LOCUS       NM_173781               4734 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus RAB6B, member RAS oncogene family (Rab6b), mRNA.
ACCESSION   NM_173781
VERSION     NM_173781.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4734)
  AUTHORS   Zhang,Y., Kunii,M., Taniguchi,M., Yoshimura,S.I. and Harada,A.
  TITLE     Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is
            Essential for the Establishment of Neuronal Polarity and Brain
            Formation
  JOURNAL   J Neurosci 44 (27), e2334232024 (2024)
   PUBMED   38830762
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4734)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4734)
  AUTHORS   Brault,J.B., Bardin,S., Lampic,M., Carpentieri,J.A., Coquand,L.,
            Penisson,M., Lachuer,H., Victoria,G.S., Baloul,S., El Marjou,F.,
            Boncompain,G., Miserey-Lenkei,S., Belvindrah,R., Fraisier,V.,
            Francis,F., Perez,F., Goud,B. and Baffet,A.D.
  TITLE     RAB6 and dynein drive post-Golgi apical transport to prevent
            neuronal progenitor delamination
  JOURNAL   EMBO Rep 23 (10), e54605 (2022)
   PUBMED   35979738
REFERENCE   4  (bases 1 to 4734)
  AUTHORS   Dominguez Cadena,L.C., Schultz,T.E., Zamoshnikova,A., Donovan,M.L.,
            Mathmann,C.D., Yu,C.H., Mori,G., Stow,J.L. and Blumenthal,A.
  TITLE     Rab6b localizes to the Golgi complex in murine macrophages and
            promotes tumor necrosis factor release in response to mycobacterial
            infection
  JOURNAL   Immunol Cell Biol 99 (10), 1067-1076 (2021)
   PUBMED   34555867
  REMARK    GeneRIF: Rab6b localizes to the Golgi complex in murine macrophages
            and promotes tumor necrosis factor release in response to
            mycobacterial infection.
REFERENCE   5  (bases 1 to 4734)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4734)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   7  (bases 1 to 4734)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   8  (bases 1 to 4734)
  AUTHORS   Monier,S., Jollivet,F., Janoueix-Lerosey,I., Johannes,L. and
            Goud,B.
  TITLE     Characterization of novel Rab6-interacting proteins involved in
            endosome-to-TGN transport
  JOURNAL   Traffic 3 (4), 289-297 (2002)
   PUBMED   11929610
REFERENCE   9  (bases 1 to 4734)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   10 (bases 1 to 4734)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC156633.2.
            
            On Nov 17, 2006 this sequence version replaced NM_173781.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060618.1, AK035893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC156633.2         48142-48294
            154-212             AC156633.2         76450-76508
            213-266             AC156633.2         96888-96941
            267-372             AC156633.2         97132-97237
            373-484             AC156633.2         98610-98721
            485-578             AC156633.2         99878-99971
            579-645             AC156633.2         103174-103240
            646-4734            AC156633.2         117250-121338
FEATURES             Location/Qualifiers
     source          1..4734
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 54.88 cM"
     gene            1..4734
                     /gene="Rab6b"
                     /gene_synonym="9630015C03; C330006L04Rik; D9Bwg0185e"
                     /note="RAB6B, member RAS oncogene family"
                     /db_xref="GeneID:270192"
                     /db_xref="MGI:MGI:107283"
     exon            1..153
                     /gene="Rab6b"
                     /gene_synonym="9630015C03; C330006L04Rik; D9Bwg0185e"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..710
                     /gene="Rab6b"
                     /gene_synonym="9630015C03; C330006L04Rik; D9Bwg0185e"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-6B"
