LOCUS       NM_001293654            2222 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus RAB7, member RAS oncogene family (Rab7), transcript
            variant 4, mRNA.
ACCESSION   NM_001293654 XM_006505762
VERSION     NM_001293654.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2222)
  AUTHORS   Ke,J., Pan,J., Lin,H., Huang,S., Zhang,J., Wang,C., Chang,A.C.Y.
            and Gu,J.
  TITLE     Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid
            Toxicity in Diabetic Cardiomyopathy
  JOURNAL   Adv Sci (Weinh) 11 (29), e2401676 (2024)
   PUBMED   38837607
  REMARK    GeneRIF: Targeting Rab7-Rilp Mediated Microlipophagy Alleviates
            Lipid Toxicity in Diabetic Cardiomyopathy.
REFERENCE   2  (bases 1 to 2222)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2222)
  AUTHORS   Kim,M., Park,J.H., Go,M., Lee,N., Seo,J., Lee,H., Kim,D., Ha,H.,
            Kim,T., Jeong,M.S., Kim,S., Kim,T., Kim,H.S., Kang,D., Shim,H. and
            Lee,S.Y.
  TITLE     RUFY4 deletion prevents pathological bone loss by blocking
            endo-lysosomal trafficking of osteoclasts
  JOURNAL   Bone Res 12 (1), 29 (2024)
   PUBMED   38744829
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2222)
  AUTHORS   Li,C., Fu,J., Shao,S. and Luo,Z.Q.
  TITLE     Legionella pneumophila exploits the endo-lysosomal network for
            phagosome biogenesis by co-opting SUMOylated Rab7
  JOURNAL   PLoS Pathog 20 (5), e1011783 (2024)
   PUBMED   38739652
  REMARK    GeneRIF: Legionella pneumophila exploits the endo-lysosomal network
            for phagosome biogenesis by co-opting SUMOylated Rab7.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2222)
  AUTHORS   Liang,X., Wang,Y., Li,S., Fan,J., Zhou,F., Li,X., Li,S. and Li,Y.
  TITLE     Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression Improves
            Mitophagy in Alzheimer's Disease Models
  JOURNAL   J Alzheimers Dis 100 (1), 279-296 (2024)
   PUBMED   38848175
  REMARK    GeneRIF: Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression
            Improves Mitophagy in Alzheimer's Disease Models.
REFERENCE   6  (bases 1 to 2222)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (bases 1 to 2222)
  AUTHORS   Chiariello,M., De Gregorio,L., Vitelli,R., Alifano,P.,
            Dragani,T.A., Bruni,C.B. and Bucci,C.
  TITLE     Genetic mapping of the mouse Rab7 gene and pseudogene and of the
            human RAB7 homolog
  JOURNAL   Mamm Genome 9 (6), 448-452 (1998)
   PUBMED   9585432
REFERENCE   8  (bases 1 to 2222)
  AUTHORS   Vitelli,R., Chiariello,M., Lattero,D., Bruni,C.B. and Bucci,C.
  TITLE     Molecular cloning and expression analysis of the human Rab7 GTP-ase
            complementary deoxyribonucleic acid
  JOURNAL   Biochem Biophys Res Commun 229 (3), 887-890 (1996)
   PUBMED   8954989
REFERENCE   9  (bases 1 to 2222)
  AUTHORS   Vitelli,R., Chiariello,M., Bruni,C.B. and Bucci,C.
  TITLE     Cloning and expression analysis of the murine Rab7 cDNA
  JOURNAL   Biochim Biophys Acta 1264 (3), 268-270 (1995)
   PUBMED   8547311
REFERENCE   10 (bases 1 to 2222)
  AUTHORS   Carroll,J.M., Romero,M.R. and Watt,F.M.
  TITLE     Suprabasal integrin expression in the epidermis of transgenic mice
            results in developmental defects and a phenotype resembling
            psoriasis
  JOURNAL   Cell 83 (6), 957-968 (1995)
   PUBMED   8521519
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135659.1, AK158971.1 and CD774636.1.
