LOCUS       NM_033475               1721 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus RAB34, member RAS oncogene family (Rab34), transcript
            variant 1, mRNA.
ACCESSION   NM_033475 XM_912468
VERSION     NM_033475.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1721)
  AUTHORS   Yamaguchi,H., Barrell,W.B., Faisal,M., Liu,K.J. and Komatsu,Y.
  TITLE     Ciliary and non-ciliary functions of Rab34 during craniofacial bone
            development
  JOURNAL   Biochem Biophys Res Commun 724, 150174 (2024)
   PUBMED   38852507
REFERENCE   2  (bases 1 to 1721)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1721)
  AUTHORS   Chee,J.M., Lanoue,L., Clary,D., Higgins,K., Bower,L., Flenniken,A.,
            Guo,R., Adams,D.J., Bosch,F., Braun,R.E., Brown,S.D.M., Chin,H.G.,
            Dickinson,M.E., Hsu,C.W., Dobbie,M., Gao,X., Galande,S.,
            Grobler,A., Heaney,J.D., Herault,Y., de Angelis,M.H., Mammano,F.,
            Nutter,L.M.J., Parkinson,H., Qin,C., Shiroishi,T., Sedlacek,R.,
            Seong,J.K., Xu,Y., Brooks,B., McKerlie,C., Lloyd,K.C.K.,
            Westerberg,H. and Moshiri,A.
  CONSRTM   International Mouse Phenotyping Consortium
  TITLE     Genome-wide screening reveals the genetic basis of mammalian
            embryonic eye development
  JOURNAL   BMC Biol 21 (1), 22 (2023)
   PUBMED   36737727
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1721)
  AUTHORS   Ganga,A.K., Kennedy,M.C., Oguchi,M.E., Gray,S., Oliver,K.E.,
            Knight,T.A., De La Cruz,E.M., Homma,Y., Fukuda,M. and Breslow,D.K.
  TITLE     Rab34 GTPase mediates ciliary membrane formation in the
            intracellular ciliogenesis pathway
  JOURNAL   Curr Biol 31 (13), 2895-2905 (2021)
   PUBMED   33989527
  REMARK    GeneRIF: Rab34 GTPase mediates ciliary membrane formation in the
            intracellular ciliogenesis pathway.
REFERENCE   5  (bases 1 to 1721)
  AUTHORS   Stuck,M.W., Chong,W.M., Liao,J.C. and Pazour,G.J.
  TITLE     Rab34 is necessary for early stages of intracellular ciliogenesis
  JOURNAL   Curr Biol 31 (13), 2887-2894 (2021)
   PUBMED   33989524
  REMARK    GeneRIF: Rab34 is necessary for early stages of intracellular
            ciliogenesis.
REFERENCE   6  (bases 1 to 1721)
  AUTHORS   Sun,P., Yamamoto,H., Suetsugu,S., Miki,H., Takenawa,T. and Endo,T.
  TITLE     Small GTPase Rah/Rab34 is associated with membrane ruffles and
            macropinosomes and promotes macropinosome formation
  JOURNAL   J Biol Chem 278 (6), 4063-4071 (2003)
   PUBMED   12446704
  REMARK    GeneRIF: association with membrane ruffles and macropinosomes and
            promotes macropinosome formation
REFERENCE   7  (bases 1 to 1721)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   8  (bases 1 to 1721)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   9  (bases 1 to 1721)
  AUTHORS   Segre,J.A., Nemhauser,J.L., Taylor,B.A., Nadeau,J.H. and
            Lander,E.S.
  TITLE     Positional cloning of the nude locus: genetic, physical, and
            transcription maps of the region and mutations in the mouse and rat
  JOURNAL   Genomics 28 (3), 549-559 (1995)
   PUBMED   7490093
REFERENCE   10 (bases 1 to 1721)
  AUTHORS   Morimoto,B.H., Chuang,C.C. and Koshland,D.E. Jr.
  TITLE     Molecular cloning of a member of a new class of
            low-molecular-weight GTP-binding proteins
  JOURNAL   Genes Dev 5 (12B), 2386-2391 (1991)
   PUBMED   1752434
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY195955.1, BY234941.1, BB643883.1, AB082927.1 and AV142766.1.
