LOCUS       NM_021411               2193 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus RAB37, member RAS oncogene family (Rab37), transcript
            variant 1, mRNA.
ACCESSION   NM_021411
VERSION     NM_021411.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2193)
  AUTHORS   Wu,S.Y., Wang,Y.C., Zuchini,R., Lan,K.Y., Liu,H.S. and Lan,S.H.
  TITLE     Secretory autophagy-promoted cargo exocytosis requires active RAB37
  JOURNAL   Autophagy 20 (4), 933-934 (2024)
   PUBMED   37151129
  REMARK    GeneRIF: Secretory autophagy-promoted cargo exocytosis requires
            active RAB37.
REFERENCE   2  (bases 1 to 2193)
  AUTHORS   Kuo,W.T., Kuo,I.Y., Hsieh,H.C., Wu,S.T., Su,W.C. and Wang,Y.C.
  TITLE     Rab37 mediates trafficking and membrane presentation of PD-1 to
            sustain T cell exhaustion in lung cancer
  JOURNAL   J Biomed Sci 31 (1), 20 (2024)
   PUBMED   38321486
  REMARK    GeneRIF: Rab37 mediates trafficking and membrane presentation of
            PD-1 to sustain T cell exhaustion in lung cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2193)
  AUTHORS   Huang,H., Liang,L., Sun,D., Li,J., Wang,W., Zha,L., Yang,J.,
            Pan,K., Fan,X., He,C., Tang,X. and Zhang,P.
  TITLE     Rab37 Promotes Endothelial Differentiation and Accelerates
            ADSC-Mediated Diabetic Wound Healing through Regulating Secretion
            of Hsp90alpha and TIMP1
  JOURNAL   Stem Cell Rev Rep 19 (4), 1019-1033 (2023)
   PUBMED   36627432
  REMARK    GeneRIF: Rab37 Promotes Endothelial Differentiation and Accelerates
            ADSC-Mediated Diabetic Wound Healing through Regulating Secretion
            of Hsp90alpha and TIMP1.
REFERENCE   4  (bases 1 to 2193)
  AUTHORS   Wu,S.Y., Wu,H.T., Wang,Y.C., Chang,C.J., Shan,Y.S., Wu,S.R.,
            Chiu,Y.C., Hsu,C.L., Juan,H.F., Lan,K.Y., Chu,C.W., Lee,Y.R.,
            Lan,S.H. and Liu,H.S.
  TITLE     Secretory autophagy promotes RAB37-mediated insulin secretion under
            glucose stimulation both in vitro and in vivo
  JOURNAL   Autophagy 19 (4), 1239-1257 (2023)
   PUBMED   36109708
REFERENCE   5  (bases 1 to 2193)
  AUTHORS   Wu,S.Y., Chen,J.W., Liu,H.Y., Wang,Y.C., Chu,Y.S., Huang,C.Y.,
            Lan,K.Y., Liu,H.S. and Lan,S.H.
  TITLE     Secretory autophagy promotes Rab37-mediated exocytosis of tissue
            inhibitor of metalloproteinase 1
  JOURNAL   J Biomed Sci 29 (1), 103 (2022)
   PUBMED   36457117
  REMARK    GeneRIF: Secretory autophagy promotes Rab37-mediated exocytosis of
            tissue inhibitor of metalloproteinase 1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2193)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   7  (bases 1 to 2193)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   8  (bases 1 to 2193)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   9  (bases 1 to 2193)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   10 (bases 1 to 2193)
  AUTHORS   Masuda,E.S., Luo,Y., Young,C., Shen,M., Rossi,A.B., Huang,B.C.,
            Yu,S., Bennett,M.K., Payan,D.G. and Scheller,R.H.
  TITLE     Rab37 is a novel mast cell specific GTPase localized to secretory
            granules
  JOURNAL   FEBS Lett 470 (1), 61-64 (2000)
   PUBMED   10722846
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY131048.1, AK040216.1, AK050483.1 and BB084455.1.
