LOCUS       NM_133685               3476 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus RAB31, member RAS oncogene family (Rab31), mRNA.
ACCESSION   NM_133685 NM_134121
VERSION     NM_133685.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3476)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3476)
  AUTHORS   Qiu,C., Liu,Y., Huang,S., Ning,B., He,S. and Zhong,L.
  TITLE     Rab31 promotes activation of hepatic stellate cells by accelerating
            TGF-beta receptor II complex endocytosis
  JOURNAL   Int J Biochem Cell Biol 144, 106170 (2022)
   PUBMED   35091093
  REMARK    GeneRIF: Rab31 promotes activation of hepatic stellate cells by
            accelerating TGF-beta receptor II complex endocytosis.
REFERENCE   3  (bases 1 to 3476)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3476)
  AUTHORS   Zhang,M., Chen,D., Xia,J., Han,W., Cui,X., Neuenkirchen,N.,
            Hermes,G., Sestan,N. and Lin,H.
  TITLE     Post-transcriptional regulation of mouse neurogenesis by Pumilio
            proteins
  JOURNAL   Genes Dev 31 (13), 1354-1369 (2017)
   PUBMED   28794184
REFERENCE   5  (bases 1 to 3476)
  AUTHORS   Yeo,J.C., Wall,A.A., Luo,L. and Stow,J.L.
  TITLE     Rab31 and APPL2 enhance FcgammaR-mediated phagocytosis through
            PI3K/Akt signaling in macrophages
  JOURNAL   Mol Biol Cell 26 (5), 952-965 (2015)
   PUBMED   25568335
  REMARK    GeneRIF: Rab31, with APPL2 as its effector, play a role in
            FcgammaR-mediated phagocytosis through PI3K/Akt signaling in
            macrophages.
REFERENCE   6  (bases 1 to 3476)
  AUTHORS   Chua,C.E. and Tang,B.L.
  TITLE     Engagement of the small GTPase Rab31 protein and its effector,
            early endosome antigen 1, is important for trafficking of the
            ligand-bound epidermal growth factor receptor from the early to the
            late endosome
  JOURNAL   J Biol Chem 289 (18), 12375-12389 (2014)
   PUBMED   24644286
REFERENCE   7  (bases 1 to 3476)
  AUTHORS   Luo,L., King,N.P., Yeo,J.C., Jones,A. and Stow,J.L.
  TITLE     Single-step protease cleavage elution for identification of
            protein-protein interactions from GST pull-down and mass
            spectrometry
  JOURNAL   Proteomics 14 (1), 19-23 (2014)
   PUBMED   24259493
REFERENCE   8  (bases 1 to 3476)
  AUTHORS   Ng,E.L., Ng,J.J., Liang,F. and Tang,B.L.
  TITLE     Rab22B is expressed in the CNS astroglia lineage and plays a role
            in epidermal growth factor receptor trafficking in A431 cells
  JOURNAL   J Cell Physiol 221 (3), 716-728 (2009)
   PUBMED   19725050
  REMARK    GeneRIF: Rab22B is exceptionally enriched in nestin and
            RC2-positive radial glia of the embryonic mouse brain. In the adult
            brain, Rab22B is rather specifically expressed in glial fibrillary
            acidic protein (GFAP)-positive mature astrocytes.
REFERENCE   9  (bases 1 to 3476)
  AUTHORS   Lodhi,I.J., Chiang,S.H., Chang,L., Vollenweider,D., Watson,R.T.,
            Inoue,M., Pessin,J.E. and Saltiel,A.R.
  TITLE     Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates
            Glut4 trafficking in adipocytes
  JOURNAL   Cell Metab 5 (1), 59-72 (2007)
   PUBMED   17189207
  REMARK    GeneRIF: Insulin recruits the CIP4/Gapex-5 complex to the plasma
            membrane, thus reducing Rab31 activity and permitting Glut4
            vesicles to translocate to the cell surface, where Glut4 docks and
            fuses to transport glucose into the cell.
REFERENCE   10 (bases 1 to 3476)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139751.2, AK051270.1, AK159095.1, AC166058.2 and BY761495.1.
