LOCUS       NM_145509               4498 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus RAB7B, member RAS oncogene family (Rab7b), transcript
            variant 1, mRNA.
ACCESSION   NM_145509
VERSION     NM_145509.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4498)
  AUTHORS   Vestre,K., Persiconi,I., Borg Distefano,M., Mensali,N.,
            Guadagno,N.A., Bretou,M., Walchli,S., Arnold-Schrauf,C., Bakke,O.,
            Dalod,M., Lennon-Dumenil,A.M. and Progida,C.
  TITLE     Rab7b regulates dendritic cell migration by linking lysosomes to
            the actomyosin cytoskeleton
  JOURNAL   J Cell Sci 134 (18) (2021)
   PUBMED   34494097
REFERENCE   2  (bases 1 to 4498)
  AUTHORS   Marubashi,S. and Fukuda,M.
  TITLE     Rab7B/42 Is Functionally Involved in Protein Degradation on
            Melanosomes in Keratinocytes
  JOURNAL   Cell Struct Funct 45 (1), 45-55 (2020)
   PUBMED   32037382
  REMARK    GeneRIF: Rab7B/42 Is Functionally Involved in Protein Degradation
            on Melanosomes in Keratinocytes.
REFERENCE   3  (bases 1 to 4498)
  AUTHORS   Usami,Y., Hatano,T., Imai,S., Kubo,S., Sato,S., Saiki,S.,
            Fujioka,Y., Ohba,Y., Sato,F., Funayama,M., Eguchi,H., Shiba,K.,
            Ariga,H., Shen,J. and Hattori,N.
  TITLE     DJ-1 associates with synaptic membranes
  JOURNAL   Neurobiol Dis 43 (3), 651-662 (2011)
   PUBMED   21645620
REFERENCE   4  (bases 1 to 4498)
  AUTHORS   Yao,M., Liu,X., Li,D., Chen,T., Cai,Z. and Cao,X.
  TITLE     Late endosome/lysosome-localized Rab7b suppresses TLR9-initiated
            proinflammatory cytokine and type I IFN production in macrophages
  JOURNAL   J Immunol 183 (3), 1751-1758 (2009)
   PUBMED   19587007
REFERENCE   5  (bases 1 to 4498)
  AUTHORS   Trost,M., English,L., Lemieux,S., Courcelles,M., Desjardins,M. and
            Thibault,P.
  TITLE     The phagosomal proteome in interferon-gamma-activated macrophages
  JOURNAL   Immunity 30 (1), 143-154 (2009)
   PUBMED   19144319
REFERENCE   6  (bases 1 to 4498)
  AUTHORS   Wang,Y., Chen,T., Han,C., He,D., Liu,H., An,H., Cai,Z. and Cao,X.
  TITLE     Lysosome-associated small Rab GTPase Rab7b negatively regulates
            TLR4 signaling in macrophages by promoting lysosomal degradation of
            TLR4
  JOURNAL   Blood 110 (3), 962-971 (2007)
   PUBMED   17395780
REFERENCE   7  (bases 1 to 4498)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   8  (bases 1 to 4498)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   9  (bases 1 to 4498)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   10 (bases 1 to 4498)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030688.1, AC138277.16 and AK163610.1.
            
            On Jul 24, 2015 this sequence version replaced NM_145509.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030688.1, CX203101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AK030688.1         1-182
            183-183             AC138277.16        81248-81248         c
            184-1834            AK030688.1         184-1834
            1835-2519           AK030688.1         1836-2520
            2520-4498           AK163610.1         971-2949
FEATURES             Location/Qualifiers
     source          1..4498
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.18 cM"
     gene            1..4498
                     /gene="Rab7b"
                     /gene_synonym="5430435G22Rik"
                     /note="RAB7B, member RAS oncogene family"
                     /db_xref="GeneID:226421"
                     /db_xref="MGI:MGI:2442295"
     exon            1..141
                     /gene="Rab7b"
                     /gene_synonym="5430435G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            142..209
