LOCUS       NM_019773               1448 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus RAB9, member RAS oncogene family (Rab9), mRNA.
ACCESSION   NM_019773
VERSION     NM_019773.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1448)
  AUTHORS   Xu,C., Song,Y., Liu,W., Liu,R., Bai,Q., Li,L., Wang,C. and Yan,G.
  TITLE     IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and
            Golgi fragmentation by increasing autophagy flux and mitochondrial
            oxidative stress
  JOURNAL   Redox Biol 71, 103090 (2024)
   PUBMED   38373380
  REMARK    GeneRIF: IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3
            inflammasomes, and Golgi fragmentation by increasing autophagy flux
            and mitochondrial oxidative stress.
REFERENCE   2  (bases 1 to 1448)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1448)
  AUTHORS   Nah,J., Shirakabe,A., Mukai,R., Zhai,P., Sung,E.A., Ivessa,A.,
            Mizushima,W., Nakada,Y., Saito,T., Hu,C., Jung,Y.K. and
            Sadoshima,J.
  TITLE     Ulk1-dependent alternative mitophagy plays a protective role during
            pressure overload in the heart
  JOURNAL   Cardiovasc Res 118 (12), 2638-2651 (2022)
   PUBMED   35018428
  REMARK    GeneRIF: Ulk1-dependent alternative mitophagy plays a protective
            role during pressure overload in the heart.
REFERENCE   4  (bases 1 to 1448)
  AUTHORS   Mareninova,O.A., Dillon,D.L., Wightman,C.J.M., Yakubov,I.,
            Takahashi,T., Gaisano,H.Y., Munson,K., Ohmuraya,M., Dawson,D.,
            Gukovsky,I. and Gukovskaya,A.S.
  TITLE     Rab9 Mediates Pancreatic Autophagy Switch From Canonical to
            Noncanonical, Aggravating Experimental Pancreatitis
  JOURNAL   Cell Mol Gastroenterol Hepatol 13 (2), 599-622 (2022)
   PUBMED   34610499
  REMARK    GeneRIF: Rab9 Mediates Pancreatic Autophagy Switch From Canonical
            to Noncanonical, Aggravating Experimental Pancreatitis.
REFERENCE   5  (bases 1 to 1448)
  AUTHORS   Saito,T., Nah,J., Oka,S.I., Mukai,R., Monden,Y., Maejima,Y.,
            Ikeda,Y., Sciarretta,S., Liu,T., Li,H., Baljinnyam,E.,
            Fraidenraich,D., Fritzky,L., Zhai,P., Ichinose,S., Isobe,M.,
            Hsu,C.P., Kundu,M. and Sadoshima,J.
  TITLE     An alternative mitophagy pathway mediated by Rab9 protects the
            heart against ischemia
  JOURNAL   J Clin Invest 129 (2), 802-819 (2019)
   PUBMED   30511961
  REMARK    GeneRIF: Mitophagy mediated through the Ulk1/Rab9/Rip1/Drp1 pathway
            protected the heart against ischemia by maintaining healthy
            mitochondria.
REFERENCE   6  (bases 1 to 1448)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   7  (bases 1 to 1448)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1448)
  AUTHORS   Zhao,H., Ettala,O. and Vaananen,H.K.
  TITLE     Intracellular membrane trafficking pathways in bone-resorbing
            osteoclasts revealed by cloning and subcellular localization
            studies of small GTP-binding rab proteins
  JOURNAL   Biochem Biophys Res Commun 293 (3), 1060-1065 (2002)
   PUBMED   12051767
REFERENCE   9  (bases 1 to 1448)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   10 (bases 1 to 1448)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672174.8 and AK017301.1.
            
            [WARNING] On Feb 26, 2025 this sequence was replaced by
            NM_019773.3.
