LOCUS       NM_009005               2173 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus RAB7, member RAS oncogene family (Rab7), transcript
            variant 2, mRNA.
ACCESSION   NM_009005 XM_006505761
VERSION     NM_009005.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2173)
  AUTHORS   Ke,J., Pan,J., Lin,H., Huang,S., Zhang,J., Wang,C., Chang,A.C.Y.
            and Gu,J.
  TITLE     Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid
            Toxicity in Diabetic Cardiomyopathy
  JOURNAL   Adv Sci (Weinh) 11 (29), e2401676 (2024)
   PUBMED   38837607
  REMARK    GeneRIF: Targeting Rab7-Rilp Mediated Microlipophagy Alleviates
            Lipid Toxicity in Diabetic Cardiomyopathy.
REFERENCE   2  (bases 1 to 2173)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2173)
  AUTHORS   Kim,M., Park,J.H., Go,M., Lee,N., Seo,J., Lee,H., Kim,D., Ha,H.,
            Kim,T., Jeong,M.S., Kim,S., Kim,T., Kim,H.S., Kang,D., Shim,H. and
            Lee,S.Y.
  TITLE     RUFY4 deletion prevents pathological bone loss by blocking
            endo-lysosomal trafficking of osteoclasts
  JOURNAL   Bone Res 12 (1), 29 (2024)
   PUBMED   38744829
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2173)
  AUTHORS   Li,C., Fu,J., Shao,S. and Luo,Z.Q.
  TITLE     Legionella pneumophila exploits the endo-lysosomal network for
            phagosome biogenesis by co-opting SUMOylated Rab7
  JOURNAL   PLoS Pathog 20 (5), e1011783 (2024)
   PUBMED   38739652
  REMARK    GeneRIF: Legionella pneumophila exploits the endo-lysosomal network
            for phagosome biogenesis by co-opting SUMOylated Rab7.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2173)
  AUTHORS   Liang,X., Wang,Y., Li,S., Fan,J., Zhou,F., Li,X., Li,S. and Li,Y.
  TITLE     Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression Improves
            Mitophagy in Alzheimer's Disease Models
  JOURNAL   J Alzheimers Dis 100 (1), 279-296 (2024)
   PUBMED   38848175
  REMARK    GeneRIF: Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression
            Improves Mitophagy in Alzheimer's Disease Models.
REFERENCE   6  (bases 1 to 2173)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (bases 1 to 2173)
  AUTHORS   Chiariello,M., De Gregorio,L., Vitelli,R., Alifano,P.,
            Dragani,T.A., Bruni,C.B. and Bucci,C.
  TITLE     Genetic mapping of the mouse Rab7 gene and pseudogene and of the
            human RAB7 homolog
  JOURNAL   Mamm Genome 9 (6), 448-452 (1998)
   PUBMED   9585432
REFERENCE   8  (bases 1 to 2173)
  AUTHORS   Vitelli,R., Chiariello,M., Lattero,D., Bruni,C.B. and Bucci,C.
  TITLE     Molecular cloning and expression analysis of the human Rab7 GTP-ase
            complementary deoxyribonucleic acid
  JOURNAL   Biochem Biophys Res Commun 229 (3), 887-890 (1996)
   PUBMED   8954989
REFERENCE   9  (bases 1 to 2173)
  AUTHORS   Vitelli,R., Chiariello,M., Bruni,C.B. and Bucci,C.
  TITLE     Cloning and expression analysis of the murine Rab7 cDNA
  JOURNAL   Biochim Biophys Acta 1264 (3), 268-270 (1995)
   PUBMED   8547311
REFERENCE   10 (bases 1 to 2173)
  AUTHORS   Carroll,J.M., Romero,M.R. and Watt,F.M.
  TITLE     Suprabasal integrin expression in the epidermis of transgenic mice
            results in developmental defects and a phenotype resembling
            psoriasis
  JOURNAL   Cell 83 (6), 957-968 (1995)
   PUBMED   8521519
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY291181.1, AK148117.1, AK158971.1 and CD774636.1.
