LOCUS       NM_001293655            2135 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus RAB7, member RAS oncogene family (Rab7), transcript
            variant 5, mRNA.
ACCESSION   NM_001293655
VERSION     NM_001293655.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2135)
  AUTHORS   Ke,J., Pan,J., Lin,H., Huang,S., Zhang,J., Wang,C., Chang,A.C.Y.
            and Gu,J.
  TITLE     Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid
            Toxicity in Diabetic Cardiomyopathy
  JOURNAL   Adv Sci (Weinh) 11 (29), e2401676 (2024)
   PUBMED   38837607
  REMARK    GeneRIF: Targeting Rab7-Rilp Mediated Microlipophagy Alleviates
            Lipid Toxicity in Diabetic Cardiomyopathy.
REFERENCE   2  (bases 1 to 2135)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2135)
  AUTHORS   Kim,M., Park,J.H., Go,M., Lee,N., Seo,J., Lee,H., Kim,D., Ha,H.,
            Kim,T., Jeong,M.S., Kim,S., Kim,T., Kim,H.S., Kang,D., Shim,H. and
            Lee,S.Y.
  TITLE     RUFY4 deletion prevents pathological bone loss by blocking
            endo-lysosomal trafficking of osteoclasts
  JOURNAL   Bone Res 12 (1), 29 (2024)
   PUBMED   38744829
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2135)
  AUTHORS   Li,C., Fu,J., Shao,S. and Luo,Z.Q.
  TITLE     Legionella pneumophila exploits the endo-lysosomal network for
            phagosome biogenesis by co-opting SUMOylated Rab7
  JOURNAL   PLoS Pathog 20 (5), e1011783 (2024)
   PUBMED   38739652
  REMARK    GeneRIF: Legionella pneumophila exploits the endo-lysosomal network
            for phagosome biogenesis by co-opting SUMOylated Rab7.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2135)
  AUTHORS   Liang,X., Wang,Y., Li,S., Fan,J., Zhou,F., Li,X., Li,S. and Li,Y.
  TITLE     Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression Improves
            Mitophagy in Alzheimer's Disease Models
  JOURNAL   J Alzheimers Dis 100 (1), 279-296 (2024)
   PUBMED   38848175
  REMARK    GeneRIF: Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression
            Improves Mitophagy in Alzheimer's Disease Models.
REFERENCE   6  (bases 1 to 2135)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (bases 1 to 2135)
  AUTHORS   Chiariello,M., De Gregorio,L., Vitelli,R., Alifano,P.,
            Dragani,T.A., Bruni,C.B. and Bucci,C.
  TITLE     Genetic mapping of the mouse Rab7 gene and pseudogene and of the
            human RAB7 homolog
  JOURNAL   Mamm Genome 9 (6), 448-452 (1998)
   PUBMED   9585432
REFERENCE   8  (bases 1 to 2135)
  AUTHORS   Vitelli,R., Chiariello,M., Lattero,D., Bruni,C.B. and Bucci,C.
  TITLE     Molecular cloning and expression analysis of the human Rab7 GTP-ase
            complementary deoxyribonucleic acid
  JOURNAL   Biochem Biophys Res Commun 229 (3), 887-890 (1996)
   PUBMED   8954989
REFERENCE   9  (bases 1 to 2135)
  AUTHORS   Vitelli,R., Chiariello,M., Bruni,C.B. and Bucci,C.
  TITLE     Cloning and expression analysis of the murine Rab7 cDNA
  JOURNAL   Biochim Biophys Acta 1264 (3), 268-270 (1995)
   PUBMED   8547311
REFERENCE   10 (bases 1 to 2135)
  AUTHORS   Carroll,J.M., Romero,M.R. and Watt,F.M.
