LOCUS       NM_001402313            4246 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus RAB3 GTPase activating protein subunit 1 (Rab3gap1),
            transcript variant 1, mRNA.
ACCESSION   NM_001402313 XM_006529405
VERSION     NM_001402313.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4246)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4246)
  AUTHORS   Liegel,R.P., Handley,M.T., Ronchetti,A., Brown,S., Langemeyer,L.,
            Linford,A., Chang,B., Morris-Rosendahl,D.J., Carpanini,S.,
            Posmyk,R., Harthill,V., Sheridan,E., Abdel-Salam,G.M., Terhal,P.A.,
            Faravelli,F., Accorsi,P., Giordano,L., Pinelli,L., Hartmann,B.,
            Ebert,A.D., Barr,F.A., Aligianis,I.A. and Sidjanin,D.J.
  TITLE     Loss-of-function mutations in TBC1D20 cause cataracts and male
            infertility in blind sterile mice and Warburg micro syndrome in
            humans
  JOURNAL   Am J Hum Genet 93 (6), 1001-1014 (2013)
   PUBMED   24239381
REFERENCE   3  (bases 1 to 4246)
  AUTHORS   Sdek,P., Zhao,P., Wang,Y., Huang,C.J., Ko,C.Y., Butler,P.C.,
            Weiss,J.N. and Maclellan,W.R.
  TITLE     Rb and p130 control cell cycle gene silencing to maintain the
            postmitotic phenotype in cardiac myocytes
  JOURNAL   J Cell Biol 194 (3), 407-423 (2011)
   PUBMED   21825075
  REMARK    GeneRIF: Rb and p130 have overlapping roles in maintaining the
            postmitotic state of adult cardiac myocytes through their
            interaction with HP1-gamma to direct heterochromatin formation and
            silencing of proliferation-promoting genes
REFERENCE   4  (bases 1 to 4246)
  AUTHORS   Rocha-Sanchez,S.M., Scheetz,L.R., Contreras,M., Weston,M.D.,
            Korte,M., McGee,J. and Walsh,E.J.
  TITLE     Mature mice lacking Rbl2/p130 gene have supernumerary inner ear
            hair cells and supporting cells
  JOURNAL   J Neurosci 31 (24), 8883-8893 (2011)
   PUBMED   21677172
  REMARK    GeneRIF: The histological and physiological cochlear phenotype in
            p130-/- mice suggests a role for p130-mediated SC quiescence in the
            apical and upper middle turns of the cochlea.
REFERENCE   5  (bases 1 to 4246)
  AUTHORS   Szodorai,A., Kuan,Y.H., Hunzelmann,S., Engel,U., Sakane,A.,
            Sasaki,T., Takai,Y., Kirsch,J., Muller,U., Beyreuther,K., Brady,S.,
            Morfini,G. and Kins,S.
  TITLE     APP anterograde transport requires Rab3A GTPase activity for
            assembly of the transport vesicle
  JOURNAL   J Neurosci 29 (46), 14534-14544 (2009)
   PUBMED   19923287
REFERENCE   6  (bases 1 to 4246)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   7  (bases 1 to 4246)
  AUTHORS   Sakane,A., Manabe,S., Ishizaki,H., Tanaka-Okamoto,M., Kiyokage,E.,
            Toida,K., Yoshida,T., Miyoshi,J., Kamiya,H., Takai,Y. and Sasaki,T.
  TITLE     Rab3 GTPase-activating protein regulates synaptic transmission and
            plasticity through the inactivation of Rab3
  JOURNAL   Proc Natl Acad Sci U S A 103 (26), 10029-10034 (2006)
   PUBMED   16782817
REFERENCE   8  (bases 1 to 4246)
  AUTHORS   Aligianis,I.A., Johnson,C.A., Gissen,P., Chen,D., Hampshire,D.,
            Hoffmann,K., Maina,E.N., Morgan,N.V., Tee,L., Morton,J.,
            Ainsworth,J.R., Horn,D., Rosser,E., Cole,T.R., Stolte-Dijkstra,I.,
            Fieggen,K., Clayton-Smith,J., Megarbane,A., Shield,J.P.,
            Newbury-Ecob,R., Dobyns,W.B., Graham,J.M. Jr., Kjaer,K.W.,
            Warburg,M., Bond,J., Trembath,R.C., Harris,L.W., Takai,Y.,
            Mundlos,S., Tannahill,D., Woods,C.G. and Maher,E.R.