            
            On Apr 18, 2009 this sequence version replaced NM_033475.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160308.1, AB082927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BY195955.1         2-2
            2-391               BY234941.1         1-390
            392-501             BB643883.1         146-255             c
            502-1716            AB082927.1         415-1629
            1717-1721           AV142766.1         161-165
FEATURES             Location/Qualifiers
     source          1..1721
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..1721
                     /gene="Rab34"
                     /gene_synonym="Narr; Rah; Rah1"
                     /note="RAB34, member RAS oncogene family"
                     /db_xref="GeneID:19376"
                     /db_xref="MGI:MGI:104606"
     exon            1..643
                     /gene="Rab34"
                     /gene_synonym="Narr; Rah; Rah1"
                     /inference="alignment:Splign:2.1.0"
     CDS             590..1369
                     /gene="Rab34"
                     /gene_synonym="Narr; Rah; Rah1"
                     /note="rab-39; ras-related homolog; ras-related protein
                     Rah; ras-related protein Rab-39; RAB34, member of RAS
                     oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-34"
                     /protein_id="NP_258436.2"
                     /db_xref="CCDS:CCDS25094.1"
                     /db_xref="GeneID:19376"
                     /db_xref="MGI:MGI:104606"
                     /translation="MNILAPVRRDRVLAELPQCLKKEAALHVRKDFHPRVTCACQEHR
                     TGTVGFKISKVIVVGDLSVGKTCLINRFCKDTFDKNYKATIGVDFEMERFEVLGVPFS
                     LQLWDTAGQERFKCIASTYYRGAQAIIIVFNLNDVASLEHTKQWLTDALKENDPSNVL
                     LFLVGSKKDLSTPAQYSLMEKDALKVAQEIKAEYWAVSSLTGENVREFFFRVAALTFE
                     ANVLAELEKSGARHIADVVRINSDDKNLYLTASKKKATCCP"
     exon            644..735
                     /gene="Rab34"
                     /gene_synonym="Narr; Rah; Rah1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..801
                     /gene="Rab34"
                     /gene_synonym="Narr; Rah; Rah1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..903
                     /gene="Rab34"
                     /gene_synonym="Narr; Rah; Rah1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..968
                     /gene="Rab34"
                     /gene_synonym="Narr; Rah; Rah1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1020
                     /gene="Rab34"
                     /gene_synonym="Narr; Rah; Rah1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1102
                     /gene="Rab34"
                     /gene_synonym="Narr; Rah; Rah1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1193
                     /gene="Rab34"
                     /gene_synonym="Narr; Rah; Rah1"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1301
                     /gene="Rab34"
                     /gene_synonym="Narr; Rah; Rah1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1721
                     /gene="Rab34"
                     /gene_synonym="Narr; Rah; Rah1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1697..1702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab34"
                     /gene_synonym="Narr; Rah; Rah1"
                     /note="hexamer: ATTAAA"
     polyA_site      1716
                     /gene="Rab34"
                     /gene_synonym="Narr; Rah; Rah1"
                     /note="major polyA site"
ORIGIN      
        1 aggaatttcc ggggatcgtg ttgcaacgct cgcagagtgg gacggcgggc ctcgctgcgc
       61 gtctagggtt gtcgccccct cctctcaccg gtcgagggcg tcggcagttg ctgcccctgc
      121 gcaaagtgac cccgtgtggc ggggcggccc cgagcccccc caggcctctc tgttatggta
      181 gggccatccc agccccgagt tgtcgtcggg tctccgcggc cccgggttat cgtaggggct
      241 atccgacccc gtgtcattgt aggatccgcg cgggcccggg ctccccggga cgcgactccc
      301 cgcccacaac tagcggccgg gggatctccc cgcccccgag tggtcttcgg gacgccccgg
      361 gctcgggtga ttgtgggctc tcccagaccc ggggtgattg tctcgtcccc ttggcccgcg
      421 gtggtcgtag cgtctccaag gccgagggct cccacaggct ctccgtggcc ccgggtgatt
      481 gtcggtaccc cgcggccgcg gataatcgtc gggtctccac gggtcccggc cgccggggcg
      541 gatcaggcct ctgcgccttc ccggggagcc ccgcaaggcc gcagacaaga tgaacattct
      601 ggcgcccgtg cggagggacc gcgtcctggc ggagctgccc cagtgcctga agaaagaggc
      661 cgctttgcac gtgcgcaaag acttccaccc ccgcgtcact tgcgcctgcc aggagcaccg
      721 gacaggcacc gtgggattta agatatccaa ggtcatcgtt gtgggagacc tatctgtggg
      781 gaagacctgt ctcattaata ggttctgcaa agacaccttc gataagaatt acaaggctac
      841 catcggagtg gattttgaga tggaacgatt tgaagtcttg ggtgtcccct tcagtctcca
      901 actttgggac acggctggtc aggaaaggtt caagtgcatt gcttccacct actaccgtgg
      961 agctcaagcc atcatcattg tcttcaacct gaatgacgtg gcatccctgg aacacaccaa
     1021 gcagtggctc actgatgccc tcaaggagaa cgacccttcc aacgtgctcc tcttccttgt
     1081 gggttccaag aaggacctga gtactcctgc tcagtattcc ctaatggaga aggatgccct
     1141 caaggtggcc caagagatta aggccgagta ctgggcggtg tcctccctca ctggtgagaa
     1201 tgtccgggaa ttcttcttcc gtgtggcagc actaaccttt gaggccaatg tcctggcgga
     1261 gctggagaaa tccggggctc ggcacattgc agatgttgtt cgcatcaaca gcgatgacaa
     1321 aaacctgtac ctaactgcca gcaagaaaaa ggccacatgt tgtccctgag cagtgaggac
     1381 tgtccagaga cttcccattt ccggggtacc gtgctacctg caactgctcc agaactcaac
     1441 ccctggacat ttgcactgac tttttccaga ccaaagagct atccattgat gtcagtgccc
     1501 cccagaaggt gacagggacc atgctagtca tttgctgccc ccaggcacca tgccaaagac
     1561 tggatgaccc tctgttcctc tggggctctc cagggtgcct ggtgaggggc agtgttcttg
     1621 ctgcttttgc tcagcctgct gggcctttca tgtataaaaa tgcttaatga ttttagcctt
     1681 acactgtgcc ttatgcatta aagtccatta ttagcatttt c
//
