LOCUS       NM_025887               2364 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus RAB5A, member RAS oncogene family (Rab5a), mRNA.
ACCESSION   NM_025887
VERSION     NM_025887.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2364)
  AUTHORS   Ye,H., Yang,Q., Guo,H., Wang,X., Cheng,L., Han,B., Hong,M., Ma,F.,
            Li,M., Wu,X., Chen,F., Zhu,J., Chen,S., Zheng,S. and Li,J.
  TITLE     Internalisation of neutrophils extracellular traps by macrophages
            aggravate rheumatoid arthritis via Rab5a
  JOURNAL   RMD Open 10 (1), e003847 (2024)
   PUBMED   38485453
  REMARK    GeneRIF: Internalisation of neutrophils extracellular traps by
            macrophages aggravate rheumatoid arthritis via Rab5a.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2364)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2364)
  AUTHORS   Mestres,I., Einsiedel,M., Moller,J. and Cardoso de Toledo,B.
  TITLE     Smad anchor for receptor activation nuclear localization during
            development identifies Layers V and VI of the neocortex
  JOURNAL   J Comp Neurol 528 (13), 2161-2173 (2020)
   PUBMED   32037591
REFERENCE   4  (bases 1 to 2364)
  AUTHORS   Cong,X.X., Gao,X.K., Rao,X.S., Wen,J., Liu,X.C., Shi,Y.P., He,M.Y.,
            Shen,W.L., Shen,Y., Ouyang,H., Hu,P., Low,B.C., Meng,Z.X., Ke,Y.H.,
            Zheng,M.Z., Lu,L.R., Liang,Y.H., Zheng,L.L. and Zhou,Y.T.
  TITLE     Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and
            myoblast differentiation during muscle regeneration
  JOURNAL   Cell Death Differ 27 (8), 2344-2362 (2020)
   PUBMED   32051546
  REMARK    GeneRIF: Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling
            and myoblast differentiation during muscle regeneration.
REFERENCE   5  (bases 1 to 2364)
  AUTHORS   Miao,L., Li,J., Li,J., Lu,Y., Shieh,D., Mazurkiewicz,J.E.,
            Barroso,M., Schwarz,J.J., Xin,H.B., Singer,H.A., Vincent,P.A.,
            Zhong,W., Radice,G.L., Wan,L.Q., Fan,Z.C., Huang,G. and Wu,M.
  TITLE     Cardiomyocyte orientation modulated by the Numb family
            proteins-N-cadherin axis is essential for ventricular wall
            morphogenesis
  JOURNAL   Proc Natl Acad Sci U S A 116 (31), 15560-15569 (2019)
   PUBMED   31300538
REFERENCE   6  (bases 1 to 2364)
  AUTHORS   Hilditch-Maguire,P., Trettel,F., Passani,L.A., Auerbach,A.,
            Persichetti,F. and MacDonald,M.E.
  TITLE     Huntingtin: an iron-regulated protein essential for normal nuclear
            and perinuclear organelles
  JOURNAL   Hum Mol Genet 9 (19), 2789-2797 (2000)
   PUBMED   11092755
REFERENCE   7  (bases 1 to 2364)
  AUTHORS   Gruenheid,S., Pinner,E., Desjardins,M. and Gros,P.
  TITLE     Natural resistance to infection with intracellular pathogens: the
            Nramp1 protein is recruited to the membrane of the phagosome
  JOURNAL   J Exp Med 185 (4), 717-730 (1997)
   PUBMED   9034150
REFERENCE   8  (bases 1 to 2364)
  AUTHORS   Barbosa,M.D., Wakeland,E.K., Zerial,M. and Kingsmore,S.F.
  TITLE     Genetic mapping of the Rab5a and Rab5b genes on mouse Chromosomes
            17 and 2, respectively
  JOURNAL   Mamm Genome 7 (2), 166-167 (1996)
   PUBMED   8835543
REFERENCE   9  (bases 1 to 2364)
  AUTHORS   Murphy,C. and Zerial,M.
