LOCUS       NM_023537               3320 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus RAB3B, member RAS oncogene family (Rab3b), mRNA.
ACCESSION   NM_023537
VERSION     NM_023537.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3320)
  AUTHORS   Jing,J., Feng,J., Yuan,Y., Guo,T., Lei,J., Pei,F., Ho,T.V. and
            Chai,Y.
  TITLE     Spatiotemporal single-cell regulatory atlas reveals neural crest
            lineage diversification and cellular function during tooth
            morphogenesis
  JOURNAL   Nat Commun 13 (1), 4803 (2022)
   PUBMED   35974052
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3320)
  AUTHORS   Avagliano Trezza,R., Punt,A.M., Mientjes,E., van den Berg,M.,
            Zampeta,F.I., de Graaf,I.J., van der Weegen,Y., Demmers,J.A.A.,
            Elgersma,Y. and Distel,B.
  TITLE     Mono-ubiquitination of Rabphilin 3A by UBE3A serves a
            non-degradative function
  JOURNAL   Sci Rep 11 (1), 3007 (2021)
   PUBMED   33542309
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3320)
  AUTHORS   Bubier,J.A., Philip,V.M., Dickson,P.E., Mittleman,G. and
            Chesler,E.J.
  TITLE     Discovery of a Role for Rab3b in Habituation and Cocaine Induced
            Locomotor Activation in Mice Using Heterogeneous Functional Genomic
            Analysis
  JOURNAL   Front Neurosci 14, 721 (2020)
   PUBMED   32742255
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3320)
  AUTHORS   Persoon,C.M., Hoogstraaten,R.I., Nassal,J.P., van Weering,J.R.T.,
            Kaeser,P.S., Toonen,R.F. and Verhage,M.
  TITLE     The RAB3-RIM Pathway Is Essential for the Release of
            Neuromodulators
  JOURNAL   Neuron 104 (6), 1065-1080 (2019)
   PUBMED   31679900
REFERENCE   5  (bases 1 to 3320)
  AUTHORS   Lefebvre,J., Clarkson,M., Massa,F., Bradford,S.T., Charlet,A.,
            Buske,F., Lacas-Gervais,S., Schulz,H., Gimpel,C., Hata,Y.,
            Schaefer,F. and Schedl,A.
  TITLE     Alternatively spliced isoforms of WT1 control podocyte-specific
            gene expression
  JOURNAL   Kidney Int 88 (2), 321-331 (2015)
   PUBMED   25993318
REFERENCE   6  (bases 1 to 3320)
  AUTHORS   Schluter,O.M., Khvotchev,M., Jahn,R. and Sudhof,T.C.
  TITLE     Localization versus function of Rab3 proteins. Evidence for a
            common regulatory role in controlling fusion
  JOURNAL   J Biol Chem 277 (43), 40919-40929 (2002)
   PUBMED   12167638
REFERENCE   7  (bases 1 to 3320)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   8  (bases 1 to 3320)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   9  (bases 1 to 3320)
  AUTHORS   Leenders,A.G., Lopes da Silva,F.H., Ghijsen,W.E. and Verhage,M.
  TITLE     Rab3a is involved in transport of synaptic vesicles to the active
            zone in mouse brain nerve terminals
  JOURNAL   Mol Biol Cell 12 (10), 3095-3102 (2001)
   PUBMED   11598194
REFERENCE   10 (bases 1 to 3320)
  AUTHORS   Bergo,M.O., Leung,G.K., Ambroziak,P., Otto,J.C., Casey,P.J.,
            Gomes,A.Q., Seabra,M.C. and Young,S.G.
  TITLE     Isoprenylcysteine carboxyl methyltransferase deficiency in mice
  JOURNAL   J Biol Chem 276 (8), 5841-5845 (2001)
   PUBMED   11121396
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL607070.19.
