr-Abl-caused
            lymphoblastic leukemia.
REFERENCE   8  (bases 1 to 1078)
  AUTHORS   Corbetta,S., Gualdoni,S., Albertinazzi,C., Paris,S., Croci,L.,
            Consalez,G.G. and de Curtis,I.
  TITLE     Generation and characterization of Rac3 knockout mice
  JOURNAL   Mol Cell Biol 25 (13), 5763-5776 (2005)
   PUBMED   15964829
  REMARK    GeneRIF: The generation and characterization of Rac3 knockout mice
            are described.
REFERENCE   9  (bases 1 to 1078)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   10 (bases 1 to 1078)
  AUTHORS   Bolis,A., Corbetta,S., Cioce,A. and de Curtis,I.
  TITLE     Differential distribution of Rac1 and Rac3 GTPases in the
            developing mouse brain: implications for a role of Rac3 in Purkinje
            cell differentiation
  JOURNAL   Eur J Neurosci 18 (9), 2417-2424 (2003)
   PUBMED   14622142
  REMARK    GeneRIF: data implicate Rac3 in neuronal differentiation, and
            support a specific role of this GTPase in actin-mediated
            remodelling of Purkinje cell neuritic terminals at time of
            synaptogenesis
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL663030.12.
            
            On May 1, 2007 this sequence version replaced NM_133223.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150203.1, AB040819.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AL663030.12        177282-177455
            175-246             AL663030.12        178045-178116
            247-364             AL663030.12        178323-178440
            365-427             AL663030.12        178620-178682
            428-587             AL663030.12        178995-179154
            588-1078            AL663030.12        179293-179783
FEATURES             Location/Qualifiers
     source          1..1078
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.46 cM"
     gene            1..1078
                     /gene="Rac3"
                     /gene_synonym="Rac1B"
                     /note="Rac family small GTPase 3"
                     /db_xref="GeneID:170758"
                     /db_xref="MGI:MGI:2180784"
     exon            1..174
                     /gene="Rac3"
                     /gene_synonym="Rac1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..718
                     /gene="Rac3"
                     /gene_synonym="Rac1B"
                     /EC_number="3.6.5.2"
                     /note="p21-Rac3; RAS-related C3 botulinum substrate 3"
                     /codon_start=1
                     /product="ras-related C3 botulinum toxin substrate 3"
                     /protein_id="NP_573486.1"
                     /db_xref="CCDS:CCDS25754.1"
                     /db_xref="GeneID:170758"
                     /db_xref="MGI:MGI:2180784"
                     /translation="MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANV
                     MVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVR
                     HHCPHTPILLVGTKLDLRDDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSAL
                     TQRGLKTVFDEAIRAVLCPPPVKKPGKKCTVF"
     exon            175..246
                     /gene="Rac3"
                     /gene_synonym="Rac1B"
                     /inference="alignment:Splign:2.1.0"
     exon            247..364
                     /gene="Rac3"
                     /gene_synonym="Rac1B"
                     /inference="alignment:Splign:2.1.0"
     exon            365..427
                     /gene="Rac3"
                     /gene_synonym="Rac1B"
                     /inference="alignment:Splign:2.1.0"
     exon            428..587
                     /gene="Rac3"
                     /gene_synonym="Rac1B"
                     /inference="alignment:Splign:2.1.0"
     exon            588..1078
                     /gene="Rac3"
                     /gene_synonym="Rac1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1060..1065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rac3"
                     /gene_synonym="Rac1B"
                     /note="hexamer: AATAAA"
     polyA_site      1078
                     /gene="Rac3"
                     /gene_synonym="Rac1B"
                     /note="major polyA site"
ORIGIN      
        1 gtcttcgcac ccgacactcg gcggtgctcg gctgtctccg gccgctcgct cggcgttcgg
       61 gtccgcggcc gctgcggcgc cgggcatttc tccgcagctc ggctcgcggc cgcgcccgcc
      121 gccgcccggc cccgcgccca tgcaggccat caagtgcgtg gtggttggcg atggtgccgt
      181 ggggaagacg tgcctgctga tcagctacac gaccaacgcc ttcccaggag aatatatccc
      241 cacagttttc gacaactact cagccaacgt gatggtggat gggaagccag ttaacctggg
      301 gctgtgggac actgctggcc aggaagacta cgataggctt cggccactct cctatcctca
      361 aacagatgtc tttctgatct gcttctccct ggtgagccca gcctcctttg agaatgtccg
      421 tgccaagtgg tacccagagg tgcggcacca ctgcccacac acacccatcc ttctggtggg
      481 caccaagctg gacctccgtg atgacaagga tacgattgaa cggctgcggg acaagaagct
      541 ggcacccata acctaccccc aaggcctggc catggcccga gagattggtt ccgtcaagta
      601 cctggagtgc tcagctctga cccagagagg tctgaagaca gtgttcgacg aggccatccg
      661 ggctgtgctc tgcccacctc cagtgaaaaa gccaggcaag aagtgcactg tattctagag
      721 ccttgcctgg ccagcctggc tgcagagcgc tggctcaagt aggcgctcgt gttgagctgt
      781 gtgatgtccc tgagtctgct gtggggagtg gtgtgggtgg gcaggggaag catgaggaca
      841 aggctggggt gatggggtcc tgtcccctat gcctcctttt tctgggatat agctccagcc
      901 ttccctggtc cctatgggag gccaggaggg agccgggtct ccctcagggt tgcaggggtg
      961 ggtccagggc agccccagga tgggcttccc tggagggaag ggtgggggtg gttttgttca
     1021 tcatgtccca ggaaagggcg gccccttctt attttataca ataaacattc accacctc
//
