LOCUS       NM_029391               1170 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus RAB4B, member RAS oncogene family (Rab4b), mRNA.
ACCESSION   NM_029391 XM_991144
VERSION     NM_029391.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1170)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1170)
  AUTHORS   Gilleron,J., Bouget,G., Ivanov,S., Meziat,C., Ceppo,F., Vergoni,B.,
            Djedaini,M., Soprani,A., Dumas,K., Jacquel,A., Yvan-Charvet,L.,
            Venteclef,N., Tanti,J.F. and Cormont,M.
  TITLE     Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance,
            Adipose Tissue Dysfunction, and Insulin Resistance
  JOURNAL   Cell Rep 25 (12), 3329-3341 (2018)
   PUBMED   30566860
  REMARK    GeneRIF: the obesity-induced loss of Rab4b in adipose T cells may
            contribute to maladaptive white adipose tissue remodeling and
            insulin resistance by altering adipose T cell fate.
REFERENCE   3  (bases 1 to 1170)
  AUTHORS   Kaddai,V., Gonzalez,T., Keslair,F., Gremeaux,T., Bonnafous,S.,
            Gugenheim,J., Tran,A., Gual,P., Le Marchand-Brustel,Y. and
            Cormont,M.
  TITLE     Rab4b is a small GTPase involved in the control of the glucose
            transporter GLUT4 localization in adipocyte
  JOURNAL   PLoS One 4 (4), e5257 (2009)
   PUBMED   19590752
  REMARK    GeneRIF: Data conclude that Rab4b is a new important player in the
            control of GLUT4 trafficking in adipocyte.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1170)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   5  (bases 1 to 1170)
  AUTHORS   Davies,S.R., Li,J., Okazaki,K. and Sandell,L.J.
  TITLE     Tissue-restricted expression of the Cdrap/Mia gene within a
            conserved multigenic housekeeping locus
  JOURNAL   Genomics 83 (4), 667-678 (2004)
   PUBMED   15028289
REFERENCE   6  (bases 1 to 1170)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   7  (bases 1 to 1170)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   8  (bases 1 to 1170)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   9  (bases 1 to 1170)
  AUTHORS   Barbosa,M.D., Johnson,S.A., Achey,K., Gutierrez,M.J.,
            Wakeland,E.K., Zerial,M. and Kingsmore,S.F.
  TITLE     The Rab protein family: genetic mapping of six Rab genes in the
            mouse
  JOURNAL   Genomics 30 (3), 439-444 (1995)
   PUBMED   8825628
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC157553.10.
            
            On Mar 21, 2007 this sequence version replaced NM_029391.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005314.1, BC007147.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AC157553.10        11143-11299
            158-238             AC157553.10        13788-13868
            239-353             AC157553.10        14133-14247
            354-416             AC157553.10        15248-15310
            417-571             AC157553.10        15450-15604
            572-667             AC157553.10        17067-17162
            668-798             AC157553.10        17259-17389
            799-1170            AC157553.10        21222-21593
FEATURES             Location/Qualifiers
     source          1..1170
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.84 cM"
     gene            1..1170
                     /gene="Rab4b"
                     /gene_synonym="1500031G17Rik"
                     /note="RAB4B, member RAS oncogene family"
                     /db_xref="GeneID:19342"
                     /db_xref="MGI:MGI:105071"
     exon            1..157
                     /gene="Rab4b"
                     /gene_synonym="1500031G17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..783
                     /gene="Rab4b"
                     /gene_synonym="1500031G17Rik"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-4B"
                     /protein_id="NP_083667.1"
                     /db_xref="CCDS:CCDS21012.1"
                     /db_xref="GeneID:19342"
                     /db_xref="MGI:MGI:105071"
                     /translation="MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVE
                     FGSRVVNVGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAW
                     LTDARTLASPNIVVILCGNKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEE
                     AFLKCARTILNKIDSGELDPERMGSGIQYGDISLRQLRQPRSAQAVAPQPCGC"
     exon            158..238
                     /gene="Rab4b"
                     /gene_synonym="1500031G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            239..353
                     /gene="Rab4b"
                     /gene_synonym="1500031G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            354..416
                     /gene="Rab4b"
                     /gene_synonym="1500031G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            417..571
                     /gene="Rab4b"
                     /gene_synonym="1500031G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            572..667
                     /gene="Rab4b"
                     /gene_synonym="1500031G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            668..798
                     /gene="Rab4b"
                     /gene_synonym="1500031G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            799..1170
                     /gene="Rab4b"
                     /gene_synonym="1500031G17Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcggtgaa ggcggaagtg gcggcgccgg gtccagaagt ggaaaggagc tgaggctgca
       61 gcccgagtgg agcggctgcc agccgaggaa caggcgcggc tgcggcgcca tattgcggcc
      121 ctcagcggtc gccactgagc catggccgag acctacgact tcctcttcaa attcctggtg
      181 attggcagtg ctggaactgg caaatcatgt cttctccacc agtttattga gaataagttc
      241 aaacaggact ccaaccacac tatcggcgtg gagtttggat ccagggtggt caacgttggg
      301 gggaagactg tgaaactaca gatttgggac actgctggcc aggagcggtt tcggtcggtg
      361 acgcggagtt attaccgagg ggcagctgga gccctgctgg tgtatgacat caccagccgg
      421 gagacataca actcactcgc tgcttggcta actgatgccc ggacactggc cagccccaac
      481 atcgtggtca tcctctgtgg caacaagaag gacctggatc ccgagcgtga ggtcactttc
      541 ctagaggctt ctcgctttgc tcaggagaat gagctgatgt tcctggagac cagcgctctc
      601 acgggtgaga atgtggaaga agctttcctc aagtgcgcgc gcaccatcct caacaagatc
      661 gactcaggtg aactagaccc agagaggatg ggttcaggca ttcagtatgg cgacatatcc
      721 ctccgccagc tgcggcagcc tcgcagcgcc caagccgtgg cccctcagcc ctgtggctgc
      781 tgagatgtgc agaaccagct cacctgttct tctggaccag ccctgcccga aggctggggc
      841 tcagaaccag gccccaagag gccaggcccc aatctgcccc agtctcagaa aagttactcc
      901 atcccccatc ccccttcgct ggcctggtgg ggcctggctg tggggcaaga ttgagccaca
      961 ggggaaaggg gaccccatac ctgctgctgc ttcctctgcc ttggctaact ctagtccccc
     1021 tgagccccaa accctacctg aagaactccc aaagcttgag accagggccg tttggcccca
     1081 acttcctgcc tggccccgct gttgcaagtc tgttatttat tacctggagg cctgttccat
     1141 cctgtcctgg tcctccataa agcattgttt
//
