LOCUS       NM_173413               4751 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus RAB8B, member RAS oncogene family (Rab8b), mRNA.
ACCESSION   NM_173413
VERSION     NM_173413.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4751)
  AUTHORS   Wu,J., Moriwaki,K., Asuka,T., Nakai,R., Kanda,S., Taniguchi,M.,
            Sugiyama,T., Yoshimura,S.I., Kunii,M., Nagasawa,T., Hosen,N.,
            Miyoshi,E. and Harada,A.
  TITLE     EHBP1L1, an apicobasal polarity regulator, is critical for nuclear
            polarization during enucleation of erythroblasts
  JOURNAL   Blood Adv 7 (14), 3382-3394 (2023)
   PUBMED   37042948
  REMARK    Erratum:[Blood Adv. 2024 Mar 12;8(5):1151. doi:
            10.1182/bloodadvances.2023011838.. PMID: 38421726]
REFERENCE   2  (bases 1 to 4751)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4751)
  AUTHORS   Azizoglu,D.B., Braitsch,C., Marciano,D.K. and Cleaver,O.
  TITLE     Afadin and RhoA control pancreatic endocrine mass via lumen
            morphogenesis
  JOURNAL   Genes Dev 31 (23-24), 2376-2390 (2017)
   PUBMED   29330353
REFERENCE   4  (bases 1 to 4751)
  AUTHORS   Burikhanov,R., Hebbar,N., Noothi,S.K., Shukla,N., Sledziona,J.,
            Araujo,N., Kudrimoti,M., Wang,Q.J., Watt,D.S., Welch,D.R.,
            Maranchie,J., Harada,A. and Rangnekar,V.M.
  TITLE     Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell
            Apoptosis and Inhibition of Metastasis
  JOURNAL   Cell Rep 18 (2), 508-519 (2017)
   PUBMED   28076793
REFERENCE   5  (bases 1 to 4751)
  AUTHORS   Kobayashi,S., Suzuki,T., Kawaguchi,A., Phongphaew,W., Yoshii,K.,
            Iwano,T., Harada,A., Kariwa,H., Orba,Y. and Sawa,H.
  TITLE     Rab8b Regulates Transport of West Nile Virus Particles from
            Recycling Endosomes
  JOURNAL   J Biol Chem 291 (12), 6559-6568 (2016)
   PUBMED   26817838
  REMARK    GeneRIF: Rab8b is involved in trafficking of WNV particles from
            recycling endosomes to the plasma membrane.
REFERENCE   6  (bases 1 to 4751)
  AUTHORS   Roux,I., Safieddine,S., Nouvian,R., Grati,M., Simmler,M.C.,
            Bahloul,A., Perfettini,I., Le Gall,M., Rostaing,P., Hamard,G.,
            Triller,A., Avan,P., Moser,T. and Petit,C.
  TITLE     Otoferlin, defective in a human deafness form, is essential for
            exocytosis at the auditory ribbon synapse
  JOURNAL   Cell 127 (2), 277-289 (2006)
   PUBMED   17055430
REFERENCE   7  (bases 1 to 4751)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   8  (bases 1 to 4751)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   9  (bases 1 to 4751)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   10 (bases 1 to 4751)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY322741.1, BC059208.1 and AC142504.2.
            
            On Oct 24, 2009 this sequence version replaced NM_173413.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059208.1, AK084650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BY322741.1         2-19
            19-1439             BC059208.1         1-1421
            1440-4751           AC142504.2         3580-6891
FEATURES             Location/Qualifiers
     source          1..4751
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 36.17 cM"
     gene            1..4751
                     /gene="Rab8b"
                     /gene_synonym="5930437D16; D330025I23Rik"
                     /note="RAB8B, member RAS oncogene family"
                     /db_xref="GeneID:235442"
                     /db_xref="MGI:MGI:2442982"
     exon            1..196
                     /gene="Rab8b"
                     /gene_synonym="5930437D16; D330025I23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..696
                     /gene="Rab8b"
                     /gene_synonym="5930437D16; D330025I23Rik"
                     /note="RAB44, member RAS oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-8B"
                     /protein_id="NP_775589.1"
                     /db_xref="CCDS:CCDS23309.1"
