LOCUS       NM_030566               2539 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus rabaptin, RAB GTPase binding effector protein 2
            (Rabep2), mRNA.
ACCESSION   NM_030566
VERSION     NM_030566.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2539)
  AUTHORS   Binder,N.F., El Amki,M., Gluck,C., Middleham,W., Reuss,A.M.,
            Bertolo,A., Thurner,P., Deffieux,T., Lambride,C., Epp,R.,
            Handelsmann,H.L., Baumgartner,P., Orset,C., Bethge,P., Kulcsar,Z.,
            Aguzzi,A., Tanter,M., Schmid,F., Vivien,D., Wyss,M.T., Luft,A.,
            Weller,M., Weber,B. and Wegener,S.
  TITLE     Leptomeningeal collaterals regulate reperfusion in ischemic stroke
            and rescue the brain from futile recanalization
  JOURNAL   Neuron 112 (9), 1456-1472 (2024)
   PUBMED   38412858
REFERENCE   2  (bases 1 to 2539)
  AUTHORS   Faber,J.E., Zhang,H., Xenakis,J.G., Bell,T.A., Hock,P.,
            Pardo-Manuel de Villena,F., Ferris,M.T. and Rzechorzek,W.
  TITLE     Large differences in collateral blood vessel abundance among
            individuals arise from multiple genetic variants
  JOURNAL   J Cereb Blood Flow Metab 43 (11), 1983-2004 (2023)
   PUBMED   37572089
REFERENCE   3  (bases 1 to 2539)
  AUTHORS   Lee,H.K., Kwon,D.H., Aylor,D.L. and Marchuk,D.A.
  TITLE     A cross-species approach using an in vivo evaluation platform in
            mice demonstrates that sequence variation in human RABEP2 modulates
            ischemic stroke outcomes
  JOURNAL   Am J Hum Genet 109 (10), 1814-1827 (2022)
   PUBMED   36167069
REFERENCE   4  (bases 1 to 2539)
  AUTHORS   Kofler,N., Corti,F., Rivera-Molina,F., Deng,Y., Toomre,D. and
            Simons,M.
  TITLE     The Rab-effector protein RABEP2 regulates endosomal trafficking to
            mediate vascular endothelial growth factor receptor-2
            (VEGFR2)-dependent signaling
  JOURNAL   J Biol Chem 293 (13), 4805-4817 (2018)
   PUBMED   29425100
  REMARK    GeneRIF: These results implicate RABEP2 as a key modulator of
            VEGFR2 endosomal trafficking, and demonstrate the importance of
            RABEP2 and Rab4 for VEGFR2 signaling in endothelial cells.
REFERENCE   5  (bases 1 to 2539)
  AUTHORS   Kao,Y.J., Oyarzabal,E.A., Zhang,H., Faber,J.E. and Shih,Y.I.
  TITLE     Role of Genetic Variation in Collateral Circulation in the
            Evolution of Acute Stroke: A Multimodal Magnetic Resonance Imaging
            Study
  JOURNAL   Stroke 48 (3), 754-761 (2017)
   PUBMED   28188261
REFERENCE   6  (bases 1 to 2539)
  AUTHORS   Lucitti,J.L., Sealock,R., Buckley,B.K., Zhang,H., Xiao,L.,
            Dudley,A.C. and Faber,J.E.
  TITLE     Variants of Rab GTPase-Effector Binding Protein-2 Cause Variation
            in the Collateral Circulation and Severity of Stroke
  JOURNAL   Stroke 47 (12), 3022-3031 (2016)
   PUBMED   27811335
  REMARK    GeneRIF: Naturally occurring variants of Rabep2 are major
            determinants of variation in collateral extent and stroke severity
            in mice.
REFERENCE   7  (bases 1 to 2539)
  AUTHORS   Airik,R., Schueler,M., Airik,M., Cho,J., Ulanowicz,K.A.,
            Porath,J.D., Hurd,T.W., Bekker-Jensen,S., Schroder,J.M.,
            Andersen,J.S. and Hildebrandt,F.
