LOCUS       NM_001404682            1951 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Rab40B, member RAS oncogene family (Rab40b),
            transcript variant 1, mRNA.
ACCESSION   NM_001404682 XM_036156620
VERSION     NM_001404682.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1951)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1951)
  AUTHORS   .
  TITLE     Rab40b and Tks5 interact at invadopodia during metastasis
  JOURNAL   J Cell Sci 129 (23), e2301 (2016)
   PUBMED   27909076
  REMARK    GeneRIF: This is the first study that identifies a new Rab40b-Tks5-
            and miR-204-dependent invadopodia transport pathway that regulates
            MMP2 and MMP9 secretion, and extracellular matrix remodeling during
            cancer progression.
REFERENCE   3  (bases 1 to 1951)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   4  (bases 1 to 1951)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   5  (bases 1 to 1951)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   6  (bases 1 to 1951)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   7  (bases 1 to 1951)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663088.10.
            
            On Apr 13, 2022 this sequence version replaced XM_036156620.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1175831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               AL663088.10        77567-77823         c
            258-318             AL663088.10        53073-53133         c
            319-405             AL663088.10        52374-52460         c
            406-466             AL663088.10        49129-49189         c
            467-544             AL663088.10        48344-48421         c
            545-767             AL663088.10        47429-47651         c
            768-1951            AL663088.10        45694-46877         c
FEATURES             Location/Qualifiers
     source          1..1951
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 85.28 cM"
     gene            1..1951
                     /gene="Rab40b"
                     /gene_synonym="rar; SEC4L"
                     /note="Rab40B, member RAS oncogene family"
                     /db_xref="GeneID:217371"
                     /db_xref="MGI:MGI:2183451"
     exon            1..257
                     /gene="Rab40b"
                     /gene_synonym="rar; SEC4L"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1039
                     /gene="Rab40b"
                     /gene_synonym="rar; SEC4L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ras-related protein Rab-40B; SOCS box-containing protein
                     RAR; RAR SOCS box containing protein"
                     /codon_start=1
                     /product="ras-related protein Rab-40B isoform 1"
                     /protein_id="NP_001391611.1"
                     /db_xref="GeneID:217371"
                     /db_xref="MGI:MGI:2183451"
                     /translation="MSSLGSPVRAYDFLLKFLLVGDSDVGKGEILASLQDGAAESPYG
                     HPAGIDHKTTTILLDGRRVKLQLWKPGLFYCTLPEASGTRTMLKNNQSQKLERDTSGQ
                     GRFCTIFRSYSRGAQGVVLVYDIANRWSFDGINRWIKEIDEHAPGVPKILVGNRLHLA
                     FKRQVPTEQAQAYAERLGVTFFEVSPLCNFNITESFTELARIVLLRHGMDRLWRPSKV
                     LSLQELCCRAVVSCTPGHLVDKLPLPVALRSHLKSFSMASGLNTRMMHGRSYSLTANS
                     SHKRNSFRKVRTIRPPQSPPRNCARNSCKIS"
     exon            258..318
                     /gene="Rab40b"
                     /gene_synonym="rar; SEC4L"
                     /inference="alignment:Splign:2.1.0"
     exon            319..405
