LOCUS       NM_175122               3402 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RAB39B, member RAS oncogene family (Rab39b), mRNA.
ACCESSION   NM_175122
VERSION     NM_175122.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3402)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3402)
  AUTHORS   Wang,Z., Niu,M., Zheng,N., Meng,J., Jiang,Y., Yang,D., Yao,P.,
            Yao,T., Luo,H., Xu,H., Ge,Y., Zhang,Y.W. and Zhang,X.
  TITLE     Increased level of RAB39B leads to neuronal dysfunction and
            behavioural changes in mice
  JOURNAL   J Cell Mol Med 27 (9), 1214-1226 (2023)
   PUBMED   36977207
  REMARK    GeneRIF: Increased level of RAB39B leads to neuronal dysfunction
            and behavioural changes in mice.
REFERENCE   3  (bases 1 to 3402)
  AUTHORS   Mignogna,M.L., Ficarella,R., Gelmini,S., Marzulli,L., Ponzi,E.,
            Gabellone,A., Peschechera,A., Alessio,M., Margari,L., Gentile,M.
            and D'Adamo,P.
  TITLE     Clinical characterization of a novel RAB39B nonstop mutation in a
            family with ASD and severe ID causing RAB39B downregulation and
            study of a Rab39b knock down mouse model
  JOURNAL   Hum Mol Genet 31 (9), 1389-1406 (2022)
   PUBMED   34761259
  REMARK    GeneRIF: Clinical characterization of a novel RAB39B nonstop
            mutation in a family with ASD and severe ID causing RAB39B
            downregulation and study of a Rab39b knock down mouse model.
REFERENCE   4  (bases 1 to 3402)
  AUTHORS   Mignogna,M.L., Musardo,S., Ranieri,G., Gelmini,S., Espinosa,P.,
            Marra,P., Belloli,S., Murtaj,V., Moresco,R.M., Bellone,C. and
            D'Adamo,P.
  TITLE     RAB39B-mediated trafficking of the GluA2-AMPAR subunit controls
            dendritic spine maturation and intellectual disability-related
            behaviour
  JOURNAL   Mol Psychiatry 26 (11), 6531-6549 (2021)
   PUBMED   34035473
  REMARK    GeneRIF: RAB39B-mediated trafficking of the GluA2-AMPAR subunit
            controls dendritic spine maturation and intellectual
            disability-related behaviour.
REFERENCE   5  (bases 1 to 3402)
  AUTHORS   Niu,M., Zheng,N., Wang,Z., Gao,Y., Luo,X., Chen,Z., Fu,X., Wang,Y.,
            Wang,T., Liu,M., Yao,T., Yao,P., Meng,J., Zhou,Y., Ge,Y., Wang,Z.,
            Ma,Q., Xu,H. and Zhang,Y.W.
  TITLE     RAB39B Deficiency Impairs Learning and Memory Partially Through
            Compromising Autophagy
  JOURNAL   Front Cell Dev Biol 8, 598622 (2020)
   PUBMED   33364235
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3402)
  AUTHORS   Mori,Y., Matsui,T., Omote,D. and Fukuda,M.
  TITLE     Small GTPase Rab39A interacts with UACA and regulates the retinoic
            acid-induced neurite morphology of Neuro2A cells
  JOURNAL   Biochem Biophys Res Commun 435 (1), 113-119 (2013)
   PUBMED   23624502
REFERENCE   7  (bases 1 to 3402)
  AUTHORS   Takenaka,M., Inoue,H., Takeshima,A., Kakura,T. and Hori,T.
  TITLE     C. elegans Rassf homolog, rasf-1, is functionally associated with
            rab-39 Rab GTPase in oxidative stress response
  JOURNAL   Genes Cells 18 (3), 203-210 (2013)
   PUBMED   23294242
REFERENCE   8  (bases 1 to 3402)
  AUTHORS   Lee,M.P. and Yutzey,K.E.
  TITLE     Twist1 directly regulates genes that promote cell proliferation and
            migration in developing heart valves
  JOURNAL   PLoS One 6 (12), e29758 (2011)
   PUBMED   22242143
REFERENCE   9  (bases 1 to 3402)
  AUTHORS   Giannandrea,M., Bianchi,V., Mignogna,M.L., Sirri,A., Carrabino,S.,
            D'Elia,E., Vecellio,M., Russo,S., Cogliati,F., Larizza,L.,
            Ropers,H.H., Tzschach,A., Kalscheuer,V., Oehl-Jaschkowitz,B.,
            Skinner,C., Schwartz,C.E., Gecz,J., Van Esch,H., Raynaud,M.,
            Chelly,J., de Brouwer,A.P., Toniolo,D. and D'Adamo,P.
