LOCUS       NM_016858               3488 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RAB33B, member RAS oncogene family (Rab33b), mRNA.
ACCESSION   NM_016858
VERSION     NM_016858.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3488)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3488)
  AUTHORS   Dimori,M., Pokrovskaya,I.D., Liu,S., Sherrill,J.T.,
            Gomez-Acevedo,H., Fu,Q., Storrie,B., Lupashin,V.V. and Morello,R.
  TITLE     A Rab33b missense mouse model for Smith-McCort dysplasia shows bone
            resorption defects and altered protein glycosylation
  JOURNAL   Front Genet 14, 1204296 (2023)
   PUBMED   37359363
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3488)
  AUTHORS   Metje-Sprink,J., Groffmann,J., Neumann,P., Barg-Kues,B., Ficner,R.,
            Kuhnel,K., Schalk,A.M. and Binotti,B.
  TITLE     Crystal structure of the Rab33B/Atg16L1 effector complex
  JOURNAL   Sci Rep 10 (1), 12956 (2020)
   PUBMED   32737358
  REMARK    GeneRIF: Crystal structure of the Rab33B/Atg16L1 effector complex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3488)
  AUTHORS   Itoh,T., Fujita,N., Kanno,E., Yamamoto,A., Yoshimori,T. and
            Fukuda,M.
  TITLE     Golgi-resident small GTPase Rab33B interacts with Atg16L and
            modulates autophagosome formation
  JOURNAL   Mol Biol Cell 19 (7), 2916-2925 (2008)
   PUBMED   18448665
  REMARK    GeneRIF: Rab33 modulates autophagosome formation through
            interaction with Atg16L
REFERENCE   5  (bases 1 to 3488)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   6  (bases 1 to 3488)
  AUTHORS   Eathiraj,S., Pan,X., Ritacco,C. and Lambright,D.G.
  TITLE     Structural basis of family-wide Rab GTPase recognition by
            rabenosyn-5
  JOURNAL   Nature 436 (7049), 415-419 (2005)
   PUBMED   16034420
REFERENCE   7  (bases 1 to 3488)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   8  (bases 1 to 3488)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   9  (bases 1 to 3488)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   10 (bases 1 to 3488)
  AUTHORS   Zheng,J.Y., Koda,T., Fujiwara,T., Kishi,M., Ikehara,Y. and
            Kakinuma,M.
  TITLE     A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized
            to the medial Golgi cisternae
  JOURNAL   J Cell Sci 111 (Pt 8), 1061-1069 (1998)
   PUBMED   9512502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC065076.1, AB004665.1 and AC102860.13.
            
            On Apr 17, 2007 this sequence version replaced NM_016858.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065076.1, AB004665.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3165              BC065076.1         1-3165
            3166-3454           AB004665.1         3133-3421
            3455-3488           AC102860.13        35758-35791
FEATURES             Location/Qualifiers
     source          1..3488
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 22.49 cM"
     gene            1..3488
                     /gene="Rab33b"
                     /note="RAB33B, member RAS oncogene family"
                     /db_xref="GeneID:19338"
                     /db_xref="MGI:MGI:1330805"
     exon            1..615
                     /gene="Rab33b"
                     /inference="alignment:Splign:2.1.0"
     CDS             367..1056
                     /gene="Rab33b"
                     /note="RAB33B, member of RAS oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-33B"
                     /protein_id="NP_058554.1"
                     /db_xref="CCDS:CCDS38427.1"
                     /db_xref="GeneID:19338"
                     /db_xref="MGI:MGI:1330805"
                     /translation="MTSEMESSLEVSFSSSCAVSGASGCLPPARSRIFKIIVIGDSNV
                     GKTCLTYRFCAGRFPDRTEATIGVDFRERAVDIDGERIKIQLWDTAGQERFRKSMVQH
                     YYRNVHAVVFVYDMTNMASFHSLPAWIEECKQHLLANDIPRILVGNKCDLRSAIQVPT
                     DLAQKFADTHSMPLFETSAKNPNDNDHVEAIFMTLAHKLKSHKPLMLSQLPDNRISLK
                     PETKPAVTCWC"
     exon            616..3488
                     /gene="Rab33b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3145..3150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab33b"
                     /note="hexamer: AATAAA"
     polyA_site      3165
                     /gene="Rab33b"
                     /note="major polyA site"
     regulatory      3206..3211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab33b"
                     /note="hexamer: ATTAAA"
