LOCUS       NM_009008               3036 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus Rac family small GTPase 2 (Rac2), mRNA.
ACCESSION   NM_009008 XM_001000836
VERSION     NM_009008.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3036)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3036)
  AUTHORS   Cheng,T., Agwu,C., Shim,K., Wang,B., Jain,S. and Mahjoub,M.R.
  TITLE     Aberrant centrosome biogenesis disrupts nephron and collecting duct
            progenitor growth and fate resulting in fibrocystic kidney disease
  JOURNAL   Development 150 (24) (2023)
   PUBMED   37982452
REFERENCE   3  (bases 1 to 3036)
  AUTHORS   Ilarraza,R., Chao,D.V., Bodman,J.A.R., Chesley,A., Humble,A.,
            Shaheen,F., Eitzen,G. and Lacy,P.
  TITLE     Rac2 regulates immune complex-mediated granule polarization and
            exocytosis in neutrophils
  JOURNAL   J Leukoc Biol 114 (2), 116-125 (2023)
   PUBMED   37017007
  REMARK    GeneRIF: Rac2 regulates immune complex-mediated granule
            polarization and exocytosis in neutrophils.
REFERENCE   4  (bases 1 to 3036)
  AUTHORS   Bosteels,V., Marechal,S., De Nolf,C., Rennen,S., Maelfait,J.,
            Tavernier,S.J., Vetters,J., Van De Velde,E., Fayazpour,F.,
            Deswarte,K., Lamoot,A., Van Duyse,J., Martens,L., Bosteels,C.,
            Roelandt,R., Emmaneel,A., Van Gassen,S., Boon,L., Van Isterdael,G.,
            Guillas,I., Vandamme,N., Hoglinger,D., De Geest,B.G., Le Goff,W.,
            Saeys,Y., Ravichandran,K.S., Lambrecht,B.N. and Janssens,S.
  TITLE     LXR signaling controls homeostatic dendritic cell maturation
  JOURNAL   Sci Immunol 8 (83), eadd3955 (2023)
   PUBMED   37172103
REFERENCE   5  (bases 1 to 3036)
  AUTHORS   Zhu,Y., Meng,X., Yang,W., Wang,J., Zhang,J., Tian,R., Wang,R.,
            Su,Q. and Jin,W.
  TITLE     HIF-1alpha promotes paraquat induced acute lung injury and
            implicates a role NF-kappaB and Rac2 activity
  JOURNAL   Toxicology 483, 153388 (2023)
   PUBMED   36462643
  REMARK    GeneRIF: HIF-1alpha promotes paraquat induced acute lung injury and
            implicates a role NF-kappaB and Rac2 activity.
REFERENCE   6  (bases 1 to 3036)
  AUTHORS   Roberts,A.W., Kim,C., Zhen,L., Lowe,J.B., Kapur,R., Petryniak,B.,
            Spaetti,A., Pollock,J.D., Borneo,J.B., Bradford,G.B.,
            Atkinson,S.J., Dinauer,M.C. and Williams,D.A.
  TITLE     Deficiency of the hematopoietic cell-specific Rho family GTPase
            Rac2 is characterized by abnormalities in neutrophil function and
            host defense
  JOURNAL   Immunity 10 (2), 183-196 (1999)
   PUBMED   10072071
REFERENCE   7  (bases 1 to 3036)
  AUTHORS   Takenaka,M., Imai,E., Kaneko,T., Ito,T., Moriyama,T., Yamauchi,A.,
            Hori,M., Kawamoto,S. and Okubo,K.
  TITLE     Isolation of genes identified in mouse renal proximal tubule by
            comparing different gene expression profiles
  JOURNAL   Kidney Int 53 (3), 562-572 (1998)
   PUBMED   9507200
REFERENCE   8  (bases 1 to 3036)
  AUTHORS   Hall,A.
  TITLE     Rho GTPases and the actin cytoskeleton
  JOURNAL   Science 279 (5350), 509-514 (1998)
   PUBMED   9438836
  REMARK    Review article
REFERENCE   9  (bases 1 to 3036)
  AUTHORS   Hall,A.
