LOCUS       NM_001324531            3825 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus RAB3D, member RAS oncogene family (Rab3d), transcript
            variant 2, mRNA.
ACCESSION   NM_001324531 XM_006510103
VERSION     NM_001324531.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3825)
  AUTHORS   Macke,A.J., Divita,T.E., Pachikov,A.N., Mahalingam,S.,
            Bellamkonda,R., Rasineni,K., Casey,C.A. and Petrosyan,A.
  TITLE     Alcohol-induced Golgiphagy is triggered by the downregulation of
            Golgi GTPase RAB3D
  JOURNAL   Autophagy 20 (7), 1537-1558 (2024)
   PUBMED   38591519
  REMARK    GeneRIF: Alcohol-induced Golgiphagy is triggered by the
            downregulation of Golgi GTPase RAB3D.
REFERENCE   2  (bases 1 to 3825)
  AUTHORS   Yu,Z., Li,J., Govindarajan,G., Hamm-Alvarez,S.F., Alam,J., Li,D.Q.
            and de Paiva,C.S.
  TITLE     Cathepsin S is a novel target for age-related dry eye
  JOURNAL   Exp Eye Res 214, 108895 (2022)
   PUBMED   34910926
REFERENCE   3  (bases 1 to 3825)
  AUTHORS   Teng,F., Hu,F. and Zhang,M.
  TITLE     MicroRNA-125a-5p modulates the proliferation and apoptosis of TM4
            Sertoli cells by targeting RAB3D and regulating the PI3K/AKT
            signaling pathway
  JOURNAL   Mol Hum Reprod 27 (9) (2021)
   PUBMED   34273154
  REMARK    GeneRIF: MicroRNA-125a-5p modulates the proliferation and apoptosis
            of TM4 Sertoli cells by targeting RAB3D and regulating the PI3K/AKT
            signaling pathway.
REFERENCE   4  (bases 1 to 3825)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3825)
  AUTHORS   Avagliano Trezza,R., Punt,A.M., Mientjes,E., van den Berg,M.,
            Zampeta,F.I., de Graaf,I.J., van der Weegen,Y., Demmers,J.A.A.,
            Elgersma,Y. and Distel,B.
  TITLE     Mono-ubiquitination of Rabphilin 3A by UBE3A serves a
            non-degradative function
  JOURNAL   Sci Rep 11 (1), 3007 (2021)
   PUBMED   33542309
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3825)
  AUTHORS   Wang,X., Hu,B., Zimmermann,B. and Kilimann,M.W.
  TITLE     Rim1 and rabphilin-3 bind Rab3-GTP by composite determinants
            partially related through N-terminal alpha -helix motifs
  JOURNAL   J Biol Chem 276 (35), 32480-32488 (2001)
   PUBMED   11431472
REFERENCE   7  (bases 1 to 3825)
  AUTHORS   Bergo,M.O., Leung,G.K., Ambroziak,P., Otto,J.C., Casey,P.J.,
            Gomes,A.Q., Seabra,M.C. and Young,S.G.
  TITLE     Isoprenylcysteine carboxyl methyltransferase deficiency in mice
  JOURNAL   J Biol Chem 276 (8), 5841-5845 (2001)
   PUBMED   11121396
REFERENCE   8  (bases 1 to 3825)
  AUTHORS   Adachi,R., Nigam,R., Tuvim,M.J., DeMayo,F. and Dickey,B.F.
  TITLE     Genomic organization, chromosomal localization, and expression of
            the murine RAB3D gene
  JOURNAL   Biochem Biophys Res Commun 273 (3), 877-883 (2000)
   PUBMED   10891340
REFERENCE   9  (bases 1 to 3825)
  AUTHORS   Inoue,S., Sano,H. and Ohta,M.
  TITLE     Growth suppression of Escherichia coli by induction of expression
            of mammalian genes with transmembrane or ATPase domains
  JOURNAL   Biochem Biophys Res Commun 268 (2), 553-561 (2000)
   PUBMED   10679242
REFERENCE   10 (bases 1 to 3825)
  AUTHORS   Baldini,G., Hohl,T., Lin,H.Y. and Lodish,H.F.
  TITLE     Cloning of a Rab3 isotype predominantly expressed in adipocytes
  JOURNAL   Proc Natl Acad Sci U S A 89 (11), 5049-5052 (1992)
   PUBMED   1594612
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK048395.1, AK169369.1 and BQ033745.1.
            
            On May 12, 2016 this sequence version replaced XM_006510103.2.
