LOCUS       NM_001039394            4605 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus RAB43, member RAS oncogene family (Rab43), transcript
            variant 1, mRNA.
ACCESSION   NM_001039394
VERSION     NM_001039394.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4605)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4605)
  AUTHORS   Wang,Y., Zhang,W., Xu,Y., Wu,D., Gao,Z., Zhou,J., Qian,H., He,B.
            and Wang,G.
  TITLE     Extracellular HMGB1 Impairs Macrophage-Mediated Efferocytosis by
            Suppressing the Rab43-Controlled Cell Surface Transport of CD91
  JOURNAL   Front Immunol 13, 767630 (2022)
   PUBMED   35392093
  REMARK    GeneRIF: Extracellular HMGB1 Impairs Macrophage-Mediated
            Efferocytosis by Suppressing the Rab43-Controlled Cell Surface
            Transport of CD91.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4605)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4605)
  AUTHORS   Kretzer,N.M., Theisen,D.J., Tussiwand,R., Briseno,C.G.,
            Grajales-Reyes,G.E., Wu,X., Durai,V., Albring,J., Bagadia,P.,
            Murphy,T.L. and Murphy,K.M.
  TITLE     RAB43 facilitates cross-presentation of cell-associated antigens by
            CD8alpha+ dendritic cells
  JOURNAL   J Exp Med 213 (13), 2871-2883 (2016)
   PUBMED   27899443
  REMARK    GeneRIF: These results suggest that RAB43 provides a specialized
            activity used in cross-presentation selectively by CD8alpha(+) DCs
            but not other antigen-presenting cells.
REFERENCE   5  (bases 1 to 4605)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 4605)
  AUTHORS   Trost,M., English,L., Lemieux,S., Courcelles,M., Desjardins,M. and
            Thibault,P.
  TITLE     The phagosomal proteome in interferon-gamma-activated macrophages
  JOURNAL   Immunity 30 (1), 143-154 (2009)
   PUBMED   19144319
REFERENCE   7  (bases 1 to 4605)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   8  (bases 1 to 4605)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   9  (bases 1 to 4605)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   10 (bases 1 to 4605)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY753078.1 and AC158626.6.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ534465.1, BY753078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-693               BY753078.1         2-694
            694-4605            AC158626.6         70686-74597
FEATURES             Location/Qualifiers
     source          1..4605
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.13 cM"
     gene            1..4605
                     /gene="Rab43"
                     /gene_synonym="1810048P08Rik; 2500004H21Rik"
                     /note="RAB43, member RAS oncogene family"
                     /db_xref="GeneID:69834"
                     /db_xref="MGI:MGI:1917084"
     exon            1..433
                     /gene="Rab43"
                     /gene_synonym="1810048P08Rik; 2500004H21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..868
                     /gene="Rab43"
                     /gene_synonym="1810048P08Rik; 2500004H21Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     ras-related protein Rab-43"
                     /codon_start=1
                     /product="ras-related protein Rab-43 isoform a"
                     /protein_id="NP_001034483.1"
                     /db_xref="CCDS:CCDS20329.1"
                     /db_xref="GeneID:69834"
