LOCUS       NM_139154               2466 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus Rab40C, member RAS oncogene family (Rab40c), mRNA.
ACCESSION   NM_139154 XM_914182 XM_923103
VERSION     NM_139154.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2466)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2466)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 2466)
  AUTHORS   Yatsu,A., Shimada,H., Ohbayashi,N. and Fukuda,M.
  TITLE     Rab40C is a novel Varp-binding protein that promotes proteasomal
            degradation of Varp in melanocytes
  JOURNAL   Biol Open 4 (3), 267-275 (2015)
   PUBMED   25661869
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2466)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2466)
  AUTHORS   Tan,R., Wang,W., Wang,S., Wang,Z., Sun,L., He,W., Fan,R., Zhou,Y.,
            Xu,X., Hong,W. and Wang,T.
  TITLE     Small GTPase Rab40c associates with lipid droplets and modulates
            the biogenesis of lipid droplets
  JOURNAL   PLoS One 8 (4), e63213 (2013)
   PUBMED   23638186
  REMARK    GeneRIF: Stimulation for adipocyte differentiation increases the
            expression of Rab40c in 3T3-L1 cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2466)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   7  (bases 1 to 2466)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   8  (bases 1 to 2466)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2466)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   10 (bases 1 to 2466)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159277.3.
            
            On Aug 21, 2009 this sequence version replaced NM_139154.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027008.1, SRR7345562.738050.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC159277.3         113654-113716
            64-248              AC159277.3         113819-114003
            249-309             AC159277.3         142022-142082
            310-370             AC159277.3         142670-142730
            371-448             AC159277.3         148216-148293
            449-671             AC159277.3         148566-148788
            672-2466            AC159277.3         149460-151254
FEATURES             Location/Qualifiers
     source          1..2466
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.97 cM"
     gene            1..2466
                     /gene="Rab40c"
                     /gene_synonym="RAR3"
                     /note="Rab40C, member RAS oncogene family"
                     /db_xref="GeneID:224624"
                     /db_xref="MGI:MGI:2183454"
     exon            1..63
                     /gene="Rab40c"
                     /gene_synonym="RAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            64..248
                     /gene="Rab40c"
                     /gene_synonym="RAR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..952
                     /gene="Rab40c"
                     /gene_synonym="RAR3"
                     /note="RAR (RAS like GTPASE) like; SOCS box containing
                     protein RAR3"
                     /codon_start=1
                     /product="ras-related protein Rab-40C"
                     /protein_id="NP_631893.1"
                     /db_xref="CCDS:CCDS28537.1"
                     /db_xref="GeneID:224624"
                     /db_xref="MGI:MGI:2183454"
                     /translation="MGTQGSPVKSYDYLLKFLLVGDSDVGKGEILESLQDGAAESPYA
                     YSNGIDYKTTTILLDGRRVKLELWDTSGQGRFCTIFRSYSRGAQGILLVYDITNRWSF
                     DGIDRWIKEIDEHAPGVPRILVGNRLHLAFKRQVPTEQARAYAEKNCMTFFEVSPLCN
                     FNVIESFTELSRIVLMRHGMEKIWRPNRVFSLQDLCCRAIVSCTPVHLIDKLPLPVTI
                     KSHLKSFSMANGMNAVMMHGRSYSLASGAGGSGSKGNSLKRSKSIRPPQSPPQNCSRS
                     NCKIS"
     exon            249..309
                     /gene="Rab40c"
                     /gene_synonym="RAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            310..370
                     /gene="Rab40c"
