LOCUS       NM_024456               1921 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RAB5C, member RAS oncogene family (Rab5c), transcript
            variant 1, mRNA.
ACCESSION   NM_024456
VERSION     NM_024456.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1921)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1921)
  AUTHORS   Wang,X., Cheng,J., Shen,L., Chen,M., Sun,K., Li,J., Li,M., Ma,C.
            and Wei,L.
  TITLE     Rab5c promotes RSV and ADV replication by autophagy in respiratory
            epithelial cells
  JOURNAL   Virus Res 341, 199324 (2024)
   PUBMED   38242290
  REMARK    GeneRIF: Rab5c promotes RSV and ADV replication by autophagy in
            respiratory epithelial cells.
REFERENCE   3  (bases 1 to 1921)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1921)
  AUTHORS   Welliver,T.P. and Swanson,J.A.
  TITLE     A growth factor signaling cascade confined to circular ruffles in
            macrophages
  JOURNAL   Biol Open 1 (8), 754-760 (2012)
   PUBMED   23213469
REFERENCE   5  (bases 1 to 1921)
  AUTHORS   Zeigerer,A., Gilleron,J., Bogorad,R.L., Marsico,G., Nonaka,H.,
            Seifert,S., Epstein-Barash,H., Kuchimanchi,S., Peng,C.G.,
            Ruda,V.M., Del Conte-Zerial,P., Hengstler,J.G., Kalaidzidis,Y.,
            Koteliansky,V. and Zerial,M.
  TITLE     Rab5 is necessary for the biogenesis of the endolysosomal system in
            vivo
  JOURNAL   Nature 485 (7399), 465-470 (2012)
   PUBMED   22622570
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1921)
  AUTHORS   Gurkan,C., Lapp,H., Alory,C., Su,A.I., Hogenesch,J.B. and
            Balch,W.E.
  TITLE     Large-scale profiling of Rab GTPase trafficking networks: the
            membrome
  JOURNAL   Mol Biol Cell 16 (8), 3847-3864 (2005)
   PUBMED   15944222
REFERENCE   7  (bases 1 to 1921)
  AUTHORS   Merithew,E., Hatherly,S., Dumas,J.J., Lawe,D.C., Heller-Harrison,R.
            and Lambright,D.G.
  TITLE     Structural plasticity of an invariant hydrophobic triad in the
            switch regions of Rab GTPases is a determinant of effector
            recognition
  JOURNAL   J Biol Chem 276 (17), 13982-13988 (2001)
   PUBMED   11278565
REFERENCE   8  (bases 1 to 1921)
  AUTHORS   Bucci,C., Lutcke,A., Steele-Mortimer,O., Olkkonen,V.M., Dupree,P.,
            Chiariello,M., Bruni,C.B., Simons,K. and Zerial,M.
  TITLE     Co-operative regulation of endocytosis by three Rab5 isoforms
  JOURNAL   FEBS Lett 366 (1), 65-71 (1995)
   PUBMED   7789520
REFERENCE   9  (bases 1 to 1921)
  AUTHORS   Lutcke,A., Jansson,S., Parton,R.G., Chavrier,P., Valencia,A.,
            Huber,L.A., Lehtonen,E. and Zerial,M.
  TITLE     Rab17, a novel small GTPase, is specific for epithelial cells and
            is induced during cell polarization
  JOURNAL   J Cell Biol 121 (3), 553-564 (1993)
   PUBMED   8486736
REFERENCE   10 (bases 1 to 1921)
  AUTHORS   Chavrier,P., Simons,K. and Zerial,M.
  TITLE     The complexity of the Rab and Rho GTP-binding protein subfamilies
            revealed by a PCR cloning approach
  JOURNAL   Gene 112 (2), 261-264 (1992)
   PUBMED   1555775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY081527.1, AK159832.1, BE447216.1 and AL591469.9.