  TITLE     Mutations in the small GTPase gene RAB39B are responsible for
            X-linked mental retardation associated with autism, epilepsy, and
            macrocephaly
  JOURNAL   Am J Hum Genet 86 (2), 185-195 (2010)
   PUBMED   20159109
  REMARK    GeneRIF: These results demonstrate developmental and functional
            neuronal alteration as a consequence of downregulation of RAB39B
            and emphasize the critical role of vesicular trafficking in the
            development of neurons and human intellectual abilities.
REFERENCE   10 (bases 1 to 3402)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY257784.1, BC052472.1 and
            AV172496.1.
            
            On Jun 8, 2013 this sequence version replaced NM_175122.5.
            
            Summary: This gene encodes a member of the Ras-related small
            GTPases, which regulate membrane trafficking in organelles and
            transport vesicles. This protein has been reported to be enriched
            in mouse brain, and specifically within neurons, and may play a
            role in synapse formation. In humans mutations in this gene are
            associated with X-linked cognitive disability. [provided by RefSeq,
            Jun 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY257784.1, BC050853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BY257784.1         1-75
            76-3390             BC052472.1         1-3315
            3391-3402           AV172496.1         192-203
FEATURES             Location/Qualifiers
     source          1..3402
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.26 cM"
     gene            1..3402
                     /gene="Rab39b"
                     /gene_synonym="6330580M05Rik"
                     /note="RAB39B, member RAS oncogene family"
                     /db_xref="GeneID:67790"
                     /db_xref="MGI:MGI:1915040"
     exon            1..439
                     /gene="Rab39b"
                     /gene_synonym="6330580M05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..866
                     /gene="Rab39b"
                     /gene_synonym="6330580M05Rik"
                     /codon_start=1
                     /product="ras-related protein Rab-39B"
                     /protein_id="NP_780331.1"
                     /db_xref="CCDS:CCDS30242.1"
                     /db_xref="GeneID:67790"
                     /db_xref="MGI:MGI:1915040"
                     /translation="MEAIWLYQFRLIVIGDSTVGKSCLIRRFTEGRFAQVSDPTVGVD
                     FFSRLVEIEPGKRIKLQIWDTAGQERFRSITRAYYRNSVGGLLLFDITNRRSFQNVHE
                     WLEETKVHVQPYQIVFVLVGHKCDLDTQRQVTRHEAEKLAAAYGMKYIETSARDAINV
                     EKAFTDLTRDIYELVKRGEITIQEGWEGVKSGFVPNVVHSSEEVIKSERRCLC"
     exon            440..3402
                     /gene="Rab39b"
                     /gene_synonym="6330580M05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      925..930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab39b"
                     /gene_synonym="6330580M05Rik"
                     /note="hexamer: AATAGA"
     polyA_site      952
                     /gene="Rab39b"
                     /gene_synonym="6330580M05Rik"
     regulatory      3369..3374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab39b"
                     /gene_synonym="6330580M05Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      3390
                     /gene="Rab39b"
                     /gene_synonym="6330580M05Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtcagagtgc gtggtgctga tgctgctgcc atttcatcac ctttgcgagc gcagcatcca
       61 tcccttcgtt cccccagcgc ctgggcctac cttgcttcag gctaccaggc cagtgatgtt
      121 ctcgcggccg atctagaaac gggttgatct gtgctaaggc cttggtgggg cgccccctcc
      181 cgcctcccca ggcccgggcc gaagagtcct gccaggccac tgccatggag gccatctggc
      241 tgtaccagtt ccggctcatt gtcatcggcg attccacggt gggcaagtcc tgcctgatcc