            
            On Nov 17, 2006 this sequence version replaced NM_023537.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082959.1, SRR1660817.232054.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AL607070.19        136112-136260
            150-377             AL607070.19        147350-147577
            378-496             AL607070.19        180948-181066
            497-621             AL607070.19        186444-186568
            622-3320            AL607070.19        197668-200366
FEATURES             Location/Qualifiers
     source          1..3320
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.67 cM"
     gene            1..3320
                     /gene="Rab3b"
                     /gene_synonym="2610528C18Rik"
                     /note="RAB3B, member RAS oncogene family"
                     /db_xref="GeneID:69908"
                     /db_xref="MGI:MGI:1917158"
     exon            1..149
                     /gene="Rab3b"
                     /gene_synonym="2610528C18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..809
                     /gene="Rab3b"
                     /gene_synonym="2610528C18Rik"
                     /codon_start=1
                     /product="ras-related protein Rab-3B"
                     /protein_id="NP_076026.1"
                     /db_xref="CCDS:CCDS18459.1"
                     /db_xref="GeneID:69908"
                     /db_xref="MGI:MGI:1917158"
                     /translation="MASVTDGKTGIKDASDQNFDYMFKLLIIGNSSVGKTSFLFRYAD
                     DTFTPAFVSTVGIDFKVKTVYRHEKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMY
                     DITNEESFNAVQDWATQIKTYSWDNAQVILVGNKCDMEEERVVPTEKGRLLAEQLGFD
                     FFEASAKENISVRQAFERLVDAICDKMSDSMDTDPSVLGASKTTRLSDTPPLLQQNCS
                     C"
     exon            150..377
                     /gene="Rab3b"
                     /gene_synonym="2610528C18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            378..496
                     /gene="Rab3b"
                     /gene_synonym="2610528C18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            497..621
                     /gene="Rab3b"
                     /gene_synonym="2610528C18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            622..3320
                     /gene="Rab3b"
                     /gene_synonym="2610528C18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1064..1069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab3b"
                     /gene_synonym="2610528C18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1087
                     /gene="Rab3b"
                     /gene_synonym="2610528C18Rik"
                     /note="major polyA site"
     regulatory      1162..1167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab3b"
                     /gene_synonym="2610528C18Rik"
                     /note="hexamer: ATTAAA"
     regulatory      1166..1171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab3b"
                     /gene_synonym="2610528C18Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      1184
                     /gene="Rab3b"
                     /gene_synonym="2610528C18Rik"
                     /note="major polyA site"
     polyA_site      1187
                     /gene="Rab3b"
                     /gene_synonym="2610528C18Rik"
     regulatory      3285..3290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab3b"
                     /gene_synonym="2610528C18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3307
                     /gene="Rab3b"
                     /gene_synonym="2610528C18Rik"
ORIGIN      
        1 ggacccagcg ggaacccaac ccatcttcag ccagagcctc agccctccgt agccgaggtg
       61 ggaaccagac ccgcctcgcc tgcctctcac ccactatcgc caagtgcaac agtccggctg
      121 cactgtccgt gagccagctc ttatccgaga tggcttcagt gactgatggt aagactggaa
      181 tcaaagatgc ctccgaccag aactttgact acatgttcaa actgctcatc attggcaaca