                     /db_xref="MGI:MGI:1917084"
                     /translation="MAGPGPGDQDEHYDFLFKLVLVGDASVGKTCVVQRFKTGAFSAR
                     QGSTIGVDFTMKTLEIQGKRVKLQIWDTAGQERFRTITQSYYRSANGAILAYDISKRS
                     TFLSVPHWIEDVRKYAGSNIVQLLIGNKSDLADFREVPLAEAQSLAEHYDILCAIETS
                     AKDSSNVEEAFTRVATELIMRHGGPMFSEKNTDHIQLDSKDIAESWGCGC"
     exon            434..617
                     /gene="Rab43"
                     /gene_synonym="1810048P08Rik; 2500004H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            618..4605
                     /gene="Rab43"
                     /gene_synonym="1810048P08Rik; 2500004H21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4574..4579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab43"
                     /gene_synonym="1810048P08Rik; 2500004H21Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4593
                     /gene="Rab43"
                     /gene_synonym="1810048P08Rik; 2500004H21Rik"
                     /note="major polyA site"
ORIGIN      
        1 agagagctgc ggagggccgg gcggtgcgct cccgggcgga gccgagtcct cggggctccg
       61 gagcggagcg gggcggggcg gagcgggacg gtcgatcggt ccgccgtgca gctcgttcag
      121 gtgccgccgc cgctccacgt agcccggcgg cgggccggct agggcacacg gacctcggcc
      181 cgcggctgtc cttagcccaa gccgggccct tgcgtcccag gactcccgcg gagccatggc
      241 gggccctggc ccgggagatc aggacgaaca ctacgatttc ctgttcaagc tggtgttagt
      301 gggcgacgcg agcgtgggca agacgtgcgt ggtgcagcgc ttcaagaccg gcgccttctc
      361 ggcgcgtcag ggcagcacca tcggtgtcga cttcaccatg aagacgctgg agatccaggg
      421 caagcgggtc aagttacaga tttgggacac agctggccag gagcggttcc ggaccatcac
      481 ccagagctac taccgaagtg ccaatggggc tatccttgcg tacgacatca gcaagaggag
      541 caccttcttg tcagtgcctc actggatcga ggatgtgagg aagtacgcgg gttccaacat
      601 cgtgcagctg ctgattggga acaagtcaga ccttgccgat ttccgggagg tcccattggc
      661 ggaggcacag agcctggctg agcactatga catcctctgt gccatcgaga cctccgcaaa
      721 ggactccagc aatgtggagg aggccttcac cagagtggcc acggagctca tcatgaggca
      781 cggaggtccc atgttcagtg agaagaacac agaccacatc cagctggaca gcaaggacat
      841 tgcggagagc tggggctgtg ggtgctgacc tcccctcctc ctctgtctcc agcctgtcaa
      901 gccccaccct tcagagtcag ccctcccggg cactggcttc tctagaggga ttctgcaccc
      961 ctggcctgga tgctgtgtag gaagggagat gctatgcagg gtatcctgtg tagaaggcta
     1021 tcggtccagg gcaggatgtg gaccatccca ccagccagca tctgctctct cgatgttctt
     1081 cacattccag gactagcctg agcctccagc atagactgtg gtgggaaatg ggctggctgt
     1141 gctgcccaac tgcctcgtgc tggtgttgac cttctcctgc cttgactgct gcagacgtgc
     1201 agtgggttgc tgctctccag ggatgtggct ggtaccccag gttcttccag gtcattctcc
     1261 tgcctcttac caaagtataa aaagcacatc aattagaccc acagactggt gccgagcctt
     1321 gtcccgggga ggcctgagcc catcaggtgg gatcagcatc tgtcctcact gccagcttgg
     1381 agctccgagc tccctgggcc tggctcgatg ccttaccaag acctctcaga tgttttcttt
     1441 tccatgtagc atcccatttt cactgaccca attgtagagt catggtcagg ggccaactgg
     1501 gaactgtctc tgggcttaag gcccaaaatg ttgccagtca ggttgcaaaa gcagctaatc
     1561 tttcagtgtg gttgaagggt gagataggaa agtggaggtt taagaaaaaa ggagcagctt
     1621 tcgaggggca gctcgtgggt agagcacatg cttagcacat gccaggcccc aagttcagtc
     1681 ctcagcacca aaaacaacag aggagcagct ttcgaggggc agctcgtggg tagagcacat
     1741 gcttagcaca tgccaggccc caagttcagt cctcagcacc aaaaacaaca gaacagcagc
     1801 ttctggggtg tgtctgaggt tgagggccct atggatgcca gccttgcccc gtgtggagaa