            
            On or before Jun 12, 2014 this sequence version replaced
            XM_006505761.1, NM_009005.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086793.1, AK154234.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BY291181.1         2-8
            8-1178              AK148117.1         1-1171
            1179-2148           AK158971.1         1063-2032
            2149-2173           CD774636.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2173
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.13 cM"
     gene            1..2173
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="RAB7, member RAS oncogene family"
                     /db_xref="GeneID:19349"
                     /db_xref="MGI:MGI:105068"
     exon            1..198
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            199..259
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..830
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-7a"
                     /protein_id="NP_033031.2"
                     /db_xref="CCDS:CCDS39552.1"
                     /db_xref="GeneID:19349"
                     /db_xref="MGI:MGI:105068"
                     /translation="MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGAD
                     FLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSW
                     RDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAI
                     NVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKASAESCSC"
     exon            260..386
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            387..605
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            606..734
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            735..2159
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1761..1766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="hexamer: ATTAAA"
     polyA_site      1782
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
     regulatory      2133..2138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="hexamer: AATAAA"
     polyA_site      2154
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="major polyA site"
ORIGIN      
        1 gtctcgtgac agacacttcc gctcggggcg gcggcggtgg cggaagtgga agcaaggccg
       61 gagctttgac cataaagccc aaggcggcgg cgttggcggc ggtgtttggg gccgggcagc
      121 tccgaggagc ctgctggagc cggaatcgga cgtctctgtt gcggcctgcg ttgtgtctcc
      181 tcctccgttg accctgcgct tcaaggatga cctctaggaa gaaagtgttg ctgaaggtca
      241 tcatcctggg ggactctggt gttggaaaga cctctctcat gaaccagtat gtgaacaaga
      301 agttcagtaa ccagtacaaa gccacaatag gagcggactt tctgaccaag gaggtgatgg
      361 tggacgacag acttgttacc atgcagatct gggacacagc cggtcaagaa cggttccagt
      421 ctcttggtgt ggccttctac agaggtgcag attgctgtgt tctggtgttt gatgtgactg
      481 cccccaacac tttcaaaacc ctcgacagct ggagagacga gtttctcatc caggccagcc
      541 cccgggatcc cgagaacttc ccttttgttg tgttgggaaa caagattgac ctggaaaaca
      601 gacaagtggc cacaaagagg gcacaggctt ggtgctacag caaaaacaac attccttact
      661 tcgagaccag tgccaaggag gccatcaatg tggagcaggc cttccagaca attgctcgga
      721 atgcccttaa acaggaaaca gaagtggaac tgtacaatga attccctgaa cccatcaaac
      781 tggacaagaa tgaccgggcc aaggcctccg cagaaagctg cagttgttga aggggcagtg
      841 agcacagagt ccttcacaga ccaagaacac acacgtaggc cttcaatatg cgtccctcct
      901 cctccaaaca gaccagaacg tgagctctca catccagctg ccaaaagaaa ctccaccgaa
      961 cagttaccca acacacacac atacacaaaa cacactcgtg cacacaaaaa cacatacaca
     1021 caacacacac acagcaagca aactccagcc tgtgcctgtc agggctcctg gggcagctgc
     1081 ccgcctcgtg ggccctgtgt atggcaggca tatggcagag accctgggtg ctctggggtg
     1141 cagtgggcat ggaaagctta ctctttttgt ccactggaga gtgagagaac tgttcacagt
     1201 tcatctgtgt ctaattatct gatttttttt ttaacggtct tgtggtcttt tacccctccc
     1261 tccttgaagg tcctgtggga aggctggtgc ccaggctccg ttctgagcag gctgttttgt
     1321 atgtatctgt taatgcttgt tacttttaac taatcagatc tttttacagt atccatttat
     1381 tatgtaatgc ttcttagaaa agaatcttat agtacatgtt aatatatgca accaattaaa
     1441 atgtataaat tagtgtaagg aattcctgga ttgtgtgttt aagtcctcta acgcaggcgt
     1501 gcaaggtgga gggttgaacc ctgtctggat tacagagtgt tagagactca agtttggaag
     1561 tccagctagc ggcagtattc tgtacagtag acacaagaat tatgtacgcc ttttatcaca
     1621 gacttaagag ccaaaaagct tttcatctct ctgaagggaa aactgaacta gacagttccc
     1681 ttctgtgtct aaattttcca aaaggttgat ttgcttaata tagtagtgta tacaatggat
     1741 aaattgctgt tacttcaaga attaaaattc tcattttctc cctttctgtt ttttttcctt
     1801 atattcaaca ctttatgatg cccttttgtc actatcctac tcaaagagga aaggagaacc
     1861 caccagacct gtcccagtga ctctaccttt gttctagaag gcgctccttt cagggttgtg
     1921 gtacctgtag gttagcagac cctcctcctt tcccacccac ccaagtgtgg cccagcacta
     1981 acccaccgtc tcttgggttg agccctggca gttctgtccc ttcccgaggt cctgccctgc
     2041 atcatggctt gcttcctgga gcacttcccc ttcagaggtc tacattctag ggtgtaggct
     2101 gagttcttct gtaaagagac gaacgtgatg ccaataaaat ttaacaagaa caaagaacaa
     2161 aaaaaaaaaa aaa
//