  TITLE     Small GTP-binding proteins and the regulation of the actin
            cytoskeleton
  JOURNAL   Annu Rev Cell Biol 10, 31-54 (1994)
   PUBMED   7888179
  REMARK    Review article
REFERENCE   10 (bases 1 to 3036)
  AUTHORS   Shirsat,N.V., Pignolo,R.J., Kreider,B.L. and Rovera,G.
  TITLE     A member of the ras gene superfamily is expressed specifically in
            T, B and myeloid hemopoietic cells
  JOURNAL   Oncogene 5 (5), 769-772 (1990)
   PUBMED   2189110
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK171321.1 and AL590144.10.
            
            On or before May 4, 2006 this sequence version replaced
            XM_001000836.1, NM_009008.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144136.1, AK171321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1359              AK171321.1         2-1360
            1360-3036           AL590144.10        17264-18940
FEATURES             Location/Qualifiers
     source          1..3036
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.57 cM"
     gene            1..3036
                     /gene="Rac2"
                     /note="Rac family small GTPase 2"
                     /db_xref="GeneID:19354"
                     /db_xref="MGI:MGI:97846"
     exon            1..173
                     /gene="Rac2"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..717
                     /gene="Rac2"
                     /EC_number="3.6.5.2"
                     /note="p21-Rac2; EN-7 protein; protein EN-7; RAS-related
                     C3 botulinum substrate 2"
                     /codon_start=1
                     /product="ras-related C3 botulinum toxin substrate 2"
                     /protein_id="NP_033034.1"
                     /db_xref="CCDS:CCDS27619.1"
                     /db_xref="GeneID:19354"
                     /db_xref="MGI:MGI:97846"
                     /translation="MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANV
                     MVDSKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVR
                     HHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKDIDSVKYLECSAL
                     TQRGLKTVFDEAIRAVLCPQPTRQQKRPCSLL"
     exon            174..245
                     /gene="Rac2"
                     /inference="alignment:Splign:2.1.0"
     exon            246..363
                     /gene="Rac2"
                     /inference="alignment:Splign:2.1.0"
     exon            364..426
                     /gene="Rac2"
                     /inference="alignment:Splign:2.1.0"
     exon            427..586
                     /gene="Rac2"
                     /inference="alignment:Splign:2.1.0"
     exon            587..719
                     /gene="Rac2"
                     /inference="alignment:Splign:2.1.0"
     exon            720..3036
                     /gene="Rac2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1334..1339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rac2"
                     /note="hexamer: AATAAA"
     polyA_site      1335
                     /gene="Rac2"
                     /note="major polyA site"
ORIGIN      
        1 cttccgtttc ctcccgcctc ttgagctggg gtgctgctcc tcactgccgg gtacctccta
       61 gccactccat accactggtg tccacagcaa cgctcctggc ccccaactgt catccctggc
      121 tgctgggcct cagatgcaat gcaggccatc aagtgtgtgg tggtgggtga tggagccgtg
      181 ggcaagacgt gtcttctcat cagctacacc accaacgcct tccctggaga atacatcccc
      241 actgtatttg acaactactc agccaatgtg atggtggaca gtaagccggt gaacctgggg
