LOCUS       NM_009007               2284 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus Rac family small GTPase 1 (Rac1), transcript variant
            2, mRNA.
ACCESSION   NM_009007 XM_357522
VERSION     NM_009007.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2284)
  AUTHORS   He,Y., Wang,H., Hong,T., Hu,L., Gao,C., Gao,L., Cui,Y., Tan,R.,
            Pu,D. and Wu,J.
  TITLE     HFM1 is essential for the germ cell intercellular bridge transport
            in primordial follicle formation in mice
  JOURNAL   Cell Mol Life Sci 82 (1), 28 (2024)
   PUBMED   39725823
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2284)
  AUTHORS   Takaya,K., Imbe,Y., Wang,Q., Okabe,K., Sakai,S., Aramaki-Hattori,N.
            and Kishi,K.
  TITLE     Rac1 inhibition regenerates wounds in mouse fetuses via altered
            actin dynamics
  JOURNAL   Sci Rep 14 (1), 27213 (2024)
   PUBMED   39516580
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2284)
  AUTHORS   He,S., Gao,X., Yang,L., Li,X., Mo,Y., He,Z., Hou,R., Yuan,X.,
            Fang,L. and Yu,D.
  TITLE     MiR-144/451 attenuates lipopolysaccharide-induced lung inflammation
            by downregulating Rac1 and STAT-3 in macrophages
  JOURNAL   J Biochem Mol Toxicol 38 (11), e70006 (2024)
   PUBMED   39467210
  REMARK    GeneRIF: MiR-144/451 attenuates lipopolysaccharide-induced lung
            inflammation by downregulating Rac1 and STAT-3 in macrophages.
REFERENCE   4  (bases 1 to 2284)
  AUTHORS   Li,F., Zhang,X., Xu,J., Zhang,Y., Li,G., Yang,X., Deng,G., Dai,Y.,
            Liu,B., Kosan,C., Chen,X. and Cai,Y.
  TITLE     SIRT7 remodels the cytoskeleton via RAC1 to enhance host resistance
            to Mycobacterium tuberculosis
  JOURNAL   mBio 15 (10), e0075624 (2024)
   PUBMED   39287444
  REMARK    GeneRIF: SIRT7 remodels the cytoskeleton via RAC1 to enhance host
            resistance to Mycobacterium tuberculosis.
REFERENCE   5  (bases 1 to 2284)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2284)
  AUTHORS   Madaule,P., Furuyashiki,T., Reid,T., Ishizaki,T., Watanabe,G.,
            Morii,N. and Narumiya,S.
  TITLE     A novel partner for the GTP-bound forms of rho and rac
  JOURNAL   FEBS Lett 377 (2), 243-248 (1995)
   PUBMED   8543060
REFERENCE   7  (bases 1 to 2284)
  AUTHORS   Emara,M.G., Tout,N.L., Kaushik,A. and Lam,J.S.
  TITLE     Diverse VH and V kappa genes encode antibodies to Pseudomonas
            aeruginosa LPS
  JOURNAL   J Immunol 155 (8), 3912-3921 (1995)
   PUBMED   7561098
REFERENCE   8  (bases 1 to 2284)
  AUTHORS   Hall,A.
  TITLE     Small GTP-binding proteins and the regulation of the actin
            cytoskeleton
  JOURNAL   Annu Rev Cell Biol 10, 31-54 (1994)
   PUBMED   7888179
  REMARK    Review article
REFERENCE   9  (bases 1 to 2284)
  AUTHORS   Miki,T., Smith,C.L., Long,J.E., Eva,A. and Fleming,T.P.
  TITLE     Oncogene ect2 is related to regulators of small GTP-binding
            proteins
  JOURNAL   Nature 362 (6419), 462-465 (1993)
   PUBMED   8464478
  REMARK    Erratum:[Nature 1993 Aug 19;364(6439):737]
REFERENCE   10 (bases 1 to 2284)
  AUTHORS   Moll,J., Sansig,G., Fattori,E. and van der Putten,H.
  TITLE     The murine rac1 gene: cDNA cloning, tissue distribution and
            regulated expression of rac1 mRNA by disassembly of actin
            microfilaments
  JOURNAL   Oncogene 6 (5), 863-866 (1991)
   PUBMED   1905006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX242948.1, CO425367.1, BQ444803.1 and CX566679.1.
