LOCUS       NM_172601               2770 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus RAB2B, member RAS oncogene family (Rab2b), mRNA.
ACCESSION   NM_172601
VERSION     NM_172601.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2770)
  AUTHORS   Wang,H., Iida-Norita,R., Mashiko,D., Pham,A.H., Miyata,H. and
            Ikawa,M.
  TITLE     Golgi associated RAB2 interactor protein family contributes to
            murine male fertility to various extents by assuring correct
            morphogenesis of sperm heads
  JOURNAL   PLoS Genet 20 (6), e1011337 (2024)
   PUBMED   38935810
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2770)
  AUTHORS   Morohoshi,A., Miyata,H., Oyama,Y., Oura,S., Noda,T. and Ikawa,M.
  TITLE     FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome
            formation and male fertility in mice
  JOURNAL   Development 148 (21) (2021)
   PUBMED   34714330
REFERENCE   3  (bases 1 to 2770)
  AUTHORS   Takahama,M., Fukuda,M., Ohbayashi,N., Kozaki,T., Misawa,T.,
            Okamoto,T., Matsuura,Y., Akira,S. and Saitoh,T.
  TITLE     The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate
            Immune Responses
  JOURNAL   Cell Rep 20 (12), 2944-2954 (2017)
   PUBMED   28930687
  REMARK    GeneRIF: the RAB2B-GARIL5 complex promotes IFN responses against
            DNA viruses by regulating the cGAS-STING signaling axis.
REFERENCE   4  (bases 1 to 2770)
  AUTHORS   Fujita,N., Huang,W., Lin,T.H., Groulx,J.F., Jean,S., Nguyen,J.,
            Kuchitsu,Y., Koyama-Honda,I., Mizushima,N., Fukuda,M. and
            Kiger,A.A.
  TITLE     Genetic screen in Drosophila muscle identifies autophagy-mediated
            T-tubule remodeling and a Rab2 role in autophagy
  JOURNAL   Elife 6, e23367 (2017)
   PUBMED   28063257
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2770)
  AUTHORS   Fukuda,M., Kanno,E., Ishibashi,K. and Itoh,T.
  TITLE     Large scale screening for novel rab effectors reveals unexpected
            broad Rab binding specificity
  JOURNAL   Mol Cell Proteomics 7 (6), 1031-1042 (2008)
   PUBMED   18256213
REFERENCE   6  (bases 1 to 2770)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   7  (bases 1 to 2770)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   8  (bases 1 to 2770)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   9  (bases 1 to 2770)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY020048.1, AK038393.1 and BI732997.1.
            
            On Oct 20, 2009 this sequence version replaced NM_172601.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046334.1, SRR1660815.60895.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               BY020048.1         2-381
            381-1871            AK038393.1         316-1806
            1872-2248           AK038393.1         1808-2184
            2249-2770           BI732997.1         1-522
FEATURES             Location/Qualifiers
     source          1..2770
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.87 cM"
     gene            1..2770
                     /gene="Rab2b"
                     /gene_synonym="1500012D09Rik; 4930528G15Rik; A230002G14;
                     D530043M21Rik"
                     /note="RAB2B, member RAS oncogene family"
                     /db_xref="GeneID:76338"
                     /db_xref="MGI:MGI:1923588"
     exon            1..200
                     /gene="Rab2b"
                     /gene_synonym="1500012D09Rik; 4930528G15Rik; A230002G14;
                     D530043M21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..805
                     /gene="Rab2b"
                     /gene_synonym="1500012D09Rik; 4930528G15Rik; A230002G14;
                     D530043M21Rik"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-2B"
                     /protein_id="NP_766189.1"
                     /db_xref="CCDS:CCDS27052.1"
                     /db_xref="GeneID:76338"
                     /db_xref="MGI:MGI:1923588"
                     /translation="MTYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFG
                     ARMVNIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRETFNHLTSWLE
                     DARQHSSSNMVIMLIGNKSDLESRRDVKREEGEAFAREHGLIFMETSAKTACNVEEAY
                     INTAKEIYRKIQQGLFDVHNEANGIKIGPQQSITSSVGPCSPQQNVSDIGPDSGCC"
     exon            201..272
                     /gene="Rab2b"
                     /gene_synonym="1500012D09Rik; 4930528G15Rik; A230002G14;
                     D530043M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            273..340
                     /gene="Rab2b"
                     /gene_synonym="1500012D09Rik; 4930528G15Rik; A230002G14;
                     D530043M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            341..423
                     /gene="Rab2b"
                     /gene_synonym="1500012D09Rik; 4930528G15Rik; A230002G14;