                     /gene="Rab40b"
                     /gene_synonym="rar; SEC4L"
                     /inference="alignment:Splign:2.1.0"
     exon            406..466
                     /gene="Rab40b"
                     /gene_synonym="rar; SEC4L"
                     /inference="alignment:Splign:2.1.0"
     exon            467..544
                     /gene="Rab40b"
                     /gene_synonym="rar; SEC4L"
                     /inference="alignment:Splign:2.1.0"
     exon            545..767
                     /gene="Rab40b"
                     /gene_synonym="rar; SEC4L"
                     /inference="alignment:Splign:2.1.0"
     exon            768..1951
                     /gene="Rab40b"
                     /gene_synonym="rar; SEC4L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1923..1928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab40b"
                     /gene_synonym="rar; SEC4L"
                     /note="hexamer: AATAAA"
     polyA_site      1951
                     /gene="Rab40b"
                     /gene_synonym="rar; SEC4L"
                     /note="major polyA site"
ORIGIN      
        1 agctgtcaag ctcccccgac cggtggagcg ttcgaggggc ccgcggcgct cggggaccct
       61 ccgccgcctg cgcgcagcct tgggccggta tgggcggggt ggctgggccg gcatgatgag
      121 ctccctgggc agcccggtgc gggcctacga ttttctactt aagttcctgt tggtgggcga
      181 cagcgacgtg ggcaagggag agatcctggc cagcttgcag gacggagcag ccgagtctcc
      241 ttacggccac ccggcgggaa ttgatcacaa gacgaccacc atcctgctag atggccgaag
      301 ggtgaaactg cagctttgga agccaggcct attttactgc actcttccag aggcttcagg
      361 gactcgtacc atgctcaaaa acaatcaatc ccagaagctg gagagggaca cctcggggca
      421 ggggagattt tgtaccatat tccgctcata ctccagaggt gcacagggtg tggtcctggt
      481 ctatgacatt gccaaccgat ggtcctttga tggcattaat cgatggatta aggagattga
      541 tgagcatgcc cctggggttc ctaaaatctt ggtgggaaat cggctgcacc tggcattcaa
      601 gcgacaggtg cccactgaac aggcccaggc ctacgccgag cgcctgggtg tgaccttctt
      661 tgaggttagc cctctgtgca acttcaacat tacagagtcc ttcacagagc tggctaggat
      721 cgtgctgctg cggcatggga tggaccgtct ctggaggccg agcaaggtac tgagtttgca
      781 agagctctgc tgccgtgctg tggtgtcctg cacgcctggg cacctggtag acaagctccc
      841 cctccctgtc gccttaagaa gccaccttaa gtctttctcg atggccagtg gcctgaacac
      901 caggatgatg catggccgct cctactccct cactgccaac tccagccaca agaggaacag
      961 cttccggaaa gtcaggacca tccgcccacc ccagagcccg cccaggaact gtgccaggaa
     1021 cagctgcaaa atttcttaga ggctggaatt ggtggcagtg gcctgtaatc tcagctactc
     1081 aagaggctga ggcaggagga tcacaagctc aaggcccatc taagctacag agtgagttca
     1141 aggccagcgt gggcaatttt gagactccac ctcaaaatta aaaagtgagc tggctctctg
     1201 ggagagtctg aagacagaga cctttccaga ctcgaggaac atgttctgca tttattaacg
     1261 gtaacgatgc tgcttccttt ggaatgccac tgccgtggta ggaatgccca gtgcgctgtg
     1321 actgacactt ttgtgtggat gtgcatgaag ctcttgttct agacttgtgt gtgcaaaggg
     1381 aaaaaaatta gtattcttct ctactcttga taatatgaaa ttatggatgt gactttttat
     1441 catgattgtt gtgcaacttt ttctgtaact gcttttatat ggctgataaa atgtgtgtag
     1501 tgaatacatg ttcaaggaaa tttcagaagc aatgataatc agataatcta gcattactga
     1561 tactacaaga ggggcctttt gtaaacattt taatgtcaaa gccccaactt ataaaaaatg
     1621 ctgcagtttc acaggttgtg tacaacaggt ctgtcccatt tgggtaggac atggatttga
     1681 taaagttttt gctatgttgt ttactacatt ttgagattaa taagtaatct atattcatat
     1741 ttttctgtaa acctacatat tttgtacaaa gtatcctaca agttctgaaa ctatgggaag
     1801 aaaatgccaa agatatctcc aattatgttg aacaaagcca gcattgtttc aacagattag
     1861 caaggagaga ggtatttcag taaaggagaa gtaaaaacag ttatttaagg actatgtttc
     1921 tcaataaagt ggatacttgc tcctctcttg a
//
