LOCUS       NM_146121               4967 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RAB GTPase activating protein 1 (Rabgap1), transcript
            variant 1, mRNA.
ACCESSION   NM_146121
VERSION     NM_146121.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4967)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4967)
  AUTHORS   Oh,R.Y., Deshwar,A.R., Marwaha,A., Sabha,N., Tropak,M., Hou,H.,
            Yuki,K.E., Wilson,M.D., Rump,P., Lunsing,R., Elserafy,N.,
            Chung,C.W.T., Hewson,S., Klein-Rodewald,T., Calzada-Wack,J.,
            Sanz-Moreno,A., Kraiger,M., Marschall,S., Fuchs,H.,
            Gailus-Durner,V., Hrabe de Angelis,M., Dowling,J. and Schulze,A.
  TITLE     Biallelic loss-of-function variants in RABGAP1 cause a novel
            neurodevelopmental syndrome
  JOURNAL   Genet Med 24 (11), 2399-2407 (2022)
   PUBMED   36083289
  REMARK    GeneRIF: Biallelic loss-of-function variants in RABGAP1 cause a
            novel neurodevelopmental syndrome.
REFERENCE   3  (bases 1 to 4967)
  AUTHORS   Samarelli,A.V., Ziegler,T., Meves,A., Fassler,R. and Bottcher,R.T.
  TITLE     Rabgap1 promotes recycling of active beta1 integrins to support
            effective cell migration
  JOURNAL   J Cell Sci 133 (18) (2020)
   PUBMED   32843574
  REMARK    GeneRIF: Rabgap1 promotes recycling of active beta1 integrins to
            support effective cell migration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4967)
  AUTHORS   Fededa,J.P., Esk,C., Mierzwa,B., Stanyte,R., Yuan,S., Zheng,H.,
            Ebnet,K., Yan,W., Knoblich,J.A. and Gerlich,D.W.
  TITLE     MicroRNA-34/449 controls mitotic spindle orientation during
            mammalian cortex development
  JOURNAL   EMBO J 35 (22), 2386-2398 (2016)
   PUBMED   27707753
REFERENCE   5  (bases 1 to 4967)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY021872.1 and AK220489.1.
            
            On Oct 4, 2005 this sequence version replaced NM_146121.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.180075.1,
                                           SRR1660811.176800.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               BY021872.1         2-180
            180-4967            AK220489.1         1-4788
FEATURES             Location/Qualifiers
     source          1..4967
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.19 cM"
     gene            1..4967
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /note="RAB GTPase activating protein 1"
                     /db_xref="GeneID:227800"
                     /db_xref="MGI:MGI:2385139"
     exon            1..172
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            173..372
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..3417
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /note="isoform a is encoded by transcript variant 1; rab6
                     GTPase activating protein (GAP and centrosome-associated);
                     rab GTPase-activating protein 1; GAP and
                     centrosome-associated protein; rab6 GTPase-activating
                     protein GAPCenA"
                     /codon_start=1
                     /product="rab GTPase-activating protein 1 isoform a"
                     /protein_id="NP_666233.2"
                     /db_xref="CCDS:CCDS16002.1"
                     /db_xref="GeneID:227800"
                     /db_xref="MGI:MGI:2385139"
                     /translation="MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDD
                     EKTGLKIVGNGSEQQLQKELADVLMDPPMDDQPGERSQLDGEGDGPLSNQLSASSTIN
                     PVPLVGLPKPEMSLPVKPGQGDSEVSSPFTPVADEDSVVFNKLTYLGCASVNAPRSEV
                     EALRMMSILRSQCQISLDVTLSVPNVSEGTVRLLDPQTNTEIANYPIYKILFCVRGHD
                     GTPESDCFAFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSATAA
                     PQTPDSDIFTFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVICVQQTANK
                     ELAIERCFGLLLSPGKDVRNSDMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNE
                     ETPKDKVLFMTTAVDLVITEVQEPVRFLLETKVRVCSPNERLFWPFSKRSTTENFFLK
                     LKQIKQKEKKNNADTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSMIPSPPEDD
                     EEEDNDEPLLSGFGDVSKECAEKILETWGELLSKWHLNLSVRPKQLSSLVRSGVPEAL
                     RGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQD
                     SLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQN
                     FEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHII
                     DLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKRLMEL
                     ACNTKISQKKLKKFEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAH
                     ELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEDEKRRLEEESAQLKEMCRRE
                     LDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCDRCRDFFN
                     KEGRVKGISSAKGVSDEDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLEHHL
                     GLALSEVQAAKKTWFNRTLSSIKTATGVQGKETC"
     exon            373..592
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            593..797
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            798..972
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1130
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1241
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1308
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1411
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1581
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1756
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1850
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..2001
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2115
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2190
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2316
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2460
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2502
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2631
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2724
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2835
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2940
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3024
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3096
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3294
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..4967
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4945..4950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /note="hexamer: ATTAAA"
     polyA_site      4966
                     /gene="Rabgap1"
                     /gene_synonym="Gapcena; mKIAA4104"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgaggc cagggaatcg ggctgcggag ggtcggcttc gtgagctctg ctgcttgtgg
       61 ttcttcggta gaaggcgggc ccgagctctc ttcttcgcgg ctgcagtcac gaagtgctcc
      121 cgctgaccgt tgcctgcatg ggcctgagca gcctgtctgc gaacaagccg tggcattaaa
      181 aaaatattta accattcatg agttgagcct cattcttgag ttatggatga caaggcctct
      241 gttggaaaaa tcagtgtctc atcagactca gtgtctactc ttaatagtga agattttgtc
      301 ttggtttcca ggcaaggaga tgagacacca tctacaaata atgggagtga tgatgagaag
      361 acgggactca agattgtagg aaatggaagt gagcagcagc ttcagaaaga gctagcagat
      421 gtgctgatgg atcctcccat ggacgaccag ccaggggaaa ggtcacaact ggatggtgaa
      481 ggagatgggc ctctttctaa tcaactctca gcttcatcca ccattaatcc tgtgcctctg
      541 gtagggcttc cgaaaccaga gatgagcctg ccagtgaaac ctggacaagg agattctgaa
      601 gtatcaagtc cttttacacc agtggctgat gaggatagtg tggttttcaa taaactaact
      661 tacttaggct gtgcttcagt aaatgctccc cggagtgaag tggaagcctt gaggatgatg
      721 tccatcttga gaagtcagtg tcagatttct ctggatgtaa ccctctcagt gccgaatgta
      781 tctgaaggaa ctgtgagact tttagatcct caaacaaaca ctgaaatagc aaactaccct
      841 atctacaaaa tcctcttctg tgtcagagga catgatggga ctcctgagag tgactgtttt
      901 gcattcactg aaagtcacta caacgcagag ctcttcagga tacatgtctt tcgctgtgaa
      961 atacaagaag ctgtgagccg gatactttac agttttgcca ccgccttccg ccgctctgcc
     1021 aagcagaccc cactctcagc cacagctgca ccacagactc ctgacagcga catctttacc
     1081 ttctctgtgt ctttagaaat aaaagaagat gatggtaaag gttattttag tgctgttccc
     1141 aaagacaagg acaggcaatg ctttaaactt cgacaaggaa ttgataagaa gattgttatc
     1201 tgtgtgcagc aaacagctaa caaagaactt gccattgaaa ggtgctttgg tcttctcctt
     1261 agcccaggaa aagatgtccg aaacagtgat atgcacttgc tggatttgga gtctatgggc
     1321 aaaagttcag atggaaaatc atatgttatt actggaagct ggaacccgaa atccccacat
     1381 tttcaagttg tgaatgaaga aactcctaaa gataaagtgc tgttcatgac aacagctgtg
     1441 gatttggtga taactgaagt acaggaacct gttcgatttc ttctagagac aaaagttcga
     1501 gtgtgctcac ctaatgaaag gttattctgg cccttcagca aacgaagcac tactgaaaac
