LOCUS       NM_001163663            3046 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus RAB6A, member RAS oncogene family (Rab6a), transcript
            variant 1, mRNA.
ACCESSION   NM_001163663
VERSION     NM_001163663.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3046)
  AUTHORS   Zhang,Y., Kunii,M., Taniguchi,M., Yoshimura,S.I. and Harada,A.
  TITLE     Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is
            Essential for the Establishment of Neuronal Polarity and Brain
            Formation
  JOURNAL   J Neurosci 44 (27), e2334232024 (2024)
   PUBMED   38830762
  REMARK    GeneRIF: Rab6-Mediated Polarized Transport of Synaptic Vesicle
            Precursors Is Essential for the Establishment of Neuronal Polarity
            and Brain Formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3046)
  AUTHORS   Wang,S., Matsumoto,K., Mehlferber,M.M., Zhang,G., Aronova,M.A. and
            Yamada,K.M.
  TITLE     Microtubule-dependent apical polarization of basement membrane
            matrix mRNAs in mouse epithelial cells
  JOURNAL   Cells Dev 177, 203898 (2024)
   PUBMED   38103869
REFERENCE   3  (bases 1 to 3046)
  AUTHORS   Brault,J.B., Goud,B. and Baffet,A.
  TITLE     [Should I stay or should I go? Neural stem cell anchorage during
            cerebral cortex development requires the GTPase RAB6 and dynein]
  JOURNAL   Med Sci (Paris) 39 (1), 9-12 (2023)
   PUBMED   36692257
  REMARK    GeneRIF: [Should I stay or should I go? Neural stem cell anchorage
            during cerebral cortex development requires the GTPase RAB6 and
            dynein].
REFERENCE   4  (bases 1 to 3046)
  AUTHORS   Brault,J.B., Bardin,S., Lampic,M., Carpentieri,J.A., Coquand,L.,
            Penisson,M., Lachuer,H., Victoria,G.S., Baloul,S., El Marjou,F.,
            Boncompain,G., Miserey-Lenkei,S., Belvindrah,R., Fraisier,V.,
            Francis,F., Perez,F., Goud,B. and Baffet,A.D.
  TITLE     RAB6 and dynein drive post-Golgi apical transport to prevent
            neuronal progenitor delamination
  JOURNAL   EMBO Rep 23 (10), e54605 (2022)
   PUBMED   35979738
REFERENCE   5  (bases 1 to 3046)
  AUTHORS   Cayre,S., Faraldo,M.M., Bardin,S., Miserey-Lenkei,S., Deugnier,M.A.
            and Goud,B.
  TITLE     RAB6 GTPase regulates mammary secretory function by controlling the
            activation of STAT5
  JOURNAL   Development 147 (19) (2020)
   PUBMED   32895290
  REMARK    GeneRIF: RAB6 GTPase regulates mammary secretory function by
            controlling the activation of STAT5.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3046)
  AUTHORS   Ahnert-Hilger,G., Kutay,U., Chahoud,I., Rapoport,T. and
            Wiedenmann,B.
  TITLE     Synaptobrevin is essential for secretion but not for the
            development of synaptic processes
  JOURNAL   Eur J Cell Biol 70 (1), 1-11 (1996)
   PUBMED   8738414
REFERENCE   7  (bases 1 to 3046)
  AUTHORS   Antony,C., Huchet,M., Changeux,J.P. and Cartaud,J.
  TITLE     Developmental regulation of membrane traffic organization during
            synaptogenesis in mouse diaphragm muscle
  JOURNAL   J Cell Biol 130 (4), 959-968 (1995)
   PUBMED   7642711
REFERENCE   8  (bases 1 to 3046)
  AUTHORS   Janoueix-Lerosey,I., Jollivet,F., Camonis,J., Marche,P.N. and
            Goud,B.
  TITLE     Two-hybrid system screen with the small GTP-binding protein Rab6.
            Identification of a novel mouse GDP dissociation inhibitor isoform
            and two other potential partners of Rab6
  JOURNAL   J Biol Chem 270 (24), 14801-14808 (1995)
   PUBMED   7782346
REFERENCE   9  (bases 1 to 3046)
  AUTHORS   Landsman,D. and Wolffe,A.P.
  TITLE     Common sequence and structural features in the heat-shock factor
            and Ets families of DNA-binding domains
  JOURNAL   Trends Biochem Sci 20 (6), 225-226 (1995)
   PUBMED   7631419
REFERENCE   10 (bases 1 to 3046)
  AUTHORS   Chavrier,P., Simons,K. and Zerial,M.
  TITLE     The complexity of the Rab and Rho GTP-binding protein subfamilies
            revealed by a PCR cloning approach
  JOURNAL   Gene 112 (2), 261-264 (1992)
   PUBMED   1555775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124531.5.
