LOCUS       NM_001293652            2395 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus RAB7, member RAS oncogene family (Rab7), transcript
            variant 1, mRNA.
ACCESSION   NM_001293652
VERSION     NM_001293652.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2395)
  AUTHORS   Ke,J., Pan,J., Lin,H., Huang,S., Zhang,J., Wang,C., Chang,A.C.Y.
            and Gu,J.
  TITLE     Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid
            Toxicity in Diabetic Cardiomyopathy
  JOURNAL   Adv Sci (Weinh) 11 (29), e2401676 (2024)
   PUBMED   38837607
  REMARK    GeneRIF: Targeting Rab7-Rilp Mediated Microlipophagy Alleviates
            Lipid Toxicity in Diabetic Cardiomyopathy.
REFERENCE   2  (bases 1 to 2395)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2395)
  AUTHORS   Kim,M., Park,J.H., Go,M., Lee,N., Seo,J., Lee,H., Kim,D., Ha,H.,
            Kim,T., Jeong,M.S., Kim,S., Kim,T., Kim,H.S., Kang,D., Shim,H. and
            Lee,S.Y.
  TITLE     RUFY4 deletion prevents pathological bone loss by blocking
            endo-lysosomal trafficking of osteoclasts
  JOURNAL   Bone Res 12 (1), 29 (2024)
   PUBMED   38744829
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2395)
  AUTHORS   Li,C., Fu,J., Shao,S. and Luo,Z.Q.
  TITLE     Legionella pneumophila exploits the endo-lysosomal network for
            phagosome biogenesis by co-opting SUMOylated Rab7
  JOURNAL   PLoS Pathog 20 (5), e1011783 (2024)
   PUBMED   38739652
  REMARK    GeneRIF: Legionella pneumophila exploits the endo-lysosomal network
            for phagosome biogenesis by co-opting SUMOylated Rab7.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2395)
  AUTHORS   Liang,X., Wang,Y., Li,S., Fan,J., Zhou,F., Li,X., Li,S. and Li,Y.
  TITLE     Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression Improves
            Mitophagy in Alzheimer's Disease Models
  JOURNAL   J Alzheimers Dis 100 (1), 279-296 (2024)
   PUBMED   38848175
  REMARK    GeneRIF: Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression
            Improves Mitophagy in Alzheimer's Disease Models.
REFERENCE   6  (bases 1 to 2395)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (bases 1 to 2395)
  AUTHORS   Chiariello,M., De Gregorio,L., Vitelli,R., Alifano,P.,
            Dragani,T.A., Bruni,C.B. and Bucci,C.
  TITLE     Genetic mapping of the mouse Rab7 gene and pseudogene and of the
            human RAB7 homolog
  JOURNAL   Mamm Genome 9 (6), 448-452 (1998)
   PUBMED   9585432
REFERENCE   8  (bases 1 to 2395)
  AUTHORS   Vitelli,R., Chiariello,M., Lattero,D., Bruni,C.B. and Bucci,C.
  TITLE     Molecular cloning and expression analysis of the human Rab7 GTP-ase
            complementary deoxyribonucleic acid
  JOURNAL   Biochem Biophys Res Commun 229 (3), 887-890 (1996)
   PUBMED   8954989
REFERENCE   9  (bases 1 to 2395)
  AUTHORS   Vitelli,R., Chiariello,M., Bruni,C.B. and Bucci,C.
  TITLE     Cloning and expression analysis of the murine Rab7 cDNA
  JOURNAL   Biochim Biophys Acta 1264 (3), 268-270 (1995)
   PUBMED   8547311
REFERENCE   10 (bases 1 to 2395)
  AUTHORS   Carroll,J.M., Romero,M.R. and Watt,F.M.