            
            Transcript Variant: This variant (2) uses an alternate splice
            acceptor site in the 5' UTR, compared to variant 1. Variants 1 and
            2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048395.1, BC020010.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1852              AK048395.1         2-1853
            1853-2291           AK169369.1         1792-2230
            2292-3128           AK048395.1         2295-3131
            3129-3129           BQ033745.1         1-1                 c
            3130-3825           AK048395.1         3132-3827
FEATURES             Location/Qualifiers
     source          1..3825
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.91 cM"
     gene            1..3825
                     /gene="Rab3d"
                     /gene_synonym="C130057E11Rik"
                     /note="RAB3D, member RAS oncogene family"
                     /db_xref="GeneID:19340"
                     /db_xref="MGI:MGI:97844"
     exon            1..162
                     /gene="Rab3d"
                     /gene_synonym="C130057E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            163..401
                     /gene="Rab3d"
                     /gene_synonym="C130057E11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..833
                     /gene="Rab3d"
                     /gene_synonym="C130057E11Rik"
                     /codon_start=1
                     /product="ras-related protein Rab-3D"
                     /protein_id="NP_001311460.1"
                     /db_xref="CCDS:CCDS22912.1"
                     /db_xref="GeneID:19340"
                     /db_xref="MGI:MGI:97844"
                     /translation="MASASEPPASPRDAADQNFDYMFKLLLIGNSSVGKTSFLFRYAD
                     DSFTPAFVSTVGIDFKVKTVYRHDKRIKLQIWDTAGQERYRTITTAYYRGAMGFLLMY
                     DIANQESFTAVQDWATQIKTYSWDNAQVILVGNKCDLEDERVVPAEDGRRLADDLGFE
                     FFEASAKENINVKQVFERLVDIICDKMNESLEPSSSPGSNGKGPALGDTPPPQPSSCS
                     C"
     exon            402..520
                     /gene="Rab3d"
                     /gene_synonym="C130057E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            521..645
                     /gene="Rab3d"
                     /gene_synonym="C130057E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            646..3825
                     /gene="Rab3d"
                     /gene_synonym="C130057E11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2274..2279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab3d"
                     /gene_synonym="C130057E11Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2297
                     /gene="Rab3d"
                     /gene_synonym="C130057E11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcctagtctt ctgcggcctc gccccctccg cctgggcgga gccggcgcgg gatccgggtg
       61 tcagtgttgg cagcgccggc agctgtgggg cgagggtcgc agccctgtgc ggggccgtag
      121 caacttcgtg ggcggatcct ggtgtgcaag gcgggacccg agatcccact gagatggcat
      181 ccgctagtga gccccctgcc agcccaagag acgctgctga ccagaacttt gactacatgt
      241 tcaaactgct cttgatcggg aacagcagcg tgggcaagac atccttcctg ttccgctatg
      301 ccgatgactc cttcacccct gccttcgtga gcacagtggg catcgacttc aaggtcaaga
      361 cggtctaccg acatgacaag aggatcaagc tgcagatttg ggacacagca ggccaggagc
      421 gctaccggac aatcaccacg gcctactatc gcggagctat gggtttcctg ctcatgtatg
      481 acatcgccaa ccaggagtcc ttcaccgcgg tgcaggactg ggctacgcag atcaaaacct
      541 attcctggga caatgcccag gtaatcctcg tggggaacaa gtgtgacctg gaagacgaac
      601 gggtcgtacc tgctgaggat ggccggaggc tcgccgatga tcttggtttt gagttctttg
      661 aggccagcgc caaggagaat atcaatgtga agcaggtgtt cgagcgcctg gtggacatca
      721 tctgtgacaa gatgaatgaa tccctggaac ccagctccag cccaggcagc aatggaaaag