            
            On Nov 10, 2006 this sequence version replaced NM_009007.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051053.1, BC003828.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-664               CX242948.1         38-701
            665-1371            CO425367.1         77-783
            1372-2044           BQ444803.1         134-806
            2045-2268           CX566679.1         540-763
            2269-2284           CX566679.1         765-780
FEATURES             Location/Qualifiers
     source          1..2284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 82.22 cM"
     gene            1..2284
                     /gene="Rac1"
                     /gene_synonym="D5Ertd559e"
                     /note="Rac family small GTPase 1"
                     /db_xref="GeneID:19353"
                     /db_xref="MGI:MGI:97845"
     exon            1..231
                     /gene="Rac1"
                     /gene_synonym="D5Ertd559e"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..775
                     /gene="Rac1"
                     /gene_synonym="D5Ertd559e"
                     /EC_number="3.6.5.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ras-related C3 botulinum toxin substrate 1; p21-Rac1;
                     RAS-related C3 botulinum substrate 1"
                     /codon_start=1
                     /product="ras-related C3 botulinum toxin substrate 1
                     isoform 2"
                     /protein_id="NP_033033.1"
                     /db_xref="CCDS:CCDS19843.1"
                     /db_xref="GeneID:19353"
                     /db_xref="MGI:MGI:97845"
                     /translation="MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANV
                     MVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVR
                     HHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSAL
                     TQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL"
     exon            232..303
                     /gene="Rac1"
                     /gene_synonym="D5Ertd559e"
                     /inference="alignment:Splign:2.1.0"
     exon            304..421
                     /gene="Rac1"
                     /gene_synonym="D5Ertd559e"
                     /inference="alignment:Splign:2.1.0"
     exon            422..484
                     /gene="Rac1"
                     /gene_synonym="D5Ertd559e"
                     /inference="alignment:Splign:2.1.0"
     exon            485..644
                     /gene="Rac1"
                     /gene_synonym="D5Ertd559e"
                     /inference="alignment:Splign:2.1.0"
     exon            645..2269
                     /gene="Rac1"
                     /gene_synonym="D5Ertd559e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2251..2256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rac1"
                     /gene_synonym="D5Ertd559e"
                     /note="hexamer: AATAAA"
     polyA_site      2269
                     /gene="Rac1"
                     /gene_synonym="D5Ertd559e"
                     /note="major polyA site"
ORIGIN      
        1 agttttcccc agctttgggt ggtggctgct gctgcgcttc gccttcccgt gcgctgaggg
       61 cccggcggcg tggacagcag tcccggcact cggcgccccg ccgcccgcag cctcgcccag
      121 cgcttcccga gcccgccgct tcgcgcctca gccaccggcc gccgccgccg ccgccgcggc
      181 ccaccgagcg gcccagatgc aggccatcaa gtgtgtggtg gtgggagacg gagctgttgg
      241 taaaacctgc ctgctcatca gttacacgac caatgcattt cctggagagt acatccccac
      301 cgtctttgac aactattctg ccaatgttat ggtagatgga aaaccagtga atctgggcct
      361 atgggacaca gctggacaag aagattatga cagattgcgt cccctctcct acccgcagac
      421 agacgtgttc ttaatttgct tttcccttgt gagtcctgca tcatttgaaa atgtccgtgc
      481 aaagtggtat cctgaagtgc gacaccactg tcccaatact cctatcatcc tcgtggggac
      541 gaagcttgat cttagggatg ataaggacac cattgagaag ctgaaggaga agaagctgac
      601 tcccatcacc tacccgcagg ggctggccat ggcgaaagag atcggtgctg tcaaatacct
      661 ggagtgctca gctctcacac agcgaggact caagacagtg tttgacgaag ctatccgagc
      721 ggttctctgt ccccctcctg tcaagaagag gaagagaaaa tgcctgctgt tgtaaatgtc
      781 ggagcccctc gttctcggtc ctgcctggaa cctttgtacg ctttgctcaa aaatcagcga
      841 gccttcgcat ttgatgccaa gtttttgtta cagattaatt tttccataaa accattttga
      901 accaatgaac cagtcaataa ttttaaggtt ctgttttaaa tgtaagaatt ccaacttaca
      961 gtctattaaa attcagccct aaaatgacaa agccttctta aagccttatt tttaaaatcc
     1021 cccattcttg ctcagattaa aaattgccaa aataccttct gaactaagtt gcgttgtgct
     1081 gagaacacct aagcactaaa ctctcttgag agacttctgt tgctaagaag accgcagctt
     1141 ctggagccag gggtgcagac ccttccagag ttcccagacc gtgtgacaca gcacagcctc
     1201 cttaatgaca cgttgccatg taacgcacct gtaacttatc agcccatgtt cattacgtaa
     1261 ctttgtactg tacgtcacag tgatgagtgt gacagctcag ctctttgatt tcatagtgag
     1321 ttttctaaaa gaccagccga ctagcttttg cagactttga acagaactct ggttcctgtg
     1381 ttgcctctaa tgaagtattc tgttcctagt tgtgggtgtg ctgggtggag tgtgaaacac
     1441 gacatgatca aaggagacag acagtatttt gactaatatg aagtagagat tactttacac
     1501 tacattgtac atggagtaat tcaactgaat aaaagtgtca cgggtaaagc tttttaacgg
     1561 ttaatttctg tcaaacagta ggtgacaaat ggccgatctt atcagtgtct cttgagcatc
     1621 ccttcgcgcc ccccaccctc cactgccgtc cctccccaga tggggcgttg agtccatatt
     1681 taaactggcc accctcacag ttctaactta gcaagtgctt ttctttagaa ccccttctta
     1741 acgagcaata tgtctgacct gtactataag atctttctga taacgcagag attttttgtt
     1801 tttttttggt agctcagtag aagtgcgtcc tgttttcgcc ttactttact cagagctagt
     1861 tagtgcttcc ttagtttcct agcaactagg tgtgcaaatc atgtgttgca gctttacggt
     1921 ttttaaacta ttttagatat tcttaaacta tgaaccttct aaacagtacc aacactgtca
     1981 tgtgactaat gctgcctcta gacctcgccc acgtggacag acgcttcctg tcatggctct
     2041 gcctagagat gttccttggg gtctgtgagg ttctgtcaac tgctagtgct aacgctgtcc
     2101 tgtacaacct aactcactgg caagaatgca gtgttgggcc tttcaaccac tagaacaaac
     2161 ttttttcaat tgacagttgc agaattgtgg agtgttttta cattgatctt ttgctaatgc
     2221 agttagcagt atgttttgca tgtatgaatt aataaatcct tgaatcataa aaaaaaaaaa
     2281 aaaa
//