            
            On Jul 31, 2009 this sequence version replaced NM_021411.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050757.1, AK050483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BY131048.1         12-60
            50-862              AK040216.1         50-862
            863-2181            AK050483.1         857-2175
            2182-2193           BB084455.1         172-183
FEATURES             Location/Qualifiers
     source          1..2193
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.59 cM"
     gene            1..2193
                     /gene="Rab37"
                     /gene_synonym="B230331O03Rik; B230354I04Rik"
                     /note="RAB37, member RAS oncogene family"
                     /db_xref="GeneID:58222"
                     /db_xref="MGI:MGI:1929945"
     exon            1..114
                     /gene="Rab37"
                     /gene_synonym="B230331O03Rik; B230354I04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..693
                     /gene="Rab37"
                     /gene_synonym="B230331O03Rik; B230354I04Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GTPase Rab37; ras-related protein Rab-37; RAB37, member of
                     RAS oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-37 isoform 1"
                     /protein_id="NP_067386.3"
                     /db_xref="CCDS:CCDS25620.1"
                     /db_xref="GeneID:58222"
                     /db_xref="MGI:MGI:1929945"
                     /translation="MTGTPGAATAGDGEAPERSPPFSPNYDLTGKVMLLGDSGVGKTC
                     FLIQFKDGAFLSGTFIATVGIDFRNKVVTVDGARVKLQIWDTAGQERFRSVTHAYYRD
                     AQALLLLYDITNQSSFDNIRAWLTEIHEYAQRDVVIMLLGNKADVSSERVIRSEDGET
                     LAREYGVPFMETSAKTGMNVELAFLAIAKELKYRAGRQPDEPSFQIRDYVESQKKRSS
                     CCSFV"
     exon            115..225
                     /gene="Rab37"
                     /gene_synonym="B230331O03Rik; B230354I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            226..267
                     /gene="Rab37"
                     /gene_synonym="B230331O03Rik; B230354I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            268..334
                     /gene="Rab37"
                     /gene_synonym="B230331O03Rik; B230354I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            335..387
                     /gene="Rab37"
                     /gene_synonym="B230331O03Rik; B230354I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            388..453
                     /gene="Rab37"
                     /gene_synonym="B230331O03Rik; B230354I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            454..510
                     /gene="Rab37"
                     /gene_synonym="B230331O03Rik; B230354I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            511..587
                     /gene="Rab37"
                     /gene_synonym="B230331O03Rik; B230354I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            588..2193
                     /gene="Rab37"
                     /gene_synonym="B230331O03Rik; B230354I04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      848..853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab37"
                     /gene_synonym="B230331O03Rik; B230354I04Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      872
                     /gene="Rab37"
                     /gene_synonym="B230331O03Rik; B230354I04Rik"
     regulatory      2162..2167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab37"
                     /gene_synonym="B230331O03Rik; B230354I04Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2187
                     /gene="Rab37"
                     /gene_synonym="B230331O03Rik; B230354I04Rik"
                     /note="major polyA site"
ORIGIN      
        1 cacctctgac tgtccgggga catgactggc acaccaggag ctgctaccgc tggggatggc
       61 gaggcccctg agcgctcccc gcccttcagc ccgaactacg atctcaccgg caaggtgatg
      121 cttcttggag actcgggcgt cggcaaaacc tgtttcctga tccaattcaa agacggggcc
      181 ttcctgtccg gaaccttcat agccaccgtc ggcatagact tcaggaataa agtggtgaca
      241 gtggatggtg ccagggtgaa gcttcagatc tgggacactg caggacagga gcgcttccgc
      301 agtgtgaccc atgcttatta ccgagatgct caggctttgc tcctgttgta tgacatcacc
      361 aaccagtcct cttttgacaa catcagggcc tggctcacag agattcatga gtatgcccag
      421 agagacgtgg tgattatgct tctaggcaac aaggccgatg taagcagcga aagggtgatc
      481 cgttctgaag atggagagac actggccagg gaatatggtg ttcctttcat ggagaccagt
      541 gccaagactg gcatgaacgt ggagttggcc tttctggcaa ttgccaagga actgaaatac
      601 cgtgcaggga ggcagcctga tgagcccagc ttccagatcc gagactatgt ggagtcccag
      661 aagaagcgct ccagctgctg ctcctttgtg tgacccccta ggggctaaga ggaggcccag
      721 agacccttgg ggatgcagta ctccaactgc cacaccaact aggagaagct gggggctcag
      781 tgggcagccc ctgccaaggg agtagccatt accctaggtt ctttagcttc cctgcatcat
      841 gggaaggatt aaatactcat actttatctt aatatacata aactaataac acaaaaggta
      901 cccgtatgcc ccccaaaacc aaaataggtc gggactcggt ggtcctttgc tttctgggac
      961 taagttctaa aaggctgggc ctctctccta gcaagagtgt tactgcacca gcatagcacc
     1021 agggggcgcc aaagcactgc tagggtgtgg gagctggttg tgaccccatc accaatcctc
     1081 actaaggggg tgaaggagac cccagacttc tcctctccca gctcccagaa agataataag
     1141 ggccctcatg cagggagcta gcccaaagcc ttgggcaaga taaacatgga gattgtccta
     1201 agaggaatag caattactag gtactgagtc tgcttggcta cctctggctt tcccaaccct
     1261 ccttctggaa gcgtgcacgg gctttttctt cagcacacac gagcagtggg gcacctgaaa
     1321 acactccttc ctgatctctg gacctcacat cccaggggat gccccgctct cccatggaac
     1381 ctctcttgtc aactttccac ctgggttcct agacaaccag aggtcagagt ctggaaaaaa
     1441 cttcccctcc ctcccaatcc cgagacaagg tgtacagcac cacggatatt taaggcagag
     1501 gtcagagcca gataaagaac ttgttggctc ctggaatggg tgggaggcag aactgaacaa
     1561 agccataggc cagtttttcc cactaagccc cagcttgctc gctctctctc tctctccctc
     1621 tctctcttta acttcagacc aatactaggg caaaatggtt ttatcttttc ctcttccgct
     1681 aaatcgggtt gagagggtgg gaagttgtcg atttgggggc gggctgatgc tatgtgcaca
     1741 aaacaaggaa gtatgagcaa gtctggggta cggagagggg caacaagccc tgtaggccca
     1801 aggccatgtg tctcccaaag ctctgatctg acccttagaa ggaaggacac tcggaggtgt
     1861 gcagatccat gaccaaagga agctttacta catctatata ggttgggcag cgagtgaggc
     1921 tccaagaaag tatgcattac acatatctga ggttactata tttgctttca aggcagaaat
     1981 cttgctccca gagcaaagtc agcactctaa acttgggttg ataaggaaac tctctgtgac
     2041 ctctcatagg aagatcaggg aggagcctgg gctccgggtt ctcttctggg gctctgagct
     2101 gattgctgga gctctagtca catacatagc tctgggcctc tggcatttct gtttttccag
     2161 aattaaattg cagtattttg gaaaatatac tct
//