                     /gene="Rab7b"
                     /gene_synonym="5430435G22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..756
                     /gene="Rab7b"
                     /gene_synonym="5430435G22Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ras-related protein Rab-7b"
                     /codon_start=1
                     /product="ras-related protein Rab-7b isoform 1"
                     /protein_id="NP_663484.1"
                     /db_xref="CCDS:CCDS15272.1"
                     /db_xref="GeneID:226421"
                     /db_xref="MGI:MGI:2442295"
                     /translation="MNPRKKVDLKLIIVGALGVGKTSLLHQYVHKTFFEEYQTTLGAS
                     ILSKIIILDDTTLKLQIWDTGGQERFRSMVSTFYKGSDGCILAFDVTDPESFEALDIW
                     RDDVLAKIIPMEQSYPMVVLGNKIDLEDRKVSQEVVHGWCKEKDMPYFEVSAKNDINV
                     VQAFEVLASRALLRYQGTAENHLIDSIKLSPGQPKSRCC"
     exon            210..336
                     /gene="Rab7b"
                     /gene_synonym="5430435G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            337..552
                     /gene="Rab7b"
                     /gene_synonym="5430435G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            553..678
                     /gene="Rab7b"
                     /gene_synonym="5430435G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            679..4498
                     /gene="Rab7b"
                     /gene_synonym="5430435G22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2501..2506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab7b"
                     /gene_synonym="5430435G22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2523
                     /gene="Rab7b"
                     /gene_synonym="5430435G22Rik"
                     /note="major polyA site"
ORIGIN      
        1 aagtctgtgc acagaaagag aggaggaaaa ctcagaggga agtggcctct caccaaaacc
       61 gtttgcgttc tcaatactgg ccagattgaa actgccactc ctagaagaga gacccagacc
      121 tagaactccc acctgtgtga ggccctgaag cccctcatga atccccgaaa gaaagtggac
      181 ttgaaactta tcattgttgg tgcacttggc gtgggaaaga cctctcttct tcaccaatat
      241 gtacacaaaa catttttcga ggaataccag accacactgg gggccagcat cctctccaaa
      301 atcatcatat tggatgacac aactttgaag ctgcagatct gggacacagg tggtcaggag
      361 cggttccgct caatggtatc aacattctac aaaggttccg atggctgtat cctggcattt
      421 gatgttactg atccagagtc ctttgaagcc ctggatatct ggagggatga tgtcctggca
      481 aagattatcc ctatggagca gtcatatccc atggtggtgc tggggaacaa aatcgatctg
      541 gaagatagga aggtgtccca ggaggtggtc catgggtggt gtaaagagaa ggatatgcca
      601 tattttgaag ttagtgcgaa gaatgacatc aatgtggtac aagcctttga ggttctggcc
      661 agccgggctc tgttgaggta ccagggcacc gcagagaacc acctcataga ctccatcaag
      721 ctctctccag gccagccaaa gagcagatgc tgctgatctc ggcctccctc cggactcccg
      781 atgacagctg tgcagccatt ccaagtgcaa tcccaccagc cggtactcag ctaggaggct
      841 ggggcactgc agcaggaaag aatgtcacag gcaaatcctg gccccagaga aatcacgggc
      901 gtctccatga ctcaagctcc tctttctcct ctgcctcaac accgtcctgc tcatctctgc
      961 agacaaactg ctcccttcag caccacggac cgacaggttt ggatggagat gcaggtctga
     1021 ttccctcagc agtcagaaca tggaccgctc ctgacaggca gaagcctaca ggcctgagac
     1081 ttcccacagc ttctttcagg gagagctgag ggagcaagat aaaaacagtt gtacctattt
     1141 cctgggtgct caaacagctc ccataactga ccaggcctca gtgcgccctc tgccaaatga
     1201 gagttcccaa ggcttcccca tatcctaggg cgactgagaa ccataatctt catttaaatc
     1261 ccacgtgctg gtgtggacac acaggctcac tcctttggag agtatttttg atgccttcga
     1321 tgtacattgc actgaagtca ccagacacac aaagcagaca tgagtccttc actcccagaa
     1381 gcgcacctgg agagagaggg ccagcagaca tgagcaagac agacaacagc aacaaggtac
     1441 tgttttagac aaaggggcca agagggcttt cctgtgacgg tgaccgttgg gctggcagct
