LOCUS       NM_001293653            2056 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus RAB7, member RAS oncogene family (Rab7), transcript
            variant 3, mRNA.
ACCESSION   NM_001293653
VERSION     NM_001293653.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2056)
  AUTHORS   Ke,J., Pan,J., Lin,H., Huang,S., Zhang,J., Wang,C., Chang,A.C.Y.
            and Gu,J.
  TITLE     Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid
            Toxicity in Diabetic Cardiomyopathy
  JOURNAL   Adv Sci (Weinh) 11 (29), e2401676 (2024)
   PUBMED   38837607
  REMARK    GeneRIF: Targeting Rab7-Rilp Mediated Microlipophagy Alleviates
            Lipid Toxicity in Diabetic Cardiomyopathy.
REFERENCE   2  (bases 1 to 2056)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2056)
  AUTHORS   Kim,M., Park,J.H., Go,M., Lee,N., Seo,J., Lee,H., Kim,D., Ha,H.,
            Kim,T., Jeong,M.S., Kim,S., Kim,T., Kim,H.S., Kang,D., Shim,H. and
            Lee,S.Y.
  TITLE     RUFY4 deletion prevents pathological bone loss by blocking
            endo-lysosomal trafficking of osteoclasts
  JOURNAL   Bone Res 12 (1), 29 (2024)
   PUBMED   38744829
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2056)
  AUTHORS   Li,C., Fu,J., Shao,S. and Luo,Z.Q.
  TITLE     Legionella pneumophila exploits the endo-lysosomal network for
            phagosome biogenesis by co-opting SUMOylated Rab7
  JOURNAL   PLoS Pathog 20 (5), e1011783 (2024)
   PUBMED   38739652
  REMARK    GeneRIF: Legionella pneumophila exploits the endo-lysosomal network
            for phagosome biogenesis by co-opting SUMOylated Rab7.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2056)
  AUTHORS   Liang,X., Wang,Y., Li,S., Fan,J., Zhou,F., Li,X., Li,S. and Li,Y.
  TITLE     Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression Improves
            Mitophagy in Alzheimer's Disease Models
  JOURNAL   J Alzheimers Dis 100 (1), 279-296 (2024)
   PUBMED   38848175
  REMARK    GeneRIF: Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression
            Improves Mitophagy in Alzheimer's Disease Models.
REFERENCE   6  (bases 1 to 2056)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (bases 1 to 2056)
  AUTHORS   Chiariello,M., De Gregorio,L., Vitelli,R., Alifano,P.,
            Dragani,T.A., Bruni,C.B. and Bucci,C.
  TITLE     Genetic mapping of the mouse Rab7 gene and pseudogene and of the
            human RAB7 homolog
  JOURNAL   Mamm Genome 9 (6), 448-452 (1998)
   PUBMED   9585432
REFERENCE   8  (bases 1 to 2056)
  AUTHORS   Vitelli,R., Chiariello,M., Lattero,D., Bruni,C.B. and Bucci,C.
  TITLE     Molecular cloning and expression analysis of the human Rab7 GTP-ase
            complementary deoxyribonucleic acid
  JOURNAL   Biochem Biophys Res Commun 229 (3), 887-890 (1996)
   PUBMED   8954989
REFERENCE   9  (bases 1 to 2056)
  AUTHORS   Vitelli,R., Chiariello,M., Bruni,C.B. and Bucci,C.
  TITLE     Cloning and expression analysis of the murine Rab7 cDNA
  JOURNAL   Biochim Biophys Acta 1264 (3), 268-270 (1995)
   PUBMED   8547311
REFERENCE   10 (bases 1 to 2056)
  AUTHORS   Carroll,J.M., Romero,M.R. and Watt,F.M.
