LOCUS       NM_001378892            1371 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus RAB3A, member RAS oncogene family (Rab3a), transcript
            variant 4, mRNA.
ACCESSION   NM_001378892 XM_006509603
VERSION     NM_001378892.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1371)
  AUTHORS   Izumida,M., Kakoki,K., Hayashi,H., Matsuyama,T. and Kubo,Y.
  TITLE     Rab3a, a small GTP-binding protein, is required for the
            stabilization of the murine leukaemia virus Gag protein
  JOURNAL   Small GTPases 13 (1), 162-182 (2022)
   PUBMED   34180342
  REMARK    GeneRIF: Rab3a, a small GTP-binding protein, is required for the
            stabilization of the murine leukaemia virus Gag protein.
REFERENCE   2  (bases 1 to 1371)
  AUTHORS   Luo,K., Wang,L., Shen,Y., She,S., Cui,Y. and Liu,K.
  TITLE     TET3-mediated accumulation of DNA hydroxymethylation contributes to
            the activity-dependent gene expression of Rab3a in post-mitotic
            neurons
  JOURNAL   J Integr Neurosci 20 (3), 529-539 (2021)
   PUBMED   34645086
  REMARK    GeneRIF: TET3-mediated accumulation of DNA hydroxymethylation
            contributes to the activity-dependent gene expression of Rab3a in
            post-mitotic neurons.
REFERENCE   3  (bases 1 to 1371)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1371)
  AUTHORS   Avagliano Trezza,R., Punt,A.M., Mientjes,E., van den Berg,M.,
            Zampeta,F.I., de Graaf,I.J., van der Weegen,Y., Demmers,J.A.A.,
            Elgersma,Y. and Distel,B.
  TITLE     Mono-ubiquitination of Rabphilin 3A by UBE3A serves a
            non-degradative function
  JOURNAL   Sci Rep 11 (1), 3007 (2021)
   PUBMED   33542309
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1371)
  AUTHORS   Hanes,A.L., Koesters,A.G., Fong,M.F., Altimimi,H.F., Stellwagen,D.,
            Wenner,P. and Engisch,K.L.
  TITLE     Divergent Synaptic Scaling of Miniature EPSCs following Activity
            Blockade in Dissociated Neuronal Cultures
  JOURNAL   J Neurosci 40 (21), 4090-4102 (2020)
   PUBMED   32312887
REFERENCE   6  (bases 1 to 1371)
  AUTHORS   Geppert,M., Goda,Y., Stevens,C.F. and Sudhof,T.C.
  TITLE     The small GTP-binding protein Rab3A regulates a late step in
            synaptic vesicle fusion
  JOURNAL   Nature 387 (6635), 810-814 (1997)
   PUBMED   9194562
REFERENCE   7  (bases 1 to 1371)
  AUTHORS   Dechesne,C.J., Kauff,C., Stettler,O. and Tavitian,B.
  TITLE     Rab3A immunolocalization in the mammalian vestibular end-organs
            during development and comparison with synaptophysin expression
  JOURNAL   Brain Res Dev Brain Res 99 (1), 103-111 (1997)
   PUBMED   9088571
REFERENCE   8  (bases 1 to 1371)
  AUTHORS   Inagaki,N., Mizuta,M. and Seino,S.
  TITLE     Cloning of a mouse Rabphilin-3A expressed in hormone-secreting
            cells
  JOURNAL   J Biochem 116 (2), 239-242 (1994)
   PUBMED   7822236
REFERENCE   9  (bases 1 to 1371)
  AUTHORS   Geppert,M., Bolshakov,V.Y., Siegelbaum,S.A., Takei,K., De
            Camilli,P., Hammer,R.E. and Sudhof,T.C.
  TITLE     The role of Rab3A in neurotransmitter release
  JOURNAL   Nature 369 (6480), 493-497 (1994)
   PUBMED   7911226
REFERENCE   10 (bases 1 to 1371)
  AUTHORS   Baumert,M., Fischer von Mollard,G., Jahn,R. and Sudhof,T.C.
  TITLE     Structure of the murine rab3A gene: correlation of genomic
            organization with antibody epitopes
  JOURNAL   Biochem J 293 (Pt 1) (Pt 1), 157-163 (1993)
   PUBMED   7687127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CAAA01070179.1.
