LOCUS       NM_177411               3180 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus RAB5B, member RAS oncogene family (Rab5b), mRNA.
ACCESSION   NM_177411
VERSION     NM_177411.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3180)
  AUTHORS   Shin,S.W., Vogt,E.J., Jimenez-Movilla,M., Baibakov,B. and Dean,J.
  TITLE     Cytoplasmic cleavage of DPPA3 is required for intracellular
            trafficking and cleavage-stage development in mice
  JOURNAL   Nat Commun 8 (1), 1643 (2017)
   PUBMED   29158485
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3180)
  AUTHORS   Ali,N., Jurczyluk,J., Shay,G., Tnimov,Z., Alexandrov,K.,
            Munoz,M.A., Skinner,O.P., Pavlos,N.J. and Rogers,M.J.
  TITLE     A highly sensitive prenylation assay reveals in vivo effects of
            bisphosphonate drug on the Rab prenylome of macrophages outside the
            skeleton
  JOURNAL   Small GTPases 6 (4), 202-211 (2015)
   PUBMED   26399387
  REMARK    GeneRIF: clear effect of subcutaneous zoledronic acid
            administration in vivo on the prenylation of Rab1A, Rab5B, Rab7A
            and Rab14 in mouse peritoneal macrophages, confirming that systemic
            treatment with bisphosphonate drug can inhibit prenylation in
            myeloid cells in vivo outside the skeleton.
REFERENCE   3  (bases 1 to 3180)
  AUTHORS   Segawa,T., Hazeki,K., Nigorikawa,K., Morioka,S., Guo,Y.,
            Takasuga,S., Asanuma,K. and Hazeki,O.
  TITLE     Inpp5e increases the Rab5 association and phosphatidylinositol
            3-phosphate accumulation at the phagosome through an interaction
            with Rab20
  JOURNAL   Biochem J 464 (3), 365-375 (2014)
   PUBMED   25269936
REFERENCE   4  (bases 1 to 3180)
  AUTHORS   Welliver,T.P. and Swanson,J.A.
  TITLE     A growth factor signaling cascade confined to circular ruffles in
            macrophages
  JOURNAL   Biol Open 1 (8), 754-760 (2012)
   PUBMED   23213469
REFERENCE   5  (bases 1 to 3180)
  AUTHORS   Zeigerer,A., Gilleron,J., Bogorad,R.L., Marsico,G., Nonaka,H.,
            Seifert,S., Epstein-Barash,H., Kuchimanchi,S., Peng,C.G.,
            Ruda,V.M., Del Conte-Zerial,P., Hengstler,J.G., Kalaidzidis,Y.,
            Koteliansky,V. and Zerial,M.
  TITLE     Rab5 is necessary for the biogenesis of the endolysosomal system in
            vivo
  JOURNAL   Nature 485 (7399), 465-470 (2012)
   PUBMED   22622570
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3180)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   7  (bases 1 to 3180)
  AUTHORS   Gwynn,B., Korsgren,C., Cohen,C.M., Ciciotte,S.L. and Peters,L.L.
  TITLE     The gene encoding protein 4.2 is distinct from the mouse platelet
            storage pool deficiency mutation pallid
  JOURNAL   Genomics 42 (3), 532-535 (1997)
   PUBMED   9205130
REFERENCE   8  (bases 1 to 3180)
  AUTHORS   Barbosa,M.D., Wakeland,E.K., Zerial,M. and Kingsmore,S.F.
  TITLE     Genetic mapping of the Rab5a and Rab5b genes on mouse Chromosomes
            17 and 2, respectively
  JOURNAL   Mamm Genome 7 (2), 166-167 (1996)
   PUBMED   8835543
REFERENCE   9  (bases 1 to 3180)
  AUTHORS   Bucci,C., Lutcke,A., Steele-Mortimer,O., Olkkonen,V.M., Dupree,P.,
            Chiariello,M., Bruni,C.B., Simons,K. and Zerial,M.
  TITLE     Co-operative regulation of endocytosis by three Rab5 isoforms
  JOURNAL   FEBS Lett 366 (1), 65-71 (1995)
   PUBMED   7789520
REFERENCE   10 (bases 1 to 3180)
  AUTHORS   Chavrier,P., Simons,K. and Zerial,M.