  TITLE     Suprabasal integrin expression in the epidermis of transgenic mice
            results in developmental defects and a phenotype resembling
            psoriasis
  JOURNAL   Cell 83 (6), 957-968 (1995)
   PUBMED   8521519
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158971.1 and CD774636.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158971.1, ERR3363659.63885.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2031              AK158971.1         2-2032
            2032-2056           CD774636.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2056
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.13 cM"
     gene            1..2056
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="RAB7, member RAS oncogene family"
                     /db_xref="GeneID:19349"
                     /db_xref="MGI:MGI:105068"
     exon            1..81
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            82..142
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..713
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-7a"
                     /protein_id="NP_001280582.1"
                     /db_xref="CCDS:CCDS39552.1"
                     /db_xref="GeneID:19349"
                     /db_xref="MGI:MGI:105068"
                     /translation="MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGAD
                     FLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSW
                     RDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAI
                     NVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKASAESCSC"
     exon            143..269
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            270..488
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            489..617
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            618..2042
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1644..1649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="hexamer: ATTAAA"
     polyA_site      1665
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
     regulatory      2016..2021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="hexamer: AATAAA"
     polyA_site      2037
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtcctcg gcgagccgag cgccgagctg ggccgggcca ggcggggcgg cgcccggcgg
       61 gcggagggcg atcggcgatc gcttcaagga tgacctctag gaagaaagtg ttgctgaagg
      121 tcatcatcct gggggactct ggtgttggaa agacctctct catgaaccag tatgtgaaca
      181 agaagttcag taaccagtac aaagccacaa taggagcgga ctttctgacc aaggaggtga
      241 tggtggacga cagacttgtt accatgcaga tctgggacac agccggtcaa gaacggttcc
      301 agtctcttgg tgtggccttc tacagaggtg cagattgctg tgttctggtg tttgatgtga
      361 ctgcccccaa cactttcaaa accctcgaca gctggagaga cgagtttctc atccaggcca
      421 gcccccggga tcccgagaac ttcccttttg ttgtgttggg aaacaagatt gacctggaaa
      481 acagacaagt ggccacaaag agggcacagg cttggtgcta cagcaaaaac aacattcctt
      541 acttcgagac cagtgccaag gaggccatca atgtggagca ggccttccag acaattgctc
      601 ggaatgccct taaacaggaa acagaagtgg aactgtacaa tgaattccct gaacccatca
      661 aactggacaa gaatgaccgg gccaaggcct ccgcagaaag ctgcagttgt tgaaggggca
      721 gtgagcacag agtccttcac agaccaagaa cacacacgta ggccttcaat atgcgtccct
      781 cctcctccaa acagaccaga acgtgagctc tcacatccag ctgccaaaag aaactccacc
      841 gaacagttac ccaacacaca cacatacaca aaacacactc gtgcacacaa aaacacatac
      901 acacaacaca cacacagcaa gcaaactcca gcctgtgcct gtcagggctc ctggggcagc
      961 tgcccgcctc gtgggccctg tgtatggcag gcatatggca gagaccctgg gtgctctggg
     1021 gtgcagtggg catggaaagc ttactctttt tgtccactgg agagtgagag aactgttcac
     1081 agttcatctg tgtctaatta tctgattttt tttttaacgg tcttgtggtc ttttacccct
     1141 ccctccttga aggtcctgtg ggaaggctgg tgcccaggct ccgttctgag caggctgttt
     1201 tgtatgtatc tgttaatgct tgttactttt aactaatcag atctttttac agtatccatt
     1261 tattatgtaa tgcttcttag aaaagaatct tatagtacat gttaatatat gcaaccaatt
     1321 aaaatgtata aattagtgta aggaattcct ggattgtgtg tttaagtcct ctaacgcagg
     1381 cgtgcaaggt ggagggttga accctgtctg gattacagag tgttagagac tcaagtttgg
     1441 aagtccagct agcggcagta ttctgtacag tagacacaag aattatgtac gccttttatc
     1501 acagacttaa gagccaaaaa gcttttcatc tctctgaagg gaaaactgaa ctagacagtt
     1561 cccttctgtg tctaaatttt ccaaaaggtt gatttgctta atatagtagt gtatacaatg
     1621 gataaattgc tgttacttca agaattaaaa ttctcatttt ctccctttct gttttttttc
     1681 cttatattca acactttatg atgccctttt gtcactatcc tactcaaaga ggaaaggaga
     1741 acccaccaga cctgtcccag tgactctacc tttgttctag aaggcgctcc tttcagggtt
     1801 gtggtacctg taggttagca gaccctcctc ctttcccacc cacccaagtg tggcccagca
     1861 ctaacccacc gtctcttggg ttgagccctg gcagttctgt cccttcccga ggtcctgccc
     1921 tgcatcatgg cttgcttcct ggagcacttc cccttcagag gtctacattc tagggtgtag
     1981 gctgagttct tctgtaaaga gacgaacgtg atgccaataa aatttaacaa gaacaaagaa
     2041 caaaaaaaaa aaaaaa
//