     1561 ttctttctga aactgaagca gataaagcaa aaggagaaaa agaataatgc tgacacttta
     1621 tatgaagttg tgtgtttgga gagtgagtca gagagagaga ggaggaaaac cacagccagt
     1681 ccttcagttc gcctgccaca gtctggatcc cagagctcca tgatcccctc tcccccagaa
     1741 gatgatgaag aagaagataa tgatgaacct ctcttgagtg gatttgggga tgtatccaaa
     1801 gaatgtgcag aaaaaattct tgaaacatgg ggagaactgc tgtcaaaatg gcatctcaac
     1861 ttgagtgtga gaccgaagca gttgtcatcc ttagtgagaa gtggtgttcc tgaagctctt
     1921 cgtggagaag tctggcagct gctagcaggc tgccacaaca acgatcactt agtagaaaag
     1981 taccgaattc tcatcacaaa ggagtctcct caagacagtg ctatcaccag agatattaac
     2041 cgcacatttc cagctcatga ctacttcaag gacacaggag gagatggaca agattcttta
     2101 tataaaatat gcaaggcata ttctgtgtat gatgaagaga ttggttactg ccagggccag
     2161 tccttcctcg cagctgtact gcttctccac atgcccgaag aacaggcatt cagtgttctg
     2221 gtcaagatca tgtttgacta tggtctcagg gaacttttca aacaaaattt tgaagatctt
     2281 cattgcaagt tctaccagtt ggagcgcctt atgcaggaat acattcctga cctgtacaac
     2341 cacttcctgg atatcagcct tgaagcacac atgtacgcct cccagtggtt ccttacactt
     2401 ttcactgcaa aattccctct ctacatggtc ttccatatca tcgacctgct cttatgtgag
     2461 ggaataagtg tcatctttaa tgtcgccctt ggattactaa agacttccaa ggatgacttg
     2521 ctgttgacag actttgaggg tgccttgaag ttcttcaggg ttcagctccc taaaagatac
     2581 cgctcagaag aaaatgcaaa gaggctcatg gagcttgcct gtaacacaaa gattagccag
     2641 aagaagctga agaagtttga aaaagagtac cataccatga gggagcagca ggcccaacag
     2701 gaagacccca tcgagcgatt tgagcgggaa aataggcggc tgcaagaagc taacatgagg
     2761 ttggaacagg aaaacgatga cttagctcat gaactagtca ccagcaaaat tgcattgcgg
     2821 aaggacctgg ataatgcaga ggaaaaggca gatgcattga ataaggagct gctgatgacc
     2881 aagcagaagc tgattgatgc agaagacgag aagaggaggt tagaagagga gtctgcacag
     2941 ttaaaggaaa tgtgccgccg ggaacttgac aaggcagaat cagagattaa aaaaaacagc
     3001 tctatcattg gtgactataa gcagatttgt tctcaattga gtgaaagact ggaaaagcaa
     3061 cagacagcca ataaagtgga aattgagaaa atccggcaaa aggtagatga ctgtgaccgc
     3121 tgccgagact tcttcaacaa agaagggcga gtgaagggta tcagctcagc caagggagtt
     3181 tcagatgagg acacagatga agaaaaagag acactcaaga accagcttcg ggagatggag
     3241 ctagagctgg cacaaaccaa actgcagctg gtagaagctg aatgcaagat ccaggacttg
     3301 gaacaccact tgggccttgc cctcagtgag gtgcaggcag ccaagaagac ctggtttaac
     3361 cgaacactga gctccataaa gacagcaact ggtgttcaag ggaaagagac atgttgagaa
     3421 cagctgctgc ctccagacac ctccagaaaa cacaccacct tttgttgcct tctttggcca
     3481 gatgtgtgat tctgtgatat gttgcaggac cagaatgaac ctaggtcaga gctgtatagt
     3541 atattgttag gtcagtgggc tagggctcct gcagcaggct gccaacccaa ctgatgcttt
     3601 gggtatgcac cagagtcctt cctcctagtg ccattcaggc ctcttttctg tataggaagg
     3661 aacacttcac acagccagac ttggggaata ccccaatgta ttgggttttc tttttctaaa
     3721 ccctttaaaa aaattgtgtg tgtgtgtgtg tatgtgtaca catatacaca catgcacaca
     3781 ctctatcctt tgagttgggg agcaggggtt cagaaatttg agtaattctt atctatcagt
     3841 gccagcaaaa gcccctagga gatgagaagc actttgagta gaagggtctc atagtcacag
     3901 ttcaagtcac ctaatttttt tttaaactaa tatagtgcat aggttttgat ttggaattat
     3961 tcatattgct gagcaattct atgcaactct catagtcgtg tctttttttt ttttttaaac
     4021 aaaacaaaac attagctgcc aaactacttc taaaggctgg aatgggccac atgactgtga
     4081 gactgaatca atcatgacac ggacagctct tattttgttt aaagtgtaca tatatatgtg
     4141 tgtgtatata tatgtgtgtg tgtataaata tatatatata tatagatata tatatagata
     4201 catttcccag taccctgaac tgacagtgtt taagtcccag acaacctgct aatctaccac
     4261 tgccgtctgt ggtcatgggg cacttccttt cacttgaggt ttattgggct ttgttcttcc
     4321 tgccaatgta ggagctggca agagctccat gacctctaat gtgtgcatag caggtcgttc
     4381 aagagagcaa gactgaatac atgaaagtcc ctacacactg taaagtccta ctttcctggc
     4441 tggatctctg tcaggcctct gaagcctcca ggggggccag gtgtacatct cactggtcag
     4501 gtgatgggct gtggattctc actttaaagc tatgaaatgg cagttttagc accttttttt
     4561 taattaaaaa caaaaccttt tgactcttaa tttatatgct gacaagtggt gtcacaagtg
     4621 gctcatcctc tctgctctgt gtgcaggtag cttgggtttg tatataagga cactagttat
     4681 tttttctttc cctgttggct tttctaatgc ttgatgaggt catctacagt ggggagataa
     4741 taagtggcct gctcttcccc agaccatccc ctacaccact tcctgtgtct gtctcgttca
     4801 gttaacccaa acagtataag cccatcttaa actaggtgtg tggacattgt gtgctagggt
     4861 agtttgtgtg tcaactccat gaactgaaat ataaatcagt aaaactgtat tactatttct
     4921 tttgtttgtt ttaacagcat attcattaaa tattttggta caaacag
//