  TITLE     Suprabasal integrin expression in the epidermis of transgenic mice
            results in developmental defects and a phenotype resembling
            psoriasis
  JOURNAL   Cell 83 (6), 957-968 (1995)
   PUBMED   8521519
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY291181.1, AK152666.1, AK158971.1 and CD774636.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, 3, 4, and 5 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152666.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849381,
                                           SAMN00849385 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BY291181.1         2-26
            26-1682             AK152666.1         1-1657
            1683-2370           AK158971.1         1345-2032
            2371-2395           CD774636.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2395
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.13 cM"
     gene            1..2395
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="RAB7, member RAS oncogene family"
                     /db_xref="GeneID:19349"
                     /db_xref="MGI:MGI:105068"
     exon            1..198
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            199..285
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            286..420
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            421..481
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             429..1052
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-7a"
                     /protein_id="NP_001280581.1"
                     /db_xref="CCDS:CCDS39552.1"
                     /db_xref="GeneID:19349"
                     /db_xref="MGI:MGI:105068"
                     /translation="MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGAD
                     FLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSW
                     RDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAI
                     NVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKASAESCSC"
     exon            482..608
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            609..827
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            828..956
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     exon            957..2381
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1983..1988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="hexamer: ATTAAA"
     polyA_site      2004
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
     regulatory      2355..2360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="hexamer: AATAAA"
     polyA_site      2376
                     /gene="Rab7"
                     /gene_synonym="Rab7a"
                     /note="major polyA site"
ORIGIN      
        1 gtctcgtgac agacacttcc gctcggggcg gcggcggtgg cggaagtgga agcaaggccg
       61 gagctttgac cataaagccc aaggcggcgg cgttggcggc ggtgtttggg gccgggcagc
      121 tccgaggagc ctgctggagc cggaatcgga cgtctctgtt gcggcctgcg ttgtgtctcc
      181 tcctccgttg accctgcggc tttaggaccg gggattgagc tcaggtcatc aggtttggag
      241 gcaagagccc ttatctgctg agccatctca ctgaccccag agacaacggg gtttctctgt
      301 atagccctgg ctgtcctgga actcactctg tagaccacgc tggcctcgaa ctcagaaatc
      361 cgcctgcctc tgcctccgga gtgctgggat caaaggcgtg caccaccacg cccggcctat
      421 cttcaaggat gacctctagg aagaaagtgt tgctgaaggt catcatcctg ggggactctg
      481 gtgttggaaa gacctctctc atgaaccagt atgtgaacaa gaagttcagt aaccagtaca
      541 aagccacaat aggagcggac tttctgacca aggaggtgat ggtggacgac agacttgtta
      601 ccatgcagat ctgggacaca gccggtcaag aacggttcca gtctcttggt gtggccttct
      661 acagaggtgc agattgctgt gttctggtgt ttgatgtgac tgcccccaac actttcaaaa
      721 ccctcgacag ctggagagac gagtttctca tccaggccag cccccgggat cccgagaact
      781 tcccttttgt tgtgttggga aacaagattg acctggaaaa cagacaagtg gccacaaaga
      841 gggcacaggc ttggtgctac agcaaaaaca acattcctta cttcgagacc agtgccaagg
      901 aggccatcaa tgtggagcag gccttccaga caattgctcg gaatgccctt aaacaggaaa
      961 cagaagtgga actgtacaat gaattccctg aacccatcaa actggacaag aatgaccggg
     1021 ccaaggcctc cgcagaaagc tgcagttgtt gaaggggcag tgagcacaga gtccttcaca
     1081 gaccaagaac acacacgtag gccttcaata tgcgtccctc ctcctccaaa cagaccagaa
     1141 cgtgagctct cacatccagc tgccaaaaga aactccaccg aacagttacc caacacacac
     1201 acatacacaa aacacactcg tgcacacaaa aacacataca cacaacacac acacagcaag
     1261 caaactccag cctgtgcctg tcagggctcc tggggcagct gcccgcctcg tgggccctgt
     1321 gtatggcagg catatggcag agaccctggg tgctctgggg tgcagtgggc atggaaagct
     1381 tactcttttt gtccactgga gagtgagaga actgttcaca gttcatctgt gtctaattat
     1441 ctgatttttt ttttaacggt cttgtggtct tttacccctc cctccttgaa ggtcctgtgg
     1501 gaaggctggt gcccaggctc cgttctgagc aggctgtttt gtatgtatct gttaatgctt
     1561 gttactttta actaatcaga tctttttaca gtatccattt attatgtaat gcttcttaga
     1621 aaagaatctt atagtacatg ttaatatatg caaccaatta aaatgtataa attagtgtaa
     1681 ggaattcctg gattgtgtgt ttaagtcctc taacgcaggc gtgcaaggtg gagggttgaa
     1741 ccctgtctgg attacagagt gttagagact caagtttgga agtccagcta gcggcagtat
     1801 tctgtacagt agacacaaga attatgtacg ccttttatca cagacttaag agccaaaaag
     1861 cttttcatct ctctgaaggg aaaactgaac tagacagttc ccttctgtgt ctaaattttc
     1921 caaaaggttg atttgcttaa tatagtagtg tatacaatgg ataaattgct gttacttcaa
     1981 gaattaaaat tctcattttc tccctttctg ttttttttcc ttatattcaa cactttatga
     2041 tgcccttttg tcactatcct actcaaagag gaaaggagaa cccaccagac ctgtcccagt
     2101 gactctacct ttgttctaga aggcgctcct ttcagggttg tggtacctgt aggttagcag
     2161 accctcctcc tttcccaccc acccaagtgt ggcccagcac taacccaccg tctcttgggt
     2221 tgagccctgg cagttctgtc ccttcccgag gtcctgccct gcatcatggc ttgcttcctg
     2281 gagcacttcc ccttcagagg tctacattct agggtgtagg ctgagttctt ctgtaaagag
     2341 acgaacgtga tgccaataaa atttaacaag aacaaagaac aaaaaaaaaa aaaaa
//