                     /gene_synonym="RAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            371..448
                     /gene="Rab40c"
                     /gene_synonym="RAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            449..671
                     /gene="Rab40c"
                     /gene_synonym="RAR3"
                     /inference="alignment:Splign:2.1.0"
     exon            672..2466
                     /gene="Rab40c"
                     /gene_synonym="RAR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2445..2450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab40c"
                     /gene_synonym="RAR3"
                     /note="hexamer: AGTAAA"
     polyA_site      2466
                     /gene="Rab40c"
                     /gene_synonym="RAR3"
                     /note="major polyA site"
ORIGIN      
        1 gccgtgcggg aagcggcggg tggcggcggc ggcagcggcg gcggcggcgg ctaggaggct
       61 gaggtctggc ggcggtgccg tgggccgcgg tgcggcgggc gggaggatgg gcacccaggg
      121 cagtccagtg aagagctacg attacctgct caagttcctg ctggtgggcg acagcgacgt
      181 gggcaaaggc gagatcctgg agagccttca ggacggcgca gctgaatccc cgtacgccta
      241 cagcaacggg atagactata agactaccac catcctcctg gatggacggc gtgtcaagct
      301 ggagctatgg gacacatcgg gccagggaag gttctgtacc atcttcaggt cctactcaag
      361 gggtgcacag ggaatccttc tggtgtacga catcaccaac cgttggtcct ttgatggcat
      421 tgaccggtgg atcaaggaga tcgatgagca tgcacctggt gttccccgga tcctggttgg
      481 gaaccggctg cacctggcct tcaagcggca agttccaacg gagcaggcca gagcctatgc
      541 agagaagaac tgcatgacct tctttgaagt cagccccctg tgcaacttca acgtcattga
      601 gtccttcact gagctctccc gtatcgtgct catgcggcat ggcatggaga agatctggag
      661 acccaatcga gttttcagcc tgcaggacct ctgctgccgt gccattgtct cctgtacccc
      721 tgtgcacctc atcgacaagc tcccactacc tgtcaccatc aaaagccacc tcaagtcctt
      781 ttccatggcc aacggcatga acgctgtcat gatgcacggc cgctcctact ccctggcaag
      841 tggggccggg ggcagtggca gcaagggcaa cagccttaag aggtctaagt ccatccggcc
      901 ccctcagagc ccacctcaga actgctctcg gagcaactgc aagatctcct agcgggacac
      961 atgggttccg cctgttcaga cttggggctt acgctggagc actcctgacc atgcgctagg
     1021 ccctgctgtg tgcaggaaga cttggctaca caaccctgcc tgggtctctc caggctttcc
     1081 tccacatctg agctagtgga gggaggggca tgcaggagag aacatgctcc gcaaaccagg
     1141 cagcagggct gctggtgcta cgggaccagg ggtgagccag tcctggactc cagactggaa
     1201 gtgagccagg ctccccttta tttatatgga gaacatttta cctgttttgt acatttttaa
     1261 agggctgtca gggaagcctg gatgcccctc atagccacat cagccgttgg ggaagctcag
     1321 gatgtcaggg aaggagggat gaagcagtgg tggggggttt cagtgttgaa gccagatctt
     1381 tagatttata aataccctgc ctgggtgttg ctcagaggcc actggggaac agtgtatttc
     1441 agatgcttct agcagcaggc ttggctccgg cttccatatc tgacaaaggt gatcagtatg
     1501 ctgggcatag gcaaggtttc agctcctaag acctaggaga agagccgttg atgcacctgg
     1561 gaaaccccac taatccctcc tattgtgccc tggccctttc agtgatgttt actatacaca
     1621 tctccagccg gggctacaga gcttctggcg ggctccgtgc atctgggcat gggcacaggg
     1681 cctaggaccc cagtgtctag cagcttgtac tcatcaacct cggctgtgtt tcatagctgc
     1741 gacttgcctc ttgtggccct tctgccttta agttcatgtc actagaatct ctttgacctg
     1801 tttcttagtg acactctctg gaacaccaag cccctcctta gggactcact ggcctgagca
     1861 acttgtgaag ccatggactg ttcccccaca atgctcctcc tctcccagtc tgggctgggc
     1921 agccttctcc cctgtgggga tgctgtcccc agtggatgtc ctgtgtgact gcttccctgt
     1981 ccttgcctgg tgacacagcc ctcaggcacg ctggtgctta actctacctc ctgccctcag
     2041 ggccctggcc ataacaggag ccatgacccc tgactgggga cctctaagtg cacgtttcct
     2101 aagatcatct taccatggat gttactaggg cactggtaga cgctgcgcca gcctgctgtt
     2161 ctgggagatt gagtcaatgc ctgtagggag ggacggggct atggttgtgg gaactgcctg
     2221 ataagcagca gcctgacctg ggagcctgac ccagaggctg ggtacaatca agcatcacct
     2281 ttccccacca gtcctgttgc tgttgacaga gaccttttct ctggaatcgc gatagaatgg
     2341 tatagacttt gaggacctgg attggcctgc gtgcacacca tcaacactac acttgctgct
     2401 gtggactcca ctattcctgg ttctttgttc ttacttcttt gtacagtaaa tgtacttcag
     2461 cagtga
//