                     /protein_id="NP_776142.1"
                     /db_xref="CCDS:CCDS23449.1"
                     /db_xref="GeneID:270192"
                     /db_xref="MGI:MGI:107283"
                     /translation="MSAGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQA
                     TIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNLNSFQ
                     QTSKWIDDVRTERGSDVIIMLVGNKTDLADKRQITIEEGEQRAKELSVMFIETSAKTG
                     YNVKQLFRRVASALPGMENVQEKSKEGMIDIKLDKPQEPPASEGGCSC"
     exon            154..212
                     /gene="Rab6b"
                     /gene_synonym="9630015C03; C330006L04Rik; D9Bwg0185e"
                     /inference="alignment:Splign:2.1.0"
     exon            213..266
                     /gene="Rab6b"
                     /gene_synonym="9630015C03; C330006L04Rik; D9Bwg0185e"
                     /inference="alignment:Splign:2.1.0"
     exon            267..372
                     /gene="Rab6b"
                     /gene_synonym="9630015C03; C330006L04Rik; D9Bwg0185e"
                     /inference="alignment:Splign:2.1.0"
     exon            373..484
                     /gene="Rab6b"
                     /gene_synonym="9630015C03; C330006L04Rik; D9Bwg0185e"
                     /inference="alignment:Splign:2.1.0"
     exon            485..578
                     /gene="Rab6b"
                     /gene_synonym="9630015C03; C330006L04Rik; D9Bwg0185e"
                     /inference="alignment:Splign:2.1.0"
     exon            579..645
                     /gene="Rab6b"
                     /gene_synonym="9630015C03; C330006L04Rik; D9Bwg0185e"
                     /inference="alignment:Splign:2.1.0"
     exon            646..4734
                     /gene="Rab6b"
                     /gene_synonym="9630015C03; C330006L04Rik; D9Bwg0185e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccctcctc ctctcccctc cctgctcctt caccgcttcc tcctcctcct cctcctcctc
       61 gcccggcccc agctgccagc accatgtccg cagggggaga ttttgggaac ccgctgcgaa
      121 aattcaagtt ggttttccta ggggagcaga gcgtcgggaa gacgtctctg atcacgaggt
      181 tcatgtatga cagcttcgac aacacctacc aggcaaccat cgggattgac ttcttgtcaa
      241 aaaccatgta cttggaagac cgtacggttc gactgcagct ctgggacact gctgggcaag
      301 agaggttccg cagcctgatc cccagctaca tccgagactc cacggtggct gtggtggtat
      361 atgacattac taatctcaac tccttccagc agacttctaa atggattgat gacgtcagga
      421 cggagagggg cagtgacgtg atcatcatgc ttgtgggtaa caagacggat ctggctgata
      481 agaggcagat aaccatcgag gaaggagaac agcgggccaa agaactgagc gtcatgttca
      541 tcgagaccag cgcgaagact ggctacaacg tgaagcagct cttccgacgt gtggcgtcag
      601 ctctgcccgg catggagaat gtccaggaga agagcaaaga agggatgatt gacatcaagc
      661 tggacaagcc tcaggagccc ccggccagcg agggcggctg ctcctgttaa tgcaccgccc
      721 actcggcttc ctcagcgcca ctcacttgtt ttgcctccta tagcttccta acggggtggg
      781 aactgagttt atcaagactg gaggatcttt cttttctctc tctctctctc tctaggagta
      841 gggtgggaca tggggaggga ggctgggcat cagggaccac gtcactctta acagctgtta
      901 cctaaacaac tattttttgg tttggttgta atatattgta ctttattaag attgccaaaa
      961 actgttaaaa tttaaaaaaa aaatttaaat catgtgtata caactttttg ccagattaga
     1021 aaagtagtca tttttatttg aaagaagtgc ttttttgttt gtttgttttt gtatatttgt
     1081 aaacttacag agaacctctc cacacacttc ttccttcctg ttctcttgga actgtgtgtc
     1141 acctctattt tcctcctacc cccgcccccc ccagcccaga aaattaaagc aattaactga
     1201 acagtagtaa ttacattcta gttctgggtc acatggccca aaccaaccaa acccgcactc
     1261 cacagtcaaa tccaacttta atctaacaaa acagcctctg agggggtatt gtcgagttct
     1321 tccctggcag agtgggacac attggcaggc ccctgagagg agatgaaggc ccgtggactg
     1381 tagattcagc agcagctcct tggctgcttc cgcctcttct ccttccctga aaaaaataac
     1441 catagagcca gaaagcacag gcaacagtgt gttctctggg ctgacccggt gacagacagc
     1501 aagaagttac tggaaggatg gggtgcgctt ggcagctgag ggctgaggca gtgtgtaatc
     1561 tactggccca accattgaca cacatggtta ggctgactcg ccaactcaat gtgtgatgct