      781 gcccagccct tggggatacc ccacccccac agccgagcag ctgcagctgt taggttcagc
      841 cccttacctc cccacacctg tcccttcttg cctcttcaag gacagcagct aaggtgtgag
      901 ctatggggac tgtctctcag ctcagggcac ccttgcctct gggccacttc ccactcctct
      961 tgcacaagtt catgtccctt tctctccatg tcagaatgct cagacactcc tggttagagc
     1021 ccacacaccc cgggctctgc tcagcattgt ctgaggggtt ggggtaccca cacaggtgct
     1081 tgctgcttcc cacggcattt tgatggaggt agctgtggcg gcattgcctt ccctgagtga
     1141 gagaggggat gttcatgcct tctgccttag aaccatttcc caggtctact cttcatatcg
     1201 ctggctgaag ttgtcacctg gcgtgggttg ctgtccaact tagtcctggc agcctctcta
     1261 tctcaggtcc accagtttgg ccttgaaacc tgcctgtgaa ctgactgcta gccaaggaca
     1321 caggcagggc tgcagtctcc atcctctgcc tccctggcgt ctaccggaag ggaaaacctg
     1381 ttttctggtt aaagaaggga cagagttgga gctacccctg gcaccgggaa ctctccaaag
     1441 tgccttccca gcttcccctg agtctatcca ctcagtgtgg gttaatctac tcccagaatt
     1501 aaattttgga gtattccagg gcctgtcaca tggggctgag aatcgcccac cctagcagtc
     1561 cagctttctg tcagttcacc tcagagccag ggaactgagg ccgcctgccc aggctcccat
     1621 ctgtctgcct ggtggtggct taggcaagag ctttacaaac cttacatcct gtgtagaaac
     1681 ggaagtggag aaagcagccc acagagggtg tgcccttgct ggtcagtttc ttatgacagg
     1741 atttgggctt ctccacatga ggactcttgt gtagacccag tgtcagcatc atggccgttg
     1801 cccagggaca ctggggctgt ggggaaggac tgggggaagg cactagtggg caacccagtc
     1861 cgtcatggga gcaggagtcc ttcctgtgaa ttagggatgg gctgtgggtt gtgactgctt
     1921 tctctacaaa gcttgagacg tagcccctag gaccctgggt tctatttcta ttcactgacc
     1981 agactcccct aaacactatc tgacatttca tggtccaggt gacagatgct ctgtgtcaca
     2041 cacccctgac tctgtatggg gggtggagtg tactccttca gcccccacag ccagaatcac
     2101 ttctgcagcc ttcctgagct cagcaccctc cctgactgtg tatgacctac agtgcctggt
     2161 tcagatgtat ttctagccct gccagtggct gtctttgtac agattggaca agcagagtga
     2221 aggtgtctaa acacttagag gaaagactca attttttaaa atgttgcttt atcattaaat
     2281 agtcaaaacg gtgcaaatta tgttcttaag attcagcaac ctgcagggcg ttgtggtggt
     2341 gaaaattttt gatcccagca ttctggaggc agaggcaggt ggatctctga gttcgagacc
     2401 agcctgatct acagagcaag ttccaggata gccagggcta cacagagaaa ccctgttttg
     2461 aaaaacagag agaaggagag agagagcaag agagaatgat gcagctagtc tggaaggaac
     2521 ctggaactag ctctctcgct agcatttgcc tactgttttg cacagggtcc tggcttgaag
     2581 acccagcact gcacaaacta ggcacgtgct ccagggatgt cattctagta gaggcaggag
     2641 gatcggaagt ttggagtcac ctttgagtac tacctaggaa gtttgaggct agcctggagc
     2701 tataagaggc tgacacgggg cgggggtggg aggaaggcct gtcaaagact ctatggacca
     2761 gtccattccc aagcagagtc gtggagatcc tgcccgtagt tagctaagac cggtcctgac
     2821 gttttgtgtc aactaaatcg cgtctgactg tatcttggac ttagtctcgg cttcctgttg
     2881 ctagaagagg ctccttcact tctactctga acacccacag aggaagccac cctgtggttt
     2941 tcttacaact ggggatttgg ctggtggaat ggctcatctg aagacactgc caccaagcct
     3001 gatgacctga gttagacctc gggatccatg aggtagaaga agagaaatga gccctttaag
     3061 ccaccatctc ccctccacgg tgagcaaggg tgtgtgcaca gtcagtgtca gacaaaaaaa
     3121 aaaaaaaaat aaccctactg tggaaactga ataatgtgga aacctccttg tttcttcctc
     3181 ccatgaaagg tgatttgaac cttttgattc ttccattagg ttttacggag gatgggtgag
     3241 gggtcactaa gtgaacagga gctggccgtc tgtgcagatg gccgagaggg acgggagcct
     3301 gatgggttta taaacagaag ccatgggcat ggggaatgct tctctgcagg agactcagga
     3361 gtagttagcc tccagagctt tatccccctg tcctcccagg gaggagtggc catggctttg
     3421 gttttgcttg ttcttattta tgggtctcat gctgtagacc aggctggtcc tgaactcaca
     3481 aagatccacc tgcctgtgcc tcctagtgct ggaattagag gcatacatca ttatgtctgg
     3541 ctgacgttct tgcctgctac atggtgcagt tataggttgc accaccatac tctgatgcag
     3601 tgctagggat ggagcccagg acttcctgca tgctaggcaa acattctacc aactgggcct
     3661 tggccccgtc ctggtctctg tttccgtgtg ctgattctgc tcctggctcc acgctagcaa
     3721 ttctgaagca acagtgaatc aactctggtc tggcactgcc tattctccct gttctccagt
     3781 ccaggaaaaa atgtataata aaataaagga agccatcatg cctgt
//
