LOCUS       NM_001360387            2356 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus Rab geranylgeranyl transferase, a subunit (Rabggta),
            transcript variant 1, mRNA.
ACCESSION   NM_001360387 XM_006519294
VERSION     NM_001360387.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2356)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2356)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 2356)
  AUTHORS   Coxon,F.P., Taylor,A., Stewart,C.A., Baron,R., Seabra,M.C.,
            Ebetino,F.H. and Rogers,M.J.
  TITLE     The gunmetal mouse reveals Rab geranylgeranyl transferase to be the
            major molecular target of phosphonocarboxylate analogues of
            bisphosphonates
  JOURNAL   Bone 49 (1), 111-121 (2011)
   PUBMED   21419243
REFERENCE   4  (bases 1 to 2356)
  AUTHORS   Taylor,A., Mules,E.H., Seabra,M.C., Helfrich,M.H., Rogers,M.J. and
            Coxon,F.P.
  TITLE     Impaired prenylation of Rab GTPases in the gunmetal mouse causes
            defects in bone cell function
  JOURNAL   Small GTPases 2 (3), 131-142 (2011)
   PUBMED   21776414
REFERENCE   5  (bases 1 to 2356)
  AUTHORS   Anderson,M.G., Hawes,N.L., Trantow,C.M., Chang,B. and John,S.W.
  TITLE     Iris phenotypes and pigment dispersion caused by genes influencing
            pigmentation
  JOURNAL   Pigment Cell Melanoma Res 21 (5), 565-578 (2008)
   PUBMED   18715234
REFERENCE   6  (bases 1 to 2356)
  AUTHORS   Odorizzi,G., Cowles,C.R. and Emr,S.D.
  TITLE     The AP-3 complex: a coat of many colours
  JOURNAL   Trends Cell Biol 8 (7), 282-288 (1998)
   PUBMED   9714600
  REMARK    Review article
REFERENCE   7  (bases 1 to 2356)
  AUTHORS   O'Brien,E.P., Zhen,L., Jiang,S.Y., Novak,E.K. and Swank,R.T.
  TITLE     High-resolution genetic mapping of the gunmetal gene which
            regulates platelet production
  JOURNAL   Mamm Genome 7 (3), 206-208 (1996)
   PUBMED   8833241
REFERENCE   8  (bases 1 to 2356)
  AUTHORS   Wei,L.N., Lee,C.H., Chinpaisal,C., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Hsu,Y.C.
  TITLE     Studies of cloning, chromosomal mapping, and embryonic expression
            of the mouse Rab geranylgeranyl transferase beta subunit
  JOURNAL   Cell Growth Differ 6 (5), 607-614 (1995)
   PUBMED   7544156
REFERENCE   9  (bases 1 to 2356)
  AUTHORS   Novak,E.K., Reddington,M., Zhen,L., Stenberg,P.E., Jackson,C.W.,
            McGarry,M.P. and Swank,R.T.
  TITLE     Inherited thrombocytopenia caused by reduced platelet production in
            mice with the gunmetal pigment gene mutation
  JOURNAL   Blood 85 (7), 1781-1789 (1995)
   PUBMED   7703484
REFERENCE   10 (bases 1 to 2356)
  AUTHORS   Swank,R.T., Jiang,S.Y., Reddington,M., Conway,J., Stephenson,D.,
            McGarry,M.P. and Novak,E.K.
  TITLE     Inherited abnormalities in platelet organelles and platelet
            formation and associated altered expression of low molecular weight
            guanosine triphosphate-binding proteins in the mouse pigment mutant
            gunmetal
  JOURNAL   Blood 81 (10), 2626-2635 (1993)
   PUBMED   8490171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX213914.1, AK002625.1 and CD776583.1.
            
            On Feb 3, 2018 this sequence version replaced XM_006519294.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002625.1, SRR7652917.551806.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 CX213914.1         1-6
            7-1886              AK002625.1         2-1881
            1887-2356           CD776583.1         1-470               c
FEATURES             Location/Qualifiers
     source          1..2356
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..2356
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /note="Rab geranylgeranyl transferase, a subunit"
                     /db_xref="GeneID:56187"
                     /db_xref="MGI:MGI:1860443"
     exon            1..63
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     exon            64..120
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1821
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /EC_number="2.5.1.60"
                     /note="rab GGTase alpha; rab GG transferase alpha; rab
                     geranylgeranyltransferase subunit alpha; geranylgeranyl
                     transferase type II subunit alpha; gunmetal"
                     /codon_start=1
                     /product="geranylgeranyl transferase type-2 subunit alpha"
                     /protein_id="NP_001347316.1"
                     /db_xref="CCDS:CCDS36933.1"
                     /db_xref="GeneID:56187"
                     /db_xref="MGI:MGI:1860443"
                     /translation="MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKREAGEL
                     DESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRV
                     NPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEADERNFHCWDYRRFVAAQAAVAP
                     AEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPENVLLRELELVQNA
                     FFTDPNDQSAWFYHRWLLGRAEPHDVLCCLHVSREEACLSVCFSRPLIVGSKMGTLLL
                     TVDEAPLSVEWRTPDGRNRPSHVWLCDLPAASLNDHLPQHTFRVIWTGSDTQKECVLL
                     KGHQECWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLM
                     RALDPLLYEKETLEYFSTLKAVDPMRAAYLDDLRSKFLVENSVLKMEYADVRVLHLAH
                     KDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNVLENLDGVANLP
                     RLRELLLCNNRLQQSAALQTLASCPRLVFLNLQGNSLCQEEGIRERLAEMLPSVSSIL
                     T"
     exon            121..231
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     exon            232..356
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     exon            357..544
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     exon            545..748
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     exon            749..832
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     exon            833..915
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1017
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1123
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1175
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1264
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1353
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1470
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1584
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1672
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..2347
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1863..1868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /note="hexamer: AATAAA"
     polyA_site      1903
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /note="major polyA site"
     regulatory      2325..2330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rabggta"
                     /gene_synonym="gm"
                     /note="hexamer: AATAAA"
     polyA_site      2347
                     /gene="Rabggta"
                     /gene_synonym="gm"
ORIGIN      
        1 ctagccacac tgggactcgg tggcggccgg agttgcacgt cctggcacct cctccctgag
       61 cagattgaac gggctgcctc cggacccctc ccctatcgcc aacgctgagc cgaaaccatg
      121 catgggcgcc tgaaggtgaa gacgtccgaa gagcaggcag aggccaaaag gctagagcgg
      181 gaacagaagc taaagctcta ccagtcagcc actcaagctg tcttccagaa gcgggaggca
      241 ggcgagctgg atgaatccgt cctagaactg acaagccaga ttctgggagc caaccctgat
      301 tttgccaccc tctggaactg tcgcagagaa gtgctccagc agctagaaac ccagaagtcc
      361 cctgaggagt tggctgctct tgtgaaggca gaactaggct tccttgagag ctgtctgcgt
      421 gtgaacccta agtcctatgg cacttggcac caccgctgct ggctgctgag tcgcctgcct
      481 gagcccaact gggcccggga gctggagctg tgcgctcgct tcctcgaggc cgatgagcgg
      541 aactttcatt gctgggacta tcggcgattt gtagctgcac aggctgctgt cgcgcctgca
      601 gaggaactag ccttcactga cagcctcatc acccggaact tctccaacta ttcttcctgg
      661 cattatcgct cctgcctctt gccccagctg cacccccagc cagactctgg cccccaggga
      721 cggctccctg aaaatgtact gctgagagag ctggagttgg tgcagaatgc cttctttact
      781 gaccccaatg atcagagtgc ctggttctat caccgctggc tcctggggcg ggcggagccc
      841 cacgatgttc tgtgctgcct gcatgtgagc cgggaagagg cctgtctgtc agtctgcttt
      901 tctcgtcccc tgatagtggg ctccaagatg gggaccttgc tactcacggt tgacgaggca
      961 cctttgagtg tggaatggag gactccagat ggcaggaacc ggcccagcca tgtctggctc
     1021 tgtgacctgc ctgctgcctc tctcaatgac cacttgcccc agcacacgtt tcgtgtcatc
     1081 tggacaggaa gcgataccca gaaggagtgt gtgcttttaa aaggtcacca ggagtgctgg
     1141 tgccgagact cagccactga tgaacagttg ttcaggtgtg agctgtccgt ggagaagtcc
     1201 acagtgctac agtccgagct tgagtcctgt aaggagctgc aggaactgga gcctgagaat
     1261 aaatggtgcc tgctgaccat catcctcctg atgagggcac tggaccccct cctctacgag
     1321 aaagaaacac tggagtactt cagtaccctc aaagctgtgg acccgatgag agcagcctac
     1381 ttggacgacc tgcgcagcaa gttcttggtg gaaaacagtg ttctcaagat ggagtatgct
     1441 gacgtgcgtg tgctgcacct ggctcacaag gatctcacag tgctctgcca tttggaacaa
     1501 ctgctcttgg tcactcatct tgacctgtcc cataatcgtc tccgagcctt gcccccagcc
     1561 ctggctgctc tgcgctgtct cgaggtgttg caggccagtg ataatgtcct ggagaacttg
     1621 gacggcgtgg ctaaccttcc ccggctgcgg gagctgttac tatgtaataa ccgcctccag
     1681 cagtctgctg cacttcagac tcttgcctcc tgccccaggc tagtcttcct caacctgcag
     1741 ggcaactcgc tgtgccaaga agagggcatc cgggagcgtt tggctgagat gctaccgtcc
     1801 gtcagcagca tcctcaccta ggaggcccca tctcaccctc accctttaac ttattgggac
     1861 tgaataaaga ctggagaggc ccctctaggc tgccaagcta ccattactgc tgccctgaca
     1921 acacttcctc cattaccacc actgtgcatt ttggaaaaag gaagggaggg gctctctggg
     1981 gtatggggcc actgtcctgt gattctgtct accaagaccc tcagtgttta tggctggtca
     2041 ggaccagggc tgggtctgag ttcaccatca gttttgggct atcgtggtgc ctgagcttga
     2101 agctgggata ggaattagga tcaggttgtg gtttggactg ctcatcagaa gagctgtctc
     2161 ggggctggag agatggctca gcggttaaga gcgctgactg ttcttctgaa agtcctgagt
     2221 tcaaatccca gcaaccacat ggtggctcat aaccatctgt aataagatct gacaccctct
     2281 tctggtgtct gaagacagct acagtgtact tacatataat aataaataaa tctttaagaa
     2341 aagaaaaaaa aaaaaa
//