  TITLE     The complexity of the Rab and Rho GTP-binding protein subfamilies
            revealed by a PCR cloning approach
  JOURNAL   Gene 112 (2), 261-264 (1992)
   PUBMED   1555775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY727964.1, AK081251.1 and AC117232.3.
            
            [WARNING] On Mar 25, 2024 this sequence was replaced by
            NM_177411.5.
            
            On Apr 23, 2009 this sequence version replaced NM_177411.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081251.1, SRR7974084.30328.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY727964.1         2-5
            5-1276              AK081251.1         1-1272
            1277-3180           AC117232.3         162755-164658       c
FEATURES             Location/Qualifiers
     source          1..3180
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 77.13 cM"
     gene            1..3180
                     /gene="Rab5b"
                     /gene_synonym="C030027M18Rik"
                     /note="RAB5B, member RAS oncogene family"
                     /db_xref="GeneID:19344"
                     /db_xref="MGI:MGI:105938"
     exon            1..83
                     /gene="Rab5b"
                     /gene_synonym="C030027M18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            84..344
                     /gene="Rab5b"
                     /gene_synonym="C030027M18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..829
                     /gene="Rab5b"
                     /gene_synonym="C030027M18Rik"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-5B"
                     /protein_id="NP_803130.1"
                     /db_xref="CCDS:CCDS24287.1"
                     /db_xref="GeneID:19344"
                     /db_xref="MGI:MGI:105938"
                     /translation="MTSRSTARPNGQPQASKICQFKLVLLGESAVGKSSLVLRFVKGQ
                     FHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDI
                     TNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEEAQAYADDNSLLFM
                     ETSAKTAMNVNDLFLAIAKKLPKSEPQNLGGAAGRSRGVDLHEQSQQNKSQCCSN"
     exon            345..496
                     /gene="Rab5b"
                     /gene_synonym="C030027M18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            497..619
                     /gene="Rab5b"
                     /gene_synonym="C030027M18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            620..713
                     /gene="Rab5b"
                     /gene_synonym="C030027M18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            714..3180
                     /gene="Rab5b"
                     /gene_synonym="C030027M18Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagggggta ggagtttggt tgagctgcag ctgtttgtct gttccacaca ggcttgggcc
       61 cgacggggga tacggagccc caggactgtt gaggcctgga agtccctccc cttccccttc
      121 cccctttgcc gctttgtggc attcccctcc ctctaccttc tcctactttg ataacctggc
      181 tatgactagc agaagtacag ccaggcccaa tgggcaaccc caggccagca aaatatgcca
      241 gttcaaattg gtcctgctgg gagagtctgc agtggggaag tctagcctgg tgttacgttt
      301 tgtcaaagga cagttccatg aataccagga aagcaccatt ggagcggcct tcctcaccca
      361 atccgtgtgt ttagatgaca caacagtcaa gtttgagatc tgggacactg ctgggcagga
      421 gcgataccac agtttagccc ctatgtacta caggggtgcc caggctgcaa tcgtggtcta