                     /db_xref="GeneID:235442"
                     /db_xref="MGI:MGI:2442982"
                     /translation="MAKTYDYLFKLLLIGDSGVGKTCLLFRFSEDAFNTTFISTIGID
                     FKIRTIELDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIKNW
                     IRNIEEHASSDVERMILGNKCDMNDKRQVSKERGEKLAIDYGIKFLETSAKSSTNVEE
                     AFFTLARDIMTKLNRKMNDSNSSGAGGPVKITESRSKKTSFFRCSLL"
     exon            197..257
                     /gene="Rab8b"
                     /gene_synonym="5930437D16; D330025I23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            258..318
                     /gene="Rab8b"
                     /gene_synonym="5930437D16; D330025I23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            319..396
                     /gene="Rab8b"
                     /gene_synonym="5930437D16; D330025I23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            397..486
                     /gene="Rab8b"
                     /gene_synonym="5930437D16; D330025I23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            487..552
                     /gene="Rab8b"
                     /gene_synonym="5930437D16; D330025I23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            553..603
                     /gene="Rab8b"
                     /gene_synonym="5930437D16; D330025I23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            604..4751
                     /gene="Rab8b"
                     /gene_synonym="5930437D16; D330025I23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4726..4731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab8b"
                     /gene_synonym="5930437D16; D330025I23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4751
                     /gene="Rab8b"
                     /gene_synonym="5930437D16; D330025I23Rik"
                     /note="major polyA site"
ORIGIN      
        1 agaggccccc cctccgcgct gctttccacc gcctccttgc tcttggcggt cagagagggc
       61 cggagtgaga agatggcgaa gacgtacgat tatctgttca agctgctgct catcggcgac
      121 tccggcgttg gcaagacctg cctcctgttc cgcttctcag aggacgcctt caacaccacc
      181 tttatctcca ccatcggaat tgattttaaa atcagaacga tagaactcga cggaaagaaa
      241 attaaacttc agatatggga cacggcgggc caggaaagat tccgaacaat tacgacagca
      301 tactatagag gagccatggg aattatgctg gtctatgaca tcaccaatga aaaatccttt
      361 gacaatatta aaaattggat aagaaacatt gaagagcacg cctcttcaga tgttgaaaga
      421 atgatcctgg gtaacaaatg tgatatgaac gacaaaagac aagtgtcgaa agagagaggg
      481 gagaagttag caattgacta tgggattaaa tttttggaga caagtgcaaa gtcgagtaca
      541 aatgtagaag aggcattttt tacacttgca cgggatataa tgacaaaact caacaggaaa
      601 atgaacgaca gcaattcatc aggagcaggt gggccagtga agataacaga gagccggtct
      661 aagaagacca gtttcttccg ctgttctctg ctttgatgaa ctcctcattt ctgagagact
      721 gcagaatacc tagagggcct ttccctgcct ctctgaaagc acaggctacc cagcctcaga
      781 gtcacttcgc ccggctgctg cggagagcac ccccggaact cacacagacc accaagtgga
      841 ttccagcctt gtggcctagc aaaagagcgg actcctttct ttaaaaagca gaagcagtga
      901 tgtggagaca cacataggac ctaactggtt tttccttgtt ttactgcctg tcctggaagc
      961 tgctgtcttt ctttgcacat gcgtgtcagc ctttccctgg tacagcgtaa tcttagactc
     1021 ttaactgagc actttagtgg cataaagttc tacacttgta tatttgggga tgcttaaaga
     1081 cagcagagca ttaaacagag gttgacctgc tacaattaaa ggatggttag cctgggtcac
     1141 atggccaaaa attcttctgt tggtagattt attgaagggc tttgatttat agtattccta
     1201 atttgataaa tgttcaaaat ttataaaaat gcccatctag ccagaggcca tggcattgct
     1261 gtcttttcag ggagcaatca gccatgctca tccctgagta gctgtgtccc ctttgaagtt
     1321 gcctgtcctg cctcctccat ggactcagcc tctggaaagc actgcagcct cactgttcaa
     1381 gggttctgtt tgctgtccct tctcctgtgt gacttgctgg cgttatttac ttatctaaaa
     1441 cccatagtat gtgagcattg ctgtctgcct gtgcacttca tgagcagcga tctcacatag
     1501 gtagcgacgt ggtcatcaca gctgtctgtc cacatccacc tatggtcttg tcacattaga
     1561 gtatgcagta cattttttct gcgtttcacc cactagctta tatcacccag ttcttaacca