  TITLE     Expression of Rab proteins during mouse embryonic development
  JOURNAL   Methods Enzymol 257, 324-332 (1995)
   PUBMED   8583936
REFERENCE   10 (bases 1 to 2364)
  AUTHORS   Bucci,C., Wandinger-Ness,A., Lutcke,A., Chiariello,M., Bruni,C.B.
            and Zerial,M.
  TITLE     Rab5a is a common component of the apical and basolateral endocytic
            machinery in polarized epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 5061-5065 (1994)
   PUBMED   8197185
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC165960.4.
            
            On Apr 29, 2007 this sequence version replaced NM_025887.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081999.1, AK010495.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               AC165960.4         162238-162612
            376-630             AC165960.4         166825-167079
            631-782             AC165960.4         180531-180682
            783-905             AC165960.4         181392-181514
            906-999             AC165960.4         183380-183473
            1000-2364           AC165960.4         189318-190682
FEATURES             Location/Qualifiers
     source          1..2364
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 27.82 cM"
     gene            1..2364
                     /gene="Rab5a"
                     /gene_synonym="2410015H04Rik; nnyRab5a"
                     /note="RAB5A, member RAS oncogene family"
                     /db_xref="GeneID:271457"
                     /db_xref="MGI:MGI:105926"
     exon            1..375
                     /gene="Rab5a"
                     /gene_synonym="2410015H04Rik; nnyRab5a"
                     /inference="alignment:Splign:2.1.0"
     exon            376..630
                     /gene="Rab5a"
                     /gene_synonym="2410015H04Rik; nnyRab5a"
                     /inference="alignment:Splign:2.1.0"
     exon            631..782
                     /gene="Rab5a"
                     /gene_synonym="2410015H04Rik; nnyRab5a"
                     /inference="alignment:Splign:2.1.0"
     exon            783..905
                     /gene="Rab5a"
                     /gene_synonym="2410015H04Rik; nnyRab5a"
                     /inference="alignment:Splign:2.1.0"
     exon            906..999
                     /gene="Rab5a"
                     /gene_synonym="2410015H04Rik; nnyRab5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..2364
                     /gene="Rab5a"
                     /gene_synonym="2410015H04Rik; nnyRab5a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1472..1477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab5a"
                     /gene_synonym="2410015H04Rik; nnyRab5a"
                     /note="hexamer: AATAAA"
     polyA_site      1496
                     /gene="Rab5a"
                     /gene_synonym="2410015H04Rik; nnyRab5a"
                     /note="major polyA site"
     regulatory      1532..1537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab5a"
                     /gene_synonym="2410015H04Rik; nnyRab5a"
                     /note="hexamer: AATAAA"
     polyA_site      1552
                     /gene="Rab5a"
                     /gene_synonym="2410015H04Rik; nnyRab5a"