      481 tgatattact aatcaggaaa cgtttgctcg ggcaaagaca tgggtaaagg aactacagcg
      541 gcaagccagc cctagcattg ttattgcctt ggcagggaac aaagctgacc ttgccaacaa
      601 gcgcatggtg gagtatgaag aggctcaggc atatgcagat gacaacagct tattatttat
      661 ggagacttca gctaagactg ctatgaacgt gaatgatctc ttcctggcaa tagcaaagaa
      721 gttgccaaag agcgaacccc agaatctggg gggtgcggca ggccgaagtc ggggtgtgga
      781 tcttcatgag cagtcccagc agaacaagag ccagtgttgt agcaactgag gggtggctcg
      841 aagcaaatat gtatggagtt agcacgagag ctaagaaata acctccatcc ccacccctca
      901 gcacacagtc cctacggtaa cagcacactg agccctggct cccaagggct gcctcctgac
      961 agctccgtca tggcactttt taatgcttca gcaaccaaca ccaggcagct gttgccacta
     1021 ctatgcccta cctggggctt ggggtcacat ctccccagga ccttccttcc aaaacaaact
     1081 tcttcacttc gtgttctagg tgcaagacag tgaccttctc attgtccccc acccccgtgt
     1141 ttttccagtg tttcagagaa gacttctgtc tcctgcctca catcccacct ttcatcatta
     1201 ctccctcttc ttgatcctgt ttctcctctt tacaagatga tgaagggtaa tcccagggac
     1261 tgagaaggga gggatatact tttagttaca ttaaagacct tgtggggaga gtaaggctcg
     1321 cagcaggagg gagtgaggaa acattgcttt cccattttat ttatctggta agagtttctt
     1381 gtctatgaaa cactgcggca ccaatgagta ggacttgtgg agggcgttcc taggtaggag
     1441 tgagaacagg gagtcaagct cgcaggcact gaatgggagt ttattagtag gacaaaggtt
     1501 gaggtgcagt gtcatccgtg gctctggaac ttgccccgag gctggtttcc cttttgtccc
     1561 catccactca ccccactcga gtgtggggat tggacctcag agtgctccaa agaatcttca
     1621 ctggttgcct gcacctttag ctctgctgtg atctaattgg aggaggtact ctgataccgt
     1681 cctctgaggc ctatgtatac ataggcattt cccctaccct ggccttgaga tggccttaac
     1741 cccagacacc atgcccctgc agtttgcact ttaattgatg gtagttcagt caagatacag
     1801 gtttttttgt gtgtgggggg gggggggttg attgatttac ctatccttca accgttttaa
     1861 ttaaatggaa tctacaatga atgaggtttg gccctataga agacagtagc agtggcagct
     1921 actcacaccc agtctccact gctagcttcc tgactgattc atacctctat tcttgggtat
     1981 aggtttgtct gagcaactgg ggagtggcct cagaatagca tgggccatgg tagtggagta
     2041 aagaaaggtc aggcaaaagg agtgttctat cttcccaggg ttcacattca gtttgctatg
     2101 tcttaccatg tcttttctac ttccctgtaa atacgtataa gtctttattc tctgtacagt
     2161 ctgctctgcc tcctggctcc cattagcctt cttttcttct ccttttgtta atatcttggg
     2221 tttagttcct ccttcattcc cccacttact cttacttaat ccgtgtacca ctaggggctc
     2281 ctaccacaaa ggctgcttgt ccaatgacag ggcagctaga actgaaggtg cctcacaact
     2341 gccttgtatc atcagagggc tttggtcctt cctaagtctc tggcctctct acgtcctata
     2401 ttaggtgttt gagggtgtct gtgggaagcc atcaaagcaa gaggaaactt ggtattttag
     2461 ccagagtttg ggagaaacat gcagaagaaa ggaaaagacc acggtaacct cgagttgagc
     2521 ctttctgccc cttgggctca gagactgact tgtgttccag agcagctgag gaatccatga
     2581 ggccaagatt ctcaaggacc caacttaggt tcctccactt aggactcaat tctcttcctt
     2641 ttccaggggc agccttagtt ctcatggccc tgaaacatat atttactttc ctagaacctg
     2701 ttcatctgca aaatatccag gcacatcctt tttacaagtg gagactcgag ggaagctctc
     2761 caagtctctt agaaacttaa ttccttctct gcaaaagtga agatgtttta ttgccttggg
     2821 gctgggaaac catttcccta ggctttccct ccctccctcc ttccctccct ccccccctct
     2881 cttaggaaca gtattggcct tagttcctgg cctacctgct gccttccctc tcctcctgcc
     2941 agctctcctg ccttcgctgg agctctgttg ggcttgaggg gttttgttct ctccctcccc
     3001 tcccccgtta ccttttttct tttgatcagt ttttaggggg agggctcaac atttttgcct
     3061 ttatatttct ttcctaagga agcatttgcc tttctttcac tctcctaaca taacaatcgt
     3121 ggtaacagaa tgcaactgct gatttatcga tgtatttaat gtaagtaaaa aaggaaaaaa
//