  TITLE     Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro
            syndrome
  JOURNAL   Nat Genet 37 (3), 221-223 (2005)
   PUBMED   15696165
REFERENCE   9  (bases 1 to 4246)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 4246)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163690.4.
            
            On Mar 11, 2022 this sequence version replaced XM_006529405.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC163690.4         131325-131362
            39-94               AC163690.4         131458-131513
            95-170              AC163690.4         136613-136688
            171-303             AC163690.4         151689-151821
            304-382             AC163690.4         153551-153629
            383-502             AC163690.4         164112-164231
            503-668             AC163690.4         166205-166370
            669-768             AC163690.4         172384-172483
            769-850             AC163690.4         178172-178253
            851-919             AC163690.4         180754-180822
            920-993             AC163690.4         182101-182174
            994-1086            AC163690.4         187261-187353
            1087-1253           AC163690.4         187808-187974
            1254-1343           AC163690.4         189993-190082
            1344-1516           AC163690.4         190482-190654
            1517-1571           AC163690.4         192923-192977
            1572-1943           AC163690.4         193240-193611
            1944-2081           AC163690.4         196950-197087
            2082-2309           AC163690.4         199871-200098
            2310-2406           AC163690.4         200522-200618
            2407-2510           AC163690.4         200731-200834
            2511-2626           AC163690.4         201108-201223
            2627-2729           AC163690.4         201579-201681
            2730-2750           AC163690.4         204127-204147
            2751-4246           AC163690.4         204907-206402
FEATURES             Location/Qualifiers
     source          1..4246
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 55.8 cM"
     gene            1..4246
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /note="RAB3 GTPase activating protein subunit 1"
                     /db_xref="GeneID:226407"
                     /db_xref="MGI:MGI:2445001"
     exon            1..38
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..2987
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /note="isoform 1 is encoded by transcript variant 1; rab3
                     GTPase-activating protein catalytic subunit; RAB3
                     GTPase-activating protein 130 kDa subunit"
                     /codon_start=1
                     /product="rab3 GTPase-activating protein catalytic subunit
                     isoform 1"
                     /protein_id="NP_001389242.1"
                     /db_xref="GeneID:226407"
                     /db_xref="MGI:MGI:2445001"
                     /translation="MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGPSL
                     GKPLEKGIFTSGTWEERSDEISFADFRFSVTHHYLVQESPDKERKDEELEDAIPQSMQ
                     DLLCMNNDFPPRAHCLVRWYGLREFVVIAPAAHSDAVLSESKCNLLLSSISIALGNTG
                     CQVPLFVQIHHKWRRMYMGECQGPGVRTDFEMVHLRKVPSQYTHLSGLLDIFKSKIGC
                     PLTPLPPVSIAIRLTYVLQDWQQYFWPQQPPDIDALVGGEVGGLEFGKLPFGACEDPI
                     SELHLATTWPHLTEGIIVDNDVYSDLDPVQAPHWSVRVRKADNPQCLLGDFVTEFLKI
                     CRRKESTDEILGRSTFEEEGREVADITHALSKLTEPAPVPIHKLSVSNMVHTAKKKIR
                     KHRGEESPLNSDVLNTILLFLFPDAVSEKPLDGTTSIDNSIPAPEAGDYTLYNQFKSA
                     PSDSLTYKLALCLCMINFYHGGLKGVAHLWQEFVLEMRFRWENNFLIPGLASGSPDLR
                     CCLLHQKLQMLNCCIERKKARDEGKKTSLSDSTTSAYPGDAGKTGGQLGLDHLRDTEK
                     EKGEVGKSWDSWSDSEEEFFECLSDTEDLKGNGQESGKKGGPKEMANLKPEGRLHQHG
                     KLTLLHNGEPLYIPVTQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARMQSACLLSD
                     MESFKAANPGCFLEDFVRWYSPRDYIEEEVTDEKGNVVLKGELSARMKIPSNMWVEAW
                     ETAKPVPARRQRRLFDDTREAEKVLHYLAMQKPADLARHLLPCVIHAAVLKVKEEESL
                     ENIPSVKKIIKQIIAHSSKVLHFPNPEDKKLEEIILQITTVEAIIARARSLKAKFGTE
                     KCEHEEEKEGLERFVSCLLEQPEVSVTGAGRGHAGRIIHKLFVNAQRLTESSDEAAAV
                     ALPEEELKKSGCPEERRQTLVSDFPPPAGRELILRATVPRPAPYSKALPQRMYSVLTK
                     EDFRLAGAFSSDTSFF"
     exon            39..94
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            95..170
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            171..303
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            304..382
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            383..502
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            503..668
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            669..768
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            769..850
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            851..919
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            920..993
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1086
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1253
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1343
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1516
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1571
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1943
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2081
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2309
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2406
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2510
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2626
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2729
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2750
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..4246
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3863..3868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /note="hexamer: AGTAAA"
     polyA_site      3891
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /note="major polyA site"
     regulatory      4226..4231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /note="hexamer: AATAAA"
     polyA_site      4246
                     /gene="Rab3gap1"
                     /gene_synonym="1700003B17Rik; 4732493F09Rik; p130;
                     rab3-GAP p130; Rab3gap"
                     /note="major polyA site"
ORIGIN      
        1 ctgacgctcc gctccgcaag atggcggcgg acagtgagcc cgagtccgaa gtgtttgaga
       61 tcacagactt caccacagcc tcggagtggg agaggtttat ttccaaagtt gaagaagtct
      121 tgaatgactg gaaactgatt ggaccctctc tgggaaagcc actggaaaag ggtatattta
      181 cttctggcac atgggaagag cgatcagatg aaatttcctt tgctgacttc aggttttcag
      241 tcacacatca ctatcttgta caagagtctc ctgataaaga aagaaaggat gaagaattgg
      301 aggacgctat tccacagtca atgcaagatt tgctatgtat gaataacgac tttcctccaa
      361 gagcacattg cctggtaaga tggtatggcc tgcgtgagtt tgtggtgatt gctcctgctg
      421 cacacagtga tgcagttctc agtgaatcca agtgtaacct cctccttagt tccatttcta
      481 ttgctttggg aaacactggc tgccaggtac cactgtttgt ccaaatacat cacaaatggc
      541 gacgaatgta catgggagaa tgtcaaggtc ctggtgttcg tactgacttt gaaatggttc
      601 atcttcgaaa agtgccaagt cagtacactc atttgtcagg cctgctggac atcttcaaat
      661 ccaaaattgg ctgtccttta actccattgc ctccagttag cattgcgatt cggctcacat
      721 acgtgcttca ggattggcag caatactttt ggcctcagca gcctccagat atagatgccc
      781 ttgtgggagg agaagttggg ggcctggagt tcggcaagtt gccatttggt gcctgtgaag
      841 atcctatcag tgaactccat ttagcaacaa cgtggcctca tttgacagaa gggatcattg
      901 tagataatga tgtttattct gatttggatc ctgttcaagc tccccattgg tcggttagag
      961 ttcggaaagc tgataatccc cagtgcttac taggtgattt tgttactgaa tttttaaaaa
     1021 tttgccgtcg aaaggaatca acggatgaaa ttcttggacg atccacattt gaagaagagg