            
            On Feb 20, 2015 this sequence version replaced NM_024456.4.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167599.1, AK134691.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BY081527.1         1-36
            37-1657             AK159832.1         2-1622
            1658-1915           BE447216.1         1-258               c
            1916-1921           AL591469.9         125918-125923       c
FEATURES             Location/Qualifiers
     source          1..1921
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.54 cM"
     gene            1..1921
                     /gene="Rab5c"
                     /gene_synonym="Rabl"
                     /note="RAB5C, member RAS oncogene family"
                     /db_xref="GeneID:19345"
                     /db_xref="MGI:MGI:105306"
     exon            1..138
                     /gene="Rab5c"
                     /gene_synonym="Rabl"
                     /inference="alignment:Splign:2.1.0"
     exon            139..392
                     /gene="Rab5c"
                     /gene_synonym="Rabl"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..877
                     /gene="Rab5c"
                     /gene_synonym="Rabl"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ras-related protein Rab-5C"
                     /codon_start=1
                     /product="ras-related protein Rab-5C isoform 1"
                     /protein_id="NP_077776.2"
                     /db_xref="CCDS:CCDS36333.1"
                     /db_xref="GeneID:19345"
                     /db_xref="MGI:MGI:105306"
                     /translation="MAGRGGAARPNGPAAGNKICQFKLVLLGESAVGKSSLVLRFVKG
                     QFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYD
                     ITNTDTFARAKNWVKELQRQASPNIVIALAGNKADLASKRAVEFQEAQAYADDNSLLF
                     METSAKTAMNVNEIFMAIAKKLPKNEPQNAAGAPGRTRGVDLQESNPASRSQCCSN"
     exon            393..544
                     /gene="Rab5c"
                     /gene_synonym="Rabl"
                     /inference="alignment:Splign:2.1.0"
     exon            545..667
                     /gene="Rab5c"
                     /gene_synonym="Rabl"
                     /inference="alignment:Splign:2.1.0"
     exon            668..761
                     /gene="Rab5c"
                     /gene_synonym="Rabl"
                     /inference="alignment:Splign:2.1.0"
     exon            762..1921
                     /gene="Rab5c"
                     /gene_synonym="Rabl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1631..1636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab5c"
                     /gene_synonym="Rabl"
                     /note="hexamer: AATATA"
     polyA_site      1658
                     /gene="Rab5c"
                     /gene_synonym="Rabl"
                     /note="major polyA site"
     regulatory      1753..1758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab5c"
                     /gene_synonym="Rabl"
                     /note="hexamer: ATTAAA"
     polyA_site      1771
                     /gene="Rab5c"
                     /gene_synonym="Rabl"
     regulatory      1894..1899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab5c"
                     /gene_synonym="Rabl"
                     /note="hexamer: ATTAAA"
     polyA_site      1915
                     /gene="Rab5c"
                     /gene_synonym="Rabl"
ORIGIN      
        1 agagctgaag atccggatcc ggagcggctg aaaggcggaa gtggaggccg gagcctggga
       61 caccgccggg ggtggggggg agaggagcgg agtctgtgga agccccggcc caaagtaacg
      121 ctgctgcccg gagccgcgtt ggaggcctcc cttcccatta agtgcctctt tgcatagcac
      181 cggccccacc cccacgctca ctggtactac tacagagcag cgcgccatgg cgggtcgagg
      241 aggtgcagca cgacccaatg gaccagctgc tggcaacaag atctgtcagt ttaagctggt
      301 cctcttgggc gagtctgccg tgggcaagtc cagcctggtc ctccgctttg tcaaggggca
      361 gttccatgag taccaggaga gcacaattgg agcggctttc ctcacacaga ctgtctgctt
      421 agacgataca acggtcaagt ttgagatctg ggacacagct ggccaagagc gctatcacag
      481 cctggccccg atgtactatc ggggggccca agcagccatt gtggtctatg acatcaccaa
      541 cacagataca tttgcacggg ctaagaattg ggtgaaggag ttacagaggc aggccagccc
      601 caacatcgtc attgcactag cggggaacaa agcagacctg gccagcaaga gagctgtgga
      661 gtttcaggaa gcacaagcct atgcagatga caacagcttg ctcttcatgg agacgtctgc
      721 caagactgca atgaacgtga atgaaatttt catggcaata gctaagaagc ttcccaagaa
      781 tgagccccag aatgcggctg gggctccggg ccgaaccaga ggtgtggatc tgcaggagag
      841 caacccagcc agccggagcc agtgctgcag caactgagcc cccttacctg ccactgcccc
      901 cactcctcca ccacaatgac ccgactggaa tctactctaa ccaatcgcac ttaacaactc
      961 gggccaccac tgggggcagg ggaagggtcc atcaagaatt ctccgcataa ctttgatcct
     1021 aggccggagg gagttattcc acctgcacct ttctgtacaa atactaattc aattttaagt
     1081 cttaagtcac ttttttaata tatatgatct tctgctcttc ccaggtccct ttctcccgct
     1141 cccccacttg ccctttgctg gtagtagcca tgctcctgtg ctcctcatcc gtggggacag
     1201 ggcttggagc agtcaccctt tcttcccttc ttgctggaga gcggactcag caagagcacc
     1261 cacatcttaa cttgttggga gcgtcttagg ctggggcagt gggcaggccc tgagctgggg
     1321 aagggacagg ctgctcttcc ctcagctggc tgtcaatcag gctgcagcct cctccccaac
     1381 tgactcccag ctgggagaga aaccgcagca ttacttaagc atcattattg acagccggac
     1441 acccatggcc caggatccct ccacccttgg tcactctgac ctctggctct gagccctgtt
     1501 ctgaccaaat cacgatgatg agtatttggg ggtgggtggg taaggggggg gagtgggagg
     1561 gatggaacca actttttctg tattttgtat tgtatgtttt cttcaccatg taaccaatca
     1621 gtatcttgtc aatatagtca gccgatcgat cgacctcacg cttgtcttcc tcgtccttct
     1681 ctggcagctg atcaggccat acgtagcctc tctgtttttc ctgaagttaa tttaaatgaa
     1741 tcatccaatc tcattaaatg gctctactcc ctgtgtgtga gaggatgctg gtggtcatgg
     1801 taaccaaaag aaagaagccc tgctgttggt agttctgatg gtggaagagg ataggactga
     1861 cctggggctg acatctgtct ccccccagct tacattaaag gatatgcaac ctgtatttga
     1921 a
//
