LOCUS       NM_026817               1650 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RAB, member RAS oncogene family-like 2 (Rabl2), mRNA.
ACCESSION   NM_026817
VERSION     NM_026817.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1650)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1650)
  AUTHORS   Duan,S., Li,H., Zhang,Y., Yang,S., Chen,Y., Qiu,B., Huang,C.,
            Wang,J., Li,J., Zhu,X. and Yan,X.
  TITLE     Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune
            ciliary signaling
  JOURNAL   EMBO J 40 (2), e105499 (2021)
   PUBMED   33241915
  REMARK    GeneRIF: Rabl2 GTP hydrolysis licenses BBSome-mediated export to
            fine-tune ciliary signaling.
REFERENCE   3  (bases 1 to 1650)
  AUTHORS   Ding,X., Fragoza,R., Singh,P., Zhang,S., Yu,H. and Schimenti,J.C.
  TITLE     Variants in RABL2A causing male infertility and ciliopathy
  JOURNAL   Hum Mol Genet 29 (20), 3402-3411 (2020)
   PUBMED   33075816
  REMARK    GeneRIF: Variants in RABL2A causing male infertility and
            ciliopathy.
REFERENCE   4  (bases 1 to 1650)
  AUTHORS   Phua,Y.L., Chen,K.H., Hemker,S.L., Marrone,A.K., Bodnar,A.J.,
            Liu,X., Clugston,A., Kostka,D., Butterworth,M.B. and Ho,J.
  TITLE     Loss of miR-17~92 results in dysregulation of Cftr in nephron
            progenitors
  JOURNAL   Am J Physiol Renal Physiol 316 (5), F993-F1005 (2019)
   PUBMED   30838872
REFERENCE   5  (bases 1 to 1650)
  AUTHORS   Kanie,T., Abbott,K.L., Mooney,N.A., Plowey,E.D., Demeter,J. and
            Jackson,P.K.
  TITLE     The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate
            Intraflagellar Transport at the Ciliary Base
  JOURNAL   Dev Cell 42 (1), 22-36 (2017)
   PUBMED   28625565
  REMARK    GeneRIF: CEP19 is recruited to the ciliary base by the centriolar
            CEP350/FOP complex and then specifically captures GTP-bound RABL2B,
            which is activated via its intrinsic nucleotide exchange.
REFERENCE   6  (bases 1 to 1650)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1650)
  AUTHORS   Lo,J.C., Jamsai,D., O'Connor,A.E., Borg,C., Clark,B.J.,
            Whisstock,J.C., Field,M.C., Adams,V., Ishikawa,T., Aitken,R.J.,
            Whittle,B., Goodnow,C.C., Ormandy,C.J. and O'Bryan,M.K.
  TITLE     RAB-like 2 has an essential role in male fertility, sperm
            intra-flagellar transport, and tail assembly
  JOURNAL   PLoS Genet 8 (10), e1002969 (2012)
   PUBMED   23055941
  REMARK    GeneRIF: Our data demonstrate a novel function for the RABL protein
            family, an essential role for RABL2 in male fertility and a
            previously uncharacterised mechanism for protein delivery to the
            flagellum.
REFERENCE   8  (bases 1 to 1650)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1650)
  AUTHORS   Takasato,M., Osafune,K., Matsumoto,Y., Kataoka,Y., Yoshida,N.,
            Meguro,H., Aburatani,H., Asashima,M. and Nishinakamura,R.
  TITLE     Identification of kidney mesenchymal genes by a combination of
            microarray analysis and Sall1-GFP knockin mice
  JOURNAL   Mech Dev 121 (6), 547-557 (2004)
   PUBMED   15172686
REFERENCE   10 (bases 1 to 1650)
  AUTHORS   Nelms,K.A. and Goodnow,C.C.
  TITLE     Genome-wide ENU mutagenesis to reveal immune regulators
  JOURNAL   Immunity 15 (3), 409-418 (2001)
   PUBMED   11567631
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY273527.1, BQ887131.1, AC122401.3 and BX635556.1.