            
            On Jun 12, 2014 this sequence version replaced XM_006505762.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135659.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164131,
                                           SAMN01164139 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-670               AK135659.1         2-671
            671-2197            AK158971.1         506-2032
            2198-2222           CD774636.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2222
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.13 cM"
     gene            1..2222
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="RAB7, member RAS oncogene family"
                     /db_xref="GeneID:19349"
                     /db_xref="MGI:MGI:105068"
     exon            1..160
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            161..247
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            248..308
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..879
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-7a"
                     /protein_id="NP_001280583.1"
                     /db_xref="CCDS:CCDS39552.1"
                     /db_xref="GeneID:19349"
                     /db_xref="MGI:MGI:105068"
                     /translation="MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGAD
                     FLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSW
                     RDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAI
                     NVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKASAESCSC"
     exon            309..435
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            436..654
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            655..783
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            784..2208
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1810..1815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="hexamer: ATTAAA"
     polyA_site      1831
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
     regulatory      2182..2187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="hexamer: AATAAA"
     polyA_site      2203
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="major polyA site"
ORIGIN      
        1 gatttggcaa ctgttctcac cgggaacggc aacgtggctg gctttctggc acactcttag
       61 agttttgggc tattccacct tctctctcaa gctccatcgt gtgcagtagc acctcagttg
      121 cccaggtaca ggaaaggccc cggaaggttg gaaagtggag gctttaggac cggggattga
      181 gctcaggtca tcaggtttgg aggcaagagc ccttatctgc tgagccatct cactgacccc
      241 agagacactt caaggatgac ctctaggaag aaagtgttgc tgaaggtcat catcctgggg
      301 gactctggtg ttggaaagac ctctctcatg aaccagtatg tgaacaagaa gttcagtaac
      361 cagtacaaag ccacaatagg agcggacttt ctgaccaagg aggtgatggt ggacgacaga
      421 cttgttacca tgcagatctg ggacacagcc ggtcaagaac ggttccagtc tcttggtgtg
      481 gccttctaca gaggtgcaga ttgctgtgtt ctggtgtttg atgtgactgc ccccaacact
      541 ttcaaaaccc tcgacagctg gagagacgag tttctcatcc aggccagccc ccgggatccc
      601 gagaacttcc cttttgttgt gttgggaaac aagattgacc tggaaaacag acaagtggcc
      661 acaaagaggg cacaggcttg gtgctacagc aaaaacaaca ttccttactt cgagaccagt
      721 gccaaggagg ccatcaatgt ggagcaggcc ttccagacaa ttgctcggaa tgcccttaaa
      781 caggaaacag aagtggaact gtacaatgaa ttccctgaac ccatcaaact ggacaagaat
      841 gaccgggcca aggcctccgc agaaagctgc agttgttgaa ggggcagtga gcacagagtc
      901 cttcacagac caagaacaca cacgtaggcc ttcaatatgc gtccctcctc ctccaaacag
      961 accagaacgt gagctctcac atccagctgc caaaagaaac tccaccgaac agttacccaa
     1021 cacacacaca tacacaaaac acactcgtgc acacaaaaac acatacacac aacacacaca
     1081 cagcaagcaa actccagcct gtgcctgtca gggctcctgg ggcagctgcc cgcctcgtgg
     1141 gccctgtgta tggcaggcat atggcagaga ccctgggtgc tctggggtgc agtgggcatg
     1201 gaaagcttac tctttttgtc cactggagag tgagagaact gttcacagtt catctgtgtc
     1261 taattatctg attttttttt taacggtctt gtggtctttt acccctccct ccttgaaggt
     1321 cctgtgggaa ggctggtgcc caggctccgt tctgagcagg ctgttttgta tgtatctgtt
     1381 aatgcttgtt acttttaact aatcagatct ttttacagta tccatttatt atgtaatgct
     1441 tcttagaaaa gaatcttata gtacatgtta atatatgcaa ccaattaaaa tgtataaatt
     1501 agtgtaagga attcctggat tgtgtgttta agtcctctaa cgcaggcgtg caaggtggag
     1561 ggttgaaccc tgtctggatt acagagtgtt agagactcaa gtttggaagt ccagctagcg
     1621 gcagtattct gtacagtaga cacaagaatt atgtacgcct tttatcacag acttaagagc
     1681 caaaaagctt ttcatctctc tgaagggaaa actgaactag acagttccct tctgtgtcta
     1741 aattttccaa aaggttgatt tgcttaatat agtagtgtat acaatggata aattgctgtt
     1801 acttcaagaa ttaaaattct cattttctcc ctttctgttt tttttcctta tattcaacac
     1861 tttatgatgc ccttttgtca ctatcctact caaagaggaa aggagaaccc accagacctg
     1921 tcccagtgac tctacctttg ttctagaagg cgctcctttc agggttgtgg tacctgtagg
     1981 ttagcagacc ctcctccttt cccacccacc caagtgtggc ccagcactaa cccaccgtct
     2041 cttgggttga gccctggcag ttctgtccct tcccgaggtc ctgccctgca tcatggcttg
     2101 cttcctggag cacttcccct tcagaggtct acattctagg gtgtaggctg agttcttctg
     2161 taaagagacg aacgtgatgc caataaaatt taacaagaac aaagaacaaa aaaaaaaaaa
     2221 aa
//