            
            On Mar 12, 2020 this sequence version replaced XM_006509603.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4140697.1,
                                           ERR3363658.4409494.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               CAAA01070179.1     13563-13750         c
            189-416             CAAA01070179.1     12770-12997         c
            417-535             CAAA01070179.1     12288-12406         c
            536-660             CAAA01070179.1     11592-11716         c
            661-1371            CAAA01070179.1     10246-10956         c
FEATURES             Location/Qualifiers
     source          1..1371
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..1371
                     /gene="Rab3a"
                     /note="RAB3A, member RAS oncogene family"
                     /db_xref="GeneID:19339"
                     /db_xref="MGI:MGI:97843"
     exon            1..188
                     /gene="Rab3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..851
                     /gene="Rab3a"
                     /codon_start=1
                     /product="ras-related protein Rab-3A"
                     /protein_id="NP_001365821.1"
                     /db_xref="GeneID:19339"
                     /db_xref="MGI:MGI:97843"
                     /translation="MASATDSRYGQKESSDQNFDYMFKILIIGNSSVGKTSFLFRYAD
                     DSFTPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMY
                     DITNEESFNAVQDWSTQIKTYSWDNAQVLLVGNKCDMEDERVVSSERGRQLADHLGFE
                     FFEASAKDNINVKQTFERLVDVICEKMSESLDTADPAVTGAKQGPQLTDQQAPPHQDC
                     AC"
     exon            189..416
                     /gene="Rab3a"
                     /inference="alignment:Splign:2.1.0"
     exon            417..535
                     /gene="Rab3a"
                     /inference="alignment:Splign:2.1.0"
     exon            536..660
                     /gene="Rab3a"
                     /inference="alignment:Splign:2.1.0"
     exon            661..1371
                     /gene="Rab3a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1348..1353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab3a"
                     /note="hexamer: AATAAA"
     polyA_site      1371
                     /gene="Rab3a"
                     /note="major polyA site"
ORIGIN      
        1 gaacacgcgt gtgcgcgccc gctgggcatg gagaggctcg agtgaccgca ggacgcgcag
       61 cgtgcacact tgtgatacgt tgtgcgtgca tggtccgcgt gcgcggtgcg cgtggatctt
      121 agttcaagta tgtgctcaca cgcgtgtgga gccatgcgcg tgtgtggtgt gtcctcccgg
      181 atggccagat ggcttccgcc acagactctc gctatgggca gaaggagtcc tcagaccaga
      241 acttcgacta tatgttcaag atcctgatca ttgggaacag cagcgtgggc aaaacctcgt
      301 tcctcttccg ctacgcagat gactccttca ctccagcctt tgtcagcacc gttggcatag
      361 acttcaaggt caaaaccatc taccgcaacg acaagaggat caagctgcag atctgggaca
      421 cagcagggca agagcggtac cgcaccatca ccacagccta ttaccgaggc gccatgggct
      481 tcatcctaat gtatgacatc accaatgagg agtcatttaa tgcagtgcag gactggtcca
      541 ctcagatcaa aacttactcg tgggacaatg cccaggtgct gctggtggga aacaagtgtg
      601 acatggaaga tgagcgagtg gtgtcctcag agcgtggccg gcagctggct gaccacctgg
      661 gctttgagtt ctttgaggcc agcgccaagg acaacattaa tgtcaagcag acgtttgaac
      721 gtctggtgga cgtgatctgt gagaagatgt cagagtccct ggatactgca gaccctgcgg
      781 tcaccggtgc caagcagggc ccgcagctca ccgaccagca ggcgccacct catcaggatt
      841 gtgcctgctg agccacttcc cttccctgct gccaggggca cgtcccccat ccccgactac
      901 cctatttatt attgtagcta tttatttatt tattgaggat gtgccccgag cgcaccccct
      961 tcccaccctg tacatagctc cacccagctc ggccgtggtg tattgtggtc actgctgctc
     1021 cctctccttt accccccacc cccattttgt ttttgtaaac catcccgtcc acagttgtca
     1081 gttgtgaaga ggggaccaga tgtcactctg cagcaggctg atggaagatg gcggggcctg
     1141 ccaaccccga ggctggggga tcgccatatg gaccacctgg ttgacagacg gcttcttgct
     1201 tgcctgggcc ttctgcctta tactttggga taaatggggt gtaggggata tattcactac
     1261 tttgggatac ccccaaacct gttctgacgt cgtgagtgtc aaatgtgtcc cactcctccc
     1321 tagaagttat gaacactaca cacagtcaat aaagcgaatg gaccttgctg a
//