            
            On Apr 28, 2007 this sequence version replaced NM_026817.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030376.1, SRR1660813.321056.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               BY273527.1         1-395
            396-768             BQ887131.1         388-760
            769-1305            AC122401.3         111700-112236
            1306-1650           BX635556.1         1-345               c
FEATURES             Location/Qualifiers
     source          1..1650
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.96 cM"
     gene            1..1650
                     /gene="Rabl2"
                     /gene_synonym="1110031N17Rik; Rabl2a"
                     /note="RAB, member RAS oncogene family-like 2"
                     /db_xref="GeneID:68708"
                     /db_xref="MGI:MGI:1915958"
     exon            1..104
                     /gene="Rabl2"
                     /gene_synonym="1110031N17Rik; Rabl2a"
                     /inference="alignment:Splign:2.1.0"
     exon            105..258
                     /gene="Rabl2"
                     /gene_synonym="1110031N17Rik; Rabl2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..823
                     /gene="Rabl2"
                     /gene_synonym="1110031N17Rik; Rabl2a"
                     /note="RAB, member of RAS oncogene family-like 2A"
                     /codon_start=1
                     /product="rab-like protein 2A"
                     /protein_id="NP_081093.2"
                     /db_xref="CCDS:CCDS49704.1"
                     /db_xref="GeneID:68708"
                     /db_xref="MGI:MGI:1915958"
                     /translation="MAGDRNRHCELEQEKYDTHENVKIICLGDSAVGKSKLMERFLMD
                     GFQPQQLSTYALTLYKHTATVDGKTILVDFWDTAGQERFQSMHASYYHKAHACIMVFD
                     VQRKITYKNLGTWYAELREFRPEIPCILVANKIDADIQMTQKNFSFAKKFSLPLYFVS
                     AADGTNVVKLFNDAIRLAVAYKESSQDFMDEVLQELENFKLEQKEEDTSGQEQSDTTK
                     SPSPS"
     exon            259..288
                     /gene="Rabl2"
                     /gene_synonym="1110031N17Rik; Rabl2a"
                     /inference="alignment:Splign:2.1.0"
     exon            289..368
                     /gene="Rabl2"
                     /gene_synonym="1110031N17Rik; Rabl2a"
                     /inference="alignment:Splign:2.1.0"
     exon            369..448
                     /gene="Rabl2"
                     /gene_synonym="1110031N17Rik; Rabl2a"
                     /inference="alignment:Splign:2.1.0"
     exon            449..560
                     /gene="Rabl2"
                     /gene_synonym="1110031N17Rik; Rabl2a"
                     /inference="alignment:Splign:2.1.0"
     exon            561..658
                     /gene="Rabl2"
                     /gene_synonym="1110031N17Rik; Rabl2a"
                     /inference="alignment:Splign:2.1.0"
     exon            659..742
                     /gene="Rabl2"
                     /gene_synonym="1110031N17Rik; Rabl2a"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1646
                     /gene="Rabl2"
                     /gene_synonym="1110031N17Rik; Rabl2a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1619..1624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rabl2"
                     /gene_synonym="1110031N17Rik; Rabl2a"
                     /note="hexamer: AATAAA"
     regulatory      1625..1630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rabl2"
                     /gene_synonym="1110031N17Rik; Rabl2a"
                     /note="hexamer: GATAAA"
     polyA_site      1642
                     /gene="Rabl2"
                     /gene_synonym="1110031N17Rik; Rabl2a"
                     /note="major polyA site"
     polyA_site      1646
                     /gene="Rabl2"
                     /gene_synonym="1110031N17Rik; Rabl2a"
                     /note="major polyA site"
ORIGIN      
        1 ttcgggccat tgccggacag cccagctcgg ggtcctggtg cggtcgcgta gcagcggcag
       61 agacgcggcc gagctgctgc gggactgcag tcatctgtaa acggacggtg acgagacccc
      121 ggggctggca gtcgtctgcc aacaagagcc gatggcaggg gacagaaaca ggcactgtga
      181 gctggagcag gagaagtacg acacccatga gaacgtgaag atcatctgcc tgggggacag
      241 tgcggtgggc aagtccaaac tcatggagag atttctcatg gatggattcc agccacagca
      301 actgtccaca tatgctctga ctctgtataa gcacacagcc acagtagacg gcaagacgat
      361 ccttgtggac ttctgggata cagcaggcca ggagcggttc cagagcatgc atgcttccta
      421 ctaccacaag gctcacgcct gcatcatggt atttgatgtc cagaggaaaa tcacctataa
      481 gaacctgggt acctggtatg cagaacttcg ggagttcagg ccggagatcc catgcatcct
      541 ggtggccaat aaaattgatg cagacataca gatgactcaa aagaatttca gttttgccaa
      601 gaagttctcc ctgcccctgt actttgtctc ggctgctgat ggtaccaatg ttgtgaagct
      661 cttcaatgat gctattcgat tagctgtggc ttacaaagag agttcccagg acttcatgga
      721 cgaggtttta caggagctcg agaacttcaa gttggagcag aaagaagagg atacgtcagg
      781 ccaagagcag agtgacacga ccaagagccc atctccttcc taacctgagg acatccacac
      841 atggcagagt tggggtattg ggagccattt ggaacaccct acatctctgg agaacatctc
      901 taggctaccc ctgctcaact tcctgcaaac ccactgttct gtggtacatg atgaggtcaa
      961 tacaaagaaa ctagacaggc gtgataccca ccatcttcct gcatcaggat gagggatccg
     1021 tgtcattcac acacacaccc cgacccccac ccccacccca gcagcctgat agtgcagaaa
     1081 cagtgaacat gctcatgtct tcttagtaga catttaggtg tttgttgtct ttcttcccaa
     1141 actgacctca gggactgtcc cttcacttct gccgagagaa tgatgcaaac ccttgaggac
     1201 gatgtgttcc tatggaatcc atctgtgaca cctctgtccc tgtcaacaat atttttgaca
     1261 gacaaccatt aattccaaat ttgcttttct agcaccaact gttttgggag ctcttctcgg
     1321 tcagttgaga gcacagcagc aggactcgat tgcagtgcag tgaagacaag tgtagccata
     1381 tctgcttata cacacacctt actgttcccc accacgtgaa caaaaactgc ctccatctca
     1441 gggtagaaag ccttcctcca cctctctagg gcgagttaag cactgcgtct tctgtgggtg
     1501 gcagcagaca gcagggaaga gctgccctgc ttctctgcag cttgctagat gatgtcacga
     1561 ttgtcttgag catcatttgc attatcatta ttttgtttat attgtctcct ttttttacaa
     1621 taaagataaa gtttcgtaaa cactaaaaaa
//