     1621 gaatccccat ctgcgagagt taacaaaggt tagatttaga ttttagtttg cagaaaacat
     1681 acgtaacata tacagagaga gattaaacat ataattttaa aagacagcta ttcgtaaggc
     1741 tgaaagaaat gactctttgg gtttttgttt gtttgcttgt tttgttttta agtaattaga
     1801 cctagcacat cctccagaaa tcttgtcttt tcattagagc acatatgatt caggtttcag
     1861 ctttcaaata gccattgctg ggtatctaag acctagccct gtttgcttag gtttgtcatt
     1921 agagaagtgg tgtggccatc caggccaaaa cacaccatag gcgtcactgc ctttctcacc
     1981 aaatgctgat tctgatgttt cttctgtggg tgaagccact gcactgggga cggggagggt
     2041 gttcagtgtt aacttttgtg ccaactatag atcataatgt cattgctatc ctaacacaga
     2101 gaacataaaa acaggtgaca gtggcaggca cttgtacctt aagatggatg tggatagctg
     2161 gttatacaga caattctgcc tcagattaag atctctggtt tcagtgtttg gaccagtcag
     2221 gccttcccat ctgttgggaa gctcagaaac attccagtgg ctgcaagtat cccaaagtta
     2281 tttttggtgg atatgctgac tctactgttg acaaacttca gccgtttctt ctttttcttt
     2341 agttacctat tggcttaaaa tcacacattg ctacccccgt gcaagcagtt tactcattga
     2401 gaacttatta caagtctaac attgtgaaat taaatacata tttgaaaaga acaagtattt
     2461 tcttagaaat gtcttatcac tacttttctg gaaaaaaagt tcaagcagtt acattggtca
     2521 caaagtactt tgcaaaaagc acaggccgtg acaccacata cgaatgtaat tctcttagta
     2581 tttacctctg actgtttggt gtcttagcac ttcggtttct atctcagggg ttgtctgcaa
     2641 accaaaactg acatgttctg tggtcagctt tttcttttct tttcttttct tcttttttgt
     2701 ttttgttttt ttttttaaac aaacaaaacc agaatgcttt gcttttgata tctccaccct
     2761 tctcgtgtct tttgtgggtt aataactagt ctccatgaac ttctctttga aagagcctat
     2821 aaatgttagg tgagtctgaa agtgctcttt gaagcagcag caatcgggga gtatatcctt
     2881 gttatataga aatacattgt ccttgctatt ttcttacatt taactttgct aaattgtata
     2941 taatttgagc tcagaccata ggaaagtcac tttctgcatg gtagaaacaa cccaacaaat
     3001 agtctacttt gcttaataat gtacatatgt gcattatttt ttctacttgt agatgaattt
     3061 agtgacagag aattgtctgt tccctgctga ggctgaagat atctagaagt gtgtgtgtgt
     3121 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgg tgagagagag agagagagag
     3181 agagagagag agagagagag agagagagag agagagagag agcgcctttc tgtggtcttc
     3241 tggatagggt acatagggat ttttgcagca gtattagtgg ttcagtggct gcactttatt
     3301 attgtgctaa tttttgacga ttggactcga aattttcaac tagagcctga gggtatcaaa
     3361 cagtgaaatg tactgtaact aagtagcatg tgaatcagtt gattgtaaac tgttccactg
     3421 ggaacttatt ctagcctcct gtagttcagg cagatgataa caaagtgatc tacctgtgta
     3481 ccagttgctg ccataggcct ttttactgtt catgtggaca ttttatgcag tctttgttat
     3541 aaattttctg aagactatgc tctttacttt gaaggactat ttcttttatt atacctcatt
     3601 tagctaactg atattctaat aaccagtaga aaacagtgag cccgcctcca ggcattcaac
     3661 acatttaggt tgcatgtttt gttttgtctt gttttgaact ggaggaaaag agaaatactt
     3721 tcgaataaag catgcatgtc aatacccagt agcatacaaa aatatgactt tcctgtccat
     3781 ccattaatga atttagttgt gcaatataat aggttgccct gcagtttatg agtaagaaat
     3841 tgtaactgca tttttcaagc tccaaatgct gagatctgta ttatggctta taaagtgtct
     3901 tcctatgagc agtaaaagga caaattaggc agactttctt ttcaagcttg tgacttagat
     3961 tcttttataa atatagttct taatctttaa agatgagatt ctaagcctag aattttaaaa
     4021 ccacatttca ttatggtggt ttactgatct cagattttct acaattcaat tttttcagac
     4081 ttaagaacag ctaaacaaaa ccttcctcta gctttttcat cacatccagt ggcagagagg
     4141 agtgtctgcg catgaaatcc cgggattccg gaggacatag caggtcaggg tacactgata
     4201 aaagttatga atttcctgtc cgttagaaag aagctaaacg actgagcata gagatggaga
     4261 gcaacgagca tttgttttaa ggattttccg gattttactg tgtatcttga agtgtgtgcc
     4321 atatgccaag aactaacaga actttgtgtc tcctctttgt acctttttca ttttttaaag
     4381 tgaacttatg gtcgttcatt cctgtggcct tacggatggg tttgtcttga ctgtttgcaa
     4441 ctgatgctgc agttccctta atgcaaaatg ccatgaactg tctgaataca gtcaggcccc
     4501 accatgggaa ctatggcgtt tcttcataga cttctacttg tgtgcttaaa cattttcttt
     4561 tgcttcagtg gcttactgtg ggaagctcct gtggatagta tggacctgcc atgtggctag
     4621 tctgttgaag ccagttcatt aactgtactg atactgatgt tgtgtttttt aaaaatgaat
     4681 tttattccag gtgaactttt tttttttaca ataatgttca tctaaaataa aaactacatg
     4741 ttgaaaaatg a
//