     1081 gaagagaagt tgctgatata actcatgctt tgtcaaagct gactgagcca gcgccagttc
     1141 caattcataa attatcagtt tcaaatatgg tacacactgc aaagaagaag atacggaagc
     1201 acagagggga agagtcgccg ctgaacagtg atgttctcaa tactattctc ttgttcttgt
     1261 tcccagatgc tgtctctgag aagccgttag atggaactac ttcaatagac aatagcattc
     1321 ctgcaccaga ggctggagac tatactctct acaatcagtt caagtctgcg ccttccgaca
     1381 gtctaacata caaactggcc ttgtgtcttt gtatgatcaa cttctaccat ggagggctga
     1441 agggagtggc acatctctgg caggaatttg ttcttgaaat gcgtttcaga tgggaaaaca
     1501 actttctgat tccaggacta gcaagtggat caccagatct aagatgctgc ttactgcatc
     1561 agaaactaca gatgttaaat tgttgtattg aaaggaagaa agcacgtgat gaagggaaaa
     1621 agacgagcct ctcggatagt acgactagtg catatccagg ggatgctggg aaaactggag
     1681 gccagctggg cctggaccat ctcagagata cagagaagga aaagggagaa gtagggaagt
     1741 cctgggattc ctggagtgat agtgaagaag agttttttga atgcctcagt gatacggaag
     1801 accttaaagg aaacggacag gagagtggta agaaaggcgg tcccaaggag atggcaaact
     1861 taaagccaga aggccgcctg caccagcacg ggaaacttac cctgctgcat aatggagagc
     1921 ctctctacat tccagtgacc caggaaccag cacccatgac agaagatctg ctggaagagc
     1981 agtctgaggt cttagcaaaa ttagggacat ctgctgaggg ggcgcacctc cgcgcacgca
     2041 tgcagagtgc ctgtctcctc tccgatatgg agtcttttaa ggcagctaat ccaggctgct
     2101 ttctggaaga tttcgtgagg tggtactcac caagggacta cattgaggag gaggtgactg
     2161 acgagaaggg caatgtggtc ctgaaggggg agctgagtgc ccgtatgaag atccccagca
     2221 acatgtgggt agaagcctgg gagactgcta agcctgtgcc agcacgacgt cagaggagac
     2281 tgtttgatga cacccgagag gctgaaaagg tcctgcacta cctggccatg cagaagcctg
     2341 cagacctagc caggcacctc ctgccttgtg tgattcatgc agctgttctc aaggtaaagg
     2401 aagaagaaag tctggaaaac attccttctg ttaagaagat tataaagcag atcatagccc
     2461 attccagcaa agttctgcat ttccccaatc ctgaggacaa gaaactggaa gaaatcatcc
     2521 ttcagattac tactgtggaa gctataatag cccgagcccg gtccctgaag gccaaatttg
     2581 gaactgagaa gtgtgagcac gaggaggaaa aggaaggtct ggaaaggttt gtcagctgcc
     2641 tgctggagca gcctgaggta tcagtcactg gggcaggaag aggacatgct ggccgcatca
     2701 tccacaagct gtttgtgaat gctcagcggc tgactgaatc ttctgatgag gctgcggcag
     2761 tggctctgcc agaggaggag cttaagaaat caggctgccc agaggagaga agacagacct
     2821 tggtgtcaga cttcccacca cctgcaggcc gggagctgat cctgagggcc actgtgccgc
     2881 ggcctgctcc ctactccaag gccctgccac agcgtatgta cagcgtactc accaaggagg
     2941 acttcagact cgcgggtgcc ttttcctcag acacctcctt tttctagggg gaggaggagg
     3001 agcggcagct cctgccgtgg gcacctgaga cgcccttgtg gaaccagcag caggagtcac
     3061 accagcatcc agaagcatgt ccagtaccaa gcttgagcca gatggataga tttgaggtgt
     3121 cagagacttc cacctggggg gaggtggcct gtgttagggg aacctcacat cagcaggcct
     3181 cttaccttgg gggacagagt ttgttcattc tcctgtgaca gtcatctgtg tagacactta
     3241 gtagctatcc ttactagtat tccatatgca aggtagagta tccgttaact cacattctgg
     3301 acacttgctg gtagagcctt tagtcccagg atctgtgttt ttaaactgcc acgtagcatt
     3361 ctgtttattc agtcaccaga tggatggtca gctttattat gctgtttcat gagcatttga
     3421 atattctagg agaaagacta gaatttcaat tttttccatg ccactaacca aatgcatttc
     3481 ttctgataaa tctgtacatg aaatgtagct gcagattaga gctctctctg tgtgtctgtc
     3541 tgtgtgtctg tctgtctggt aggatctctc ggtcctcttg gttgcacccc tgctttgcac
     3601 tttacttctc tgcgttgctg gttagggatg gtatttaatg acatcatacg agcacatgtt
     3661 gaacacacat cctgggaaca tagatcacca tgcagttagt gagctgtggt gtgtgtgccg
     3721 aggctgtgag tgggctgaag cacccggtgc aggggtgatg gctctgtcct ctgcagctca
     3781 gaatgcatca gtacgctgct gcgggacctc tccttggtga ttgtaaatta ttttgggacc
     3841 taaaattccc acttgaatcc aaagtaaaaa atggttatgg tgaagtgtaa attccgcctg
     3901 tgtgattttt aaaaattaat agacctacac aagccctgtg ttatttttgt aaaagaaaaa
     3961 aaagagtata tatatatata tttatctgta tggtgtgcac agacacgtgt ctgtttgggt
     4021 atatgagggc caggggccaa cccctagact tcccagcgag cactctttcc tctgaaatgc
     4081 tggactttgc ttcttagaaa cccatagata cgggctgagg catgaggggc cagaacaaat
     4141 acaagacagg acagtgtttg ctttcctggg tattgatgac agaactctac agtgtggggt
     4201 tggtctaaaa tggcattgtt tatctaataa aacggactgc tgttta
//