     regulatory      1686..1691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab5a"
                     /gene_synonym="2410015H04Rik; nnyRab5a"
                     /note="hexamer: GATAAA"
     polyA_site      1706
                     /gene="Rab5a"
                     /gene_synonym="2410015H04Rik; nnyRab5a"
ORIGIN      
        1 ggctacgtgg cggagccggc ggaagcagtt cctgcgctgg agcccgagtg tttgtgtttt
       61 ggttcgtgag gagccggggc ggtctgaggg gaggagaccg agggaggagg aggaggagaa
      121 cgacgacgac gaggaagaag tcctcggaac tcgagcgcgg cgactctgga ggaggaggag
      181 aaaggaaggc ggaacggaga ggcggagacg cagcccggca ggggcggcgg cacggcgggc
      241 ggcgctcaga gtcccgcgcc ggccagggtg agaagaagga gcgagcaggc gacgccgccg
      301 ctgcagccgc ggcgcatccg atctccgggc cgggccgggc cgtgcgtggc ctcgctgccg
      361 ggagacgcgg cccaggtaat ttctccagaa agaaaacaaa attaatgcct tgcatcctgg
      421 aagttcattt aggaatctga aattagggac ttctttaaaa tttggacatg gctaatcgag
      481 gagcaacaag acccaacggg ccaaatactg gaaataaaat atgccagttc aaactggtcc
      541 ttctaggaga gtctgctgtt ggcaaatcaa gcctggttct tcgctttgtg aaaggccaat
      601 ttcatgaatt tcaagagagt accattgggg ctgcctttct aacccaaact gtgtgtcttg
      661 atgacacaac agtaaaattt gaaatatggg atacagctgg tcaagaacgg tatcatagct
      721 tagcaccaat gtactaccga ggagcacaag cagccatagt tgtgtatgat atcacaaatg
      781 aggaatcctt tgcgagagca aaaaactggg ttaaagaact tcaaaggcaa gcaagtccta
      841 atattgtgat agctttgtca ggaaacaaag ctgacttagc aaataaaaga gctgttgact
      901 tccaggaagc acagtcctat gcagatgaca acagcttatt atttatggag acatcagcta
      961 agacatcaat gaatgtaaat gaaatattta tggcaatagc taaaaagctg ccaaagaatg
     1021 aaccacagaa tcctggtgca aactcagcca gaggacgagg agtagacctt actgagcctg
     1081 cacagccagc cagaagccag tgttgtagta actgagctcc agtgtgaact tcctgaatgg
     1141 caaaaaccat ggagttggga gcatttagcc ggcccagtgt gacttccaaa aagagactat
     1201 ggtagaatca agtttctaat tctgaattat tttgagtgtt ttgaacttaa tttttaataa
     1261 catgcatgtg ctcctccagc agtagaaagg aaaatgagga ctgtgtgtac acttgttcca
     1321 tgtgaaagtg caggggaaca gctcatctcc agtgggtatg gacccactct taacccaccc
     1381 agtctccaaa ctgggataat agtcaggaat gacatgttca aaattactaa tgtatgcttt
     1441 agaaaacatt tttagaagac ttacgcttaa caataaaacc caagcaaatg gtgtaatttg
     1501 attttcttaa aaagtctaca tttcacatat taataaagca atcccaacaa aacagtcttg
     1561 catctccaga aagaaggaat gaatattgat gacatcttaa ttttattcag tcccattact
     1621 tcttaaaatt tgattgaaaa aattaagtca catgtaaccc catgctgttt taggaatatg
     1681 aaaccgataa atgcatttta atgatagtgg tcccttcata tgagcttctt ttaaaaagtg
     1741 gaaacaaacc aggtatctgc tttctagtta atcactgttg gctattccat agaggtgtgt
     1801 ctggaacagg gagggggctc tgcttccctt tgggcataat tagtcagtgc actaacaatt
     1861 atgtacattc aaacttgatt attttaaata tgatcttcag ctgtactgta aatagagtac
     1921 tgcattgtag tctccatatg tttattattt cctataatat ttaagaattg cctaaacata
     1981 tacaaaatgt acagttacta aaacagctaa ttatttcttt cttcccctat gaaaggaagg
     2041 ggctttgctg ttcttacatg gctagaacca taataaacaa tgtacttgca attgtaacat
     2101 aagtattaca atgttattag taataatctt gaagccttgt tttttgaagt ccattttatt
     2161 ttaatcagta tattgcacta attattttag gtattttcat tatatgaaat ctaccatgtg
     2221 tcagatgatt taatctattt aagtgttgat ctgctagcag aacttgtaca ttttacagta
     2281 actcaaaact agtaaggaga acagttcacc ggtgtttagt tttatattga ggtgctcagg
     2341 ttggaataaa gtgatgtaaa aagc
//