                     D530043M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            424..516
                     /gene="Rab2b"
                     /gene_synonym="1500012D09Rik; 4930528G15Rik; A230002G14;
                     D530043M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            517..628
                     /gene="Rab2b"
                     /gene_synonym="1500012D09Rik; 4930528G15Rik; A230002G14;
                     D530043M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            629..697
                     /gene="Rab2b"
                     /gene_synonym="1500012D09Rik; 4930528G15Rik; A230002G14;
                     D530043M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            698..2756
                     /gene="Rab2b"
                     /gene_synonym="1500012D09Rik; 4930528G15Rik; A230002G14;
                     D530043M21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2729..2734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab2b"
                     /gene_synonym="1500012D09Rik; 4930528G15Rik; A230002G14;
                     D530043M21Rik"
                     /note="hexamer: AATATA"
     polyA_site      2750
                     /gene="Rab2b"
                     /gene_synonym="1500012D09Rik; 4930528G15Rik; A230002G14;
                     D530043M21Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaagatttct gggggagagc aatagagacg cagcttgagc tagaagggct ggagcggagg
       61 caaataagga gacccgtaga ttgagtggct agagaggtcg gaggtaagtg gctgtagaaa
      121 tcgggaggac ccggaacaca gacgcctcgg gaccatgact tacgcttatc tcttcaagta
      181 catcatcatc ggagacacag gtgtggggaa gtcatgtctc ctccttcagt ttaccgacaa
      241 gcggttccag cccgtgcacg acctcacaat aggtgtggag tttggagcac gtatggtcaa
      301 catcgatgga aaacaaatca aactgcaaat ctgggatacg gctgggcaag agtccttccg
      361 ttctatcacc cgttcctact acaggggagc agctggagcc ctgctggtgt atgacatcac
      421 gagacgcgaa accttcaacc acctgacctc atggttagag gacgcccgcc agcactccag
      481 ctccaacatg gttataatgc tgatcgggaa taagagtgat ctagaatctc gaagggatgt
      541 gaagagagag gaaggagagg cctttgctcg tgagcacggc cttatattca tggaaacatc
      601 agccaagaca gcctgcaatg ttgaagaggc ctacattaat acagccaaag aaatatatag
      661 gaagatccag caaggtttat ttgatgtcca caatgaggca aatggcatca agattgggcc
      721 ccagcagtca attacctcct cagtaggacc gtgctcccct cagcagaacg tttctgacat
      781 agggcctgac tctggctgct gctgaacacc gggcctgagt gagcgctttc tctttcctct
      841 cggggagcag cttcaggtca gccagcgcca cgaaggagat cctcgttgct taggctgaga
      901 gcagcctctt ttcagtgtgc gatgtttcac ccttccactt aaaacatgag gagaaaattg
      961 ggccctttcc gacctgtcct cctttaggga catgagcatt ccgcgtagat tatggctctt
     1021 tcaccctcta gtttctaaaa tgttagaatc aaagttgatt gtcacagtag ctaaaaggca
     1081 aacaacttgc tgtcaacatc tatttgctag gtgttatggc acatacccat aatttcagca
     1141 ctcaggactt ttggcaaaag gattgccagg agttttggag tcagtctggg ctacataagt
     1201 ttccctaggc catctgtcta aaaaagccaa aaagaaaaga gagaaaggaa taaatacatg
     1261 tgtctgttcc tcacccaatt tttagttgct aaggtgaagg atattctgat ataacattta
     1321 gaattaaggg tctgagtagc ctttgggtga tagatctata catagtgatt tcattgcgtg
     1381 tatttccttg ccttggaaac ctgtgtgtca tatgataaga gttcctatag aagctgagtg
     1441 cctctgcact gtctcgttgc cagctccttt ttatttatta tgtgtgtaca accttgagca
     1501 tcattcctta ggatccccgc acatgggccc cacatctcta gagtgccatg cttaggcaag
     1561 gcttgctggc ctttttcatt gctagttctt ttccttaact acagaacgta gaaagcagtg
     1621 gagtgggtac cggacctgtc gccacacacc cttacctaag aaaacataag ttgttcattt
     1681 tgcttaaagg accagttcta gcattacatt ttcttttacc gaattgctct ctctactgtt
     1741 acacacacac acacacacac acacacacac acaggcacac atgcgagccc gtgcacatgc
     1801 cctggagatt aagctaggtt cttaaacatg cttaggaagt gctgaacctg agctgtgccc
     1861 tcaggagcct tctcttactt acactttttg tttacagaca ggttgctgag gctggctttg
     1921 aacttgggat cctgaggctt cagactccca ggtggctgtt tattctctct aaccagctct
     1981 gttagatatt tcctctaatc aagctaattg gttactgaaa tgacatattt atcccaactt
     2041 ctgtaccttt gcacaaactc taccctctga ccctccacta ccatcatact gacactcttt
     2101 tcctttagga aaccctcact gactgaccta gggagcccta cgaagttgtt aacacagtac
     2161 ttcttagcat tcctacgtta tccatatgta tatttatttg tatgtgtttc acgttataaa
     2221 tgttttgtag tgaacccagg gtgggtgagg gggaagcatc tgtctcacat aggctgtaag
     2281 ctctctgaga gcaggcacct gtcatcccag tccatcccac cgttccctta ctgtactctg
     2341 caactcacca tctggaatta agtgacatgc tttaaaactt aagagtttag aagaaacaaa
     2401 aggccttaga gtcatctcta tgtaattgta tcctggtttc cccatctcct tatcctgatt
     2461 tctcattgct cttctgtcct gcctcactgt aactgcctcc attctgtgca gtctacagta
     2521 agaatgcctg cttccaagac tcagatacat agggacgttt ttacccgttc cgtagactct
     2581 gtaactgtca gcccagtttg cctctgctga ctcctggcat cacctcctgg gacacttgct
     2641 gtctttttta cttgtctcat tttctttcac agcactgagg tctcaccaaa ttttctaatt
     2701 tttattgtta atgaccgttt tactattaaa tatatgcatg atccaagcta cttttaaaaa
     2761 aaaaaaaaaa
//