     polyA_site      3230
                     /gene="Rab33b"
ORIGIN      
        1 cccccggggg ctgcgcagct tcctccagag ctcgggaacc tcggacgtgg cgaggcggtc
       61 agaaggctgg agcgcggcac atagaggtcc ctcgggcgga ccttctgagc cgcagtccag
      121 ccagggagcg ccgacgcatc tttccaggta caccgcaccg actggcggag gcctactgcg
      181 cgtgcgccgg ggccttagcg gggcgccaca cctgggtggg caggggctgc tcgcgcacgc
      241 gcgccgcggt gcccgcgggc tgtggggagt tgggcgtcgt ttgtcactgc tagggagcgc
      301 tgtcgctggc gtggcgtcat tcccgcggct tctgtgctcc ggctcagctc ggggcggggc
      361 gggaggatga cttcggagat ggagtcgtcg ctggaggtca gcttctcgtc cagctgtgcg
      421 gtgtcagggg cgtctgggtg tttgcctccc gcccgctccc gcatcttcaa gatcatagtg
      481 atcggcgact cgaacgtggg caagacgtgc ctgacttacc gcttctgcgc cggccgcttc
      541 cccgaccgca ccgaggccac gatcggggtg gacttccgag agcgagccgt ggatattgat
      601 ggagagcgca tcaagatcca gttgtgggac acggcagggc aggagcggtt caggaagagc
      661 atggtccagc actactacag gaatgtgcat gctgtcgtct ttgtgtatga catgaccaac
      721 atggccagct tccacagcct gccggcttgg atagaggaat gcaaacagca cttgctggcg
      781 aacgacatac ctcgaattct ggtgggaaat aaatgtgact tgagaagcgc cattcaggtg
      841 cccacagact tggcacagaa gtttgctgac acacacagta tgcctttgtt tgagacctct
      901 gctaaaaacc ccaatgataa tgaccacgta gaagctatat tcatgacctt agctcataag
      961 ctaaagagcc acaagccatt gatgcttagc cagctgcctg ataacagaat tagcctgaaa
     1021 cctgagacca agcctgcggt gacttgctgg tgctgagtca taggtgtggc cattgcgggt
     1081 ctgacttacc tgaagagatg attgggaagt gtgacagtga tgaagttcgt aagagtaaat
     1141 cctaactgta gtagatcatt ctgctgttat cgttgttatg atgccttttg tattttgcat
     1201 cctctcaatc aagtttgtca ctgagacagc acatggaaaa ggccgcttta cagtggggat
     1261 tgaaaatgaa gactaccggg gccatctttc cagctccagc cagaagcagc agcttcaagt
     1321 gagcatgatg gaccttaaat ggttggtcct cttcctctct gggtccctgg agcagcagaa
     1381 gccatgctgg gtagtgcaca catgcagagc agctggagcg agccgcaagc taatagggtg
     1441 ctttaattac tctgtcttta agcactaaaa actaatcaaa agaaagcaag cagttgtaac
     1501 aggagtttac tttagccatg acatttaatc agaatatcaa atattctggt gccccttgtc
     1561 ctctgttccc agtcacagtc agttgggtga ctcggagctg atttcagtca gcatccattt
     1621 ggctgggttc tgtatgtatg ttcctgtaat tgtattgttg gatgaggttt tgacatgcgt
     1681 gaattttatg gccttggtat aaaaattggt aaagcaaact gttccttggt ataaaaaatg
     1741 agttaagtat tgaaaaatat cttacctgtc cctcaatgat gaaagaaatg gtttagaaag
     1801 attttttttt tttgccctaa gtacttgtag tttgagttta aaactttgca caaaggaaat
     1861 agcacgttta catatgaagg tcttagcaga gtggtgtgta agctgtgctc agcctaagtc
     1921 cgcacatcct ctttgtgaca gcttgcaacc cttgccaatt ttagaggaaa tgaagccaaa
     1981 ataatgtctt acttaaatat tttcataatg tgggaaacaa acataaccca acctagtttc
     2041 agattcttgt ttcattattc tgatggtccc aactggacag ttcatttatg aaagcaaaat
     2101 tgttctattt aataaactaa gtgaaagtaa cttaagggat gattgtacaa tttaaatatt
     2161 aattcagtaa atacaatgaa atgaagatta ggacccagat tggctttctt tgtagttaga
     2221 aagatctttc tttggttcct tctttttttc ttttttttaa tagaaggtct ctctttgtgg
     2281 gcctgactgg cctgggacag gggtggcctc agacttacag ataccgacct gcctcttcct
     2341 ccagctgctg ggagttaaag gcttctgtca ccaggactag cccaatacat ctttcttaat
     2401 catgctacaa ttaaagatta aaggttgtct tctgtctaaa tgaatgctga cttgtgaact
     2461 gttttcctgg tgacacaaaa tggcggtagt gacgggtggc tgcagatgtt tgtacggagg
     2521 aacatctggt cattgttctt ccacgttctg tacaccgagg gtggggggag ctgatctgtt
     2581 ctctaagtac ctctgtggtt ttcttctgga ctgtttcagt acagaactgt taattagtca
     2641 tttttctttt taatgtaact tttcttaatg agcattctta caattctgtg aaaagcataa
     2701 ttttttcatt ttagtattta ttaatcaaaa catatttgta actcatttgt aacgacctat
     2761 cactttagtt ttagtttttt atttgaaaaa gatacaaccc aggtgagcaa ggacaacccc
     2821 tttagatgtg gtccaaggcg cttgggctta taacgcactt tatagactat tgatattact
     2881 ttcaaaatga tggtgaggtg acatcttgtt acttttttaa gcacaaatca cacattttgt
     2941 acatctgtga ttttattttg gctgacattt aatggaaagt gtcacgtttt aggaaaaaaa
     3001 atcttaattt gtgaacagca aagcaaactc ctctggcgtc tgttgtggtt ggttgacagt
     3061 gtacacctct ttgatgttct cccaacaagg atgatagttt tgctgtgaaa cagcgccacc
     3121 tttaacactt ctcccataac gtacaataaa tcatctttgc cacgaggaag cgtttctttc
     3181 tttggttttc tgggttgaat gtaaaattaa agaacgtact tcttcctgtc tactgtggtt
     3241 ttcagaaaat atgtacggcc tacagttcgt tcatttgaaa atcccaaatc tggggctggt
     3301 gagatggctc agtgggtaag agcacctgac tgctcttccg aaggtccaga gttcaaatcc
     3361 cagcaaccac atggtggctc acaaccatcc gtaacgagat ctgactccct cttctggagt
     3421 gtctgaagac agctacaatg tacttacata taataaataa ataaatcttt aaaaaaaaaa
     3481 aaaaaaaa
//