     1861 gccatccctg cgacgactgt ccagagcttc tagttccctg tggtcctggt ctggcttaca
     1921 gtttcaaagc aaaaaagacg agtgcccact ggcctgagac ctgcctgcct taacgggtgc
     1981 ttcctgctgg ggtcagaagg agttgttccc cgcatcttcc tcctgctgac atcctaccct
     2041 tgcctcccac ctcaagcatt ctgatctgtc agcacctttc ctagggagat ctggccacag
     2101 ggcactttgc aacagctaca tggcagccca gggagacaga actgtggtga actagataaa
     2161 cagggctaga ctcactgggg tccccttcag gtaggaggca gcctgtgtac tagctgagcc
     2221 tggctctgat ggcatggaat cagggtctgc tctgagtgct ctcaggtggg gatcactgtg
     2281 gctgtactgg gttagagctg catggctcta agggctgggg accatgaagc ccgtaaggct
     2341 ttcttaaccc gtatgatcct tttgggggca tggcagtgac cttttcacag gggtcaccta
     2401 tcagaaaaca gctgactgtc ttcctttcct gggcccgatg cacttgagag agtcctgctt
     2461 gctggtttca gttggctcaa actcttatca gggagagctg gttccttccc tgaccccgcc
     2521 cctgcagagc ctgactccac ccacgggtgg gtactaccca actctgagcc tgccctttgt
     2581 actgcacatg gtcttcagag ccatctggca tctgtggttc catgagtaga acctgggggg
     2641 ttgacgtctc cagagccatt caggaaggca gcctctcatg gccctgctgg gtggtgggga
     2701 gtttgccagg tctttggttc aggtgttcaa atggaagtcc catttttagg atgtgtctgt
     2761 ctctctgagt ttagatactg accctgccat agctacccac tactacccag caagccttgc
     2821 tctttagcga taccagtgct gagcccagca ggacgttagg gttccaatgt acttagggct
     2881 tagaagaggg aggtcagaga ccttttgccc taaacagagc tctacccttt ccttcacaag
     2941 atggcaactg actggtgatg gggctcactt gccaccctgg gccatgagcc cacttttcta
     3001 gcctccaaag actggaagcc atgaagccag tgaggcagtg tttcttaagc tgtgagtctc
     3061 aaccccttta gtgagctcaa aggactctat cacaggggtt gcctatcaga aaacacagat
     3121 acttacatta cgattcataa ttagcaaaat tacagttcag taggtacgaa aataattttg
     3181 tggttggggg ttaccacacc atgagggctg tatttatgtg gcggcattag gacagttgag
     3241 gactgccaga agggcctaac ctggagtgga acagaactca gtgggctctg cttggccagg
     3301 tagcttcttc actggtggcc ccgtggctca cccagcaacc aggaagatta tttctttctt
     3361 cattcacagg acgataacct cacttccctt tcacaatccc tgggtgccgg gtgcggatga
     3421 ggtcctgccc tgtgccctta tgtaggagcg gtcctgccct aagagtttag cacaaacacc
     3481 agtctccttg acccctgcac tcccccagcc ctgccctgta accaccctac tgtctcactt
     3541 tccaggttcc agtttcactg ccaggtgcag gtctggaagg ccaggcccag ggccctcagc
     3601 cagtggggat aatcatggtc tccacagcct gcctatctct ctgctcgctg ttatgtctgg
     3661 ggccaacgtg accccctctc ccaggtctct cagccaacct gccttcttac agcacggact
     3721 cccacaagtg acccaaagca cacatctttg aggggcgatg ggccctcccc agccacaggc
     3781 cctatcccca gcatcctagc aaggatgaat tcttcccttg accccaattc tgtggcctga
     3841 gagggccctg agtcctggac tgaagctggc ttctatggag aagctgcatc cgtcccttct
     3901 aacagtagtg ccaaggctca ggccctctgc tgaggcccct gccccaccaa agtgctcaga
     3961 gcgacctttg ggcctttgtc ggaaggtgcc cagggcttga ggaccagaac ataagcaatg
     4021 cccgtttaga aacaaaccag ctgcttccct tcccctgggc aggcttggct gcctgccaac
     4081 agctgcccag ggcctctggg gcaatagaag tttaatctct tcccttgttt gaagagttac
     4141 tgaacagcag gaacaggtgg aggctgttgc tgttggggag gaagtaccca cagaagggct
     4201 ggtagggcca gggtggtagc agcaggagag aggtcctgtc cactaaaggt actagagaag
     4261 ggacctcatg tctctttggg tggaagtctg tccccaagga cacaggcccc aactggaggg
     4321 gatctacccg aaacccctgg ttcacactga acaggttgcc ctgtcccagg atactgccag
     4381 cagtgggcct ctagccaaac tcccccctgc agggcttggg caggggcaga cttgccagcc
     4441 caagggtgcc aggcacattg gggagatttt cacattacct atttatgaag atgtaagtct
     4501 ttctatcaaa tctatttttg aaacatgaaa agttgccttc ctggatatgt cagagacagt
     4561 gtacaattca accattaaac atttctgtat tgactctgtg ctcaa
//