            
            On Apr 9, 2011 this sequence version replaced NM_019773.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017301.1, BC008160.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AL672174.8         81661-81870         c
            211-1448            AK017301.1         5-1242
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 77.47 cM"
     gene            1..1448
                     /gene="Rab9"
                     /gene_synonym="2410064E05Rik; Rab9a; Sid6061p"
                     /note="RAB9, member RAS oncogene family"
                     /db_xref="GeneID:56382"
                     /db_xref="MGI:MGI:1890695"
     exon            1..328
                     /gene="Rab9"
                     /gene_synonym="2410064E05Rik; Rab9a; Sid6061p"
                     /inference="alignment:Splign:2.1.0"
     exon            329..356
                     /gene="Rab9"
                     /gene_synonym="2410064E05Rik; Rab9a; Sid6061p"
                     /inference="alignment:Splign:2.1.0"
     exon            357..1448
                     /gene="Rab9"
                     /gene_synonym="2410064E05Rik; Rab9a; Sid6061p"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..992
                     /gene="Rab9"
                     /gene_synonym="2410064E05Rik; Rab9a; Sid6061p"
                     /note="rab-9A; SID 99"
                     /codon_start=1
                     /product="ras-related protein Rab-9A"
                     /protein_id="NP_062747.1"
                     /db_xref="CCDS:CCDS30527.1"
                     /db_xref="GeneID:56382"
                     /db_xref="MGI:MGI:1890695"
                     /translation="MAGKSSLFKIILLGDGGVGKSSLMNRYVTNKFDSQLFHTIGVEF
                     LNKDLEVDGHFVTMQIWDTAGQERFRSLRTPFYRGSDCCLLTFSVDDSQSFQNLSNWK
                     KEFIYYADVKEPESFPFVILGNKTDIKERQVSTEEAQAWCKDNGDYPYFETSAKDSTN
                     VAAAFEEAVRRILATEDRSEHLIQTDTVNLHRKPKPNSSCC"
     regulatory      1090..1095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab9"
                     /gene_synonym="2410064E05Rik; Rab9a; Sid6061p"
                     /note="hexamer: AATAAA"
     polyA_site      1109
                     /gene="Rab9"
                     /gene_synonym="2410064E05Rik; Rab9a; Sid6061p"
     regulatory      1426..1431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab9"
                     /gene_synonym="2410064E05Rik; Rab9a; Sid6061p"
                     /note="hexamer: ATTAAA"
     polyA_site      1441
                     /gene="Rab9"
                     /gene_synonym="2410064E05Rik; Rab9a; Sid6061p"
                     /note="major polyA site"
ORIGIN      
        1 ctcctggcct ggtgctaccg ccacaggccc ctccccgcag ctcctggccc cgccctaaag
       61 acttaggtcc cgcccctgac ccgggtctgg ttttaccact ccagaccctg cctcactgcc
      121 tcaggccccg ccccgtcgcc ccactgtcaa ggcctcgccc ctccgtcttg gccccgcccc
      181 ggccgcccgc catattggtt cttctgcccc agtcgctccc tcttggaagc gctctcgacg
      241 ttccggagtc tctggccttc ttcctgccct ggttgcaccc aggcgtgttg gcgagccgcc
      301 cccaggacgt ccagtgtgtg tctgcaagat aatgatgctt gaactgaact actaaggatt
      361 cgaaatcaaa acttacatta ttaataatgg caggaaaatc gtctcttttt aaaataattc
      421 ttcttggaga tggtggagtt ggcaagagtt ctcttatgaa cagatatgta accaataaat
      481 ttgattccca gctcttccac acaataggtg tggaattttt aaataaagat ctggaggtgg
      541 acggacattt tgttaccatg cagatttggg acacagctgg ccaagaacgc ttccgaagcc
      601 tgaggacgcc attttaccgg ggttctgact gttgcctgct tacatttagt gtcgatgatt
      661 cacagagctt ccagaatttg agcaactgga agaaagagtt catatattac gcagatgtga
      721 aagagcctga aagctttccc tttgtgattt tgggcaacaa gactgacata aaagaacggc
      781 aggtgtctac agaagaagcc caagcctggt gcaaggacaa cggcgactat ccttactttg
      841 aaacaagtgc aaaagattcc accaatgttg ctgctgcctt tgaggaggca gttcgaagaa
      901 ttctggccac ggaagatagg tcagaacacc tgattcagac agacacagtc aatctgcacc
      961 gaaagcccaa gccaaactca tcttgctgtt gatggcatta aagggatagt tggtgcattc
     1021 taaccaacac acacacacac acacagaaag gtggagaaac aaattagtat gcagaagagt
     1081 tcatttacta ataaaattca gttaacgcat attgttgcct cattagtcgg tgggagaagg
     1141 gacactcact ctggaggaat ctatttactc agtaatggca cgttccactt ataaattgta
     1201 attgttgtct aatgtttctt taaattaaaa cattagtgct aataagatga ccaagaactg
     1261 actttactgt aattcagacg acaaccttgg ctattctaga agtacactta gattgttttg
     1321 acccacaagg aaatggaaaa ttacttttat atgtgtatat ttttatgtaa ttagcattgt
     1381 attcttggtc taggaaagta aattcctaca gcagtactat taaagattaa aatctaatgc
     1441 atttcttt
//