     1501 gcaggaagag ctacaggaag aacatgccag gagagggagc agctaggcca aggctctgag
     1561 gcaatgggca gagtgctgca ttccattccc tgaggactca aagctgctat ctcagagaaa
     1621 aaaaggccag ggatatcctg tccccagaag gtactttgat catttgatga ctggccacta
     1681 gggggcagaa gtgtcctctg cttttaggct gaggagttct gggaacactt gaaaagctgg
     1741 tgtttgtgtc aagaaaatgg ctgaagcttg tttccaggct gtaggaatgt tgaacctggg
     1801 ctagttgggt aaaaaaaaaa aaaaaaaaaa aaaatcaaat gtcttgattc aggcaacaaa
     1861 tcgaaatcag agacagatcc cagagcgagg tacttggaga gctgtggatt ctgtgtcctg
     1921 ttcatttcaa agctagaacc tatttttttt tccttctgtc ttcacactgc acagataggg
     1981 tggctcattc tgaaggaggt ggacagaacg aactttcagg gtcttcaatg gtcaggttca
     2041 tacctcatgc cttccacaga cattcctgtc tccacagaag tcttctttcc tgagttccaa
     2101 gcagatccga ggtgtcaatc tctaggaagc cagtcagggg gtaataactg ggggtctggg
     2161 ggctctgtct gcacccgcct agctctgagg tataaagcaa cttactaagg acagcagtca
     2221 caggaacaat gagccctgca tccttcagag atgaacactg tgcccccgtc acacattggt
     2281 gtggctctcc tgaagtcaga ctgtggaggg atgtgtgtgg ggaggtgtgc attcggcagc
     2341 acgatgaaca taaggaccat atctaagggt acgcagcaaa tagtatgtgt ttccattgtt
     2401 tatatccttt atgggacaat agtccctctt ggtcagtgat accagtctca gttacccatg
     2461 gtcaactgtg gaccaaaaat attaaatagc aaatcccaga aataaataac ttacaacttt
     2521 caatgcacgt gtcatttgaa ggagtgtggt gaaccgctgc gccatcctac ccaggtcagt
     2581 tgcctttgct ctattctgtg catctaatcc agcagttact ttgtagctgt ctcagatgta
     2641 tcaactgcca tcattccaaa tgcctctatt aatagtaacc aaagttacgc cacaataccc
     2701 atgtcactat ctcatcactg agatacgcca tcatctcatg ttgtcacatg aggataaggt
     2761 cgggaacagt acagtatctt tagaatatgc atttatagcc ttttattact tgtacagact
     2821 catggtcatt taatttattg tcaattattg tccatctctt gctgtaccta atttattcat
     2881 tatactctgt catacgcttg tgtgactagg aggaaacata gcacctgggg gcgggattag
     2941 tactatgtaa ctttagatat ctatggggga gggggatgtc caggagtttc tttggacgag
     3001 aagagactat ggtgtttgct ttttaatttt ttaaaaaaaa aaatctatgt cagcataatt
     3061 ggcatgtcaa cgatgttaaa gtgtaggcag taaaagccac atcatttcat ttccagggcc
     3121 ccgtaaaaaa gtgagattgt tcaaaaatta agacttcaag acagcaataa cagcatccga
     3181 cattggaggt gaaccctcct gaggactcac ctccccgtga cgtggtcctg agaaagcagt
     3241 gagctttcag ctcaaacaac agagctctgg cccgaccctg ctggacacac tgtagcctga
     3301 agggaaggct ctgccacagc cttaaagcac atgacataga ttctgtgtcc tctttagagt
     3361 catagcacag actaaatatt ccaaatggaa gcagggacct gtgggcctgg agactcacag
     3421 atatcctatt acaactggga gatgtgctga ccaatcccca gggcagagtg agctgagctg
     3481 acaaccagac ccacagtaag ggtccctgcg agccactgta gcccaaccat gagtcaccct
     3541 gagttggaga ctggccctta gcatccatgc cagcaggcac aggaacttca ccccaccaca
     3601 gcgacatcta agttgggcgc ggtggcaaca tatcccaggc cctcttcata gtcatccctt
     3661 caagaaaaag accccagtca acaggattct attgatcggg ctcaccacag cctcgctcaa
     3721 gtggagcacc cttggctgct ggtcaacgga gaactcagat caggactccc cgcagcatgt
     3781 atccttgggg ctcgggaaaa gaacaaagcc aaatcttatc accaaacaaa gcaggcttgg
     3841 acgttaggcc ctgccctcag ggacttggga aaatgcccat ttctgctgcc gtttgctccc
     3901 acataacaga gcttttctac tgctgcctgg tggttgggct gtctatccct cggccacaga
     3961 cagcttctca ggctctgctt gcagtcccac accggcctct ggcacccaag agcagccttg
     4021 tgtgcactct ctctgtgcac atcacagtga ccaacagcag cagctcgact gggacaggag
     4081 agccacagat gaggacttct gtggctttca cttaccctcg tctccctccc cctgctccag
     4141 agcagtgctg gggagctgtt ggttagacac aggtagctct gggatgagta gcgcccacta
     4201 ctgttcgcta tgcttcctct ccatgaagac agggcctgct ctagtttttg ttttgagaga
     4261 aggggtgctt tttgttgttt tttatgggga gggggctgat aggtttgtct tttgttgtag
     4321 ttattgatgc gcagccttga acttggtatt cttcggcctc aggctcccag ttgctagggt
     4381 gggcgtgttt tgattcaccg cactcagctt tacagactgg cggacagtag gggatggatg
     4441 agttttagtg gactactgcc catctattct ttaaataaat acataaatgg attttact
//
