LOCUS       NM_009003               1412 bp    mRNA    linear   ROD 29-DEC-2022
DEFINITION  Mus musculus RAB4A, member RAS oncogene family (Rab4a), mRNA.
ACCESSION   NM_009003
VERSION     NM_009003.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1412)
  AUTHORS   Sun-Wada GH, Tabata H and Wada Y.
  TITLE     Vacuolar-type proton ATPase is required for maintenance of
            apicobasal polarity of embryonic visceral endoderm
  JOURNAL   Sci Rep 11 (1), 19355 (2021)
   PUBMED   34588579
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1412)
  AUTHORS   Kawamura N, Takaoka K, Hamada H, Hadjantonakis AK, Sun-Wada GH and
            Wada Y.
  TITLE     Rab7-Mediated Endocytosis Establishes Patterning of Wnt Activity
            through Inactivation of Dkk Antagonism
  JOURNAL   Cell Rep 31 (10), 107733 (2020)
   PUBMED   32521258
REFERENCE   3  (bases 1 to 1412)
  AUTHORS   Blaszczyk M, Gajewska M, Milewska M and Grzelkowska-Kowalczyk K.
  TITLE     Insulin-dependent cytoplasmic distribution of Rab4a in mouse
            adipocytes is inhibited by interleukin-6, -8, and -15
  JOURNAL   Cell Biol Int 41 (4), 457-463 (2017)
   PUBMED   28191740
  REMARK    GeneRIF: Insulin-dependent Rab4a redistribution, probably
            reflecting stimulation of vesicle-mediated transport, is inhibited
            in adipocytes subjected to differentiation in the presence of IL-6,
            IL-8, or IL-15.
REFERENCE   4  (bases 1 to 1412)
  AUTHORS   Lucitti JL, Sealock R, Buckley BK, Zhang H, Xiao L, Dudley AC and
            Faber JE.
  TITLE     Variants of Rab GTPase-Effector Binding Protein-2 Cause Variation
            in the Collateral Circulation and Severity of Stroke
  JOURNAL   Stroke 47 (12), 3022-3031 (2016)
   PUBMED   27811335
REFERENCE   5  (bases 1 to 1412)
  AUTHORS   Schindler C, Chen Y, Pu J, Guo X and Bonifacino JS.
  TITLE     EARP is a multisubunit tethering complex involved in endocytic
            recycling
  JOURNAL   Nat Cell Biol 17 (5), 639-650 (2015)
   PUBMED   25799061
REFERENCE   6  (bases 1 to 1412)
  AUTHORS   Fukuda M, Kuroda TS and Mikoshiba K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   7  (bases 1 to 1412)
  AUTHORS   Kuroda TS, Fukuda M, Ariga H and Mikoshiba K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   8  (bases 1 to 1412)
  AUTHORS   Cormont M, Mari M, Galmiche A, Hofman P and Le Marchand-Brustel Y.
  TITLE     A FYVE-finger-containing protein, Rabip4, is a Rab4 effector
            involved in early endosomal traffic
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1637-1642 (2001)
   PUBMED   11172003
REFERENCE   9  (bases 1 to 1412)
  AUTHORS   Ikeda H, Ikegami T, Mitsui T, Sendo D and Hayasaka K.
  TITLE     Isolation and sequence determination of cDNA encoding mouse rab 4
            and candidate approach for the beige mutation in mice
  JOURNAL   Biochem Mol Biol Int 40 (4), 647-651 (1996)
   PUBMED   8950022
REFERENCE   10 (bases 1 to 1412)
  AUTHORS   Barbosa MD, Johnson SA, Achey K, Gutierrez MJ, Wakeland EK, Zerial
            M and Kingsmore SF.
  TITLE     The Rab protein family: genetic mapping of six Rab genes in the
            mouse
  JOURNAL   Genomics 30 (3), 439-444 (1995)
   PUBMED   8825628
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AEKQ02169250.1 and AC147266.6.
            
            [WARNING] On Oct 11, 2023 this sequence was replaced by
            NM_009003.5.