            
            On Nov 25, 2022 this sequence version replaced NM_001163663.1.
            
            Transcript Variant: Variants 1 and 2 include either one of two
            duplicated, alternatively spliced coding exons and are the same
            length. The resulting proteins (isoforms 1 and 2, respectively) are
            the same length but differ at three amino acid positions. This
            variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154012.1, SRR13948564.475555.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-540               AC124531.5         151211-151750       c
            541-599             AC124531.5         132894-132952       c
            600-653             AC124531.5         131047-131100       c
            654-759             AC124531.5         129733-129838       c
            760-871             AC124531.5         127651-127762       c
            872-965             AC124531.5         124766-124859       c
            966-1032            AC124531.5         122743-122809       c
            1033-3046           AC124531.5         118236-120249       c
FEATURES             Location/Qualifiers
     source          1..3046
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.36 cM"
     gene            1..3046
                     /gene="Rab6a"
                     /gene_synonym="2610028L11Rik; Rab6"
                     /note="RAB6A, member RAS oncogene family"
                     /db_xref="GeneID:19346"
                     /db_xref="MGI:MGI:894313"
     exon            1..540
                     /gene="Rab6a"
                     /gene_synonym="2610028L11Rik; Rab6"
                     /inference="alignment:Splign:2.1.0"
     CDS             471..1097
                     /gene="Rab6a"
                     /gene_synonym="2610028L11Rik; Rab6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ras-related protein Rab-6A; rab-6; RAB6, member RAS
                     oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-6A isoform 1"
                     /protein_id="NP_001157135.1"
                     /db_xref="CCDS:CCDS52323.1"
                     /db_xref="GeneID:19346"
                     /db_xref="MGI:MGI:894313"
                     /translation="MSAGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQA
                     TIGIDFLSKTMYLEDRTIRLQLWDTAGQERFRSLIPSYIRDSAAAVVVYDITNVNSFQ
                     QTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAG
                     YNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVNEGGCSC"
     exon            541..599
                     /gene="Rab6a"
                     /gene_synonym="2610028L11Rik; Rab6"
                     /inference="alignment:Splign:2.1.0"
     exon            600..653
                     /gene="Rab6a"
                     /gene_synonym="2610028L11Rik; Rab6"
                     /inference="alignment:Splign:2.1.0"
     exon            654..759
                     /gene="Rab6a"
                     /gene_synonym="2610028L11Rik; Rab6"
                     /inference="alignment:Splign:2.1.0"
     exon            760..871
                     /gene="Rab6a"
                     /gene_synonym="2610028L11Rik; Rab6"
                     /inference="alignment:Splign:2.1.0"
     exon            872..965
                     /gene="Rab6a"
                     /gene_synonym="2610028L11Rik; Rab6"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1032
                     /gene="Rab6a"
                     /gene_synonym="2610028L11Rik; Rab6"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..3046
                     /gene="Rab6a"
                     /gene_synonym="2610028L11Rik; Rab6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2958..2963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab6a"
                     /gene_synonym="2610028L11Rik; Rab6"
                     /note="hexamer: AATACA"
     polyA_site      2981
                     /gene="Rab6a"
                     /gene_synonym="2610028L11Rik; Rab6"
                     /note="major polyA site"
     regulatory      3023..3028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab6a"