            
            On Mar 24, 2009 this sequence version replaced NM_133685.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156677.1, BC013063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC139751.2         35215-35295
            82-357              AK051270.1         2-277
            358-1037            AK159095.1         247-926
            1038-3216           AC166058.2         188074-190252       c
            3217-3476           BY761495.1         436-695
FEATURES             Location/Qualifiers
     source          1..3476
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 35.03 cM"
     gene            1..3476
                     /gene="Rab31"
                     /gene_synonym="1700093E07Rik; Rab22B"
                     /note="RAB31, member RAS oncogene family"
                     /db_xref="GeneID:106572"
                     /db_xref="MGI:MGI:1914603"
     exon            1..247
                     /gene="Rab31"
                     /gene_synonym="1700093E07Rik; Rab22B"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..796
                     /gene="Rab31"
                     /gene_synonym="1700093E07Rik; Rab22B"
                     /codon_start=1
                     /product="ras-related protein Rab-31"
                     /protein_id="NP_598446.2"
                     /db_xref="CCDS:CCDS50166.1"
                     /db_xref="GeneID:106572"
                     /db_xref="MGI:MGI:1914603"
                     /translation="MMAIRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFM
                     TKTVPCGNELHKFLIWDTAGQERFHSLAPMYYRGSAAAVIVYDITKQDSFHTLKKWVK
                     ELKEHGPENIVMAIAGNKCDLSDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELF
                     QGISRQIPPLGPQENGNSGGIKLGNQSLQASRRCC"
     exon            248..327
                     /gene="Rab31"
                     /gene_synonym="1700093E07Rik; Rab22B"
                     /inference="alignment:Splign:2.1.0"
     exon            328..409
                     /gene="Rab31"
                     /gene_synonym="1700093E07Rik; Rab22B"
                     /inference="alignment:Splign:2.1.0"
     exon            410..481
                     /gene="Rab31"
                     /gene_synonym="1700093E07Rik; Rab22B"
                     /inference="alignment:Splign:2.1.0"
     exon            482..588
                     /gene="Rab31"
                     /gene_synonym="1700093E07Rik; Rab22B"
                     /inference="alignment:Splign:2.1.0"
     exon            589..698
                     /gene="Rab31"
                     /gene_synonym="1700093E07Rik; Rab22B"
                     /inference="alignment:Splign:2.1.0"
     exon            699..3476
                     /gene="Rab31"
                     /gene_synonym="1700093E07Rik; Rab22B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3454..3459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab31"
                     /gene_synonym="1700093E07Rik; Rab22B"
                     /note="hexamer: AATAAA"
     polyA_site      3473
                     /gene="Rab31"
                     /gene_synonym="1700093E07Rik; Rab22B"
                     /note="major polyA site"
ORIGIN      
        1 gaagcccggc ggccaggcta gactagacgt gacgggagga gccggccggc agcacgtgac
       61 cgacagcgga ggccgaggcc cagaaatagc cgccttggcg gttccgcccc gcggccggcg
      121 agagtcctgg gagacagcag gacgcaggct gggcgcggtg tggcccggac gatgctgctg
      181 agccccggcc gggcccgacc cagagcacat gatggcgata cgggagctca aagtgtgtct
      241 tctcggggac acgggggttg ggaaatccag cattgtgtgt cgttttgtcc aggatcactt
      301 tgaccacaac atcagcccca ctattggggc atctttcatg accaaaaccg tgccttgtgg
      361 aaatgaactt cacaaattcc tcatctggga caccgctggc caggagcggt tccactccct
      421 ggctcctatg tactaccgag gatctgctgc agccgtcatc gtctatgaca tcactaagca