      241 gcagcgtcgg gaagacctcc ttccttttcc gctatgctga tgacaccttc acccctgcct
      301 ttgtcagcac tgtgggtatc gacttcaaag tgaagacagt ctaccgccat gagaagcgtg
      361 tgaagctgca gatatgggac acagctgggc aagagcggta ccggaccatc accacagcct
      421 actaccgtgg ggccatgggc ttcattctca tgtatgacat caccaacgag gagtccttca
      481 atgctgtcca ggactgggct actcagatta agacctactc ctgggacaac gcacaggtca
      541 ttctcgtggg aaataagtgt gacatggaag aggaaagagt ggtcccaact gagaagggcc
      601 ggctcctggc agaacagctt gggtttgact tctttgaagc cagcgccaag gagaacatca
      661 gtgtgaggca ggccttcgag cggctggtgg atgccatctg cgataagatg tctgactcga
      721 tggacacaga cccctccgtg ctaggcgcct ccaagacgac gcggctctca gacaccccac
      781 ctctgctgca gcagaactgc tcttgttaga caaggcccac cctcctgttt ccccatgtcg
      841 tgccctgttt ctcctccgct tctctccatt actgtccatt ccccaatccc aagcaagatg
      901 agttctttgc cagcccctgc ggttctctgc agatggcccc agctacagat actaactgca
      961 ggttacgggg tgggtgaaca ctccttttac aacagaaaac tccctcttat gaagaaggtt
     1021 caagatagag acttggaaag aatcttttct gcccttaaaa tataataaaa ttcctttcat
     1081 ttaccaagcc cctcctccta cgcacactcc tcggggggct ggccagtgtg taaagtgagg
     1141 cccacctgca cagctaatac tattaaagaa aatgtctcaa agtacaacct gcttgtttcc
     1201 tatcaggctc cctgtggggc aagcaaagct ttgatttgta gagccctgag cctgttacca
     1261 cggatgccca cagggccccg ggcagttgct gtggtgacag gacagtgcta atccctggag
     1321 agctcagatt ctagtgatgc agaagaagca ggggctgagt cagaaacaca cttaaaagag
     1381 aaggattatc ttctgcaaaa tgtcaaaggc cccagccatc taaaagcaca atgaccagaa
     1441 ggagaaaaag caacatagat ggacacaggt tcttaccttt ctagcctgct cttttgtctc
     1501 acgatgtagc cttaggctag gctcaaatgt gttatttaat ttaggctgaa cttgaaccta
     1561 atcctcctgc ctcagtttcc ccagtgctag aatgcagatg tgtaccatca cacccagttt
     1621 ctccagttgg ttcttgactg ttgggatacc atagactttg tcactgattc tcaggccctc
     1681 agagtctgca ctctgaagct gatgagcttc ctcctccttt cccagtttat ctagtttgac
     1741 aaatcagttc cagactttct agttctggca cgtggcctgc atggctttgg gactgacttg
     1801 cccacggtga ctggcaatga agaacctata aatgcaatga agaacctaca aacacaagta
     1861 caaaaaagtt gggatatggt aggctgtggg ctctgatgga gactattact agcagcctgg
     1921 aaatgcagct ctgaacaagg aggtgggttt attatacccg aatgaggaga gaggttagct
     1981 gatctaggta aagggagctc tatagggaag caggctcagg ctgtagtggc caggagcagg
     2041 aagctgtggt tggtattttc tgcacactct tgtcaacatc cttagtggac caggggaagg
     2101 cttggttatt tccacaggcc caaggcattg tctttgacat agttgtgtta gttcaacaat
     2161 ttacattcac cctggacttc actagctccc cacaaccctc tttcttttaa agcacacctt
     2221 ctatgagatg ggagcggtgg ctcaggactg taattccagc atattgaagg ttgaggcaga
     2281 aggatcaact gttccagggc agcctgggct gcagatgccg gtcctttttt tttttttttt
     2341 tttttttaag ctagcatgtc tttggggcag gcaccagagc tgtccatagc caggatctgt
     2401 ctttgcttca aactgaaaat ggactcgggg aaacccccca ccttctcacc ccatttgcac
     2461 caattctgct gccagccatc ttcccgtccc tactcagaat ctctttgatt taagcacaag
     2521 aatcatggcc tactctttcc caggggcagc cctaactgca tatccatttg ccattctgca
     2581 gagggtcttc ccccatcttg ctcacctttt ctaacctgtc aggcactcct ccacagccca
     2641 cctggaaagg gggagtcagg cagaattaga caaggggaca tagtcctgaa caaatgctaa
     2701 tatagcgact caagggcatc tcgttgtcct ggaaaggcac acagctggta tcaggcccag
     2761 tgatcaaatg aaagggccaa atagagtcag ctctgtggac atgttgcagt ctttgataaa
     2821 ctgtaaaaga gagattttgg gtgtggaatt taggacgtct gccatttaat cagggttttt
     2881 gttagatgtt actcttacaa gacacatagt tcagcaattt ccatgtatta actcatttat
     2941 cttcgtaaca ctttagtcaa cctcagttga agatgaggaa tcaaggctct ggtttgcata
     3001 aggtcaacta attagcaaat ggtagagtgg ggatccaaag gcagggagtg catccctagg
     3061 tctgtgcttt tacaacattc tgcaccacag ctcttttcca ataagtgtga tcccgtcgct
     3121 tggaatcctg cccaagctgt caggtccaag tccacctgag aaaagatgta tgtctgtgat
     3181 atggtaacaa attgctcaac tactcggact aatctgcggt gatggatatc cagagcgcag
     3241 cagaattagt ttctgaggca accagatccc atgggcttaa gcaaaataaa atgcccattg
     3301 ctccttacga ccatgtgctg
//