     1621 gggtggctca gggacactga agcctagggc acctgccatc actgcaacta ccattgagga
     1681 agtgagagga gtcggccatg actccggaca ctccatgttg tcagaccctt ggatactaat
     1741 cttgccgaac gttgttctgg aaaagctgat tccttgatgt gtcctcacct ctggcgtggt
     1801 acgtttgaaa tctttgtatg aatacctttg ggagtgttgg cagctgcact gcacgcatct
     1861 tggagtcact gtggggtttc cagaaggctg ctgccccagg gtactgcaac ttgcccccca
     1921 gcaggctgtc cttgctattt ccactcattc cccagactga agaccttcag agtctcttag
     1981 cagagtgctc ttctcaaagc agaatagctc ttatattcta aacgctcccg gactcactgc
     2041 ccctgtctgc ctttgggcag gcctggggca gtgactctaa tcagagcagc ctagccccat
     2101 agcattggct cttctttcag actgctggtg ggcagagtga attgcctcca caaggcagaa
     2161 ctccaacaag gaggttggga tgaattatgg aatctctcaa agaatgagtt caaaatggca
     2221 gcctgtgtgg cagggctgat tctgtgagtg ggcccgtcat gcgactccat cctgggagac
     2281 tgtgtcaaag ccggttctga tgatgaagag aggaagcagg accgccctgg gtacctcctc
     2341 cagaaggcaa ggaccaatgt acgagcataa tcgaaacgtc acgtgtttag tttttatatg
     2401 tgtgtacata attatacata gagatagact tgtgtataca cccttcgcgc gcacacatac
     2461 acacactcac atcctcacat atacatgtgc tcagtgtata tcctcgtctc tcccgctcac
     2521 aacttggaac ttacattgtg attccggttt ttggaagttc aaaagtatgc agtgtattga
     2581 aataagaaat aactcaatat tgtcaaataa cttgtggttg tcttgccttc aataaaatag
     2641 tgcatagatg tgttaaacta caagcaaaag tagtccacag aactaccttt accactgctt
     2701 tttgtacctg tgtgcacagg tgtgcatgcc gtcgtgggcc agtgtccccc actgtggaca
     2761 ccccacccat gtggtgcttg ttggaagaaa gcatacttag cccgtggtga cagcagcctg
     2821 gttggcagtg aggggctttg ctggtggcct ctggcagagc cccactgaca gcactctcta
     2881 ctggctttca ctgaatgaat gtagggtgaa ttttaacctt ctggacactg aataaccttt
     2941 cttgtattcc tgtaactcga attagaaaat ccgttcactt ctcttgtgca cacagtctaa
     3001 gacatcatgg cctgctacta gaaacagcag gtaccatggc agatgccatt tctggtcgat
     3061 ctggcctaag gagccctgcc ttcctagctt gtacacaaaa ccccctcctt gagtttagac
     3121 tctcccagcc ctgcggcccc tgagaattag ggttctgccc cattgctccc ccactccaga
     3181 ggtgccctgg ccttatttcc tcagccaagc tacccatctc cttcccaaaa ggcaatcaag
     3241 gcagccaggc cccaacagaa ctaactgtag tggacctggg ctttccccct gaccgccacc
     3301 accatcctac ttgtacgtag gatccaatca ggttctcata aagacatcct gaaattatct
     3361 gtgcccccat ctttgctaaa ttcagatcag tcagaggaca aaatggaggg ttcctcttag
     3421 ggcatgatcc caatgtcgta attcagttcc tctctctgga cactgcctgg cctggcagat
     3481 gggcatggcc ctcctccttt tctttaagag acttgaaaga gagttgtcag caaaactgtg
     3541 agcagtgcag agattgtgaa agggcaggta gtgtaagtag tattgttgtg gagtcagagg
     3601 ttagaatgct gggtggttag agccttgctg ctgccagtca ctgctccccg ttgccatctt
     3661 taaacatttc gcaatatctc aagatccagg aaggcatggc catgtcagtt caatgtctca
     3721 ggcaacaaag acaagggttg caaggtggta gctaggaata tagacgcctg ggcctagtct
     3781 ctgtaaccca gtggctaacc agtgtcagag atctaagcag ggctggcttc agcctcctgt
     3841 aggcagggca gtttatccct tttccatatg gatgggggag aggctgtcag caaagtggct
     3901 gaagagagct aagttagagc tacccaagag ccagccagca ggagtctgtg tcaaatgctc
     3961 agggctcgat gctcactagt ttctaaacta cctctccccc aagaatggga ggcaccatca
     4021 ccttgccaca gcactgggag ccaaaccctt cctgtttcac gggtgggaga accagaacag
     4081 aaaaggtcac ctgcaagcca gagaggatca gaactagtgt tggcattctt gatccgttgc
     4141 tgaccttgcg gtgtccagac aggactgctg tgctagcgtc ccttaagcca tctctactcc
     4201 atggctagta cctaagggtc ttcccagcct ggctagctag agagaagata ggtgcatttt
     4261 gggctctcac tgtaaagaag agtggtcccc aaatctactt gcattgtctt gtgtacacac
     4321 acacacacac acacacacac accccagtag tcagggtacc cttttaattt ttgtttgaaa
     4381 tcaacttctt cactgtttgg aaatcttgca gtttcaatgt gcacactcct tggactccag
     4441 accctgtctg attgatactc tctgcagggt ataattatca ggaaatccac gcagcgggag
     4501 ttcagatggg cccttcagga ggcaggaagc ctccatagca acgaaggcca gcctgccatt
     4561 gtgatgtgtt gacttctcac ctcacctgtc ctttaaagtg aggagcagag ggcggcattt
     4621 ctatctgtac tgggctcaga aggcacagtg gccatattga ctttacattc aactgtgtaa
     4681 tatgtggaaa agactcagca tgttggtcaa acaataaact gtcctaattc tcga
//