      481 ggattcattt cataccttga aaaaatgggt caaggagctg aaggagcacg gcccagaaaa
      541 cattgtgatg gcgattgctg ggaacaagtg tgacctctct gatattaggg aggtgcccct
      601 gaaggacgct aaggagtacg ctgaatccat aggtgccatc gtggtggaga ccagcgcgaa
      661 gaatgccatt aacatcgagg agctctttca aggaatcagc cgccagatcc cacccttggg
      721 ccctcaggaa aatggaaaca gcggcgggat caagcttggg aatcagagct tgcaagccag
      781 ccgtcggtgc tgctgagcca agggcatggc atacagagta agaaggaagg agccagagcc
      841 ctctttgttg gtgtccagtg cacacacaag gaccccaccc gtggggctaa ctacctgccg
      901 gagagtgagc agctttgtac cctgggacac ctgctgcagg atgctgaaca gggacgtttc
      961 ctgcaaagaa atgatagaaa actctggaaa actcaccacc accgcaacat ggccttcagt
     1021 ttatgaaatg cacacagcaa ggcttgtact tgctaggtaa tagatatagt tgccgttttt
     1081 tttttttttt tttgttaaag aggtattaga aaagttttag attggtccac acacctcaga
     1141 gtgctgttct ttgctaattt cctatgtcac ctaggcaatc tcaataatgt ctccagggcc
     1201 agggccttcc tttctggcca gttcaccaaa aggcaaaggc tataatagga ggttagcgct
     1261 tagctggctt tggaagtaag tctttattag ttttctgagg gagatcagag atgcacagct
     1321 ggaccactgc ttaaactgaa aagtgaactc ctgtaagaga gacaaaagtt gcattagaaa
     1381 ccaccatccc tatctccttt catttatctg atggacattt ttctaaggta tggtcatctg
     1441 taacccaacc aaatcaaact agaatgttac atataatttt ggagtggtgg gggctgatga
     1501 aaagagttaa aattagttgc tatataagca gtggtggttg gaagatctaa atgggattcg
     1561 gggtaccccc aagcatgcac ccccctattg cagtgagttt ctacttttgg ggtgatcact
     1621 tcacagagca ttaggagaca atgtcatgat gtcacatctg gggatgtttg agcctaaatt
     1681 gtagggaaga cttctgttaa tagcagctaa tcataggttg tagcaaacca ggcagagaca
     1741 tgttaccacc ctcaaattct ggacccctaa aggtgtgaaa tcagaagaca tccttaaact
     1801 ttgccaactt tggagagaaa gggtgtcaaa cagtcagtgc ccagttcatt gacggtgctt
     1861 gtccgctcca ggacgtgagc ctcaacatag tcttcctgct tctcccaact tgggagctaa
     1921 ttgagtccta gaatacaggg gatagcaaat acttgtcctg attcaagaga atcaagactc
     1981 ctacatgtcc catagcagga gtctcactgt cagcaaatgg catctgtatg ctgtgccaga
     2041 cttctcaaga ccatcagtgc ctatcccatg tctccaatat cagcagctga caggattccc
     2101 catgctggca aagacattcg tccactcact acaggtcaaa caaacagaga acgattgagc
     2161 tgaagttgag gtgacctctc tcgagtacca agcttagttt tgaatctttc cccatttttg
     2221 gggggaacct tttgccggga gcttgtattt acctggatga cggtctagat ttccaagcca
     2281 aattggtact gttcccagga gaggatgccc cagctttgga ttgggtttgc agtggttgag
     2341 ttttgcatga actgtctggg cttcaccttg agagtgagct gccctgggtt ggatcagaga
     2401 agcattgtga gggtacgacc ccttgctttt ccccaggctg catgctgttg atgtcacagc
     2461 catgcagggg gtaagtgtgc acacgtgcca ccagcctgag cagagagaga cgtggcttgg
     2521 gcacacaact actcacacca ctttgagcct tctctgcagg taggtgctaa ggcctttgat
     2581 gcttctcctc ttggcttggc attccttttg ggatgttttt aaccactgac cctcgacaaa
     2641 gacctagaca cgacaattgc tccagacata ggatgtagtg tccttatggc tactccccaa
     2701 attctgttcc caacccccat tttcttatct ctcacaggtg agcgggtttg tatatgtgta
     2761 aatatggttt ttatgtcaac tgcacctaca tgtaatccat tttagagtgg ctgtgtttgg
     2821 ctcgtgacct tgtgcccata agtgaggcac agaatgtcaa agggattctt tctcaggaga
     2881 cgtccccaaa ggacagtggc agggctgtgc aaatgtttta tacaggtaca gaattgactc
     2941 accatttttt tttcattaaa agtggtatat tagggtactg gatatgacgt catcttgcag
     3001 actaacctgc atcctagcca acagcaaggg ctgtgcccca gtaggaatcc cgttctttcc
     3061 tgaggttagg tttggaggat caacatgttt cctccgccat aatggactct ggcttgtgta
     3121 ggcttcttgc tgctccgtag cattccgggc gaggcgtaag gaggcagtgg tggtcagcca
     3181 gggattctgg ctgtgctcat gtgatcacgg ctttcaccat tgtcgtgaca cccagtgact
     3241 cagcagtcat accgtcacac agactgtcgc cctctccggt gtttttgtaa agggtttcca
     3301 cttgggctgg acccaggttt ggtacctaga agatccttct gcagacaccg aggaccttcg
     3361 catcttgtac tctgttctct gataacgagt ttcgggttgg cgctcctttg tatcaattgc
     3421 ttttgatttt aacccattgg tatgattcct actaataaat attttaagtt ttactg
//