  TITLE     Suprabasal integrin expression in the epidermis of transgenic mice
            results in developmental defects and a phenotype resembling
            psoriasis
  JOURNAL   Cell 83 (6), 957-968 (1995)
   PUBMED   8521519
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135659.1, AK139914.1, AK158971.1 and CD774636.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139914.1, ERR3363658.1978387.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849375,
                                           SAMN00849380 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AK135659.1         2-13
            13-797              AK139914.1         4-788
            798-2110            AK158971.1         720-2032
            2111-2135           CD774636.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2135
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.13 cM"
     gene            1..2135
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="RAB7, member RAS oncogene family"
                     /db_xref="GeneID:19349"
                     /db_xref="MGI:MGI:105068"
     exon            1..160
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            161..221
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..792
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-7a"
                     /protein_id="NP_001280584.1"
                     /db_xref="CCDS:CCDS39552.1"
                     /db_xref="GeneID:19349"
                     /db_xref="MGI:MGI:105068"
                     /translation="MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGAD
                     FLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSW
                     RDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAI
                     NVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKASAESCSC"
     exon            222..348
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            349..567
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            568..696
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            697..2121
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1723..1728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="hexamer: ATTAAA"
     polyA_site      1744
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
     regulatory      2095..2100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="hexamer: AATAAA"
     polyA_site      2116
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="major polyA site"
ORIGIN      
        1 gatttggcaa ctgttctcac cgggaacggc aacgtggctg gctttctggc acactcttag
       61 agttttgggc tattccacct tctctctcaa gctccatcgt gtgcagtagc acctcagttg
      121 cccaggtaca ggaaaggccc cggaaggttg gaaagtggag cttcaaggat gacctctagg
      181 aagaaagtgt tgctgaaggt catcatcctg ggggactctg gtgttggaaa gacctctctc
      241 atgaaccagt atgtgaacaa gaagttcagt aaccagtaca aagccacaat aggagcggac
      301 tttctgacca aggaggtgat ggtggacgac agacttgtta ccatgcagat ctgggacaca
      361 gccggtcaag aacggttcca gtctcttggt gtggccttct acagaggtgc agattgctgt
      421 gttctggtgt ttgatgtgac tgcccccaac actttcaaaa ccctcgacag ctggagagac
      481 gagtttctca tccaggccag cccccgggat cccgagaact tcccttttgt tgtgttggga
      541 aacaagattg acctggaaaa cagacaagtg gccacaaaga gggcacaggc ttggtgctac
      601 agcaaaaaca acattcctta cttcgagacc agtgccaagg aggccatcaa tgtggagcag
      661 gccttccaga caattgctcg gaatgccctt aaacaggaaa cagaagtgga actgtacaat
      721 gaattccctg aacccatcaa actggacaag aatgaccggg ccaaggcctc cgcagaaagc
      781 tgcagttgtt gaaggggcag tgagcacaga gtccttcaca gaccaagaac acacacgtag
      841 gccttcaata tgcgtccctc ctcctccaaa cagaccagaa cgtgagctct cacatccagc
      901 tgccaaaaga aactccaccg aacagttacc caacacacac acatacacaa aacacactcg
      961 tgcacacaaa aacacataca cacaacacac acacagcaag caaactccag cctgtgcctg
     1021 tcagggctcc tggggcagct gcccgcctcg tgggccctgt gtatggcagg catatggcag
     1081 agaccctggg tgctctgggg tgcagtgggc atggaaagct tactcttttt gtccactgga
     1141 gagtgagaga actgttcaca gttcatctgt gtctaattat ctgatttttt ttttaacggt
     1201 cttgtggtct tttacccctc cctccttgaa ggtcctgtgg gaaggctggt gcccaggctc
     1261 cgttctgagc aggctgtttt gtatgtatct gttaatgctt gttactttta actaatcaga
     1321 tctttttaca gtatccattt attatgtaat gcttcttaga aaagaatctt atagtacatg
     1381 ttaatatatg caaccaatta aaatgtataa attagtgtaa ggaattcctg gattgtgtgt
     1441 ttaagtcctc taacgcaggc gtgcaaggtg gagggttgaa ccctgtctgg attacagagt
     1501 gttagagact caagtttgga agtccagcta gcggcagtat tctgtacagt agacacaaga
     1561 attatgtacg ccttttatca cagacttaag agccaaaaag cttttcatct ctctgaaggg
     1621 aaaactgaac tagacagttc ccttctgtgt ctaaattttc caaaaggttg atttgcttaa
     1681 tatagtagtg tatacaatgg ataaattgct gttacttcaa gaattaaaat tctcattttc
     1741 tccctttctg ttttttttcc ttatattcaa cactttatga tgcccttttg tcactatcct
     1801 actcaaagag gaaaggagaa cccaccagac ctgtcccagt gactctacct ttgttctaga
     1861 aggcgctcct ttcagggttg tggtacctgt aggttagcag accctcctcc tttcccaccc
     1921 acccaagtgt ggcccagcac taacccaccg tctcttgggt tgagccctgg cagttctgtc
     1981 ccttcccgag gtcctgccct gcatcatggc ttgcttcctg gagcacttcc ccttcagagg
     2041 tctacattct agggtgtagg ctgagttctt ctgtaaagag acgaacgtga tgccaataaa
     2101 atttaacaag aacaaagaac aaaaaaaaaa aaaaa
//