      301 ctgtgggata ccgcaggtca ggaggactat gaccgcctcc ggccactctc ctacccacag
      361 acagatgtat ttctcatctg cttctcgcta gtcagcccag cctcctatga gaatgtccgt
      421 gccaagtggt tccctgaggt acggcaccac tgccccagca cccccatcat cctggtgggt
      481 accaagctgg accttcgcga tgacaaggac accatcgaga agctgaagga gaagaagctg
      541 gctcccatca cctacccgca gggcctggca ctggccaagg atattgattc agtcaagtac
      601 ttggaatgtt ctgcactcac ccagcgaggc ctgaagaccg tcttcgatga ggcaatccgc
      661 gcagtcctct gcccacagcc cacacgacag cagaagcgcc cctgcagcct gctctagggg
      721 tgtcacccca gtcctcccat cccaatggtc ctgaccctcc agggtcccca ccaaagctca
      781 gtgacgtgct ggtggaattg ctgtttctcc gtgtggcgtt ctttcccagt tagctgcaga
      841 acttgcctct ctcctccacg gaggtccctg gggatgggcg gatgttcata ggccacatcc
      901 tatttgggag gctcctatgt tcccaggggc catcagggac ccccaagatg cagccatcca
      961 tcctcataca gagtcatatg cccacctgct ccaggccttc ctgacacctc tctcgaagct
     1021 tccggtctcc atggcctgcc actagtgtgt tcgccatgtt gggatacctt cttccctgaa
     1081 ccaaagggag agatgtggaa atctgctcct ctgttctcct ttttcagaaa agcacagaac
     1141 aaatctactt cagtaaatct ctcatctgcc cagccaagtg agggtctgag ctcagccaac
     1201 ccctactgtc tctcgagacc tcctactcta cttgaagggt agagctgttc cttcttggga
     1261 ctgtccactc cacctgccag tcaggacccg atccatagca aatggaaaat acagctctct
     1321 tgcttacaca gaaaataaat gtgttgattc ttttggtgga agtgcagtga gttcaggcac
     1381 agcttgatca aggtggggcg aagggatcag atgacaccac ggagcctggc ttcctgcctg
     1441 ttttgggtct gcctgctgct gccaggctca tttttctggc cattgattct tgggacttga
     1501 tcctccgagg tcaagttcag gtgatgtctg ccccaggcaa gctctaagga aaggtcactc
     1561 tggttgaacc agcttgtctt aggcccacct tcaatcacac aagtgtgtca gagagaggct
     1621 gcactgtggc tggctgtgag ttgtgttaga gccaggagca gaggtgatgc cagggagctg
     1681 gggtatagaa tgggtgtgtg tggcgttggg ggaataaatt ctttagggaa caaccttctt
     1741 aaaactgggt gggtatccag tagctagggt tctataaccc ccgactgtca gaggtcacgg
     1801 taagtgtcct ttctaccatt atcagggaca gtttctgccc cagctggcac taagaaaaac
     1861 agatttttta aatttgtttt tttttgtttg tttgttttgt tttgttttgt tttgttttgt
     1921 ttgagacagg gtttctctgt gtagctctgg ctgtcctgga actcactttg tagaccaggc
     1981 tgtcctcgaa ctcagaaatc tgcctgcctc tgcctcctaa gtgctgggat taaaggcgtg
     2041 caccaccatt gcccggctca tttgtttttg agataagatt ttattatata gcctgggctg
     2101 acctcagacc tgccatcctc ctgcctcagc ttcctaaatt ctgggtttac agatgtatac
     2161 ttccgtgcct ggataaggtt gaaattctta ctagagagtt ctatggaagt tgatgtggtg
     2221 tccatatcag gcacccaggg cctgggcctg agacagtcct acctacatct tccctgaatt
     2281 atcaatctat ggtcaagacc gtggcactgt ctgagcttcc acgtccttct cccaacacac
     2341 ttttgatggc ctgtctgtgt caggtgctac catagtctca gagattcagt gacatatgtg
     2401 ttgttctcca cccctccccc accccccagc cctgagtctc cgaggctgag agaaaatggc
     2461 tcccccgaca ttggaaagct agccctaagg agctcagcat tttctgtctc caagagttcc
     2521 agagctgccc cccaactcct cccccccaaa cttaagggac tccacctctg gaggggcttg
     2581 gcccagtgag ggaagcttct gttcttagct tggctcacag gagggcaaga tttctctgac
     2641 acagaaagaa aggttttaag cccacaggtg ctgtgttctc caacacggtt gagaggacct
     2701 gcacccccat cgctttgggg agttaaagac ctggggtgca cccagagtcc ctcttttagc
     2761 tctctgctcc ttttctagtg catgatacta agcaaaacct tacatgattc aaaaccgtag
     2821 atctaagccc agaacctctc aaactaagcc tctaagtagc taaacctccc cctcctcctc
     2881 ccccgccccc ttctgtagga ggcaaacccc ggcctgttac cttgagcctc tgtgtgagtt
     2941 gtggagcaca cagccagccc actgtcaccc tgacagctta tttcacccag atctcagctt
     3001 tcactttaat ctgaataaag tccccgatac ttttgc
//