            
            On Jul 30, 2020 this sequence version replaced NM_009003.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145452.1, AK161877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AEKQ02169250.1     37931-38040         c
            111-171             AC147266.6         121297-121357
            172-252             AC147266.6         139005-139085
            253-367             AC147266.6         142515-142629
            368-430             AC147266.6         144187-144249
            431-585             AC147266.6         145424-145578
            586-681             AC147266.6         147994-148089
            682-814             AC147266.6         149206-149338
            815-1412            AC147266.6         149885-150482
FEATURES             Location/Qualifiers
     source          1..1412
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.19 cM"
     gene            1..1412
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /note="RAB4A, member RAS oncogene family"
                     /db_xref="GeneID:19341"
                     /db_xref="MGI:MGI:105069"
     exon            1..171
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /inference="alignment:Splign:2.1.0"
     exon            172..252
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /inference="alignment:Splign:2.1.0"
     exon            253..367
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /inference="alignment:Splign:2.1.0"
     exon            368..430
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /inference="alignment:Splign:2.1.0"
     exon            431..585
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /inference="alignment:Splign:2.1.0"
     exon            586..681
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /inference="alignment:Splign:2.1.0"
     exon            682..814
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1412
                     /gene="Rab4a"
                     /gene_synonym="Rab4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcgcagg cgcggagccg agtcccgctg ggccgcagcc ggtggccggc tcgccgtggg
       61 cccgttcccg gctctccacg ctcggttcct ctcgctctgc ggagactgga ggacggaccc
      121 cgcggagctg tggcggcaga atggcgcaga ccgccatgtc cgagacttac gatttcttgt
      181 ttaaattctt ggtcatcgga aatgcgggaa ctggcaaatc ttgcttgctt catcagttca
      241 ttgaaaagaa attcaaagat gactcaaatc ataccatagg agtggaattt ggctcaaaga
      301 taataaatgt cggtggtaaa tatgtaaagt tacagatatg ggacacggcc ggccaggagc
      361 ggttcaggtc tgtgacgaga agctactaca gaggtgcagc tggggcactc cttgtctatg
      421 acatcaccag ccgagaaacc tacaatgcgc ttactaattg gttaacagat gccagaatgc
      481 tggcgagcca gaacatcgtc cttatcctct gcgggaacaa gaaggacttg gatgccgacc
      541 gggaagtcac cttcctcgaa gcctccaggt tcgcacaaga gaatgagctg atgttcctgg
      601 aaaccagtgc actgactggc gagaacgtcg aagaggcttt catgcagtgt gcaaggaaaa
      661 tacttaacaa aattgaatca ggtgaactgg accccgagag gatgggctct ggcatccagt
      721 atggagacgc tgccctgaga cagctgcggt cacctcggcg tacacaggct ccaagtgcac
      781 aggagtgtgg ctgctaggcg ccccagtgac acaggttcag cggtgggtcc tggagtacag
      841 ccgccggagc ctgaagaggc tggagttttt actaccatct tttctactcg gcacagaagt
      901 agatcttcct ggggaacggt gtacgctggc agccggggct cagcagccat tctgcgaact
      961 aactcagcgg acagtacctt tagatgccac atgtatgcag acccctgccc cacacgtacc
     1021 cttcacgttc tgttaaatcc agcttgtgct gcccacagca cgttcccaca gcacagagcc
     1081 ggtgtgacat gacagaaccc tgcactcagt gagctttctt tttaaactcc caggaaatgc
     1141 agttgtgaat gtgagagagc gtgcttttct cattgcgcgt tggttaactc ccaggagatg
     1201 cagtcatgaa cgtgagcgtg ctttcctcct tgtgttggtt atgcgtatga cccggtatga
     1261 aaggactctg gtgtgaacag ccagtgcgtt tcttatttaa tccctctccc cccacccctt
     1321 ttacactgtt tctgtgatcc acacctgaaa tgctaaaccc acaggactca ttaacacctg
     1381 gaaataaagt ggaacggagt ttctcacgca ca
//