  TITLE     SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is
            Required for Hedgehog Signaling
  JOURNAL   PLoS One 11 (5), e0156081 (2016)
   PUBMED   27224062
  REMARK    GeneRIF: SDCCAG8 interacts with proteins of the centriolar
            satellites (OFD1, AZI1), of the endosomal sorting complex (RABEP2,
            ERC1), and with non-muscle myosin motor proteins (MYH9, MYH10,
            MYH14) at the centrosome.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2539)
  AUTHORS   Tkach,V., Tulchinsky,E., Lukanidin,E., Vinson,C., Bock,E. and
            Berezin,V.
  TITLE     Role of the Fos family members, c-Fos, Fra-1 and Fra-2, in the
            regulation of cell motility
  JOURNAL   Oncogene 22 (32), 5045-5054 (2003)
   PUBMED   12902987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU514356.1, AK144836.1 and BY665800.1.
            
            On Apr 5, 2007 this sequence version replaced NM_030566.1.
            
            CCDS Note: The coding region has been updated to represent an
            alternative 5' splice pattern, resulting in the extension of the
            N-terminus to one that is better supported by available transcript
            and homology data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089938.1, AK144836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               BU514356.1         1-315
            316-2532            AK144836.1         2-2218
            2533-2539           BY665800.1         381-387
FEATURES             Location/Qualifiers
     source          1..2539
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.03 cM"
     gene            1..2539
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /note="rabaptin, RAB GTPase binding effector protein 2"
                     /db_xref="GeneID:70314"
                     /db_xref="MGI:MGI:1917564"
     exon            1..390
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..2030
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /note="fos-related antigen; rabaptin-5beta"
                     /codon_start=1
                     /product="rab GTPase-binding effector protein 2"
                     /protein_id="NP_085043.2"
                     /db_xref="CCDS:CCDS21829.2"
                     /db_xref="GeneID:70314"
                     /db_xref="MGI:MGI:1917564"
                     /translation="MAAAPATLALDPQPQEKQKDASESSELSRLRAELAGALAEMETM
                     KAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYETQIAALKQERQQQQQDF
                     EEKDRELGHLKQLLARAHPLDSLEKQMEKAHEDSEKLREIVLPMEQEITELKGKLQRA
                     EELIQEIQRRPRQPASLHGSTELLPLSRNPSPPLEPLEEPSGDAGPAAEAFAHNCDDS
                     ASISSFSLGGAAGSASLRGPQGLSPEQEETASLVSTGTLVPEGIFLPPPGYQLVPDSQ
                     WEQLQVEGRQLQKELESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQ
                     GTVSQAQERVQLQMAELATSHKCLSQEVKRLNEENQGLRAEQLPSSALQGSEQREDQD
                     EALPSSIQELHLLVQNTRQQARARQQAQEHEAERLRIEIVKLREALDEETAAKASLER
                     QLRVQREETDVLEASLCSLRIETERVQQEQRKAQLTDLLSEQRAKTLRLQAELETSEQ
                     VQRDFVRLSQALQVRLERIRQAETLQQVRSILDEAPLRDIRDIKDS"
     exon            391..600
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /inference="alignment:Splign:2.1.0"
     exon            601..758
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /inference="alignment:Splign:2.1.0"
     exon            759..869
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1214
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1310
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1409
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1565
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1743