      301 gccgcttcac cgagggccgc tttgctcagg tttcagatcc caccgtgggg gtagattttt
      361 tctcccgttt ggtggagatc gagccaggaa aacgcatcaa gctccagatc tgggatacag
      421 cgggtcaaga gaggttcaga tccatcactc gcgcctacta caggaattca gtaggtggtc
      481 ttctcttatt tgacattacc aaccgcaggt ccttccagaa tgtccatgag tggttagaag
      541 agaccaaagt acacgttcag ccctaccaaa ttgtatttgt tctggtgggt cacaagtgtg
      601 acctggatac acagaggcaa gtgactcgcc acgaggccga gaaactggct gctgcatacg
      661 gcatgaagta cattgagacg tcagcccgag atgccattaa tgtggagaaa gccttcacag
      721 acctgacaag agacatatat gagctggtta aaagggggga gattacaatc caggagggtt
      781 gggaaggggt gaagagtgga tttgtaccaa atgttgttca ttcttcagaa gaggttatca
      841 aatcagagag gagatgtttg tgctagttaa cccttccatt ttcaaaacat actctcccac
      901 ttgaacttaa aagttatcaa aataaataga atccttatgt gactgaagag aactcaacgt
      961 ttggataata aatgagcctt cttcctaggc ctggatctct gacaggctca tgtgtgggta
     1021 gatagggagc ctgggtgctg tgactgaggg actaaattgc tgacaggggc tggaccagac
     1081 cttgttttgt gggccaggct cagcaatggc tgctctgtgt gccctttgtg gaccacatat
     1141 taagggtctg ggtatttgaa agttaggttc caggaaaaca cctacagaca gataaacagt
     1201 tccttggtat tacaactttt cagacatggt gaccataaag aaacatatag aaagaaatca
     1261 agtatcaatt ggggacaatt aagataactg aaaaaaaaaa gagtatgata tcaacttatt
     1321 caatgataat accgtgccag atgtgtgctg ggttttatac aaacacatca agccacttct
     1381 aacagttcaa ctgtaaaatg aaaagcccat atgaatcaac tatttggtaa agctctttca
     1441 aggtctagca ttctagtaaa actgctgtga atatgaaaag ggaagtcatt cacatattgt
     1501 tgttatcaca tttgagaaaa gtgtacactg gcatgataaa gttgccaact atgtgaaaga
     1561 aattcttcca tgtaaaatga tcatgtaagg agaaaaagga aacactgtaa ctcaaaggcc
     1621 acattatttc ccctctaatc atacctggac tttcactgca tcagggaacc ataatcccga
     1681 agtaagtata ctgcttgctt cttcagatac ctgacaacga caacacagag attgtcaaca
     1741 aacaaaaacc ctaagtcaag cccttggtca ttggttctat tctgagtatt ggctcaacac
     1801 gtagtcttgg aatccttaaa aattattcat attaatttat ttcactcatt tgatcaccat
     1861 aataggactg tgagattttt gatcccattt tacataataa gaaagcaaga accaagccta
     1921 cctgatacct agcttttttc actggatcat tattcatatg aataagtgat taatttatta
     1981 acctttggag acatgtgact ataaataaat attctctaca tgatagaata tgttttcctt
     2041 gttttacagc tcagctataa tcttgcagga atctagaaat gaataaaagg taaaggccac
     2101 tcaggtatta ttgacaagag ggcattaaat aagggattaa ctgcacaact gaaaacacat
     2161 taaaactgta tgggttataa atgttcttct cacaaacact atgaatattt tattaaaagg
     2221 aaccaaatac aacaatgggg agtgggttgg ggataaagta ctcacctcac aatgaccttg
     2281 actacctgtc tgctatgtac ctacattggg ctcctgtcta cccgagagag tcagctctta
     2341 attctcaggt gaacagacag ctaaccacat cagcaaatta gaatggctga gatgaaaaat
     2401 tcattatctt cttaaaaaga agtgatgctt taaatttctt tttggattgt agccagttca
     2461 gctaggcaaa agccatactt ttgacagtaa gaaaactatt ctgattagag tcaagtttct
     2521 catatataca ttgtggtaga aagaatggca aattatattt gcaatatcct gttcgagttc
     2581 agaatgaata tgtgtgaatc tgggaatttg tttcagctaa aataacccaa ataataaaaa
     2641 ttatgaaagg ttgtttagcc acctttgctc caacttgtat aaacaagtca ttttggacca
     2701 attcacatta tcaattgcag ataaatgatc attcattcta taatcatttc acgtatttta
     2761 aattgccaga ttcttggttg tagaaggcaa atacaacctt ttttgtgggt taacacaaaa
     2821 tttcaacaat gatacacatg tctagattgt tctaaaaccc aggattatcc agtggataaa
     2881 taagagttga ttagactctt gttgactcaa gggggcaggg gtagaaataa aacaggtcta
     2941 cagttttctt gacgaaaata cattatatac tttgccattc ctggctttta aaagtgggtt
     3001 tcaaagtacc cagcataaat gcagcagagg tggctgaact tgacttcttc cataagtttt
     3061 aaaaaaatct caaaaatcct tttagtagaa ttcagtgctg ttgtcactgc aataagtggg
     3121 ttttagacaa taaatgtgaa aaaatcaggt gttcataaaa tactaaggat aatgcattag
     3181 aagctatttt actacatagg taaagaaaag attaactgta acaacgatca caactgcatg
     3241 ttggattaga ttgtcttata ttccagaaca aaatgtactg tatactttgc ctcaatttgt
     3301 tgtacactgt aatgaaatgt gaaaaattct ttatttagct gtatgtgaat gaaaatatgc
     3361 ttgtatttag taaaatggtt gatcatgtga ctgagagatt cc
//