                     /gene_synonym="2610028L11Rik; Rab6"
                     /note="hexamer: AATAAA"
     polyA_site      3046
                     /gene="Rab6a"
                     /gene_synonym="2610028L11Rik; Rab6"
                     /note="major polyA site"
ORIGIN      
        1 atccgcgcca gaggctcgcg cactcagcgg gttgtgctgc ggtggtggcg gcggcggctg
       61 ctgtgagagc ccgagcactg cgcgtgccga gacccagacg cgtctgcggc gctcgcctcg
      121 ccaccctcct ctctcacctc agtctccgcg ccgcgttctg agggaaggaa cggcgctagg
      181 ctagcgaagc ccgagcgcac cgctggctgc ctccgacacc gccctgcgtc ccttcgcggc
      241 cgcgggcccg gctcggtgct aggcgactct gcggggaggc ggcggcggcg gctgccggtc
      301 ggtggaggca ctctcccttc agcctcgccc ctctgcccgg ccctgcaggg gccgagagga
      361 ctcggaggct gccccttcag ctcggccctc ttcgttagcg ggttggagct gcagcggtct
      421 ggaagaggtc tctgggctga ggcggcggcg gcggctcctc cggctccatc atgtccgcgg
      481 gcggagactt cgggaatccg ctgaggaaat tcaagctggt gttcctggga gagcagagcg
      541 ttggaaagac gtccttgatc acccgattca tgtatgacag ttttgacaac acctatcagg
      601 caacaattgg cattgacttc ttatcaaaaa caatgtactt ggaggataga accatcaggc
      661 tgcagctgtg ggatactgcg ggtcaggaac gtttccgtag cctcattccc agttacatcc
      721 gtgactctgc tgcagccgta gtagtttacg atatcacaaa tgttaactca ttccagcaaa
      781 ctacaaaatg gattgatgat gtcagaacag agagaggaag tgatgtcatc atcatgctag
      841 taggaaataa aacagatctt gctgataaga ggcaagtgtc aattgaggag ggagagagga
      901 aagccaaaga gctgaatgtt atgtttattg aaaccagtgc aaaagcagga tacaatgtaa
      961 agcagctttt ccggcgtgtt gctgcagctt tacctggaat ggaaagcaca caggacagaa
     1021 gcagagaaga catgattgac ataaaactgg aaaagcctca ggagcaacca gtcaatgaag
     1081 gcggctgttc ctgctaatcc ccctggcatc tttcaaccct cctgcagaag ctcactgctt
     1141 tggccccata ctctttcatt gactgcagtg tgaatattgg cttgaacctt ttcccttcag
     1201 taataacgta ttgcaattca tcattgctgc ctgtttcgtg gaggtgatct attagcttca
     1261 caagcacaaa aaagtcagtg tctttattat ttatattttt taaaagccaa acaattccag
     1321 catactcgtg ataactttga ggattagata cattttctta acattttttt ccctttttaa
     1381 tgttatgata atgtacttaa aatgatgaaa atctcagcag tatgtgtgtg gcttgttaaa
     1441 gagcagcgtg ttcatagcag cgttgcctgc cttcttgctg tctatcagcc tttcttgcct
     1501 cttccttttc gccttccctg ttcttccctt tctcaaacaa acaagacatg gcaaaccgca
     1561 gtctaaccca gccctttgaa attatccata gttttacaga cagctccagg ctatgagcca
     1621 caatgtccaa aattattctt gagcactgat ataaattact tagaccttct ttgagggcag
     1681 aactcagctg ttgctctcat gatgggcagt gctggaaagg gttctggtat gtcttcaaaa
     1741 tgagtccacg agtttactga gtgcttacag gtaaaggaat gaatataaga tgtctttctg
     1801 atcagaacag gtgtcccttc acatgagctt tactagactc tgggagggaa aagtagccaa
     1861 gtacttctga accatttttt aatacttgtt tcgtcatggt gaaattatag cagttatccc
     1921 aaaatgtttt aattatcaaa atactgtctt ttaaaaaaaa aaaaaaaaaa gtaacacctt
     1981 ttaaagcatt agatttcact tgggtttctt ttccaaaaaa tgctaggtag acaaggcatt
     2041 gtaaacatga gtttccttta agaaccatca gaatataaat ttaacatgaa gaaaactgct
     2101 atatctagta gaaataatat ctaaagttta acaactaaag taccctcaca gaatagcaaa
     2161 tacccttctg ctctggacat gggttcaaat ttgaatatgg aaataatatc cttggaagtc
     2221 cctagaggca ggtcagagga agtatgcatt aagagggaaa ggagagaatg gaaataaaag
     2281 tcactataat gcagatttat gccttatttt ttagcatttt ttaaatgttg ggtctttcaa
     2341 ggtgtttttt gctttttatt agatctatat aaataagtta actagcaatt tagttttgta
     2401 tttaagctac acttaatctt tttctttggt gatatttatt tctttgcctt ttttttttta
     2461 aaaaaaactt agaattttta ggtgttttgt tgaacattta gagcttcatc accatggcaa
     2521 tatgtatttc ccttgaaaca ttgcaaacaa atatactagg agtgcaccct tttaatcttt
     2581 actagttatt gtgagattgc tgtgtaagtt aataaacaca tttgtaaata cattatttgc
     2641 aggaaaaaaa ttctgagttc tagctcagaa gcagcctgcg gagtttatgt tgtaagcatt
     2701 acttaacaca gtataaagat gagaaggtaa caaaaataac ttcatacttc ctcacctcct
     2761 cattgcagca aaatccctaa ctggaaaacc cactcccctc tccccatcct cctccacttt
     2821 cacgtactgt caccttgtaa catttggaga gcacttggat tatggatctg aatagagaaa
     2881 tactttcaga tgatcattag cccacatacc ctgtaactta tactcaaaca tgggatggag
     2941 ttgtaaagtg cttttataat acacattatt gttaaaagca aggattgact cttttgtttt
     3001 attttgacat ggcatgtcct gaaataaata tcaattcaat atggca
//