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1755
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1811
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1928
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2539
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2514..2519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /note="hexamer: AATAAA"
     polyA_site      2533
                     /gene="Rabep2"
                     /gene_synonym="2610011A08Rik; Fra"
                     /note="major polyA site"
ORIGIN      
        1 gaaggaggag gccgcgcgca gcgtcctcta ggactaagac caggcgttcc aggaggtggc
       61 ctcgagtgga gcctcagcag atcctcagca ccagagaaga ctaccgcaga cccgaagccc
      121 tcggagcttc cagggagcgc gggagcgcgg gggcggtccc acgaggctgc aagaaaggcg
      181 ggatccaggc cgcgcgtcca ctcgagtgca gtcggcgtct cttgaccatc ccgccctccc
      241 accccccgcg gcccctgcag agccgatccg gaaacagccg agcggatccg gaaacagccg
      301 agcggacccg gaagcgggag tgccatcacc agtgagtgcg ggaatccgcc gtttgggctg
      361 agacgatggc agctgcgcca gcaaccctag cgctggatcc ccagccccaa gagaagcaaa
      421 aggatgcatc cgagtcaagt gagctcagtc ggcttcgtgc cgaactggcc ggtgccctgg
      481 cagaaatgga aaccatgaag gctgtagctg aggtgagcga gagcaccaag gcggaggcag
      541 tggctgcagt gcagagacag tgccaagagg aggtggcctc cctgcaggcc atcctgaaag
      601 actccatcag cagctacgag acccagatcg cagccctgaa acaggagcgg cagcagcaac
      661 agcaggactt tgaggagaag gatcgagagc tgggccacct caaacagctg ctggcccggg
      721 cccacccttt ggactccttg gagaagcaaa tggaaaaggc tcatgaagac tcggaaaagc
      781 ttcgagagat cgtgttgccc atggagcagg agattaccga gctgaagggg aagctgcaga
      841 gggcggaaga gctgatccaa gagatccaga gacgaccacg gcagcctgcc tccctgcatg
      901 gctccacaga gttgctccct ctgtcgagga acccctcacc cccactggaa cccttggagg
      961 agccgagcgg agacgccggc ccagccgccg aggcctttgc ccacaactgc gatgacagtg
     1021 cctccatctc ttccttctcc ctcggtgggg ccgccggcag tgcctcccta cgaggccccc
     1081 aaggcctcag ccctgagcag gaagagactg cttctctggt gtctactggc actctggtcc
     1141 ctgagggcat cttcctgccc cctcctgggt accagcttgt tccagatagc cagtgggagc
     1201 aactgcaggt agaggggcgg cagctgcaga aggagctgga aagtgtcagc cgggagcggg
     1261 atgagctgca ggaaggacta agacggagca atgaagactg tgccaagcag atgcaggtgc
     1321 tcctggccca ggtccagaac tcagagcagc tgctccgaac tctgcaagga actgtgagcc
     1381 aggcccaaga gcgcgtgcag ctgcagatgg cagaactggc cacttctcac aagtgcctga
     1441 gccaagaggt taaaagactg aatgaagaaa atcaagggct ccgggctgag cagctgccat
     1501 cctctgccct tcagggctca gagcagcggg aggaccagga cgaggccctg ccaagctcca
     1561 tacaggagct acatctgctg gtgcagaata ccaggcaaca ggcgcgggcc aggcagcagg
     1621 cacaggagca tgaggctgag cgcctgcgca ttgaaattgt gaagctgcgg gaggcactgg
     1681 acgaggagac agcagccaag gccagtctgg agagacagct gagggtgcag cgagaagaga
     1741 cagacgtgct ggaggcctca ctgtgcagcc tgagaataga gacggagcgg gtccagcagg
     1801 agcagcgcaa ggcccagctc acggatctcc tctcagagca gagagccaag acactccggc
     1861 tgcaggctga gctggagacc agtgaacagg tgcagaggga ctttgtacgg ctgtcccagg
     1921 ccctacaggt acgcctggag cggatccgcc aagcagagac tctgcagcaa gtgcgtagca
     1981 tcctggatga ggcgcccctc agggacatca gggacattaa agactcttga ggggccaggc
     2041 gagaggcttc cctgctgggg aagctgcccc tttctctaca agaactatga ggcatggact
     2101 gcaggtctca gaactggagt cccatcagct gcaaacctgg atggtggtgt ccctagggcc
     2161 actacttcca cccagggtgg ctgggcctgc cctcagggat gatacctgga aaagggtccc
     2221 agcctccttc cagaaccaaa gtgcaggctg agccaggtgg ctttcgggct accatgctcc
     2281 ctcatggatc cagctctccc accctgtcac ctcaggccag tagccagtcc cagtctctgg
     2341 cacgcccagc ttgtggctag aagctggtgg attcagtggg ctcctcgcac agaggccctg
     2401 ggacatacaa ctgctttctg gactgtacga cactaaggta tttgtccgta ggcacctgaa
     2461 acaggcccca agatataagg aagcaaggcc agacttttct gtcatttatt ttcaataaat
     2521 aagcaatcag ctagtcagt
//
